Compounds > salvinorin a

Page last updated: 2024-09-03

salvinorin a and enkephalin, ala(2)-mephe(4)-gly(5)-

salvinorin a has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 10 studies

Compound Research Comparison

Studies (salvinorin a)	Trials (salvinorin a)	Recent Studies (post-2010) (salvinorin a)	Studies (enkephalin, ala(2)-mephe(4)-gly(5)-)	Trials (enkephalin, ala(2)-mephe(4)-gly(5)-)	Recent Studies (post-2010) (enkephalin, ala(2)-mephe(4)-gly(5)-)
247	7	128	151	0	71
247	7	128	2,727	1	374

Protein Interaction Comparison

Protein	Taxonomy	salvinorin a (IC50)	enkephalin, ala(2)-mephe(4)-gly(5)- (IC50)
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)		0.003
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)		0.003
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)		0.003
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)		0.003
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)		0.003
Delta-type opioid receptor	Mus musculus (house mouse)		1.2415
Mu-type opioid receptor	Rattus norvegicus (Norway rat)		0.0132
Mu-type opioid receptor	Homo sapiens (human)		0.004
Delta-type opioid receptor	Homo sapiens (human)		0.0014
Mu-type opioid receptor	Mus musculus (house mouse)		0.0048
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)		0.0283

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (40.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	1 (10.00)	2.80

Authors

Authors	Studies
Bohn, LM; Dersch, CM; Groer, CE; Harding, WW; Hiemstra, J; Lozama, A; Marquam, A; Partilla, JS; Prisinzano, TE; Rothman, RB; Schmidt, M; Tidgewell, K	1
Azar, MR; Cashman, JR; Ghirmai, S	1
Ferreira, D; Polepally, PR; Roth, BL; Vardy, E; White, K; Zjawiony, JK	1
Huben, K; Mosier, PD; Polepally, PR; Roth, BL; Setola, V; Vardy, E; Zjawiony, JK	1
Fujii, H; Hirayama, S; Hirono, S; Iwai, T; Kuroda, N; Nagase, H; Wada, N; Yamaotsu, N	1
Biscaia, M; Crowley, RS; Filizola, M; Groer, CE; Kivell, BM; Paton, K; Prisinzano, TE; Provasi, D; Riley, AP; Schneider, S; Sherwood, AM; Shivaperumal, N	1
Bow, E; Crowley, R; Deschamps, JR; Gutman, ES; Hassan, SA; Imler, GH; Jacobson, AE; Kaska, S; Lee, YS; Li, F; Prisinzano, TE; Rice, KC; Sulima, A	1
Dersch, CM; Godin, JA; Murphy, DL; Partilla, JS; Prisinzano, TE; Rothman, RB; Schmidt, M; Tidgewell, K; Xu, H	1
Benaderet, TS; Bishop-Mathis, K; Dersch, CM; Partilla, JS; Prisinzano, TE; Rothman, RB; Simpson, DS; Wang, X; Xu, H	1
Bartuzi, D; Kaczor, AA; Matosiuk, D	1

Other Studies

10 other study(ies) available for salvinorin a and enkephalin, ala(2)-mephe(4)-gly(5)-

Article	Year
Herkinorin analogues with differential beta-arrestin-2 interactions. Journal of medicinal chemistry, 2008, Apr-24, Volume: 51, Issue:8 Topics: Arrestins; beta-Arrestin 2; beta-Arrestins; Cell Line; Diterpenes; Diterpenes, Clerodane; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu	2008
Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation. Bioorganic & medicinal chemistry, 2009, Sep-15, Volume: 17, Issue:18 Topics: Alcohol Deterrents; Alcoholism; Animals; Humans; Liver; Male; Mice; Naltrexone; Nociceptin Receptor; Protein Binding; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	2009
Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands. Bioorganic & medicinal chemistry letters, 2013, May-15, Volume: 23, Issue:10 Topics: Camphanes; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; HEK293 Cells; Humans; Molecular Conformation; Panax notoginseng; Receptors, Opioid, kappa; Salvia; Salvia miltiorrhiza; Structure-Activity Relationship	2013
Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor. European journal of medicinal chemistry, 2014, Oct-06, Volume: 85 Topics: Diterpenes, Clerodane; Drug Design; HEK293 Cells; Humans; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Receptors, Opioid, kappa	2014
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. Bioorganic & medicinal chemistry letters, 2014, Oct-15, Volume: 24, Issue:20 Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Molecular Conformation; Receptors, Opioid, kappa; Structure-Activity Relationship	2014
Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. Journal of medicinal chemistry, 2016, 12-22, Volume: 59, Issue:24 Topics: Analgesics, Opioid; Animals; Cells, Cultured; CHO Cells; Cricetulus; Diterpenes; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Male; Molecular Structure; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Salvia; Structure-Activity Relationship	2016
G-Protein biased opioid agonists: 3-hydroxy- RSC medicinal chemistry, 2020, Aug-01, Volume: 11, Issue:8 Topics:	2020
Salvinorin A: allosteric interactions at the mu-opioid receptor. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:2 Topics: Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Diprenorphine; Diterpenes; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Morphinans; Receptors, Opioid, kappa; Receptors, Opioid, mu	2007
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors. Brain research bulletin, 2008, Sep-05, Volume: 77, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzamides; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Female; Furans; Gene Expression; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Morphine; Oligopeptides; Piperazines; Pyrones; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2008
Activation and Allosteric Modulation of Human μ Opioid Receptor in Molecular Dynamics. Journal of chemical information and modeling, 2015, Nov-23, Volume: 55, Issue:11 Topics: Allosteric Regulation; Allosteric Site; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Furans; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Morphine; Pyrones; Receptors, Opioid, mu; Salvia	2015