salvinorin a has been researched along with u 69593 in 18 studies
| Studies (salvinorin a) | Trials (salvinorin a) | Recent Studies (post-2010) (salvinorin a) | Studies (u 69593) | Trials (u 69593) | Recent Studies (post-2010) (u 69593) |
|---|---|---|---|---|---|
| 247 | 7 | 128 | 524 | 0 | 75 |
| Protein | Taxonomy | salvinorin a (IC50) | u 69593 (IC50) |
|---|---|---|---|
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0006 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.194 | |
| Delta-type opioid receptor | Homo sapiens (human) | 3.6437 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0021 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.058 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.588 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (55.56) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gilmour, B; Harding, WW; Holden, KG; Kannan, P; Navarro, H; Prisinzano, TE; Rothman, RB; Schmidt, M; Tidgewell, K | 1 |
| Dersch, CM; Deschamps, JR; Harding, WW; Katavic, PL; Lozama, A; Navarro, H; Parrish, D; Partilla, JS; Prisinzano, TE; Rothman, RB; Simpson, DS | 1 |
| Holden, KG; Marquam, A; Navarro, H; Prisinzano, TE; Rothman, RB; Tidgewell, K | 1 |
| Fujii, H; Hirono, S; Nagase, H; Yamaotsu, N | 1 |
| Araya, JJ; Butelman, ER; Day, VW; Dersch, CM; Kreek, MJ; Lovell, KM; Lozama, A; Prevatt-Smith, KM; Prisinzano, TE; Rothman, RB; Vasiljevik, T | 1 |
| Aubé, J; Frankowski, KJ; Katritch, V; Mosier, PD; Roth, BL; Stevens, RC; Vardy, E; Westkaemper, RB; Wu, H | 1 |
| Fujii, H; Hirayama, S; Hirono, S; Iwai, T; Kuroda, N; Nagase, H; Wada, N; Yamaotsu, N | 1 |
| Ewald, AW; Groer, CE; Kivell, BM; Prisinzano, TE; Riley, AP; Young, D | 1 |
| Cheng, J; McCorvy, JD; Tan, L; Yan, W | 1 |
| Che, T; Kalinin, DV; Loser, K; Mykicki, N; Schepmann, D; Ständer, S; Tangherlini, G; Wünsch, B | 1 |
| Fantegrossi, WE; Koreeda, M; Kugle, KM; Valdes, LJ; Woods, JH | 1 |
| Butelman, ER; Kreek, MJ; Mandau, M; Prisinzano, TE; Tidgewell, K; Yuferov, V | 1 |
| Kinder, DH; Krall, DM; McCurdy, CR; Willmore-Fordham, CB | 1 |
| Béguin, C; Berry, L; Carlezon, WA; Cohen, BM; Dinieri, JA; Liu-Chen, LY; Munro, TA; Paine, TA; Potter, DN; Richards, MR; Roth, BL; Xu, W; Zhao, Z | 1 |
| Beerepoot, P; Lam, V; Luu, A; Siebert, D; Szechtman, H; Tsoi, B | 1 |
| Baker, LE; Bell, LM; Haliw, LA; Killinger, BA; Panos, JJ; Peet, MM; Walker, SL | 1 |
| Kivell, B; Morani, AS; Prisinzano, TE; Schenk, S | 1 |
| Chefer, VI; Shippenberg, TS; Tejeda, HA; Zapata, A | 1 |
1 review(s) available for salvinorin a and u 69593
| Article | Year |
|---|---|
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.
Topics: Animals; Drug Discovery; Humans; Ligands; Receptors, G-Protein-Coupled; Signal Transduction; Structure-Activity Relationship | 2018 |
17 other study(ies) available for salvinorin a and u 69593
| Article | Year |
|---|---|
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A.
Topics: Diterpenes; Diterpenes, Clerodane; Humans; Molecular Structure; Plants, Medicinal; Receptors, Opioid, delta; Receptors, Opioid, mu; Salvia; Stereoisomerism | 2006 |
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Diterpenes, Clerodane; Furans; Humans; Molecular Structure; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salvia; Stereoisomerism; Structure-Activity Relationship | 2007 |
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position.
Topics: Binding, Competitive; Diterpenes; Diterpenes, Clerodane; Drug Evaluation, Preclinical; Furans; Humans; Molecular Structure; Pyrones; Receptors, Opioid, mu; Recombinant Proteins; Salvia; Structure-Activity Relationship | 2007 |
Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists.
Topics: Models, Chemical; Models, Molecular; Receptors, Opioid, kappa | 2010 |
Semisynthetic neoclerodanes as kappa opioid receptor probes.
Topics: Animals; Biomarkers; Diterpenes; Diterpenes, Clerodane; Humans; Macaca mulatta; Male; Microwaves; Neurons; Protein Binding; Receptors, Opioid, kappa; Salvia; Structure-Activity Relationship | 2012 |
Chemotype-selective modes of action of κ-opioid receptor agonists.
Topics: Analgesics, Opioid; Binding Sites; Crystallography, X-Ray; Dynorphins; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Receptors, Opioid, kappa; Structure-Activity Relationship | 2013 |
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Molecular Conformation; Receptors, Opioid, kappa; Structure-Activity Relationship | 2014 |
Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues.
Topics: Animals; CHO Cells; Cricetulus; Diterpenes, Clerodane; Furans; Hallucinogens; Male; Models, Molecular; Molecular Structure; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Salvia; Structure-Activity Relationship | 2014 |
Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.
Topics: Animals; Antineoplastic Agents; Binding Sites; Encephalomyelitis, Autoimmune, Experimental; HEK293 Cells; Humans; Interferon-gamma; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Protein Structure, Tertiary; Quinoxalines; Receptors, Opioid, kappa; Signal Transduction; Structure-Activity Relationship; Th1 Cells | 2019 |
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Diterpenes; Diterpenes, Clerodane; Hallucinogens; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil | 2005 |
Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans.
Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Biomarkers; Cloning, Molecular; Diterpenes; Diterpenes, Clerodane; Female; Hallucinogens; Humans; Macaca mulatta; Male; Molecular Sequence Data; Naltrexone; Prolactin; Pyrrolidines; Receptors, Opioid, kappa; Sex Characteristics | 2007 |
The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats.
Topics: Animals; Benzeneacetamides; Discrimination Learning; Diterpenes; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Hallucinogens; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Salvia | 2007 |
N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy.
Topics: Acetamides; Administration, Oral; Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Diterpenes; Diterpenes, Clerodane; Humans; Male; Membrane Transport Proteins; Microsomes, Liver; Mood Disorders; Psychotropic Drugs; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid, kappa; Salvia; Treatment Outcome | 2008 |
Effects of salvinorin A on locomotor sensitization to D2/D3 dopamine agonist quinpirole.
Topics: Analgesics; Animals; Benzeneacetamides; Central Nervous System; Diterpenes, Clerodane; Dopamine; Dopamine Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Drug Synergism; Male; Motor Activity; Pyrrolidines; Quinpirole; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Opioid, kappa; Synaptic Transmission | 2008 |
Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Discrimination, Psychological; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Hallucinogens; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Salvia | 2009 |
Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Benzeneacetamides; Cocaine; Diterpenes, Clerodane; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Administration | 2009 |
The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Corticotropin-Releasing Hormone; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Ligands; Male; Naltrexone; Neural Inhibition; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex, Startle | 2010 |