santonin and hydrastine

santonin has been researched along with hydrastine* in 1 studies

Other Studies

1 other study(ies) available for santonin and hydrastine

Article	Year
Expanding the repertoire of small molecule transcriptional activation domains. Bioorganic & medicinal chemistry, 2009, Feb-01, Volume: 17, Issue:3 Molecules that can reconstitute the function of transcriptional activators hold enormous potential as therapeutic agents and as mechanistic probes. Previously we described an isoxazolidine bearing functional groups similar to natural transcriptional activators that up-regulates transcription 80-fold at 1 microM in cell culture. In this study, we analyze analogs of this molecule to define key characteristics of small molecules that function as transcriptional activation domains in cells. Conformational rigidity is an important contributor to function as is an overall amphipathic substitution pattern. Using these criteria, we identified additional molecular scaffolds with excellent (approximately 60-fold) activity as transcriptional activation domains. These results point the way for the creation of new generations of small molecules with this function. Topics: Benzylisoquinolines; Cell Line; HeLa Cells; Humans; Isoxazoles; Protein Structure, Tertiary; Santonin; Trans-Activators; Transcription, Genetic	2009

Article

Year

Expanding the repertoire of small molecule transcriptional activation domains.

Bioorganic & medicinal chemistry, 2009, Feb-01, Volume: 17, Issue:3

Molecules that can reconstitute the function of transcriptional activators hold enormous potential as therapeutic agents and as mechanistic probes. Previously we described an isoxazolidine bearing functional groups similar to natural transcriptional activators that up-regulates transcription 80-fold at 1 microM in cell culture. In this study, we analyze analogs of this molecule to define key characteristics of small molecules that function as transcriptional activation domains in cells. Conformational rigidity is an important contributor to function as is an overall amphipathic substitution pattern. Using these criteria, we identified additional molecular scaffolds with excellent (approximately 60-fold) activity as transcriptional activation domains. These results point the way for the creation of new generations of small molecules with this function.

Topics: Benzylisoquinolines; Cell Line; HeLa Cells; Humans; Isoxazoles; Protein Structure, Tertiary; Santonin; Trans-Activators; Transcription, Genetic

2009