salvinorin a has been researched along with u-50488 in 18 studies
| Studies (salvinorin a) | Trials (salvinorin a) | Recent Studies (post-2010) (salvinorin a) | Studies (u-50488) | Trials (u-50488) | Recent Studies (post-2010) (u-50488) |
|---|---|---|---|---|---|
| 247 | 7 | 128 | 1,664 | 3 | 209 |
| Protein | Taxonomy | salvinorin a (IC50) | u-50488 (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 2.15 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0027 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 2.15 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.7171 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0958 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0537 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (66.67) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Béguin, C; Carlezon, WA; Chen, Y; Cohen, BM; Lee, DY; Liu-Chen, LY; Ma, Z; Richards, MR; Wang, Y | 1 |
| Béguin, C; Carlezon, WA; Cohen, BM; Li, JG; Liu-Chen, LY; Richards, MR; Wang, Y; Xu, W | 1 |
| Carlezon, WA; Cohen, B; He, M; Lee, DY; Li, JG; Liu-Chen, LY; Ma, Z; Wang, Y; Xu, W | 1 |
| Béguin, C; Carlezon, WA; Cohen, BM; Duncan, KK; Liu-Chen, LY; Munro, TA; Wang, Y; Xu, W | 1 |
| Bohn, LM; Dersch, CM; Groer, CE; Harding, WW; Hiemstra, J; Lozama, A; Marquam, A; Partilla, JS; Prisinzano, TE; Rothman, RB; Schmidt, M; Tidgewell, K | 1 |
| Béguin, C; Carlezon, WA; Cohen, BM; Duncan, KK; Ho, DM; Liu-Chen, LY; Munro, TA; Xu, W | 1 |
| Fujii, H; Hirono, S; Nagase, H; Yamaotsu, N | 1 |
| Deng, G; Guo, L; Lee, DY; Liu-Chen, LY; Xu, W; Yang, L | 1 |
| Béguin, C; Bohn, LM; Carlezon, WA; Cohen, BM; Groer, CE; Liu-Chen, LY; Potuzak, J; Streicher, JM; Xu, W | 1 |
| Cowan, A; Holzgrabe, U; Huang, P; Inan, S; Lee, DY; Li, JG; Liu-Chen, LY; Siebert, D; Tang, K; Wang, Y | 1 |
| Aviello, G; Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Kutrzeba, L; Sarnelli, G; Zjawiony, J | 1 |
| Benaderet, TS; Bishop-Mathis, K; Dersch, CM; Partilla, JS; Prisinzano, TE; Rothman, RB; Simpson, DS; Wang, X; Xu, H | 1 |
| Cowan, A; Inan, S; Lee, DY; Liu-Chen, LY | 1 |
| Baker, LE; Bell, LM; Haliw, LA; Killinger, BA; Panos, JJ; Peet, MM; Walker, SL | 1 |
| Kivell, B; Morani, AS; Prisinzano, TE; Schenk, S | 1 |
| Chefer, VI; Shippenberg, TS; Tejeda, HA; Zapata, A | 1 |
| Berg, KA; Chavera, TA; Clarke, WP; Jacobs, BA; Jamshidi, RJ; Prisinzano, TE; Saylor, RM; Sullivan, LC | 1 |
| Blough, BE; Brasfield, M; Follett, ME; Freeman, KB; Huskinson, SL; Platt, DM; Prisinzano, TE | 1 |
18 other study(ies) available for salvinorin a and u-50488
| Article | Year |
|---|---|
Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2).
Topics: Animals; CHO Cells; Cricetinae; Diterpenes; Diterpenes, Clerodane; Drug Evaluation, Preclinical | 2005 |
Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18).
Topics: Amides; Amines; Animals; Carbon; CHO Cells; Cricetinae; Diterpenes; Diterpenes, Clerodane; Esters; Humans; Molecular Structure; Receptors, Opioid, kappa; Structure-Activity Relationship | 2006 |
Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Diterpenes; Diterpenes, Clerodane; Humans; Receptors, Opioid, kappa | 2006 |
Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers.
Topics: Alcohols; Diterpenes; Diterpenes, Clerodane; Ethers; Methylation; Molecular Structure; Receptors, Opioid, kappa; Structure-Activity Relationship | 2008 |
Herkinorin analogues with differential beta-arrestin-2 interactions.
Topics: Arrestins; beta-Arrestin 2; beta-Arrestins; Cell Line; Diterpenes; Diterpenes, Clerodane; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor.
Topics: Diterpenes, Clerodane; Furans; Receptors, Opioid, kappa; Structure-Activity Relationship | 2009 |
Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists.
Topics: Models, Chemical; Models, Molecular; Receptors, Opioid, kappa | 2010 |
Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A.
Topics: Diterpenes, Clerodane; Halogenation; Isomerism; Kinetics; Positron-Emission Tomography; Protein Binding; Receptors, Opioid, kappa; Salvia; Structure-Activity Relationship | 2010 |
Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.
Topics: Cell Line, Tumor; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Humans; Molecular Conformation; Receptors, Opioid, kappa; Signal Transduction; Structure-Activity Relationship | 2012 |
Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antipruritics; Aza Compounds; Binding, Competitive; Diterpenes; Diterpenes, Clerodane; Down-Regulation; Endocytosis; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrocarbons, Fluorinated; Male; Mice; Morphinans; Nociceptin Receptor; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Sulfur Radioisotopes | 2005 |
The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Diterpenes; Diterpenes, Clerodane; Gastrointestinal Motility; Hallucinogens; Inflammation; Male; Mice; Mice, Inbred ICR; Plant Extracts; Plant Leaves; Receptors, Opioid, kappa; Salvia | 2008 |
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzamides; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Female; Furans; Gene Expression; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Morphine; Oligopeptides; Piperazines; Pyrones; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diterpenes, Clerodane; Diuresis; Diuretics; Dose-Response Relationship, Drug; Male; Morphinans; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spiro Compounds; Structure-Activity Relationship; Time Factors | 2009 |
Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Discrimination, Psychological; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Hallucinogens; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Salvia | 2009 |
Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Benzeneacetamides; Cocaine; Diterpenes, Clerodane; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Administration | 2009 |
The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Corticotropin-Releasing Hormone; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Ligands; Male; Naltrexone; Neural Inhibition; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex, Startle | 2010 |
Functional selectivity of kappa opioid receptor agonists in peripheral sensory neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butadienes; Cyclic AMP; Dinoprostone; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Primary Cell Culture; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensory Receptor Cells; Signal Transduction; Trigeminal Ganglion | 2015 |
Quantification of observable behaviors induced by typical and atypical kappa-opioid receptor agonists in male rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Behavior, Animal; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Macaca mulatta; Male; Morphinans; Motor Activity; Oxycodone; Receptors, Opioid, kappa; Spiro Compounds | 2020 |