Compounds > salvinorin a

Page last updated: 2024-09-03

salvinorin a and morphine

salvinorin a has been researched along with morphine in 12 studies

Compound Research Comparison

Studies (salvinorin a)	Trials (salvinorin a)	Recent Studies (post-2010) (salvinorin a)	Studies (morphine)	Trials (morphine)	Recent Studies (post-2010) (morphine)
247	7	128	44,270	5,200	8,695

Protein Interaction Comparison

Protein	Taxonomy	salvinorin a (IC50)	morphine (IC50)
Delta-type opioid receptor	Mus musculus (house mouse)		0.2939
Delta-type opioid receptor	Rattus norvegicus (Norway rat)		0.2278
Kappa-type opioid receptor	Mus musculus (house mouse)		0.0828
Mu-type opioid receptor	Rattus norvegicus (Norway rat)		0.0385
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)		0.0545
Mu-type opioid receptor	Homo sapiens (human)		0.122
Delta-type opioid receptor	Homo sapiens (human)		0.1199
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)		0.9308
Kappa-type opioid receptor	Homo sapiens (human)		0.655
Mu-type opioid receptor	Mus musculus (house mouse)		0.3305
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)		0.202
Beta-2 adrenergic receptor	Cavia porcellus (domestic guinea pig)		0.25

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (33.33)	29.6817
2010's	6 (50.00)	24.3611
2020's	2 (16.67)	2.80

Authors

Authors	Studies
Butelman, ER; Byrd, N; Cobb, H; Dersch, CM; Harding, WW; Prisinzano, TE; Rothman, RB; Tidgewell, K	1
Bohn, LM; Dersch, CM; Groer, CE; Harding, WW; Hiemstra, J; Lozama, A; Marquam, A; Partilla, JS; Prisinzano, TE; Rothman, RB; Schmidt, M; Tidgewell, K	1
Fujii, H; Hirono, S; Nagase, H; Yamaotsu, N	1
Benneyworth, MA; Kalyuzhny, AE; Le Naour, M; Lunzer, MM; Portoghese, PS; Powers, MD; Thomas, MJ	1
Biscaia, M; Crowley, RS; Filizola, M; Groer, CE; Kivell, BM; Paton, K; Prisinzano, TE; Provasi, D; Riley, AP; Schneider, S; Sherwood, AM; Shivaperumal, N	1
Che, T; Kalinin, DV; Loser, K; Mykicki, N; Schepmann, D; Ständer, S; Tangherlini, G; Wünsch, B	1
Bow, E; Crowley, R; Deschamps, JR; Gutman, ES; Hassan, SA; Imler, GH; Jacobson, AE; Kaska, S; Lee, YS; Li, F; Prisinzano, TE; Rice, KC; Sulima, A	1
Imam, MZ; Kong, D; Kuo, A; Smith, MT; Williams, CM	1
Bohn, LM; Groer, CE; Harding, WW; Moyer, RA; Prisinzano, TE; Rothman, RB; Tidgewell, K	1
Benaderet, TS; Bishop-Mathis, K; Dersch, CM; Partilla, JS; Prisinzano, TE; Rothman, RB; Simpson, DS; Wang, X; Xu, H	1
Baker, LE; Peet, MM	1
Bartuzi, D; Kaczor, AA; Matosiuk, D	1

Other Studies

12 other study(ies) available for salvinorin a and morphine

Article	Year
Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15 Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Diterpenes; Diterpenes, Clerodane; Furans; Humans; Ligands; Pyrones; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salvia; Stereoisomerism; Structure-Activity Relationship	2005
Herkinorin analogues with differential beta-arrestin-2 interactions. Journal of medicinal chemistry, 2008, Apr-24, Volume: 51, Issue:8 Topics: Arrestins; beta-Arrestin 2; beta-Arrestins; Cell Line; Diterpenes; Diterpenes, Clerodane; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu	2008
Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists. Bioorganic & medicinal chemistry, 2010, Jun-15, Volume: 18, Issue:12 Topics: Models, Chemical; Models, Molecular; Receptors, Opioid, kappa	2010
Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Analgesics; Animals; Arrestins; Avoidance Learning; beta-Arrestins; Calcium; Drug Tolerance; HEK293 Cells; Humans; Indoles; Mice; Naltrexone; Protein Multimerization; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Substance-Related Disorders	2014
Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. Journal of medicinal chemistry, 2016, 12-22, Volume: 59, Issue:24 Topics: Analgesics, Opioid; Animals; Cells, Cultured; CHO Cells; Cricetulus; Diterpenes; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Male; Molecular Structure; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Salvia; Structure-Activity Relationship	2016
Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation. Journal of medicinal chemistry, 2019, 01-24, Volume: 62, Issue:2 Topics: Animals; Antineoplastic Agents; Binding Sites; Encephalomyelitis, Autoimmune, Experimental; HEK293 Cells; Humans; Interferon-gamma; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Protein Structure, Tertiary; Quinoxalines; Receptors, Opioid, kappa; Signal Transduction; Structure-Activity Relationship; Th1 Cells	2019
G-Protein biased opioid agonists: 3-hydroxy- RSC medicinal chemistry, 2020, Aug-01, Volume: 11, Issue:8 Topics:	2020
Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources. Journal of medicinal chemistry, 2022, 02-10, Volume: 65, Issue:3 Topics: Analgesics, Opioid; Animals; Biological Products; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Discovery; Humans; Ligands; Pain; Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2022
An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. Molecular pharmacology, 2007, Volume: 71, Issue:2 Topics: Analgesics, Opioid; Animals; Arrestin; Cell Line; Diterpenes; Diterpenes, Clerodane; Drug Tolerance; Endocytosis; Humans; Mice; Morphine; Protein Transport; Receptors, Opioid, mu; Transfection	2007
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors. Brain research bulletin, 2008, Sep-05, Volume: 77, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzamides; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Female; Furans; Gene Expression; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Morphine; Oligopeptides; Piperazines; Pyrones; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2008
Salvinorin B derivatives, EOM-Sal B and MOM-Sal B, produce stimulus generalization in male Sprague-Dawley rats trained to discriminate salvinorin A. Behavioural pharmacology, 2011, Volume: 22, Issue:5-6 Topics: Animals; Discrimination Learning; Diterpenes, Clerodane; Generalization, Stimulus; Hallucinogens; Male; Morphine; Rats; Rats, Sprague-Dawley; Time Factors	2011
Activation and Allosteric Modulation of Human μ Opioid Receptor in Molecular Dynamics. Journal of chemical information and modeling, 2015, Nov-23, Volume: 55, Issue:11 Topics: Allosteric Regulation; Allosteric Site; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Furans; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Morphine; Pyrones; Receptors, Opioid, mu; Salvia	2015