salicylic acid has been researched along with aspirin in 503 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 192 (38.17) | 18.7374 |
| 1990's | 112 (22.27) | 18.2507 |
| 2000's | 90 (17.89) | 29.6817 |
| 2010's | 86 (17.10) | 24.3611 |
| 2020's | 23 (4.57) | 2.80 |
| Authors | Studies |
|---|---|
| Hannah, J; Holtz, WJ; Houser, RA; Jones, H; Kelly, KW; Matzuk, AR; Ruyle, WV; Sarett, LH; Shen, TY; Witzel, BE | 1 |
| Fordice, MW; Greenwald, RB; Hannah, J; Jacobs, A; Jones, H; Ruyle, WV; Shen, TY; Walford, GL | 1 |
| Gubernator, K; Kansy, M; Senner, F | 1 |
| Apiwattanakul, N; Cha, SH; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Tsuda, M | 1 |
| Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Carbonneau, MA; Cartron, E; Descomps, B; Fouret, G; Léger, CL | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
| Eraly, SA; Kaler, G; Khandelwal, A; Nagle, M; Nigam, SK; Swaan, PW; Truong, DM | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Biondi, S; Cena, C; Coruzzi, G; Donnola, M; Fruttero, R; Gasco, A; Guaita, E; Lazzarato, L; Marini, E; Morini, G; Ongini, E; Rolando, B | 1 |
| Bayram, E; Kufrevioglu, OI; Senturk, M; Supuran, CT | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Bandgar, BP; Gacche, RN; Hote, BS; Jalde, SS; Kinkar, SN; Korbad, BL; Patil, SA | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T | 1 |
| Cena, C; Coruzzi, G; Fruttero, R; Gasco, A; Guaita, E; Guglielmo, S; Lazzarato, L; Lolli, ML; Marini, E; Morini, G; Rolando, B | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Hong, S; Jung, Y; Kang, S; Kim, J; Kim, YM; Yum, S | 1 |
| Brun, P; Carta, D; Castagliuolo, I; Dean, A; Di Marco, V; Ferlin, MG; Surajit, P | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, X; Fu, J; Hu, Y; Sang, S; Shurlknight, KL; Soroka, DN; Zhu, Y | 1 |
| Ban, HS; Ishihara, K; Nabeyama, W; Nakamura, H; Wada, H | 1 |
| Baulard, AR; Biela, A; Blaise, M; Bourbiaux, K; Cantrelle, FX; Déprez, B; Djaout, K; Faïon, L; Flipo, M; Frita, R; Hanoulle, X; Herledan, A; Kremer, L; Leroux, F; Moune, M; Pintiala, C; Piveteau, C; Tanina, A; Vandeputte, A; Willand, N; Wintjens, R | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Asako, H; Granger, DN; Kubes, P; Wallace, J; Wolf, RE | 1 |
| Davis, MB; Soybel, DI; West, AB | 1 |
| Gutknecht, J | 1 |
| Acitores, E; Legaz, ME; Valverde, F | 1 |
| Becker, WM; Schlaak, M; Schubeler, K; Schulz, KH; Zhu, D | 1 |
| Chaiyos, N; Itthipanichpong, C; Sirivongs, P; Wittayalertpunya, S | 1 |
| Fresta, M; Micali, N; Puglisi, G; Villari, A | 2 |
| Bianchi, A; Bonina, FP; Bousquet, E; Ciampini, N; Montenegro, L; Tirendi, S | 1 |
| Klimes, J; Sedlácek, J; Sochor, J; Zahradnícek, M | 1 |
| Belliardo, F; Bruno, G; La Rosa, C; Lucarelli, C; Pelloso, R | 1 |
| Bock, R; Jurna, I; Spohrer, B | 1 |
| Mayer, AL; Sitar, DS; Tenenbein, M | 1 |
| Bromm, B; Rundshagen, I; Scharein, E | 1 |
| Ito, S; Oka, R; Tsuchida, A; Yoshioka, H | 1 |
| Efstathiou, CE; Ioannou, PC; Konstantianos, DG | 1 |
| Albrecht, M; Brandt, KD; O'Bryan-Tear, G | 1 |
| Artaza, MA; Castel, JM; Laporte, JR | 1 |
| Florey, KG | 1 |
| Vaara, M | 1 |
| Umeki, S | 1 |
| King, RL; Levine, RA; Nandi, J | 1 |
| Bennett, PN; Notarianni, LJ; Patel, DK | 1 |
| Cavrini, V; Di Pietra, AM; Gatti, R | 1 |
| Bennett, PN; Notarianni, LJ; Ogunbona, A; Patel, DK | 1 |
| Kelly, HW; McWilliams, BC; Vertrees, JE | 1 |
| Bennett, PN; Hesse, A; Notarianni, LJ; Ogunbona, A; Patel, DK | 1 |
| Drennen, JK; Lodder, RA | 1 |
| Ankersen, M; Nielsen, KK; Senning, A | 1 |
| Catanese, B; Guglielmotti, A; Martinelli, B; Romanelli, L; Valeri, P | 1 |
| Corna, D; Garattini, S; Gaspari, F; Locatelli, M; Perico, N; Remuzzi, G | 1 |
| Attardo Parrinello, G; Barzaghi, N; Gatti, G; Perucca, E; Vitiello, B | 1 |
| Miners, JO | 1 |
| Barlow, JC; Dillon, EC; Watson, WA; Wilton, JH | 1 |
| Buyniski, JP; Cavanagh, RL; Schwartz, SE | 1 |
| Cerletti, C; de Gaetano, G; Dejana, E; Latini, R | 1 |
| Bull, R; Haug, A; Mazorow, DL; McGroarty, EJ | 1 |
| Forn, J; García-Rafanell, J; Gomez, L; Ramis, J | 1 |
| Husney, RM; Sagone, AL | 1 |
| Buchanan, MR; Butt, RW; Hirsh, J; Markham, BA; Nazir, DJ | 1 |
| Aihara, H; Higuchi, S; Otomo, S; Shioiri, Y; Tanaka, N | 1 |
| Amezcua, JL; Favari, L; Mourelle, M | 1 |
| Schrör, K; Verheggen, R | 2 |
| Albors, M; De Castellarnau, C; Rutllant, ML; Sancho, MJ; Vila, L | 1 |
| Bucchi, F; Cerletti, C; Chen, ZM; de Gaetano, G; Gambino, MC; Gori, G; Latini, R; Passaghe, S | 1 |
| Atkinson, DC; Diamond, J; Zambraski, EJ | 1 |
| Bochner, F; Lloyd, JV; Morris, PM; Siebert, DM; Williams, DB | 1 |
| Day, RO; Lam, S; Paull, PD; Swanson, BR; Wade, DN; Williams, KM | 1 |
| Danesh, JZ; Duncan, A; Mitchell, G; Russell, RI | 1 |
| Anton, F; Forster, C; Handwerker, HO; Reeh, PW; Weber, E | 1 |
| Cerletti, C; de Gaetano, G; Dejana, E; Domanin, M; Latini, R; Lauri, D; Lorenzi, G; Marchi, S; Urso, R | 1 |
| Allen, A; Garner, A; Rowe, PH | 1 |
| Artaza, MA; Castel, JM; Cusidó, E; Laporte, JR; Vidal, X | 1 |
| Caveney, S | 1 |
| Levy, G; Wientjes, MG | 1 |
| Bourin, M; Kergueris, MF; Larousse, C; Lasserre, MP; Ortega, A | 1 |
| Anttila, M; Kahela, P; Uotila, P | 1 |
| Bellido, I; de la Cruz, JP; Pavia, J; Sánchez de la Cuesta, F | 1 |
| Kay, JD | 1 |
| Soper, BD; Tepperman, BL | 1 |
| Helms, RA; Jabbour, JT; Walker, PC; Wall, HP | 1 |
| Hiura, M; Kasama, T; Mayuzumi, K; Minato, M; Minohara, K; Nakai, M; Ohshiro, K; Sakaguchi, Y | 1 |
| Buchanan, WW; Darke, AC; Grace, EM; Mewa, AA; Rosenfeld, JM; Sweeney, GD | 1 |
| Ishihara, N; Kojima, S; Nakagawa, M; Shimokawa, T | 1 |
| Bochner, F; Cleland, LG; Graham, GG; Imhoff, DM; Polverino, A; Rolan, PE; Tregenza, RA | 1 |
| Vane, J | 1 |
| Gaspari, F; Locatelli, M | 1 |
| Chen, YC; Kuo, TL; Lee, TK | 1 |
| Beswick, DT; Blake, DR; d'Assis-Fonseca, A; Unsworth, J | 1 |
| Bianchine, JR; Gerber, N; Kershaw, RA; Mays, DC | 1 |
| Bochner, F; Siebert, DM | 1 |
| Ang, A; Chen, YC; Kuo, TL; Lee, TK; Lien, IN; Liu, MC | 1 |
| Caldwell, J; Hutt, AJ; Smith, RL | 1 |
| Peeters, PA; Raghoebar, M; van den Berg, WB; van Ginneken, CA | 1 |
| Cerletti, C; de Gaetano, G; Dejana, E; Galletti, F; Latini, R; Marzot, M; Urso, R | 1 |
| Amidon, GL; Fleisher, D; Lui, CY; Oberle, R | 1 |
| Abernethy, DR; Boxenbaum, HG; Greenblatt, DJ; Harmatz, JS; Matlis, R; Ochs, HR; Shader, RI | 1 |
| Chang, CW; Lau, AH; Schlesinger, PK | 1 |
| Birkett, DJ; Grgurinovich, N; Miners, JO; Robson, RA; Whitehead, AG | 1 |
| Brandt, JL; Chapron, DJ; Feig, PU; Gomolin, IH; Kramer, PA; Sweeney, KR | 1 |
| Gryglewski, RJ; Marcinkiewicz, E; Michalska, Z; Radomski, M | 1 |
| Abrams, WB; Conner, DP; Mojaverian, P; Rocci, ML; Vlasses, PH | 1 |
| Cerletti, C; Costantini, V; De Amicis, G; de Gaetano, G; Dejana, E; Lorenzi, G | 1 |
| Danon, A; Telias, ID; Zvi, ZB | 1 |
| Hiraga, K; Takahashi, O | 1 |
| Geday, E; Husted, SE; Mogensen, CE; Nielsen, HK; Petersen, T | 1 |
| Clark, L; Cohen, MM; McCready, DR; Sevelius, H | 1 |
| Ganguli, S; Miller, JD; Sperling, MA | 1 |
| Drack, E; Halter, F; Scheurer, U | 1 |
| Buchanan, MR; Butt, RW; Hirsh, J; Magas, Z; Nazir, DJ; van Ryn, J | 1 |
| Hansen, D; Salmon, JA; Whittle, BJ | 1 |
| Cerletti, C | 1 |
| Lobeck, F; Spigiel, RW | 1 |
| Chalmers, IM; Hunter, T; Sitar, DS | 1 |
| Clark, JH; Fitzgerald, JF; Nagamori, K | 1 |
| Breddin, HK; Mutschler, E; Rehders, K; Simrock, R; Spahn, H | 1 |
| Cerletti, C; de Gaetano, G; Dejana, E; Garattini, S; Latini, R; Tognoni, G | 1 |
| Bourne, DW; Heazlewood, VJ; Ho, PC; Triggs, EJ | 1 |
| Mamolo, MG; Maurich, V; Vio, L | 1 |
| Danesh, B; Omile, CI; Tebbett, IR | 1 |
| Brandon, RA; Eadie, MJ; Smith, MT | 1 |
| Altmayer, P; Cattarius-Korb, S; Krüger, B; Lang, E; Mutschler, E; Sörgel, F; Spahn, H | 1 |
| Attarchi, F; Carstensen, JT; Hou, XP | 1 |
| Feigal, D; Jang, H; Pollet, S; White, RH; Yim, CW | 1 |
| Rácz, I; Ujhelyi, G | 1 |
| Cerletti, C; de Gaetano, G; Dejana, E; Del Maschio, A; Galletti, F; Latini, R | 1 |
| Shastri, RA | 1 |
| Loftsson, T | 1 |
| Igarashi, T; Kitagawa, H; Misawa, M; Nishimura, T; Sato, T; Ueno, K; Yanaura, S | 1 |
| Jankowski, A; Skublicki, S; Szymański, W; Wichliński, LM | 1 |
| Brantmark, B; Hedner, U; Melander, A; Wåhlin-Boll, E | 1 |
| Alam, AS; Gregoriades, D; Imondi, AR | 1 |
| Mazzeo, P; Quaglia, MG; Segnalini, F | 1 |
| Alpsten, M; Bogentoft, C; Ekenved, G | 1 |
| Frawley, VL; Ou, CN | 1 |
| Hanley, SP; Hughes, J | 1 |
| Bruce, IJ; Wilkie, D | 1 |
| Thiessen, JJ | 2 |
| Ellis, RP; Knight, AP; Lucas, MJ; Morris, CJ; Phillips, RW; Wise, CM | 1 |
| Cerletti, C; De Gaetano, G; Doni, MG; Livio, M | 1 |
| Hoak, JC | 1 |
| Harding, PL; Krausse, EJ; Lolle, SJ; Morris, GP; Wallace, JL | 1 |
| Gray, DA; Langrieger, N; Reschmaier, J; Simon, E | 1 |
| O'Kruk, RJ; Paul, ML; Philp, RB | 1 |
| Block, LH; Rhyner, K; Stenger, M | 1 |
| Berlet, G; Chemnitius, KH; Schröber, R; Traeger, A; Zaumseil, J | 1 |
| Cossum, PA; McLeod, LJ; Roberts, MS; Vial, JH | 1 |
| Barary, MH; Korany, MA; Wahbi, AM | 1 |
| Hozumi, K; Kitamura, K; Takagi, M | 1 |
| Mason, WD | 1 |
| Lee, CP; Martens, ME | 1 |
| Brantmark, B; Forshell, GP; Fredholm, B; Hedner, U; Melander, A; Nitelius, E; Wåhlin-Boll, E | 1 |
| Flouvat, B; Henry, JF; Rocher, I | 1 |
| Koren, G; MacLeod, SM | 1 |
| Neuvonen, PJ; Olkkola, KT | 1 |
| Adams, MA; O'Kruk, RJ; Philp, RB | 1 |
| Badcock, NR; Everett, DS; Penna, AC; Sansom, LN | 1 |
| Beach, CA; Bianchine, JR; Gerber, N; Kershaw, RA; Mays, DC; Sharp, DE | 1 |
| Isler, H; Jerusalem, F; Rhyner, K; Smith, M | 1 |
| Bevitt, RN; Mather, JR; Sharman, DC | 1 |
| Hoogmartens, J; Roets, E; Thomis, R | 1 |
| Chen, P; Epstein, P; Fogel, J | 1 |
| Pendleton, RG; Stavorski, JM | 1 |
| Dahl, ML; Uotila, P | 1 |
| Bergren, DR; Kincaid, RJ | 1 |
| Cassell, S; Dromgoole, SH; Furst, DE; Paulus, HE | 1 |
| Brooks, PM; Roberts, MS; Rumble, RH; Thomas, D; Wanwimolruk, S | 1 |
| Bakar, SK; Niazi, S | 2 |
| Amon, I; Amon, K; Zschiesche, A | 1 |
| Coceani, F; Olley, PM; Salama, RB; Thiessen, JJ | 2 |
| Bianchine, JR; Goldlust, MB; Harrison, LI; Kehe, CR; Kvam, DC | 1 |
| Crean, GP; Hearns, J; Mitchell, KG | 1 |
| Galante, RN; Grim, WM; Visalli, AJ | 1 |
| Ashorobi, RB; Laniyonu, AA; Oyekan, AO | 1 |
| Maedge, S; Sewing, KF; Weissenborn, U | 1 |
| Breddin, HK; Lischke, V; Missalla, A; Schwidtal, P; Simrock, R | 1 |
| Cerletti, C; de Castellarnau, C; de Gaetano, G; Dejana, E; Galletti, F; Latini, R; Livio, M | 1 |
| Hansen, DG; Kauffman, GL; Ligumsky, M | 1 |
| Kitamura, K; Majima, R | 1 |
| Reidl, U | 1 |
| Proost, JH; Van Imhoff, GW; Wesseling, H | 1 |
| Innis, JD; Wenzel, DG | 1 |
| Braithwaite, RA; Chand, S; Crome, P; Dawling, S | 1 |
| Barcza, G; Lõrincz, M; Tátrai, E; Ungváry, G | 1 |
| Guidi, G; Olzer, D; Schiavon, R; Zatti, M | 1 |
| Mason, WD; Winer, N | 1 |
| Anderson, WH; Czajka, PA; Mowry, JB; Sketris, IS; Stafford, DT | 1 |
| Bochner, F; Byrne, G; Cham, BE; Gunsberg, M; Imhoff, DM | 1 |
| Grossman, MI; Kauffman, GL; Ligumsky, M | 1 |
| Rawlins, MD; Seymour, RA | 1 |
| Alpsten, M; Bogentoft, C; Ekenved, G; Sölvell, L | 1 |
| Pankey, JW; Pfeiffer, CD | 1 |
| Brantmark, B; Melander, A; Wåhlin-Boll, E | 1 |
| Bruno, R; Curto, M; Ponzetto, C; Rinaudo, MT | 1 |
| Itami, T; Kanoh, S | 1 |
| Flinn, PE; Jefferson, E; Kirchhoefer, RD | 1 |
| Lücker, PW; Procaccini, R; Tilling, W; Vance, J; Wetzelsberger, N | 1 |
| Geday, E; Husted, SE; Pedersen, AK; Petersen, T | 1 |
| Schenk, GH; Street, KW | 1 |
| Robert, A | 1 |
| Carmichael, GR; Parrott, EL; Shah, SA | 1 |
| Eppler, J; Fraga, C; Giesbrecht, E; Ito, S; Johnson, D; Rais, A; Verjee, Z; Wiggins, T | 1 |
| Bacolod, M; Dawson, C; Gonzales, C; Kishore, V; Lopez-Anaya, A | 1 |
| Azaroual, N; Imbenotte, M; Leclerc, F; Lhermitte, M; Maschke, S; Vermeersch, G | 1 |
| Buckley, CE; Corder, EH | 1 |
| Bttner, T; Gerlach, M; Kuhn, W; Müller, T | 1 |
| Eppler, J; Johnson, D; Klein, J; Lee, S | 1 |
| Ogawa, N; Ohdo, S; Song, JG | 1 |
| Coudray, C; Fatôme, M; Favier, A; Martin, S; Talla, M | 1 |
| Marangos, MN; Nicolau, DP; Nightingale, CH; Onyeji, CO | 1 |
| Blondino, FE; Byron, PR | 1 |
| Damiani, P; Ibáñez, G; Olivieri, AC | 1 |
| Abdel-Rahman, MS; Rizk, M | 1 |
| Berthon, G; Brumas, B; Brumas, V | 1 |
| Castañeda-Hernández, G; Castillo-Méndez, MS; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ | 1 |
| Chey, WY; Levine, RA; Li, P; Zhou, L | 1 |
| Hollman, PC; Janssen, PL; Katan, MB; Venema, DP | 1 |
| Gazy, AA; Hassan, EM; Wahbi, AA | 1 |
| Beving, H; Eksborg, S; Malmgren, RS; Nordlander, R; Olsson, P; Rydén, L | 1 |
| Bartos, A; Gołkiewicz, W | 1 |
| Cadórniga, R; Torrado, S | 1 |
| Damme, B; Pankow, D; Schrör, K | 1 |
| Casadevall, G; Franch, MA; Moreno, JJ; Queralt, J | 1 |
| Baker, PV; Dickinson, RG; King, AR | 1 |
| Ando, F; Arakawa, M; Kambara, K; Kano, A; Ohno, M; Segawa, T | 1 |
| Amico, MC; Morrone, LA; Romanelli, L; Valeri, P | 1 |
| Aihie, AP; Crome, P; Halpern, SM; Streete, PJ | 1 |
| Li, YF; Moody, FG; Myers, SI; Russell, DH; Weisbrodt, NW | 1 |
| Anderson, P; Andersson, R; Boréus, LO; Dahlén, B; Zetterström, O | 1 |
| Amon, I; Franke, G; Siegmund, W; Zschiesche, M | 1 |
| Bill, RL; Bowers, LD; Caywood, DD; Cipolle, RJ; Waters, DJ | 1 |
| Binder, M; Zeiller, P | 1 |
| Roberts, MS; Seddon, RJ; Shen, J; Wanwimolruk, S; Wilson, PD | 1 |
| Fitzgerald, DJ; Keimowitz, RM; Mayo, G; Pulvermacher, G | 1 |
| Goto, S; Matsumoto, Y; Ohsako, M | 1 |
| Gwoździński, K; Watała, C | 1 |
| Alemany, M; Bastida, E; Bozzo, J; Buchanan, MR; Hernández, R; Ordinas, A | 1 |
| Becker, JA; Cochran, EB; Phillips, KR; Wideman, SD | 1 |
| Chiao, SF; Chu, KM; Ho, ST; Ho, W; Hu, OY; Liu, HS | 1 |
| Hjertén, S; Lundahl, P; Zhang, R; Zhang, Y | 1 |
| Golovko, AI; Kliuntina, TV; Sofronov, GA | 1 |
| Lorén, JG; Palomar, J; Puig, M; Viñas, M | 1 |
| Daston, GP; Davis, DP; Kraus, AL; Odio, MR; York, RG | 1 |
| Brecher, P; Chobanian, AV; Farivar, RS | 1 |
| Chalasani, N; Jurado, RL; Roman, J | 1 |
| Kreysel, HW; Reeh, PW; Steen, KH | 2 |
| Freeman, DA; Hanlon, DW; Parton, K; Whittem, T | 1 |
| Benedek, IH; Joshi, AS; King, SY; Kornhauser, DM; Pieniaszek, HJ | 1 |
| Bias-Imhoff, U; Riechers, AM; Schulz, HU; Schurer, M; Schwantes, U | 1 |
| Mellick, GD; Roberts, MS | 1 |
| Grobecker, H; Jehnich, D; Kees, F | 1 |
| Arroyo, MT; Cornudella, R; Esteva, F; Hirschowitz, BI; Lanas, AI; Sáinz, R | 1 |
| Dzúrik, R; Krivosíková, Z; Spustová, V | 1 |
| Benedito, MA | 1 |
| Boland, CR; Brenner, DE; Crowell, J; Kelloff, G; Krishnan, K; Normolle, D; Peters-Golden, M; Rock, CL; Ruffin, MT; Vaerten, MA | 1 |
| Dierickx, PJ; Janssen, L; Noble, E | 1 |
| Foltínová, P; Grones, J | 1 |
| Bolton, CH; Dwight, J; Hartog, M; Hopton, MI; Steer, K | 1 |
| Mann, CK; Vickers, TJ; Wang, C | 1 |
| Kelly, MT; McMahon, GP | 1 |
| Bareggi, SR; De Benedittis, G; Pirola, R | 2 |
| Ghahramani, P; Jackson, PR; Ramsay, LE; Rowland-Yeo, K; Yeo, WW | 1 |
| Duffy, SJ; Esler, MD; Harper, RW; Meredith, IT; New, G; Tran, BT; Tudball, RN | 1 |
| Fitzgerald, DJ; Kelly, MT; le Roy, S; McMahon, GP; O'Connor, SJ | 1 |
| Barragán, M; Bellosillo, B; Castaño, E; Colomer, D; Gil, J; Montserrat, E; Piqué, M; Pons, G; Villamor, N | 1 |
| Campanella, L; Crescentini, G; Sammartino, MP; Su, Y; Tomassetti, M | 1 |
| Aubin, N; Carter, C; Curet, O; Deffois, A | 1 |
| Bjørnsdottir, I; Hansen, SH; Jensen, ME | 1 |
| Burda, K; Kokot, Z | 1 |
| Andrieu, S; Berdeaux, A; Bévérelli, F; Giudicelli, JF; Lebret, M; Maclouf, J | 1 |
| Al-Nasser, IA | 1 |
| Makino, T; Tomida, Y | 1 |
| Ishii, S; Ogawa, K; Sasaki, T; Senda, M | 1 |
| Gmeiner, B; Held, I; Hermann, M; Hofbauer, R; Kapiotis, S; Seelos, C | 1 |
| Castañeda-Hernández, G; Cruz, L; Navarrete, A | 1 |
| Kinouchi, T; Onouchi, T; Shimizu, N | 1 |
| Asea, A; Calderwood, SK; Coleman, CN; Stevenson, MA; Zhao, MJ | 1 |
| Benfeldt, E | 1 |
| Furuta, A; Imanishi, S; Kojima, H; Muramoto, N; Nakakita, M; Nakamura, K; Utsuno, K; Yamashita, K | 1 |
| Exner, M; Gmeiner, BM; Held, I; Hermann, M; Hofbauer, R; Kapiotis, S; Seelos, C; Speiser, W | 1 |
| Karabulut, AK; Pratten, MK; Ulger, H | 1 |
| Fujita, A; Takeuchi, K; Tashima, K; Umeda, M | 1 |
| Dietz, AB; Matasic, R; Vuk-Pavlovic, S | 1 |
| Coudray, C; Favier, A | 1 |
| Balakin, AA; Dodonov, AF; Novikova, LI; Talrose, VL | 1 |
| Mrestani, Y; Neubert, RH | 1 |
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20 review(s) available for salicylic acid and aspirin
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
Synthesis, properties and prodrug potential of 2-methyl-2-oxy- and 2-methyl-2-thio-4H-1,3-benzodioxin-4-ones.
Topics: Animals; Aspirin; Benzyl Alcohols; Dioxins; Hydrolysis; Models, Molecular; Molecular Structure; Prodrugs; Salicylates; Salicylic Acid | 1989 |
Drug interactions involving aspirin (acetylsalicylic acid) and salicylic acid.
Topics: Antacids; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Aspirin; Charcoal; Contraceptive Agents; Drug Interactions; Glucocorticoids; Histamine H2 Antagonists; Humans; Salicylates; Salicylic Acid | 1989 |
Pharmacology of platelet inhibition in humans: implications of the salicylate-aspirin interaction.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Blood Vessels; Cyclooxygenase Inhibitors; Drug Interactions; Female; Humans; Kinetics; Leukocytes; Male; Platelet Aggregation; Salicylates; Salicylic Acid; Superoxides; Thrombosis | 1985 |
Gastroduodenal mucosal defence mechanisms and the action of non-steroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bicarbonates; Duodenum; Gastric Mucosa; Intestinal Mucosa; Salicylates; Salicylic Acid | 1987 |
Aspirin: plasma concentration and effects.
Topics: Animals; Aspirin; Fibrinolytic Agents; Half-Life; Humans; Salicylates; Salicylic Acid | 1983 |
Mechanisms of action: aspirin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Endothelium; Humans; Ibuprofen; In Vitro Techniques; Indomethacin; Salicylates; Salicylic Acid; Thromboxanes | 1983 |
[Antiphlogistic effect of salicylic acid and its derivatives].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Humans; Inflammation; Salicylates; Salicylic Acid | 1993 |
[Salicylic acid, aspirin].
Topics: Aspirin; Drug Monitoring; Humans; Salicylic Acid | 1999 |
Salicylic acid: a link between aspirin, diet and the prevention of colorectal cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Diet; Fruit; Humans; Salicylic Acid; Vegetables | 2001 |
[Aspirin esterase: biochemical and clinical aspects of aspirin catabolism].
Topics: Aspirin; Carboxylic Ester Hydrolases; Humans; Salicylic Acid | 2001 |
[Practical analysis of toxic substances useful for clinical toxicology. 5--Salicylate salts].
Topics: Adolescent; Aspirin; Chromatography, High Pressure Liquid; Colorimetry; Female; Humans; Salicylic Acid; Spectrophotometry, Ultraviolet; Suicide, Attempted | 2003 |
Control of COX-2 and iNOS gene expressions by aspirin and salicylate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; CCAAT-Enhancer-Binding Protein-beta; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Membrane Proteins; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Salicylic Acid; Transcriptional Activation | 2003 |
[Salicylic acid, aspirin].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Aspirin; Biomarkers; Chromatography, High Pressure Liquid; Drug Interactions; Drug Monitoring; Food-Drug Interactions; Humans; Salicylic Acid; Specimen Handling | 2004 |
Is there a role for dietary salicylates in health?
Topics: Anticarcinogenic Agents; Aspirin; Colonic Neoplasms; Fruit; Humans; Salicylic Acid; Vegetables | 2006 |
The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Aspirin; Benzyl Alcohols; Glucosides; History, 18th Century; History, 19th Century; History, 20th Century; History, 21st Century; History, Ancient; History, Medieval; Humans; Salicylic Acid; Salix | 2006 |
Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Commerce; Congenital Abnormalities; Drug Monitoring; Endocrine Disruptors; Environmental Exposure; Female; Humans; Ibuprofen; Meconium; Milk, Human; Molar; Pain; Pain Management; Pregnancy; Pregnancy Outcome; Prenatal Exposure Delayed Effects; Salicylic Acid; Tooth, Deciduous; Urogenital Abnormalities | 2016 |
Bioactive food chemicals and gastrointestinal symptoms: a focus of salicylates.
Topics: Aspirin; Basophils; Food Analysis; Food Hypersensitivity; Gastrointestinal Diseases; Humans; Immunologic Tests; Irritable Bowel Syndrome; Salicylic Acid | 2017 |
The effect of aspirin on antibiotic susceptibility.
Topics: Anti-Bacterial Agents; Aspirin; Bacteria; Drug Interactions; Drug Resistance, Bacterial; Humans; Platelet Aggregation Inhibitors; Salicylic Acid | 2018 |
Shared and Related Molecular Targets and Actions of Salicylic Acid in Plants and Humans.
Topics: Aspirin; Humans; Plants; Salicylic Acid | 2023 |
33 trial(s) available for salicylic acid and aspirin
| Article | Year |
|---|---|
Multiple-dose charcoal and whole-bowel irrigation do not increase clearance of absorbed salicylate.
Topics: Administration, Oral; Adult; Aspirin; Charcoal; Female; Humans; Intestinal Absorption; Intestines; Male; Poisoning; Salicylates; Salicylic Acid; Therapeutic Irrigation | 1992 |
Central analgesic effects of acetylsalicylic acid in healthy men.
Topics: Adult; Analgesics; Arousal; Aspirin; Double-Blind Method; Electric Stimulation; Electrodes; Electroencephalography; Evoked Potentials, Auditory; Humans; Male; Reaction Time; Salicylates; Salicylic Acid | 1991 |
Large surface area activated charcoal and the inhibition of aspirin absorption.
Topics: Absorption; Adult; Aspirin; Charcoal; Double-Blind Method; Gastric Mucosa; Humans; Intestinal Absorption; Male; Random Allocation; Salicylates; Salicylic Acid; Surface Properties | 1989 |
Measurement of the analgesic effects of aspirin with a new experimental algesimetric procedure.
Topics: Analgesia; Analysis of Variance; Aspirin; Clinical Trials as Topic; Double-Blind Method; Humans; Male; Pain; Pain Measurement; Salicylates; Salicylic Acid | 1988 |
Comparative efficacy study of chewable aspirin and acetaminophen in the antipyresis of children.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Temperature; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Salicylates; Salicylic Acid; Time Factors | 1986 |
Comparative bioavailability of aspirin from buffered, enteric-coated and plain preparations.
Topics: Administration, Oral; Adult; Aspirin; Biological Availability; Buffers; Humans; Kinetics; Male; Random Allocation; Salicylates; Salicylic Acid; Tablets; Tablets, Enteric-Coated | 1986 |
Evaluation of a potential drug interaction between sucralfate and aspirin.
Topics: Adsorption; Adult; Aluminum; Aspirin; Drug Combinations; Drug Interactions; Gastric Mucosa; Hippurates; Humans; Kinetics; Male; Random Allocation; Salicylates; Salicylic Acid; Sucralfate | 1986 |
Protection against aspirin-induced antral and duodenal damage with enprostil. A double-blind endoscopic study.
Topics: Adolescent; Adult; Aspirin; Drug Evaluation; Duodenum; Enprostil; Female; Gastric Fundus; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Prostaglandins E, Synthetic; Pyloric Antrum; Random Allocation; Salicylates; Salicylic Acid | 1985 |
The effect of antacid and aspirin on the bioavailability of isofezolac in man.
Topics: Adult; Aluminum Compounds; Antacids; Anti-Inflammatory Agents; Aspirin; Biological Availability; Blood Proteins; Drug Interactions; Female; Humans; Kinetics; Phosphates; Protein Binding; Pyrazoles; Salicylates; Salicylic Acid | 1984 |
Effect of gastric pH on antidotal efficacy of activated charcoal in man.
Topics: Absorption; Adult; Antidotes; Aspirin; Charcoal; Disopyramide; Female; Gastric Acid; Gastric Acidity Determination; Humans; Magnesium Hydroxide; Male; Middle Aged; ortho-Aminobenzoates; Salicylates; Salicylic Acid | 1984 |
Saline catharsis: effect on aspirin bioavailability in combination with activated charcoal.
Topics: Adult; Aspirin; Biological Availability; Cathartics; Charcoal; Feces; Female; Humans; Intestinal Absorption; Kinetics; Male; Salicylates; Salicylic Acid; Sodium; Sulfates | 1982 |
Efficacy and pharmacokinetics of aspirin in post-operative dental pain.
Topics: Adult; Aspirin; Female; Half-Life; Humans; Kinetics; Male; Pain, Postoperative; Salicylates; Salicylic Acid; Tooth Extraction | 1982 |
Inter-individual variations of the effect of low dose aspirin regime on platelet cyclooxygenase activity.
Topics: Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Male; Middle Aged; Prostaglandin-Endoperoxide Synthases; Reference Values; Salicylates; Salicylic Acid | 1994 |
Effects of nocloprost clathrate on absorption of acetylsalicylic acid.
Topics: Acetylation; Administration, Oral; Adult; Aspirin; beta-Cyclodextrins; Chromatography, High Pressure Liquid; Cyclodextrins; Drug Interactions; Hippurates; Humans; Intestinal Absorption; Male; Prostaglandins F, Synthetic; Salicylates; Salicylic Acid; Single-Blind Method; Vasodilator Agents | 1994 |
Topical acetylsalicylic, salicylic acid and indomethacin suppress pain from experimental tissue acidosis in human skin.
Topics: Acidosis; Administration, Topical; Adult; Aspirin; Cross-Over Studies; Double-Blind Method; Female; Humans; Indomethacin; Injections, Intradermal; Isotonic Solutions; Male; Middle Aged; Palliative Care; Pressure; Salicylates; Salicylic Acid; Skin Diseases | 1995 |
Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers.
Topics: Adult; Aspirin; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Salicylic Acid | 1995 |
Lack of influence of glycine on the single dose pharmacokinetics of acetylsalicylic acid in man.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aspirin; Cross-Over Studies; Double-Blind Method; Glycine; Half-Life; Humans; Male; Salicylates; Salicylic Acid; Therapeutic Equivalency | 1996 |
Dose-dependent competitive block by topical acetylsalicylic and salicylic acid of low pH-induced cutaneous pain.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Pain; Palliative Care; Salicylates; Salicylic Acid; Skin | 1996 |
Simultaneous determination of acetylsalicylic acid and salicylic acid in human plasma by high-performance liquid chromatography.
Topics: Analgesics, Non-Narcotic; Aspirin; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Quality Control; Reproducibility of Results; Salicylates; Salicylic Acid; Specimen Handling; Therapeutic Equivalency | 1996 |
Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Colorectal Neoplasms; Drug Administration Schedule; Female; Humans; Intestinal Mucosa; Male; Middle Aged; Prostaglandins; Rectum; Salicylates; Salicylic Acid; Time Factors | 1997 |
Skin and plasma levels of acetylsalicylic acid: a comparison between topical aspirin/diethyl ether mixture and oral aspirin in acute herpes zoster and postherpetic neuralgia.
Topics: Acute Disease; Administration, Oral; Administration, Topical; Aged; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Double-Blind Method; Ether; Female; Herpes Zoster; Herpesviridae Infections; Humans; Male; Middle Aged; Neuralgia; Pain; Pain Measurement; Salicylates; Salicylic Acid; Skin; Solvents; Treatment Outcome | 1998 |
In vivo microdialysis for the investigation of drug levels in the dermis and the effect of barrier perturbation on cutaneous drug penetration. Studies in hairless rats and human subjects.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Animals; Area Under Curve; Aspirin; Female; Forearm; Humans; Keratolytic Agents; Male; Microdialysis; Middle Aged; Rats; Rats, Sprague-Dawley; Reference Values; Salicylic Acid; Skin; Skin Absorption; Time Factors | 1999 |
Interactions of aspirin and salicylic acid with prednisolone for inhibition of lymphocyte proliferation.
Topics: Adult; Algorithms; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Lymphocyte Activation; Lymphocytes; Male; Models, Biological; NF-kappa B; Prednisolone; Salicylic Acid | 2001 |
Lack of pharmacokinetic interaction between the oral anti-influenza prodrug oseltamivir and aspirin.
Topics: Acetamides; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Aspirin; Cross-Over Studies; Drug Interactions; Female; Hippurates; Humans; Male; Oseltamivir; Prodrugs; Salicylic Acid | 2002 |
Low-dose aspirin in pregnancy: maternal and neonatal aspirin concentrations and neonatal prostanoid formation.
Topics: Aspirin; Blood Platelets; Dinoprostone; Epoprostenol; Female; Fetal Blood; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prostaglandins; Salicylic Acid | 2003 |
Pharmacokinetic interaction study of a fixed combination of 500 mg acetylsalicylic acid/30 mg pseudoephedrine versus each of the single active ingredients in healthy male volunteers.
Topics: Adrenergic alpha-Agonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aspirin; Drug Combinations; Drug Interactions; Ephedrine; Humans; Male; Salicylic Acid | 2003 |
Differences in the effects of extended-release aspirin and plain-formulated aspirin on prostanoids and nitric oxide in healthy volunteers.
Topics: Adult; Aspirin; Cross-Over Studies; Delayed-Action Preparations; Dinoprost; Double-Blind Method; Epoprostenol; Female; Humans; Male; Nitric Oxide; Platelet Aggregation Inhibitors; Salicylic Acid; Thromboxane B2 | 2003 |
Relative bioavailability and bioequivalence of a newly developed fixed combination sachet of acetylsalicylic acid and pseudoephedrine compared with a preliminary combination.
Topics: Administration, Oral; Adolescent; Adult; Aspirin; Biological Availability; Chemistry, Pharmaceutical; Creatine Kinase; Dizziness; Drug Administration Schedule; Drug Combinations; Ephedrine; Half-Life; Humans; Male; Middle Aged; Nausea; Powders; Salicylic Acid; Therapeutic Equivalency | 2003 |
Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity.
Topics: Adult; Asian People; Aspirin; Drug Resistance; Gene Frequency; Genotype; Humans; Japan; Male; Membrane Glycoproteins; Membrane Proteins; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Polymorphism, Single Nucleotide; Receptors, Thromboxane A2, Prostaglandin H2; Reference Values; Salicylic Acid; Thromboxane B2 | 2007 |
UGT1A6 polymorphism and salicylic acid glucuronidation following aspirin.
Topics: Adult; Aspirin; Genotype; Glucuronides; Glucuronosyltransferase; Humans; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Salicylic Acid; Saliva | 2007 |
Analytical determination and pharmacokinetics of major metabolites of carbasalate calcium in broilers following oral administration.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chickens; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Administration Schedule; Female; Gentisates; Male; Salicylic Acid; Tandem Mass Spectrometry; Urea | 2011 |
Simultaneous extraction of acetylsalicylic acid and salicylic acid from human plasma and simultaneous estimation by liquid chromatography and atmospheric pressure chemical ionization/tandem mass spectrometry detection. Application to a pharmacokinetic stu
Topics: Area Under Curve; Aspirin; Calibration; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Stability; Half-Life; Humans; Indicators and Reagents; Reference Standards; Reproducibility of Results; Salicylic Acid; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
Dissolution and pharmacokinetics of a novel micronized aspirin formulation.
Topics: Adult; Aspirin; Chemistry, Pharmaceutical; Cross-Over Studies; Female; Humans; Male; Salicylic Acid; Solubility; Tablets | 2012 |
450 other study(ies) available for salicylic acid and aspirin
| Article | Year |
|---|---|
Novel analgesic-antiinflammatory salicylates.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Dogs; Rats; Salicylates; Structure-Activity Relationship | 1978 |
Synthesis and analgesic-antiinflammatory activity of some 4- and 5-substituted heteroarylsalicylic acids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry, Physical; Dogs; Edema; Gastrointestinal Hemorrhage; Rats; Salicylates | 1978 |
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.
Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet | 1998 |
Identification of multispecific organic anion transporter 2 expressed predominantly in the liver.
Topics: Animals; Blotting, Northern; Carrier Proteins; Ion Transport; Liver; Membrane Proteins; Organic Anion Transporters, Sodium-Independent; Rats; Salicylates; Salicylic Acid; Substrate Specificity; Xenopus laevis | 1998 |
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis | 1999 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Specific antioxidant activity of caffeoyl derivatives and other natural phenolic compounds: LDL protection against oxidation and decrease in the proinflammatory lysophosphatidylcholine production.
Topics: Antioxidants; Caffeic Acids; Humans; Inflammation Mediators; Lipoproteins, LDL; Lysophosphatidylcholines; Oxidation-Reduction; Phenols | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
Topics: Binding Sites; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Structure; Organic Anion Transport Protein 1; Organic Anion Transporters; Static Electricity; Substrate Specificity | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Aspirin; Carrageenan; Drug Evaluation, Preclinical; Edema; Humans; Hydrolysis; Male; Molecular Structure; Nitric Oxide Donors; Nitro Compounds; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Salicylic Acid; Solutions; Stereoisomerism; Vasodilator Agents; Water | 2008 |
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
Topics: Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Cytosol; Humans; Inhibitory Concentration 50; Molecular Structure; Salicylic Acid; Structure-Activity Relationship | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents.
Topics: Anti-Inflammatory Agents; Antioxidants; Chalcones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glucuronidase; Nitrogen; Trypsin; Trypsin Inhibitors | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney | 2011 |
Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Drug Stability; Edema; Humans; Hydrogen-Ion Concentration; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Salicylic Acid; Vasodilator Agents | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-α dependent NFκB activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Chemokine CXCL2; Colitis; HCT116 Cells; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; NF-kappa B; Rats; Salicylates; Spectrophotometry, Infrared; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2012 |
Peroxisome proliferator-activated receptor-γ mediates the anti-inflammatory effect of 3-hydroxy-4-pyridinecarboxylic acid derivatives: synthesis and biological evaluation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Dose-Response Relationship, Drug; Humans; Isonicotinic Acids; Lipopolysaccharides; Macrophages; Molecular Structure; PPAR gamma; RNA, Messenger; Structure-Activity Relationship; Transcription, Genetic | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Aspirin; Caspase 3; Cell Cycle; Cell Line, Tumor; Cyclins; Enzyme Activation; Female; Humans; Intestinal Absorption; Mice; Mice, Inbred C57BL; Prodrugs; Resveratrol; Stilbenes | 2015 |
Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells.
Topics: Amino Acid Substitution; Benzyl Alcohols; Cell Membrane; Goiter, Nodular; Hearing Loss, Sensorineural; HEK293 Cells; Humans; Membrane Transport Proteins; Microscopy, Fluorescence; Salicylates; Sulfate Transporters | 2017 |
Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening.
Topics: Bacterial Proteins; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fatty Acid Synthases; Molecular Structure; Mycobacterium tuberculosis; ortho-Aminobenzoates; Structure-Activity Relationship | 2020 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate.
Topics: Animals; Aspirin; Cell Adhesion; Cell Movement; Leukocytes; Leukotriene B4; Male; Platelet Activating Factor; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Splanchnic Circulation; Venules | 1992 |
Effects of aspirin on pathways of ion permeation in Necturus antrum: role of nutrient HCO3.
Topics: Acetates; Acetic Acid; Animals; Aspirin; Bicarbonates; Biological Transport; Cell Membrane; Gastric Mucosa; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Microscopy, Electron; Necturus; Pyloric Antrum; Salicylates; Salicylic Acid; Water-Electrolyte Balance | 1992 |
Aspirin, acetaminophen and proton transport through phospholipid bilayers and mitochondrial membranes.
Topics: Acetaminophen; Animals; Anions; Aspirin; Biological Transport; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Lipid Bilayers; Mitochondria; Oxidative Phosphorylation; Permeability; Phospholipids; Protons; Reye Syndrome; Salicylates; Salicylic Acid; Uncoupling Agents | 1992 |
Determination of salicylic acid by HPLC in plasma and saliva from children with juvenile chronic arthritis.
Topics: Adolescent; Arthritis, Juvenile; Aspirin; Child; Chromatography, High Pressure Liquid; Female; Humans; Male; Salicylates; Salicylic Acid; Saliva | 1992 |
The presence of specific IgE to salicyloyl and O-methylsalicyloyl in aspirin-sensitive patients.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Drug Hypersensitivity; Female; Humans; Immunoglobulin E; Male; Middle Aged; Radioallergosorbent Test; Salicylates; Salicylic Acid | 1992 |
The effect of antacid on aspirin pharmacokinetics in healthy Thai volunteers.
Topics: Adult; Aluminum Hydroxide; Aspirin; Biological Availability; Chromatography, High Pressure Liquid; Drug Interactions; Female; Hippurates; Humans; Magnesium Hydroxide; Male; Salicylates; Salicylic Acid; Thailand | 1992 |
Simultaneous spectrophotometric determination in solid phase of aspirin and its impurity salicylic acid in pharmaceutical formulations.
Topics: Aspirin; Drug Contamination; Salicylates; Salicylic Acid; Spectrophotometry | 1992 |
Bioavailability of two formulations of acetylsalicylic acid gums.
Topics: Adult; Aspirin; Biological Availability; Chewing Gum; Humans; Male; Salicylates; Salicylic Acid | 1992 |
Simultaneous high-performance liquid chromatographic determination of salicylates in whole blood, plasma and isolated erythrocytes.
Topics: Animals; Aspirin; Cells, Cultured; Chromatography, High Pressure Liquid; Erythrocytes; Gentisates; Hippurates; Hydroxybenzoates; Rabbits; Reproducibility of Results; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet | 1992 |
Evaluation of 2-(2-thiophenecarboxy)benzoic acid and related active metabolites in biological samples.
Topics: Animals; Aspirin; Benzoates; Chromatography, Liquid; Female; Hydrogen-Ion Concentration; Male; Naproxen; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet; Thiophenes; Tissue Distribution | 1992 |
Intrathecal injection of acetylsalicylic acid, salicylic acid and indomethacin depresses C fibre-evoked activity in the rat thalamus and spinal cord.
Topics: Afferent Pathways; Animals; Aspirin; Axons; Behavior, Animal; Female; Indomethacin; Injections, Spinal; Male; Nerve Fibers; Neurons; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Spinal Cord; Thalamus | 1992 |
Disposition of single-dose intravenous and oral aspirin in children.
Topics: Absorption; Administration, Oral; Aspirin; Biological Availability; Buffers; Child, Preschool; Drug Administration Schedule; Half-Life; Humans; Infusions, Intravenous; Mucocutaneous Lymph Node Syndrome; Salicylates; Salicylic Acid | 1991 |
Simultaneous determination of acetylsalicylic and salicylic acids in human serum and aspirin formulations by second-derivative synchronous fluorescence spectrometry.
Topics: Aspirin; Humans; Salicylates; Salicylic Acid; Spectrometry, Fluorescence | 1991 |
Misoprostol does not protect articular cartilage from salicylate-induced suppression of proteoglycan synthesis.
Topics: Alprostadil; Animals; Aspirin; Cartilage, Articular; Cells, Cultured; Culture Media; Dogs; Glycosaminoglycans; Humerus; Misoprostol; Salicylates; Salicylic Acid; Sodium Salicylate | 1991 |
[Pharmacokinetics of acetylsalicylic acid for the prophylaxis of cardiovascular pathology].
Topics: Adult; Aspirin; Cardiovascular Diseases; Delayed-Action Preparations; Female; Humans; Male; Salicylates; Salicylic Acid; Tablets, Enteric-Coated | 1991 |
Topical irritation of the gastrointestinal tract.
Topics: Animals; Aspirin; Colon; Rabbits; Salicylates; Salicylic Acid | 1990 |
Do salicylates and ascorbate increase the outer membrane permeability to hydrophobic antibiotics in Pseudomonas aeruginosa?
Topics: Ascorbic Acid; Aspirin; Cell Membrane Permeability; Deoxycholic Acid; Fusidic Acid; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Rifampin; Salicylates; Salicylic Acid | 1990 |
Effects of non-steroidal anti-inflammatory drugs on human neutrophil NADPH oxidase in both whole cell and cell-free systems.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell-Free System; Enzyme Activation; Humans; Indomethacin; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Salicylates; Salicylic Acid; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Aspirin potentiates prestimulated acid secretion and mobilizes intracellular calcium in rabbit parietal cells.
Topics: Adenosine Triphosphatases; Aminopyrine; Animals; Aspirin; Biological Transport; Calcium; Cyclic AMP; Dinoprostone; Gastric Juice; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Inositol Phosphates; Rabbits; Receptors, Cell Surface; Salicylates; Salicylic Acid; Signal Transduction | 1990 |
Comparative metabolism of high doses of aspirin in man and rat.
Topics: Adolescent; Adult; Animals; Aspirin; Female; Gentisates; Glucuronates; Hippurates; Humans; Kinetics; Male; Middle Aged; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1990 |
Determination of salicilic acid in saliva by high-performance liquid chromatography.
Topics: Aspirin; Biological Availability; Chromatography, High Pressure Liquid; Humans; Salicylates; Salicylic Acid; Saliva | 1990 |
Depletion of plasma glycine and effect of glycine by mouth on salicylate metabolism during aspirin overdose.
Topics: Administration, Oral; Adult; Aged; Aspirin; Drug Overdose; Female; Glycine; Glycylglycine; Hippurates; Humans; Male; Middle Aged; Salicylates; Salicylic Acid | 1990 |
Repeated oral administration of activated charcoal for treating aspirin overdose in young children.
Topics: Administration, Oral; Aspirin; Charcoal; Dialysis; Half-Life; Humans; Infant; Magnesium Sulfate; Male; Salicylates; Salicylic Acid | 1990 |
Metabolism of aspirin after therapeutic and toxic doses.
Topics: Adolescent; Adult; Aged; Aspirin; Child; Dose-Response Relationship, Drug; Female; Hippurates; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Salicylates; Salicylic Acid | 1990 |
Nondestructive near-infrared analysis of intact tablets for determination of degradation products.
Topics: Aspirin; Chromatography, High Pressure Liquid; Mathematics; Salicylates; Salicylic Acid; Spectrophotometry, Infrared; Tablets | 1990 |
Time-course of aspirin and salicylate in ocular tissues of rabbits.
Topics: Animals; Aqueous Humor; Aspirin; Ciliary Body; Cornea; Eye; Half-Life; Injections, Intravenous; Iris; Lens, Crystalline; Male; Rabbits; Retina; Salicylates; Salicylic Acid; Tissue Distribution; Vitreous Body | 1989 |
Renal handling of aspirin in the rat.
Topics: Animals; Aspirin; In Vitro Techniques; Kidney; Male; Perfusion; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1989 |
Pharmacokinetics of salicylic acid following administration of aspirin tablets and three different forms of soluble aspirin in normal subjects.
Topics: Adult; Aspirin; Buffers; Humans; Lysine; Salicylates; Salicylic Acid; Solubility; Tablets | 1989 |
Prevention of aspirin-induced gastric mucosal injury by histamine H2 receptor antagonists: a crossover endoscopic and intragastric pH study in the dog.
Topics: Animals; Aspirin; Dogs; Female; Gastric Acid; Gastric Acidity Determination; Gastric Mucosa; Gastroscopy; Histamine H2 Antagonists; Male; Salicylates; Salicylic Acid | 1987 |
Effects of aspirin, indomethacin, and sodium salicylate on human erythrocyte membranes as detected with electron spin resonance spectroscopy.
Topics: Aspirin; Blood Coagulation; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Female; Humans; Indomethacin; Kinetics; Male; Membrane Fluidity; Salicylates; Salicylic Acid; Sex Factors; Thermodynamics | 1985 |
Effect of triflusal and other salicylic acid derivatives on cyclic AMP levels in rat platelets.
Topics: Alprostadil; Animals; Aspirin; Blood Platelets; Cyclic AMP; Dipyridamole; Drug Interactions; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1986 |
Oxidation of salicylates by stimulated granulocytes: evidence that these drugs act as free radical scavengers in biological systems.
Topics: Aspirin; Benzoates; Benzoic Acid; Chloramines; Free Radicals; Granulocytes; Hydrogen Peroxide; Hydroxides; Hypochlorous Acid; Oxidation-Reduction; Salicylates; Salicylic Acid; Superoxides; Thiourea; Xanthine Oxidase; Xanthines | 1987 |
Role of lipoxygenase metabolism in platelet function: effect of aspirin and salicylate.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Aspirin; Blood Platelets; Collagen; Humans; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Platelet Adhesiveness; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Salicylates; Salicylic Acid; Thromboxane B2 | 1986 |
Two modes of analgesic action of aspirin, and the site of analgesic action of salicylic acid.
Topics: Analgesia; Animals; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Inflammation; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1986 |
Heterogeneity of changes on the disposition of aspirin in rats with CCl4-induced chronic liver damage.
Topics: Aniline Hydroxylase; Animals; Aspirin; Carbon Tetrachloride; Carboxylic Ester Hydrolases; Colchicine; Gentisates; Glucuronates; Glucuronosyltransferase; Hydroxybenzoates; Kinetics; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1987 |
Platelets, eicosanoids, and coronary vasospasm.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Coronary Vasospasm; Coronary Vessels; Eicosanoic Acids; Humans; In Vitro Techniques; Methysergide; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Salicylates; Salicylic Acid; Vasoconstriction | 1987 |
Effects and interaction studies of triflusal and other salicylic derivatives on cyclooxygenase in rats.
Topics: Alprostadil; Animals; Aorta, Thoracic; Aspirin; Blood Platelets; Drug Interactions; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Vasodilator Agents | 1988 |
Selectivity of oral aspirin as an inhibitor of platelet vs. vascular cyclooxygenase activity is reduced by portacaval shunt in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Aspirin; Blood Platelets; Blood Vessels; Cyclooxygenase Inhibitors; Gastric Mucosa; Liver; Male; Portacaval Shunt, Surgical; Rats; Salicylates; Salicylic Acid; Thromboxane B2; Time Factors | 1988 |
Effects of salicylate vs. aspirin on renal prostaglandins and function in normal and sodium-depleted dogs.
Topics: Animals; Aspirin; Blood Pressure; Diet, Sodium-Restricted; Dogs; Female; Glomerular Filtration Rate; Kidney; Male; Meclofenamic Acid; Potassium; Prostaglandins; Renal Circulation; Salicylates; Salicylic Acid | 1988 |
Pharmacokinetics of low-dose oral modified release, soluble and intravenous aspirin in man, and effects on platelet function.
Topics: Administration, Oral; Adult; Aspirin; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Platelet Aggregation; Salicylates; Salicylic Acid; Thromboxane A2 | 1988 |
The effect of concurrent aspirin upon plasma concentrations of tenoxicam.
Topics: Adult; Aspirin; Drug Interactions; Female; Humans; Male; Piroxicam; Protein Binding; Salicylates; Salicylic Acid | 1988 |
Effect of intragastric pH on mucosal protective action of sucralfate.
Topics: Animals; Aspirin; Bile Acids and Salts; Gastric Mucosa; Hydrogen-Ion Concentration; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Sucralfate | 1988 |
Pharmacokinetics of enteric-coated aspirin and inhibition of platelet thromboxane A2 and vascular prostacyclin generation in humans.
Topics: Adult; Aspirin; Blood Platelets; Epoprostenol; Female; Humans; Kinetics; Salicylates; Salicylic Acid; Saphenous Vein; Tablets, Enteric-Coated; Thromboxane A2; Thromboxane B2 | 1987 |
[Which of the various acetylsalicylic acid preparations is the most appropriate in each indication? A pharmacokinetic study].
Topics: Adult; Aspirin; Chromatography, High Pressure Liquid; Drug Evaluation; Female; Humans; Male; Salicylates; Salicylic Acid; Time Factors | 1988 |
Molecular integrity of aspirin in relation to Reye's syndrome.
Topics: Adolescent; Aspirin; Child; Child, Preschool; Humans; Hydrogen-Ion Concentration; Hydrolysis; Infant; Research; Reye Syndrome; Salicylates; Salicylic Acid; Spectrophotometry | 1988 |
Nonlinear pharmacokinetics of aspirin in rats.
Topics: Animals; Aspirin; Biological Availability; Dose-Response Relationship, Drug; Liver; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1988 |
Effects of administration route on pharmacokinetics of aspirin in the rabbit.
Topics: Animals; Aspirin; Infusions, Parenteral; Injections, Intravenous; Male; Rabbits; Salicylates; Salicylic Acid | 1988 |
The absorption of acetylsalicylic acid from an enteric-coated formulation and the inhibition of thromboxane formation.
Topics: Adult; Aspirin; Depression, Chemical; Female; Half-Life; Humans; Intestinal Absorption; Male; Salicylates; Salicylic Acid; Tablets; Tablets, Enteric-Coated; Thromboxane B2; Thromboxanes | 1988 |
Effect of triflusal and acetylsalicylic acid on platelet aggregation in human whole blood: influence of red blood cells and leukocytes.
Topics: Adult; Aspirin; Erythrocytes; Humans; In Vitro Techniques; Leukocytes; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Salicylic Acid | 1988 |
Inhibition by salicylates of urea synthesis by isolated rat hepatocytes and citrulline synthesis by isolated rat mitochondria: an effect independent of uncoupling.
Topics: Animals; Aspirin; Citrulline; Liver; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Urea | 1988 |
Prostaglandin E2 binding sites in porcine oxyntic mucosa: effects of salicylates.
Topics: Animals; Aspirin; Binding Sites; Dinoprostone; Female; Gastric Mucosa; Parietal Cells, Gastric; Prostaglandins E; Salicylates; Salicylic Acid; Swine; Tritium | 1986 |
An in situ experimental model in rabbits for the study of rectal absorption.
Topics: Animals; Aspirin; Indomethacin; Insulin; Intestinal Absorption; Kinetics; Male; Rabbits; Rectum; Salicylates; Salicylic Acid; Suppositories; Time Factors | 1986 |
Lowering of plasma isoxicam concentrations with acetylsalicylic acid.
Topics: Administration, Oral; Adult; Aged; Aspirin; Binding, Competitive; Drug Interactions; Humans; Kinetics; Male; Middle Aged; Piroxicam; Protein Binding; Salicylates; Salicylic Acid | 1986 |
Effect of clofibrate on lipid peroxidation in rats treated with aspirin and 4-pentenoic acid.
Topics: Animals; Aspirin; Clofibrate; Cytosol; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Lipid Metabolism; Lipid Peroxides; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Proteins; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Sulfhydryl Compounds | 1987 |
Salicyl phenolic glucuronide pharmacokinetics in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Female; Glucuronates; Humans; Kinetics; Male; Middle Aged; Salicylates; Salicylic Acid | 1987 |
The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Humans; Inflammation; Salicylates; Salicylic Acid | 1987 |
Determination of aspirin and salicylic acid in uremic patients' plasma using reversed-phase high-performance liquid chromatography.
Topics: Aspirin; Chromatography, High Pressure Liquid; Humans; Salicylates; Salicylic Acid; Uremia | 1987 |
Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Brain Ischemia; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Salicylates; Salicylic Acid; Sex Factors; Thromboxane B2 | 1987 |
Serum salicylate levels in a breast fed infant.
Topics: Adult; Arthritis, Juvenile; Aspirin; Breast Feeding; Female; Humans; Infant; Milk, Human; Pregnancy; Salicylates; Salicylic Acid | 1987 |
Inhibition of platelet 5-HT secretion and of 5-HT induced vasoconstriction by paracetamol.
Topics: Acetaminophen; Adenosine Diphosphate; Aspirin; Blood Platelets; Humans; In Vitro Techniques; Platelet Aggregation; Salicylates; Salicylic Acid; Serotonin; Thromboxane A2; Vasoconstriction | 1987 |
Disposition of aspirin and its metabolites in the semen of man.
Topics: Adolescent; Adult; Aspirin; Hippurates; Humans; Male; Salicylates; Salicylic Acid; Semen | 1987 |
Determination of plasma aspirin and salicylic acid concentrations after low aspirin doses by high-performance liquid chromatography with post-column hydrolysis and fluorescence detection.
Topics: Aspirin; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Humans; Hydrogen-Ion Concentration; Hydrolysis; Salicylates; Salicylic Acid; Spectrometry, Fluorescence | 1987 |
Studies of platelet hyperactivity in patients with ischemic cerebrovascular diseases: IV. Determination of the optimal dosage of aspirin by measuring plasma salicylate level.
Topics: Aged; Aspirin; Blood Platelets; Brain Ischemia; Female; Humans; Male; Middle Aged; Salicylates; Salicylic Acid; Thromboxane B2 | 1987 |
The metabolism of aspirin in man: a population study.
Topics: Adult; Aspirin; Biotransformation; Female; Glucuronates; Glycine; Hippurates; Humans; Hydrogen-Ion Concentration; Male; Salicylates; Salicylic Acid; Sex Factors | 1986 |
Mechanisms of cell association of chloroquine to leucocytes.
Topics: Aspirin; Cell Survival; Chloroquine; Humans; Hydrogen-Ion Concentration; Indomethacin; Leukocytes; Mathematics; Neutrophils; Salicylates; Salicylic Acid; Temperature; Time Factors | 1986 |
Application of a radiotelemetric system to evaluate the performance of enteric coated and plain aspirin tablets.
Topics: Animals; Aspirin; Biological Availability; Blood Specimen Collection; Dogs; Injections, Intravenous; Kinetics; Male; Salicylates; Salicylic Acid; Tablets; Tablets, Enteric-Coated; Telemetry | 1986 |
Influence of age, gender, and obesity on salicylate kinetics following single doses of aspirin.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aspirin; Body Weight; Female; Humans; Infusions, Parenteral; Kinetics; Male; Obesity; Salicylates; Salicylic Acid; Sex Factors | 1986 |
Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid.
Topics: Adult; Aspirin; Blood Proteins; Contraceptives, Oral, Hormonal; Female; Humans; Kinetics; Male; Protein Binding; Salicylates; Salicylic Acid; Sex Factors | 1986 |
Toxic interaction between acetazolamide and salicylate: case reports and a pharmacokinetic explanation.
Topics: Acetazolamide; Aged; Aged, 80 and over; Aspirin; Blood Proteins; Drug Interactions; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Protein Binding; Salicylates; Salicylic Acid | 1986 |
Salicylates and 12-lipoxygenase activity in human washed platelets.
Topics: Adult; Arachidonate 12-Lipoxygenase; Arachidonate Lipoxygenases; Aspirin; Blood Platelets; Chromatography, High Pressure Liquid; Gentisates; Humans; Hydroxybenzoates; In Vitro Techniques; Lipoxygenase Inhibitors; Salicylamides; Salicylates; Salicylic Acid | 1986 |
Effect of food on the absorption of enteric-coated aspirin: correlation with gastric residence time.
Topics: Absorption; Adult; Aspirin; Eating; Fasting; Female; Gastric Emptying; Hippurates; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Salicylates; Salicylic Acid; Tablets, Enteric-Coated | 1987 |
Differential salicylate-aspirin interaction on vascular prostacyclin and platelet thromboxane synthesis in patients undergoing saphenectomy.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Drug Interactions; Female; Humans; Middle Aged; Salicylates; Salicylic Acid; Thromboxane B2; Varicose Veins; Veins | 1985 |
Salicylate antagonizes the antiinflammatory action of aspirin in the rat.
Topics: Animals; Aspirin; Carrageenan; Drug Antagonism; Edema; Kinetics; Male; Rats; Salicylates; Salicylic Acid | 1985 |
Differences in the haemorrhagic toxicity of aspirin between rats and mice.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Gastrointestinal Hemorrhage; Gentisates; Hydroxybenzoates; Kaolin; Liver; Male; Mice; Mice, Inbred ICR; Organ Size; Partial Thromboplastin Time; Prothrombin Time; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Species Specificity; Time Factors | 1985 |
Acute effects of acetylsalicylic acid on renal and hepatic function in normal humans.
Topics: Adolescent; Adult; Alanine Transaminase; Albuminuria; Aspartate Aminotransferases; Aspirin; beta 2-Microglobulin; Female; Humans; Kidney; Liver; Male; Middle Aged; Proteinuria; Prothrombin Time; Salicylates; Salicylic Acid | 1985 |
Indomethacin and salicylate modulate effect of insulin on glucose kinetics in dogs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Glucose; Dogs; Drug Interactions; Female; Gluconeogenesis; Glucose; Indomethacin; Insulin; Kinetics; Liver; Prostaglandin Antagonists; Prostaglandins; Salicylates; Salicylic Acid; Time Factors | 1985 |
Cyclooxygenase inhibitors affect Met-enkephalin- and acetylcholine-stimulated motility of the isolated rat colon.
Topics: Acetylcholine; Animals; Aspirin; Colon; Cyclooxygenase Inhibitors; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Enkephalin, Methionine; Gastrointestinal Motility; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1985 |
Endothelial cells produce a lipoxygenase derived chemo-repellent which influences platelet/endothelial cell interactions--effect of aspirin and salicylate.
Topics: Adenine; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cell Adhesion; Cells, Cultured; Endothelium; Female; Humans; Kinetics; Lipoxygenase; Phospholipids; Platelet Adhesiveness; Pregnancy; Prostaglandin-Endoperoxide Synthases; Salicylates; Salicylic Acid; Umbilical Veins | 1985 |
Gastric ulcer formation and cyclo-oxygenase inhibition in cat antrum follows parenteral administration of aspirin but not salicylate.
Topics: Animals; Aspirin; Cats; Cyclooxygenase Inhibitors; Dinoprostone; Epoprostenol; Female; Histamine; Infusions, Parenteral; Male; Prostaglandins E; Salicylates; Salicylic Acid; Stomach Ulcer | 1985 |
Interaction of non-steroidal anti-inflammatory drugs on platelet cyclo-oxygenase and lipoxygenase activity.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Humans; Indomethacin; Kinetics; Lipoxygenase; Models, Biological; Prostaglandin-Endoperoxide Synthases; Salicylates; Salicylic Acid; Sulfinpyrazone | 1985 |
Bioavailability of sustained-release aspirin preparations.
Topics: Adult; Aspirin; Biological Availability; Delayed-Action Preparations; Humans; Male; Salicylates; Salicylic Acid; Time Factors | 1986 |
Plasma and synovial fluid concentrations of salicylic acid and its metabolites in patients with joint effusions.
Topics: Adult; Aged; Arthritis; Aspirin; Female; Gentisates; Hippurates; Humans; Hydroxybenzoates; Male; Middle Aged; Salicylates; Salicylic Acid; Synovial Fluid | 1985 |
Confirmation of serum salicylate levels in Reye's syndrome: a comparison between the Natelson colorimetric method and high performance liquid chromatography.
Topics: Ammonia; Aspirin; Child; Chromatography, High Pressure Liquid; Colorimetry; Humans; Reye Syndrome; Salicylates; Salicylic Acid | 1985 |
Plasma salicylate levels and platelet function after acute and chronic administration of slow-release acetylsalicylic acid (Monobeltin).
Topics: Adult; Aspirin; Blood Platelets; Delayed-Action Preparations; Hippurates; Humans; Male; Platelet Aggregation; Salicylates; Salicylic Acid; Time Factors | 1985 |
Inhibition of human platelet thromboxane generation by aspirin in the absence of measurable drug levels in peripheral blood.
Topics: Adult; Aspirin; Blood Platelets; Depression, Chemical; Humans; Male; Salicylates; Salicylic Acid; Thromboxanes | 1985 |
The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.
Topics: Adult; Age Factors; Aged; Aspirin; Biotransformation; Female; Hippurates; Humans; Male; Models, Biological; Salicylates; Salicylic Acid; Sex Factors | 1985 |
High-pressure liquid chromatographic analysis of paracetamol, caffeine and acetylsalicylic acid in tablets. Salicylic acid quantitation.
Topics: Acetaminophen; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Salicylates; Salicylic Acid; Tablets | 1985 |
Determination of paracetamol, salicylic acid and acetyl salicylic acid in serum by high-performance liquid chromatography.
Topics: Acetaminophen; Aspirin; Chromatography, High Pressure Liquid; Humans; Salicylates; Salicylic Acid | 1985 |
A sensitive liquid chromatographic assay for plasma aspirin and salicylate concentrations after low doses of aspirin.
Topics: Adult; Aspirin; Chromatography, Liquid; Female; Humans; Kinetics; Male; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet | 1985 |
[The bioavailability of combination preparations of acetylsalicylic acid and codeine phosphate].
Topics: Administration, Oral; Adult; Aspirin; Biological Availability; Codeine; Drug Combinations; Hippurates; Humans; Injections, Intravenous; Kinetics; Salicylates; Salicylic Acid; Suppositories | 1985 |
Decomposition of aspirin in the solid state in the presence of limited amounts of moisture.
Topics: Acetates; Aspirin; Drug Stability; Humidity; Kinetics; Salicylates; Salicylic Acid; Solubility; Temperature; Time Factors; Water | 1985 |
Aspirin dosing using 15 grain enteric coated tablets.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Osteoarthritis; Salicylates; Salicylic Acid; Tablets, Enteric-Coated; Tinnitus | 1985 |
[Reaction kinetics of the dissolution of acetylsalicylic acid and salicylic acid in aqueous solution. I. pH and temperature dependence of salicylic acid decomposition].
Topics: Aspirin; Chemical Phenomena; Chemistry; Drug Stability; Hydrogen-Ion Concentration; Kinetics; Salicylates; Salicylic Acid; Solubility; Thermodynamics | 1985 |
Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma".
Topics: Adult; Aspirin; Blood Platelets; Capsules; Humans; Kinetics; Male; Salicylates; Salicylic Acid; Tablets; Thromboxane B2 | 1985 |
Effect of antacids on salicylate kinetics.
Topics: Adult; Aluminum Hydroxide; Antacids; Aspirin; Drug Combinations; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Kinetics; Magnesium Hydroxide; Male; Salicylates; Salicylic Acid; Silicic Acid | 1985 |
The effect of ionization on partition coefficients and topical delivery.
Topics: Administration, Topical; Animals; Aspirin; Male; Mice; Mice, Hairless; Salicylates; Salicylic Acid; Solubility | 1985 |
Attenuation of aspirin analgesia by calcium loading in healthy subjects.
Topics: Adult; Analgesics; Aspirin; Calcium; Humans; Magnesium; Male; Phosphates; Salicylates; Salicylic Acid | 1985 |
Clinical-pharmacokinetic investigations of acetylsalicylic acid in cases of imminent premature delivery.
Topics: Amniotic Fluid; Aspirin; Female; Fetal Blood; Humans; Infant, Newborn; Kinetics; Obstetric Labor, Premature; Placenta; Pregnancy; Salicylates; Salicylic Acid; Time Factors | 1985 |
Salicylate inhibition of antiplatelet effect of aspirin.
Topics: Aspirin; Diflunisal; Humans; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Salicylates; Salicylic Acid | 1981 |
Bioavailability of magnesium salicylate.
Topics: Absorption; Animals; Aspirin; Biological Availability; Dogs; Female; Salicylates; Salicylic Acid | 1981 |
Determination of salicylic acid in acetylsalicylic acid by second derivative u.v.-spectrophotometry.
Topics: Aspirin; Dioxanes; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet | 1982 |
Absorption of acetylsalicylic acid from enteric-coated tablets in relation to gastric emptying and in-vivo disintegration.
Topics: Aspirin; Gastric Emptying; Humans; Intestinal Absorption; Salicylates; Salicylic Acid; Solubility; Tablets, Enteric-Coated | 1984 |
Theophylline, dyphylline, caffeine, acetaminophen, salicylate, acetylsalicylate, procainamide, and N-acetylprocainamide determined in serum with a single liquid-chromatographic assay.
Topics: Acecainide; Acetaminophen; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Humans; Pharmaceutical Preparations; Procainamide; Salicylates; Salicylic Acid; Theophylline | 1982 |
Failure of salicylate to reduce inhibition of human venous prostacyclin in synthesis by conventional dose aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Epoprostenol; Humans; Kinetics; Prostaglandins; Salicylates; Salicylic Acid; Veins | 1983 |
Selective mitochondrial activity distinguishes aspirin from salicylate and benzoate in yeast cells.
Topics: Aspirin; Benzoates; Benzoic Acid; Mitochondria; Mutation; Oxygen Consumption; Saccharomyces cerevisiae; Salicylates; Salicylic Acid | 1983 |
Effect of salicylates on intestinal secretion in calves given (intestinal loops) Escherichia coli heat-stable enterotoxin.
Topics: Animals; Aspirin; Cattle; Cattle Diseases; Diarrhea; Enterotoxins; Escherichia coli; Intestinal Secretions; Male; Mice; Osmolar Concentration; Salicylates; Salicylic Acid | 1983 |
Salicylate fails to prevent the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on human platelet cyclo-oxygenase and lipoxygenase activities.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Aspirin; Blood Platelets; Fatty Acids, Unsaturated; Humans; Indomethacin; Lipoxygenase; Prostaglandin-Endoperoxide Synthases; Salicylates; Salicylic Acid | 1983 |
Correlations between changes in indicators of gastric mucosal barrier integrity at time of exposure to "barrier breakers" and extent of hemorrhagic erosions one hour later.
Topics: Animals; Aspirin; Ethanol; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Mannitol; Prognosis; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Stomach Ulcer; Taurocholic Acid | 1984 |
The effect of acetylsalicylic acid on renal function in the Pekin duck.
Topics: Animals; Arginine Vasopressin; Aspirin; Cyclooxygenase Inhibitors; Diuresis; Ducks; Exocrine Glands; Female; Glomerular Filtration Rate; Kidney; Male; Osmolar Concentration; Renal Circulation; Salicylates; Salicylic Acid | 1984 |
Salicylate:aspirin ratios: relevance to aspirin's antithrombotic action.
Topics: Animals; Aspirin; Binding, Competitive; Cyclooxygenase Inhibitors; Fibrinolytic Agents; Kinetics; Rats; Salicylates; Salicylic Acid | 1984 |
[Divergence between the pharmacologic and clinical effects of inhibitors of prostaglandin synthesis].
Topics: Aspirin; Blood Platelets; Dipyridamole; Drug Interactions; Epoprostenol; Humans; Platelet Aggregation; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Salicylates; Salicylic Acid; Sulfinpyrazone; Thrombosis; Thromboxanes | 1984 |
[Comparison of the pharmacokinetic behavior of Turivital, Acesal and Micristin].
Topics: Adult; Ascorbic Acid; Aspirin; Biological Availability; Caffeine; Carbon Dioxide; Drug Combinations; Drug Interactions; Female; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Kinetics; Male; Salicylates; Salicylic Acid | 1984 |
Inhibition of platelet function by a controlled release acetylsalicylic acid formulation--single and chronic dosing studies.
Topics: Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Delayed-Action Preparations; Female; Humans; Male; Malondialdehyde; Platelet Aggregation; Platelet Function Tests; Salicylates; Salicylic Acid; Time Factors | 1984 |
A simple fluorometric method for the determination of salicylic acid in aluminium acetylsalicylate.
Topics: Aspirin; Hydrogen-Ion Concentration; Salicylates; Salicylic Acid; Spectrometry, Fluorescence; Tablets | 1984 |
Determination of aspirin and salicylic acid in aspirin tablets by second derivative ultraviolet spectrometry.
Topics: Aspirin; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet; Tablets | 1984 |
Comparative aspirin absorption kinetics after administration of sodium- and potassium-containing buffered solutions.
Topics: Adult; Aspirin; Buffers; Female; Hippurates; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Kinetics; Male; Potassium; Salicylates; Salicylic Acid; Sodium; Solutions | 1984 |
Reye's syndrome: salicylates and mitochondrial functions.
Topics: Animals; Aspirin; Calcium; Humans; Hydroxybutyrates; Mitochondria; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxygen Consumption; Phosphates; Rats; Reye Syndrome; Salicylates; Salicylic Acid; Structure-Activity Relationship; Succinates; Succinic Acid | 1984 |
Actions and interactions of acetylsalicylic acid, salicylic acid and diflunisal on platelet aggregation.
Topics: Adult; Aspirin; Diflunisal; Drug Interactions; Female; Humans; Male; Middle Aged; Platelet Aggregation; Salicylates; Salicylic Acid | 1984 |
Difficulty in achieving therapeutic serum concentrations of salicylate in Kawasaki disease.
Topics: Aspirin; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; Prospective Studies; Retrospective Studies; Salicylates; Salicylic Acid | 1984 |
Rapid and sensitive determination of acetylsalicylic acid and its metabolites using reversed-phase high-performance liquid chromatography.
Topics: Animals; Aspirin; Biotransformation; Chromatography, High Pressure Liquid; Gentisates; Hippurates; Humans; Hydrogen-Ion Concentration; Rats; Salicylates; Salicylic Acid; Species Specificity | 1984 |
Aspirin metabolites causing misinterpretation of paracetamol results.
Topics: Acetaminophen; Aspirin; Biotransformation; Chromatography, High Pressure Liquid; Gentisates; Humans; Hydroxybenzoates; Infant; Male; Salicylates; Salicylic Acid | 1984 |
Improved method for the determination of aspirin and its metabolites in biological fluids by high-performance liquid chromatography: applications to human and animal studies.
Topics: Animals; Aspirin; Biological Availability; Chromatography, High Pressure Liquid; Gentisates; Hippurates; Humans; Hydroxybenzoates; Kinetics; Rabbits; Rats; Salicylates; Salicylic Acid; Species Specificity | 1984 |
Salicylate prophylaxis in migraine.
Topics: Adolescent; Adult; Aged; Aspirin; Female; Humans; Male; Middle Aged; Migraine Disorders; Platelet Aggregation; Salicylates; Salicylic Acid; Vascular Headaches | 1984 |
Minimization of salicylic acid formation during preparation of aspirin products for analysis by high-performance liquid chromatography.
Topics: Aspirin; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Salicylates; Salicylic Acid | 1984 |
Analysis of tablets containing aspirin, acetaminophen, and ascorbic acid by high-performance liquid chromatography.
Topics: Acetaminophen; Ascorbic Acid; Aspirin; Chromatography, High Pressure Liquid; Drug Stability; Humidity; Hydrogen-Ion Concentration; Salicylates; Salicylic Acid; Tablets; Temperature; Time Factors | 1984 |
Simultaneous high-performance liquid chromatography assay of acetylsalicylic acid and salicylic acid in film-coated aspirin tablets.
Topics: Aspirin; Chromatography, High Pressure Liquid; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet; Tablets, Enteric-Coated | 1984 |
Effects of indomethacin, aspirin and related compounds on the transgastric potential difference in cats.
Topics: Animals; Aspirin; Cats; Dinoprostone; Female; Gastric Mucosa; Indomethacin; Infusions, Parenteral; Intubation, Gastrointestinal; Male; Membrane Potentials; Prostaglandins E; Salicylates; Salicylic Acid; Time Factors | 1983 |
Relevance to redesigning aspirin therapeutic regimens.
Topics: Aspirin; Drug Administration Schedule; Humans; Kinetics; Models, Biological; Salicylates; Salicylic Acid | 1983 |
Salicylate does not interfere with aspirin in human blood in vivo.
Topics: Adult; Aspirin; Blood Coagulation; Blood Platelets; Humans; Male; Salicylates; Salicylic Acid; Thromboxane B2; Thromboxanes | 1984 |
Rapidly-adapting receptor activity and intratracheal pressure in guinea pigs. II. Action of aspirin and salicylic acid in antagonizing mediators of allergic asthma.
Topics: Animals; Aspirin; Asthma; Bradykinin; Dinoprost; Guinea Pigs; Histamine; Mechanoreceptors; Muscle, Smooth; Pressure; Prostaglandins F; Pulmonary Stretch Receptors; Salicylates; Salicylic Acid; SRS-A; Trachea | 1984 |
Availability of salicylate from salsalate and aspirin.
Topics: Arthritis, Rheumatoid; Aspirin; Biological Availability; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Evaluation; Female; Gentisates; Humans; Hydroxybenzoates; Male; Salicylates; Salicylic Acid | 1983 |
Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease.
Topics: Adult; Aged; Aging; Aspirin; Blood Proteins; Humans; Kinetics; Liver Diseases, Alcoholic; Male; Middle Aged; Models, Biological; Protein Binding; Salicylates; Salicylic Acid | 1983 |
High-performance liquid chromatographic determination of aspirin and its metabolites in plasma and urine.
Topics: Animals; Aspirin; Biotransformation; Chromatography, High Pressure Liquid; Gentisates; Hippurates; Humans; Rats; Salicylates; Salicylic Acid | 1983 |
Effect of water deprivation on aspirin disposition kinetics.
Topics: Animals; Aspirin; Biotransformation; Heparin; Injections, Intravenous; Kinetics; Male; Rats; Salicylates; Salicylic Acid; Water Deprivation | 1983 |
[Distribution of salicylic acid and hydrolysis of acetylsalicylic acid in the human fetus in early pregnancy].
Topics: Aspirin; Female; Fetus; Humans; Hydrolysis; Maternal-Fetal Exchange; Pregnancy; Pregnancy Trimester, First; Salicylates; Salicylic Acid; Tissue Distribution | 1983 |
Placental transfer of acetylsalicylic acid (ASA) and salicylic acid (SA) in near-term ewes.
Topics: Animals; Aspirin; Female; Fetus; Gestational Age; Kinetics; Maternal-Fetal Exchange; Models, Biological; Pregnancy; Salicylates; Salicylic Acid; Sheep | 1983 |
Salicylic acid plasma levels following multiple doses of Norgesic Forte and aspirin.
Topics: Adult; Aspirin; Caffeine; Double-Blind Method; Drug Combinations; Female; Humans; Kinetics; Male; Orphenadrine; Salicylates; Salicylic Acid | 1983 |
The effect of the non-steroidal anti-inflammatory drug choline magnesium trisalicylate on gastric mucosal cell exfoliation.
Topics: Adult; Aspirin; Choline; Female; Gastric Mucosa; Humans; Male; Random Allocation; Salicylates; Salicylic Acid | 1984 |
Stabilized normal-phase high-performance liquid chromatographic analysis of aspirin and salicylic acid in solid pharmaceutical dosage forms.
Topics: Antacids; Aspirin; Buffers; Chromatography, High Pressure Liquid; Drug Stability; Salicylates; Salicylic Acid; Tablets | 1984 |
Interaction between frusemide and aspirin.
Topics: Adult; Aspirin; Diuresis; Female; Furosemide; Humans; Male; Natriuresis; Potassium; Salicylates; Salicylic Acid | 1984 |
Effect of oral 16,16-dimethyl prostaglandin E2 on gastric mucosal salicylate concentration in the rat.
Topics: Administration, Oral; Animals; Aspirin; Chromatography, High Pressure Liquid; Female; Gastric Mucosa; Injections, Intravenous; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Stomach Ulcer | 1984 |
Placental drug transfer in near-term ewes: acetylsalicylic and salicylic acid.
Topics: Animals; Aspirin; Computers; Female; Isotope Labeling; Kinetics; Maternal-Fetal Exchange; Models, Biological; Pregnancy; Salicylates; Salicylic Acid; Sheep | 1984 |
Effects of acetylsalicylic acid on human platelet function in vivo at salicylate steady state.
Topics: Adult; Aspirin; Collagen; Humans; Male; Platelet Aggregation; Platelet Function Tests; Salicylates; Salicylic Acid | 1984 |
Salicylate-aspirin interaction in the rat. Evidence that salicylate accumulating during aspirin administration may protect vascular prostacyclin from aspirin-induced inhibition.
Topics: Animals; Aspirin; Biotransformation; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Salicylates; Salicylic Acid | 1981 |
Salicylic acid blocks indomethacin- and aspirin-induced cyclo-oxygenase inhibition in rat gastric mucosa.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprost; Drug Interactions; Gastric Mucosa; Indomethacin; Male; Prostaglandin Antagonists; Prostaglandins F; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1982 |
Determination of salicylic acid in aspirin powder by second derivative ultraviolet spectrometry.
Topics: Aspirin; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet | 1983 |
Determination of acetylsalicylic acid and metabolites in biological fluids by high-performance liquid chromatography.
Topics: Animals; Aspirin; Chromatography, High Pressure Liquid; Gentisates; Hippurates; Humans; Kinetics; Male; Rabbits; Salicylates; Salicylic Acid; Specimen Handling | 1983 |
Plasma levels of acetylsalicylic acid and salicylic acid after oral ingestion of plain and buffered acetylsalicylic acid in relation to bleeding time and thrombocyte function.
Topics: Adult; Aspirin; Bleeding Time; Blood Coagulation; Blood Platelets; Buffers; Humans; Kinetics; Male; Platelet Aggregation; Platelet Function Tests; Salicylates; Salicylic Acid | 1983 |
Protection from arrhythmias of cultured heart cells by nonsteroidal antiinflammatory drugs.
Topics: Animals; Animals, Newborn; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Aspirin; Cells, Cultured; Indomethacin; Rats; Salicylates; Salicylic Acid; Sulfinpyrazone; Time Factors | 1983 |
In vitro and in vivo evaluation of two preparations of activated charcoal as adsorbents of aspirin.
Topics: Adsorption; Adult; Aspirin; Biological Availability; Charcoal; Female; Humans; Male; Salicylates; Salicylic Acid; Time Factors | 1983 |
Combined embryotoxic action of toluene, a widely used industrial chemical, and acetylsalicylic acid (aspirin).
Topics: Abnormalities, Drug-Induced; Amniotic Fluid; Animals; Aspirin; Drug Interactions; Embryo, Mammalian; Female; Gestational Age; Glycine; Pregnancy; Rats; Salicylates; Salicylic Acid; Teratogens; Toluene | 1983 |
Sensitive salicylate assay in plasma with a 'reversed' Berthelot's reaction.
Topics: Aspirin; Chemical Phenomena; Chemistry; Chloramines; Colorimetry; Humans; Pyruvates; Pyruvic Acid; Salicylates; Salicylic Acid; Time Factors | 1983 |
Influence of food on aspirin absorption from tablets and buffered solutions.
Topics: Adult; Aspirin; Buffers; Food; Humans; Intestinal Absorption; Male; Salicylates; Salicylic Acid; Solutions; Tablets | 1983 |
In vivo and in vitro studies on the binding of salicylate to human plasma proteins: evidence for one type of binding site.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Binding Sites; Blood Proteins; Female; Humans; In Vitro Techniques; Kinetics; Male; Middle Aged; Protein Binding; Salicylates; Salicylic Acid | 1982 |
Endogenous gastric mucosal prostaglandins: their role in mucosal integrity.
Topics: Animals; Aspirin; Biological Transport, Active; Dogs; Gastric Mucosa; Prostaglandins; Salicylates; Salicylic Acid; Sodium | 1982 |
Gastric emptying and absorption of acetylsalicylic acid administered as enteric-coated micro-granules.
Topics: Adult; Aspirin; Capsules; Delayed-Action Preparations; Gastric Emptying; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Male; Salicylates; Salicylic Acid | 1982 |
Determination of related compounds in aspirin by liquid chromatography.
Topics: Aspirin; Chromatography, Liquid; Salicylates; Salicylic Acid; Tablets | 1982 |
Bioavailability of acetylsalicylic acid and salicylic acid from rapid-and slow-release formulations, and in combination with dipyridamol.
Topics: Adult; Aspirin; Biological Availability; Delayed-Action Preparations; Dipyridamole; Female; Humans; Kinetics; Male; Salicylates; Salicylic Acid | 1982 |
Inhibition of anaerobic glycolysis in bovine retina extracts by salicylate and acetylsalicylate.
Topics: Animals; Aspirin; Cattle; Glucose; Glycolysis; In Vitro Techniques; Lactates; Lactic Acid; Oxygen; Retina; Salicylates; Salicylic Acid | 1982 |
[Studies on the pharmacological bases of fetal toxicity of drugs. (I). Relation of fetal toxicity and tissue concentration of acetylsalicylic acid with pyrogen in pregnant rats].
Topics: Abnormalities, Drug-Induced; Adenosine Triphosphate; Animals; Aspirin; Body Weight; Drug Synergism; Female; Fetus; Humans; Infant, Newborn; Lipopolysaccharides; Male; Maternal-Fetal Exchange; Pregnancy; Pyrogens; Rats; Salicylates; Salicylic Acid; Tissue Distribution | 1982 |
Aspirin--a national survey V: Determination of aspirin and impurities in enteric coated tablets and suppository formulations and in vitro dissolution of enteric coated tablets.
Topics: Aspirin; Chromatography, Thin Layer; Drug Contamination; Salicylates; Salicylic Acid; Solubility; Suppositories; Tablets, Enteric-Coated; United States | 1982 |
The transmural gastric potential difference in combination with pharmacokinetic profiles. A new approach to combine kinetic and dynamic properties of compounds.
Topics: Adolescent; Adult; Aspirin; Buffers; Double-Blind Method; Drug Combinations; Female; Gastric Mucosa; Humans; Kinetics; Male; Membrane Potentials; Models, Biological; Salicylates; Salicylic Acid | 1982 |
Systemic availability of acetylsalicylic acid in human subjects after oral ingestion of three different formulations.
Topics: Administration, Oral; Aspirin; Biological Availability; Biotransformation; Delayed-Action Preparations; Humans; Kinetics; Salicylates; Salicylic Acid | 1982 |
Spectrofluorometric determination of acetylsalicylic acid, salicylamide, and salicyclic acid as an impurity in pharmaceutical preparations.
Topics: Acetaminophen; Aspirin; Buffers; Caffeine; Drug Combinations; Drug Contamination; Salicylamides; Salicylates; Salicylic Acid; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1981 |
Gastric cytoprotection by sodium salicylate.
Topics: Animals; Aspirin; Ethanol; Gastric Mucosa; Indomethacin; Male; Rats; Salicylates; Salicylic Acid; Stomach Ulcer; Structure-Activity Relationship | 1981 |
General model for dissolution rates of n-component, nondisintegrating spheres.
Topics: Aspirin; Caffeine; Chemical Phenomena; Chemistry, Physical; Drug Combinations; Kinetics; Models, Chemical; Phenacetin; Salicylates; Salicylic Acid; Solubility | 1981 |
Effect of multiple-dose activated charcoal on the clearance of high-dose intravenous aspirin in a porcine model.
Topics: Animals; Antidotes; Aspirin; Charcoal; Cross-Over Studies; Disease Models, Animal; Drug Evaluation, Preclinical; Metabolic Clearance Rate; Poisoning; Salicylates; Salicylic Acid; Swine; Time Factors | 1995 |
Pharmacokinetics and pharmacodynamics in copper deficiency. I. Antiinflammatory activity of aspirin.
Topics: Analysis of Variance; Animals; Aspirin; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Copper; Diet; Edema; Male; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid | 1994 |
Salicylate poisoning: two-dimensional J-resolved NMR urinalysis.
Topics: Adolescent; Aspirin; Female; Gentisates; Hippurates; Humans; Hydroxybenzoates; Magnetic Resonance Spectroscopy; Poisoning; Salicylates; Salicylic Acid | 1995 |
Aspirin, salicylate, sulfite and tartrazine induced bronchoconstriction. Safe doses and case definition in epidemiological studies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Bronchoconstriction; Drug Hypersensitivity; Environmental Exposure; Epidemiologic Methods; False Positive Reactions; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Salicylates; Salicylic Acid; Sulfites; Tartrazine | 1995 |
Aspirin as a free radical scavenger: consequences for therapy of cerebrovascular ischemia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Cerebrovascular Disorders; Cyclooxygenase Inhibitors; Female; Free Radical Scavengers; Gentisates; Humans; Hydroxybenzoates; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; Salicylates; Salicylic Acid | 1995 |
Protein binding of acetylsalicylic acid and salicylic acid in porcine and human serum.
Topics: Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Proteins; Drug Overdose; Esterases; Humans; In Vitro Techniques; Isotope Labeling; Pilot Projects; Protein Binding; Salicylates; Salicylic Acid; Serum Albumin; Swine; Ultrafiltration | 1995 |
Chronopharmacological study of acetylsalicylic acid in mice.
Topics: Analgesics; Animals; Aspirin; Body Temperature; Circadian Rhythm; Male; Mice; Mice, Inbred ICR; Pain Measurement; Salicylates; Salicylic Acid | 1995 |
High-performance liquid chromatography-electrochemical determination of salicylate hydroxylation products as an in vivo marker of oxidative stress.
Topics: Adult; Aspirin; Calibration; Chromatography, High Pressure Liquid; Female; Free Radical Scavengers; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; Male; Oxidative Stress; Reproducibility of Results; Salicylates; Salicylic Acid; Thiobarbituric Acid Reactive Substances | 1995 |
Disposition kinetics of aspirin in female New Zealand white rabbits.
Topics: Animals; Aspirin; Body Weight; Chromatography, High Pressure Liquid; Female; Kinetics; Rabbits; Salicylates; Salicylic Acid | 1995 |
The quantitative determination of aspirin and its degradation products in a model solution aerosol.
Topics: Administration, Inhalation; Aerosols; Aspirin; Chemistry, Pharmaceutical; Chromatography; Reference Standards; Salicylates; Salicylic Acid; Solutions | 1995 |
Zero-crossing first and second derivative synchronous fluorescence spectroscopic determination of aspirin metabolites in urine.
Topics: Aspirin; Hippurates; Humans; Indicators and Reagents; Salicylates; Salicylic Acid; Spectrometry, Fluorescence | 1994 |
Salicylamide reverses the aspirin-antagonistic effect of salicylic acid on rat platelet cyclooxygenase.
Topics: Animals; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Salicylamides; Salicylates; Salicylic Acid; Thromboxane B2 | 1994 |
Copper(II) interactions with nonsteroidal antiinflammatory agents. I. Salicylic acid and acetylsalicylic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cations, Divalent; Copper; Gastric Juice; Hydrogen-Ion Concentration; In Vitro Techniques; Models, Biological; Salicylates; Salicylic Acid | 1995 |
Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat.
Topics: Animals; Aspirin; Caffeine; Drug Synergism; Female; Gentisates; Hindlimb; Hydroxybenzoates; Pain; Rats; Rats, Wistar; Salicylates; Salicylic Acid | 1994 |
Aspirin inhibits secretagogue-stimulated and postprandial pancreatic exocrine secretion in conscious rats.
Topics: Animals; Aspirin; Cholecystokinin; Dinoprostone; Food; Indomethacin; Male; Pancreas; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Secretin; Stimulation, Chemical | 1995 |
No aspirin in red wine.
Topics: Aspirin; Cardiovascular Diseases; Free Radical Scavengers; Humans; Salicylates; Salicylic Acid; Wine | 1994 |
Spectrofluorimetry at zero angle: determination of salicylic acid in an acetylsalicylic acid pharmaceutical formulation.
Topics: Aspirin; Chromatography, High Pressure Liquid; Drug Storage; Salicylates; Salicylic Acid; Spectrometry, Fluorescence | 1994 |
Use of isosbestic points of derivative absorption curves: the dissolution rate determination of aspirin.
Topics: Adsorption; Aspirin; Hydrolysis; Kinetics; Salicylates; Salicylic Acid; Solubility; Spectrophotometry, Ultraviolet | 1994 |
[Determination of trace amounts of salicylic acid and acetylsalicylic acid in polopirin and other drugs containing acetylsalicylic acid].
Topics: Aspirin; Chromatography, Liquid; Salicylates; Salicylic Acid | 1993 |
Comparison of assay methods by second-derivative spectroscopy, colorimetry and fluorescence spectroscopy of salicylic acid in aspirin preparations with a high-performance liquid chromatographic method.
Topics: Aspirin; Chromatography, High Pressure Liquid; Colorimetry; Reproducibility of Results; Salicylates; Salicylic Acid; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tablets | 1994 |
Acetylsalicylic acid--inducer of cytochrome P-450 2E1?
Topics: Animals; Aspirin; Carboxyhemoglobin; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylene Chloride; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Rats; Rats, Wistar; Salicylates; Salicylic Acid | 1994 |
N-acetyl-beta-D-glucosaminidase (NAG) and alanine aminopeptidase (AAP) excretion after acute administration of acetaminophen, salsalate and aspirin in rats.
Topics: Acetaminophen; Acetylglucosaminidase; Administration, Oral; Aminopeptidases; Animals; Aspirin; CD13 Antigens; Diuresis; Female; Kidney; Potassium; Rats; Rats, Wistar; Salicylates; Salicylic Acid; Sodium; Spectrophotometry, Atomic | 1993 |
Studies on the reactivity of acyl glucuronides--VII. Salicyl acyl glucuronide reactivity in vitro and covalent binding of salicylic acid to plasma protein of humans taking aspirin.
Topics: Animals; Aspirin; Buffers; Glucuronates; Half-Life; Humans; Hydrogen-Ion Concentration; Rats; Salicylates; Salicylic Acid; Serum Albumin | 1994 |
Effects of acetylsalicylic acid on pulmonary vascular tone and membrane permeability in blood-perfused dog lung.
Topics: 6-Ketoprostaglandin F1 alpha; Airway Resistance; Animals; Aspirin; Blood Pressure; Capillary Permeability; Dogs; Extravascular Lung Water; Female; Leukotrienes; Male; Muscle, Smooth, Vascular; Organ Size; Perfusion; Pulmonary Circulation; Salicylates; Salicylic Acid; Thromboxane B2; Vascular Resistance | 1993 |
Aspirin-like drugs inhibit neuronally evoked responses in isolated guinea-pig ileum.
Topics: Acetylcholine; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzydamine; Cyclooxygenase Inhibitors; Guinea Pigs; Ileum; Indomethacin; Isotonic Contraction; Male; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Receptors, Opioid; Salicylates; Salicylic Acid; Sincalide | 1993 |
Slow release aspirin in the elderly.
Topics: Aged; Aged, 80 and over; Aspirin; Delayed-Action Preparations; Female; Humans; Male; Salicylates; Salicylic Acid; Vascular Diseases | 1994 |
Gallbladder contractility in aspirin- and cholesterol-fed prairie dogs.
Topics: Animals; Aspirin; Cholesterol; Crystallization; Diet; Dose-Response Relationship, Drug; Gallbladder; Male; Muscle Contraction; Muscle, Smooth; Prostaglandins; Salicylates; Salicylic Acid; Sciuridae; Sincalide | 1994 |
Plasma acetylsalicylic acid and salicylic acid levels during aspirin provocation in aspirin-sensitive subjects.
Topics: Administration, Oral; Adult; Airway Obstruction; Aspirin; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Free Radical Scavengers; Humans; Male; Middle Aged; Salicylates; Salicylic Acid; Sodium Salicylate | 1994 |
Plasma salicylate concentrations in immature dogs following aspirin administration: comparison with adult dogs.
Topics: Administration, Oral; Aging; Animals; Aspirin; Dogs; Female; Fluorescence Polarization Immunoassay; Half-Life; Injections, Intravenous; Male; Salicylates; Salicylic Acid | 1993 |
A clinical trial of a slow-release formulation of acetylsalicylic acid in patients at risk for preeclampsia.
Topics: Adult; Aspirin; Delayed-Action Preparations; Female; Fetal Blood; Humans; Indicators and Reagents; Infant, Newborn; Maternal-Fetal Exchange; Pre-Eclampsia; Pregnancy; Risk; Salicylates; Salicylic Acid; Thromboxane A2 | 1993 |
Transdermal modification of platelet function. A dermal aspirin preparation selectively inhibits platelet cyclooxygenase and preserves prostacyclin biosynthesis.
Topics: Administration, Cutaneous; Adult; Aspirin; Blood Platelets; Bradykinin; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Male; Middle Aged; Salicylates; Salicylic Acid; Thromboxane B2 | 1993 |
Transport of aspirin and its metabolites through human erythrocyte membrane.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aspirin; Chemical Phenomena; Chemistry, Physical; Culture Media; Cytosol; Erythrocyte Membrane; Gentisates; Hippurates; Humans; Hydrolysis; Hydroxybenzoates; In Vitro Techniques; Salicylates; Salicylic Acid | 1993 |
Effect of aspirin on conformation and dynamics of membrane proteins in platelets and erythrocytes.
Topics: Anilino Naphthalenesulfonates; Aspirin; Blood Platelets; Cell Membrane; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Humans; Membrane Proteins; Protein Conformation; Salicylates; Salicylic Acid; Spin Labels; Tryptophan | 1993 |
Platelet adhesivity to subendothelium is influenced by polymorphonuclear leukocytes: studies with aspirin and salicylate.
Topics: 6-Ketoprostaglandin F1 alpha; Alprostadil; Animals; Aspirin; Blood Platelets; Cell Communication; Cyclooxygenase Inhibitors; Endothelium, Vascular; Humans; Lipoxygenase Inhibitors; Neutrophils; Platelet Adhesiveness; Rabbits; Salicylates; Salicylic Acid; Thromboxane B2 | 1993 |
Griseofulvin significantly decreases serum salicylate concentrations.
Topics: Aspirin; Child; Griseofulvin; Humans; Male; Rheumatic Heart Disease; Salicylates; Salicylic Acid; Tinea Capitis | 1993 |
Reinduction of the hypnotic effects of thiopental with NSAIDs by decreasing thiopental plasma protein binding in humans.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Proteins; Female; Humans; Hypnotics and Sedatives; Ibuprofen; In Vitro Techniques; Longitudinal Studies; Middle Aged; Naproxen; Protein Binding; Salicylates; Salicylic Acid; Sleep; Temperature; Thiopental | 1993 |
Liposome capillary electrophoresis for analysis of interactions between lipid bilayers and solutes.
Topics: Amino Acid Sequence; Aspirin; Electrophoresis, Capillary; Lipid Bilayers; Liposomes; Molecular Sequence Data; Molecular Structure; Peptides; Pharmaceutical Preparations; Salicylates; Salicylic Acid; Sulfasalazine; Thermodynamics; Warfarin | 1995 |
[The effect of salicylates on the toxicity of GABAlytics for mice].
Topics: Animals; Aspirin; Bicuculline; Drug Interactions; GABA Antagonists; Male; Mice; Picrotoxin; Protein Synthesis Inhibitors; Receptors, GABA-A; Salicylates; Salicylic Acid; Serum Albumin | 1995 |
Modification by analgesics of the susceptibility to antibiotics in Serratia marcescens.
Topics: Acetaminophen; Analgesics; Anti-Bacterial Agents; Aspirin; Bacterial Outer Membrane Proteins; beta-Lactamases; Cell Membrane Permeability; Drug Interactions; Drug Resistance, Microbial; Humans; In Vitro Techniques; Salicylates; Salicylic Acid; Serratia marcescens | 1995 |
Maternal reproductive effects of oral salicylic acid in Sprague-Dawley rats.
Topics: Administration, Oral; Animals; Aspirin; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Female; Fetus; Labor, Obstetric; Male; No-Observed-Adverse-Effect Level; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Structure-Activity Relationship | 1996 |
Salicylate or aspirin inhibits the induction of the inducible nitric oxide synthase in rat cardiac fibroblasts.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Enzyme Induction; Fibroblasts; Interleukin-1; Myocardium; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Salicylates; Salicylic Acid; Tumor Necrosis Factor-alpha | 1996 |
Systemic inflammatory response syndrome caused by chronic salicylate intoxication.
Topics: Acid-Base Imbalance; Adult; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Disseminated Intravascular Coagulation; Female; Fever; Humans; Hypotension; Male; Middle Aged; Pulmonary Edema; Salicylates; Salicylic Acid; Systemic Inflammatory Response Syndrome | 1996 |
The pharmacokinetics of salicylate in dairy cattle are not altered by simultaneous intravenous ceftiofur sodium and DL-lysine-acetyl salicylate (aspirin).
Topics: Animals; Aspirin; Cattle; Cephalosporins; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Half-Life; Injections, Intravenous; Reference Standards; Salicylates; Salicylic Acid | 1996 |
The disposition of aspirin and salicylic acid in the isolated perfused rat liver: the effect of normal and retrograde flow on availability and mean transit time.
Topics: Animals; Aspirin; Female; In Vitro Techniques; Liver; Perfusion; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Sucrose | 1996 |
Aspirin related gastrointestinal bleeders have an exaggerated bleeding time response due to aspirin use.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Blood Coagulation; Factor VIII; Female; Gastrointestinal Hemorrhage; Hematocrit; Humans; Male; Middle Aged; Regression Analysis; Risk Factors; Salicylates; Salicylic Acid; Smoking; von Willebrand Factor | 1996 |
A highly sensitive HPLC method for the simultaneous determination of acetylsalicylic, salicylic and salicyluric acids in biologic fluids: pharmacokinetic, metabolic and monitoring implications.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromatography, High Pressure Liquid; Female; Hippurates; Humans; Male; Salicylates; Salicylic Acid | 1996 |
Fluorimetric determination of tissue distribution and differences between the activity of aspirin esterases I and II in mice and rats.
Topics: Adrenal Glands; Animals; Aspirin; Brain; Carboxylic Ester Hydrolases; In Vitro Techniques; Isoenzymes; Kidney; Liver; Male; Mice; Organ Specificity; Rats; Rats, Wistar; Salicylates; Salicylic Acid; Species Specificity; Spectrometry, Fluorescence | 1997 |
Comparative cytotoxicity of 5-aminosalicylic acid (mesalazine) and related compounds in different cell lines.
Topics: Aminosalicylic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Dogs; Glutathione; Humans; Kidney Tubules; Mesalamine; Neutral Red; Rats; Salicylates; Salicylic Acid; Structure-Activity Relationship; Swine; Tumor Cells, Cultured | 1997 |
Euglena gracilis as an eukaryotic test organism for detecting mutagens and antimutagens.
Topics: 4-Aminobenzoic Acid; Aminosalicylic Acid; Animals; Antimutagenic Agents; Aspirin; Chloroplasts; Euglena gracilis; Eukaryotic Cells; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenicity Tests; Mutagens; Mutation; ortho-Aminobenzoates; Pigmentation; Salicylates; Salicylic Acid; Sodium Salicylate | 1997 |
Effect of aspirin and salicylate on LDL oxidation in vitro.
Topics: Aspirin; Humans; Kinetics; Lipoproteins, LDL; Salicylates; Salicylic Acid; Ultraviolet Rays | 1997 |
Direct assay and shelf-life monitoring of aspirin tablets using Raman spectroscopy.
Topics: Anti-Inflammatory Agents; Aspirin; Chromatography, High Pressure Liquid; Drug Storage; Reproducibility of Results; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Tablets | 1997 |
Determination of aspirin and salicylic acid in human plasma by column-switching liquid chromatography using on-line solid-phase extraction.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Specimen Collection; Chromatography, High Pressure Liquid; Humans; Salicylates; Salicylic Acid | 1998 |
Determination of acetylsalicylic acid and salicylic acid in skin and plasma by high-performance liquid chromatography.
Topics: Administration, Oral; Administration, Topical; Area Under Curve; Aspirin; Chromatography, High Pressure Liquid; Epidermis; Humans; Reference Values; Reproducibility of Results; Salicylates; Salicylic Acid; Sensitivity and Specificity; Skin | 1998 |
Protein binding of aspirin and salicylate measured by in vivo ultrafiltration.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Proteins; Female; Half-Life; Humans; Male; Middle Aged; Protein Binding; Reference Values; Salicylates; Salicylic Acid; Ultrafiltration | 1998 |
Continuous release of vasodilator prostanoids contributes to regulation of resting forearm blood flow in humans.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Adult; Aspirin; Dose-Response Relationship, Drug; Female; Forearm; Humans; Male; Nitroprusside; Norepinephrine; Oxygen Consumption; Prostaglandins; Regional Blood Flow; Rest; Salicylates; Salicylic Acid; Time Factors; Vasodilation | 1998 |
Determination of aspirin and salicylic acid in transdermal perfusates.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calibration; Chromatography, High Pressure Liquid; Indicators and Reagents; Mice; Reference Standards; Reproducibility of Results; Salicylates; Salicylic Acid; Skin | 1998 |
Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells.
Topics: Aged; Amino Acid Chloromethyl Ketones; Annexins; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; B-Lymphocytes; Cell Survival; Cyclooxygenase Inhibitors; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Activation; Female; Humans; Indomethacin; Ketorolac; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Proteins; Nitrobenzenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Salicylates; Salicylic Acid; Sulfonamides; Tolmetin; Tumor Cells, Cultured | 1998 |
A new salicylate ISFET for the determination of salicylic and acetylsalicylic acid in drugs.
Topics: Aspirin; Ion-Selective Electrodes; Membranes, Artificial; Ointments; Polyvinyl Chloride; Potentiometry; Salicylates; Salicylic Acid; Tablets; Transistors, Electronic | 1995 |
Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspirin; Body Temperature; Corpus Striatum; Cyclooxygenase Inhibitors; Dexamethasone; Dopamine; Hydroxybenzoates; Hydroxyl Radical; Lysine; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; MPTP Poisoning; Salicylates; Salicylic Acid; Serotonin; Synaptosomes | 1998 |
Assay of acetylsalicylic acid and three of its metabolites in human plasma and urine using non-aqueous capillary electrophoresis with reversed electroosmotic flow.
Topics: Acetonitriles; Aspirin; Electrophoresis, Capillary; Gentisates; Hexadimethrine Bromide; Hippurates; Humans; Hydrogen-Ion Concentration; Hydroxybenzoates; In Vitro Techniques; Methanol; Osmosis; Reproducibility of Results; Salicylic Acid; Temperature | 1998 |
Simultaneous determination of salicylic acid and acetylsalicylic acid in aspirin delayed-release tablet formulations by second-derivative UV spectrophotometry.
Topics: Aspirin; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Salicylic Acid; Spectrophotometry, Ultraviolet; Tablets | 1998 |
Effects of antiaggregant and antiinflammatory doses of aspirin on coronary hemodynamics and myocardial reactive hyperemia in conscious dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Bradykinin; Coronary Disease; Coronary Vessels; Cyclooxygenase Inhibitors; Diclofenac; Dogs; Dose-Response Relationship, Drug; Hyperemia; Male; Myocardium; Nitric Oxide Synthase; Nitroarginine; Salicylic Acid; Thromboxane B2; Time Factors | 1999 |
Salicylate-induced kidney mitochondrial permeability transition is prevented by cyclosporin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium; Cyclosporine; Immunosuppressive Agents; In Vitro Techniques; Kidney; Male; Mitochondria; Mitochondrial Swelling; Permeability; Rats; Rats, Sprague-Dawley; Salicylic Acid | 1999 |
Prevention of small black spots on sugar-coated tablets containing aluminum acetylsalicylic acid.
Topics: Acetic Acid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbohydrates; Chelating Agents; Drug Contamination; Drug Interactions; Ferric Compounds; Humidity; Hydrochloric Acid; Magnesium; Salicylic Acid; Tablets, Enteric-Coated; Talc | 1999 |
Synthesis of [11C]salicylic acid and related compounds and their biodistribution in mice.
Topics: Acetylation; Animals; Anti-Infective Agents; Aspirin; Brain; Carbon Radioisotopes; Hydroxybenzoate Ethers; Isotope Labeling; Male; Mice; Radiopharmaceuticals; Salicylates; Salicylic Acid; Tissue Distribution | 1999 |
Salicylate promotes myeloperoxidase-initiated LDL oxidation: antagonization by its metabolite gentisic acid.
Topics: Arteriosclerosis; Aspirin; Free Radical Scavengers; Free Radicals; Gentisates; Humans; Hydroxybenzoates; In Vitro Techniques; Lipid Peroxidation; Lipoproteins, LDL; Neutrophils; Oxidants; Oxidation-Reduction; Peroxidase; Phenols; Salicylic Acid; Tyrosine | 1999 |
Ingestion of chilli pepper (Capsicum annuum) reduces salicylate bioavailability after oral asprin administration in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biological Availability; Capsicum; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Salicylic Acid | 1999 |
Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes.
Topics: 3T3 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Interphase; Lipopolysaccharides; Mice; Mitogens; Monocytes; NF-kappa B; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Ribosomal Protein S6 Kinases; Salicylic Acid; Substrate Specificity; Transcription, Genetic | 1999 |
Aspirin and salicylic acid do not inhibit methyl jasmonate-inducible expression of a gene for ornithine decarboxylase in tobacco BY-2 cells.
Topics: Acetates; Amino Acids; Aspirin; Bacterial Toxins; Cells, Cultured; Cloning, Molecular; Cyclopentanes; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Indenes; Molecular Sequence Data; Nicotiana; Ornithine Decarboxylase; Oxylipins; Plants, Toxic; Salicylic Acid | 2000 |
The salicylate metabolite gentisic acid, but not the parent drug, inhibits glucose autoxidation-mediated atherogenic modification of low density lipoprotein.
Topics: Arteriosclerosis; Aspirin; Cells, Cultured; Diabetic Angiopathies; Endothelium, Vascular; Gentisates; Glucose; Humans; Hydroxybenzoates; Iron Chelating Agents; Lipoproteins, LDL; Male; Oxidation-Reduction; Prodrugs; Reactive Oxygen Species; Salicylic Acid; Thromboplastin | 2000 |
Protection by free oxygen radical scavenging enzymes against salicylate-induced embryonic malformations in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Drug Interactions; Embryonic and Fetal Development; Female; Free Radical Scavengers; Glutathione; Male; Organ Culture Techniques; Pregnancy; Rats; Rats, Wistar; Reactive Oxygen Species; Salicylic Acid; Sodium Salicylate; Superoxide Dismutase | 2000 |
Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Diabetes Mellitus, Experimental; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Male; Nitric Oxide Donors; Nitro Compounds; Omeprazole; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Salicylic Acid; Stomach Diseases; Stomach Ulcer | 2000 |
Cyclooxygenase-independent inhibition of dendritic cell maturation by aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Culture Techniques; Cell Differentiation; Cyclooxygenase Inhibitors; Dendritic Cells; Dinoprostone; Humans; Interleukin-12; Lymphocyte Activation; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Salicylic Acid; T-Lymphocytes | 2000 |
Determination of salicylate hydroxylation products as an in vivo oxidative stress marker.
Topics: Adult; Aspirin; Biomarkers; Chromatography, High Pressure Liquid; Humans; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Oxidative Stress; Salicylic Acid; Sensitivity and Specificity | 2000 |
The solvent shells of cluster ions produced by direct electric field extraction from glycerol/water mixtures.
Topics: Algorithms; Amino Acids; Ascorbic Acid; Aspartic Acid; Aspirin; Glutamic Acid; Glycerol; Hydrocarbons, Halogenated; Ions; Membranes; Models, Theoretical; Molecular Structure; Niacin; Salicylic Acid; Spectrometry, Mass, Electrospray Ionization; Water | 2001 |
Non-ionic micellar affinity capillary electrophoresis for analysis of interactions between micelles and drugs.
Topics: Aspirin; Benzoic Acid; Chromatography, Micellar Electrokinetic Capillary; Hydroxybenzoates; Micelles; Picrates; Salicylic Acid | 2001 |
Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caffeine; Cell Division; Cell Line; Cyclooxygenase Inhibitors; Drug Interactions; Flow Cytometry; Indomethacin; Kidney Tubules, Collecting; Mice; Microscopy, Electron; Salicylic Acid | 2001 |
Salicylic acid in the serum of subjects not taking aspirin. Comparison of salicylic acid concentrations in the serum of vegetarians, non-vegetarians, and patients taking low dose aspirin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromatography, High Pressure Liquid; Diet, Vegetarian; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Salicylic Acid | 2001 |
[Research on the separation behavior of acidic drugs in capillary electrophoresis with reversed direction of electroosmotic flow].
Topics: Aspirin; Cetrimonium; Cetrimonium Compounds; Electrophoresis, Capillary; Salicylic Acid; Surface-Active Agents | 1998 |
Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoic Acid; Hydroxybenzoates; Parabens; Protein Conformation; Salicylic Acid; Spectrophotometry; Temperature; Time Factors | 2002 |
Zeta-crystallin displays strong selectivity for salicylic acid over aspirin.
Topics: Animals; Aspirin; Camelus; Crystallins; Kinetics; NADP; Salicylic Acid; Spectrometry, Fluorescence | 2002 |
Endogenous salicylates, aspirin, and inflammation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-Reactive Protein; Humans; Inflammation; Salicylic Acid | 2002 |
Prevention by parenteral aspirin of indomethacin-induced gastric lesions in rats: mediation by salicylic acid.
Topics: Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastrointestinal Motility; Indomethacin; Injections, Subcutaneous; Male; Rats; Rats, Sprague-Dawley; Salicylic Acid | 2002 |
Surface-enhanced Raman scattering of some water insoluble drugs in silver hydrosols.
Topics: Acetaminophen; Aspirin; Pharmaceutical Preparations; Powders; Salicylic Acid; Silver; Solubility; Spectrum Analysis, Raman; Surface Properties; Tretinoin; Water | 2003 |
[Determination of aspirin and free salicylic acid in lysinipirine injection by high performance liquid chromatography].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calibration; Chromatography, High Pressure Liquid; Lysine; Salicylic Acid | 2002 |
Non-prostaglandin effects of aspirin III and salicylate: inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NF kappa B (P105)-knockout mice.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Aggregation; Cyclooxygenase 2; Humans; Integrins; Isoenzymes; Membrane Proteins; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Neutrophils; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Salicylic Acid | 2002 |
[Separation of salicylic acid drugs by aqueous and nonaqueous capillary electrophoresis with conductance detector].
Topics: Aspirin; Benzenesulfonates; Electrophoresis, Capillary; Ethanol; Salicylates; Salicylic Acid; Sensitivity and Specificity; Tablets; Water | 2003 |
Determination of free salicylic acid in chewing aspirin tablets by HPLC.
Topics: Aspirin; Chromatography, High Pressure Liquid; Drug Stability; Mastication; Salicylic Acid; Tablets | 2003 |
Investigation of some complexes formed in solution by caffeine. III. Interactions between caffeine and aspirin, p-hydroxybenzoic acid, m-hydroxybenzoic acid, salicylic acid, salicylate ion, and butyl paraben.
Topics: Aspirin; Benzoates; Caffeine; Hydroxybenzoates; Parabens; Pharmaceutical Solutions; Salicylates; Salicylic Acid; Solutions | 1953 |
Some recent advances in the pharmacology of salicylates.
Topics: Aspirin; Salicylates; Salicylic Acid | 1953 |
Spectrophotometric determination of acetylsalicylic and salicylic acids.
Topics: Aspirin; Salicylates; Salicylic Acid; Spectrophotometry | 1954 |
Investigation of complexes formed in solution by caffeine. VI. Comparison of complexing behaviors of methylated xanthines with p-aminobenzoic acid, salicylic acid, acetylsalicylic acid, and p-hydroxybenzoic acid.
Topics: 4-Aminobenzoic Acid; Aspirin; Benzoates; Caffeine; Hydroxybenzoates; Pharmaceutical Solutions; Salicylic Acid; Solutions; Theobromine; Theophylline; Xanthines | 1954 |
[Gastrointestinal hemorrhage after salicylic acid therapy in peptic ulcer of long duration].
Topics: Aspirin; Gastrointestinal Hemorrhage; Humans; Melena; Peptic Ulcer; Salicylic Acid | 1955 |
The hydrolysis of aspirin in pharmaceutical preparations; a limit test for free salicylic acid.
Topics: Aspirin; Humans; Hydrolysis; Salicylic Acid | 1955 |
The effect of salicylic acid and acetylsalicylic acid on uric acid excretion and plasma uric acid concentration in the normal human subject.
Topics: Aspirin; Blood; Body Fluids; Humans; Salicylic Acid; Uric Acid; Urine | 1955 |
[Metabolic studies on drugs. II. Metabolic products of salicylic, acetylsalicylic, gentisic, and salicyluric acids in rat urine].
Topics: Animals; Aspirin; Biochemical Phenomena; Gentisates; Hippurates; Rats; Salicylates; Salicylic Acid; Uric Acid | 1957 |
[Contribution to the treatment of rheumatism diseases with a para-aminobenzoic acid-salicylic combination A 55].
Topics: 4-Aminobenzoic Acid; Aspirin; Phenacetin; Rheumatic Diseases; Salicylamides; Salicylic Acid | 1958 |
A study of the oxidative metabolism of acetylsalicylic, salicylic, and gentisic acid in fevered animals.
Topics: Animals; Aspirin; Fever; Gentisates; Salicylates; Salicylic Acid | 1958 |
[Cortico-salicylic therapy of chronic rheumatic diseases].
Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Humans; Prednisone; Rheumatic Diseases; Salicylic Acid | 1958 |
[Proposals for the DAB 7. 6. Acetanilid, acetylsalicylic acid, salicylic acid, sodium salicylate].
Topics: Acetanilides; Aspirin; Salicylates; Salicylic Acid; Sodium Salicylate | 1959 |
[Comparative toxicity of salicylic acid in the white mouse].
Topics: Animals; Aspirin; Mice; Salicylic Acid | 1959 |
[Detection methods for the active constituents of antineuralgia and sleeping tablets separated by thinlayer chromatography].
Topics: Antipyrine; Aspirin; Benzoates; Chromatography, Thin Layer; Codeine; Hypnotics and Sedatives; Noscapine; Phenacetin; Salicylamides; Salicylic Acid; Sleep; Tablets | 1963 |
[On the mechanism of action of salicylic acid, acetylsalicylic acid and salicylamide].
Topics: Aspirin; Salicylamides; Salicylates; Salicylic Acid | 1963 |
"Alka-seltzer" and haematemesis.
Topics: Aspirin; Citrates; Drug Combinations; Hematemesis; Humans; Salicylic Acid; Sodium Bicarbonate | 1963 |
[Evaluation of the behavior of the erythrocyte sedimentation rate during salicylic therapy. II. The changes in sedimentometry during salicylic therapy or rneumatic disease].
Topics: Aspirin; Blood Sedimentation; Hematologic Tests; Humans; Rheumatic Heart Disease; Salicylic Acid; Sodium Salicylate | 1962 |
"SALICYLURIA"--A RECAPITULATION.
Topics: Aspirin; Chemistry Techniques, Analytical; Chlorides; Fluorescence; Humans; Iron; Salicylic Acid; Toxicology; Ultraviolet Rays; Urine; X-Ray Diffraction | 1964 |
ANTACID AND ANTIULCER PROPERTIES OF THE POLYSACCHARIDE CHITOSAN IN THE RAT.
Topics: Antacids; Anti-Ulcer Agents; Aspirin; Blood; Carrageenan; Chitosan; Colorimetry; Gastric Acidity Determination; Glycosaminoglycans; Magnesium; Peptic Ulcer; Pharmacology; Polysaccharides; Pylorus; Rats; Research; Salicylic Acid | 1964 |
A CLINICAL APPRAISAL OF A NEW EFFECTIVE SUSTAINED RELEASE ASPIRIN TABLET.
Topics: Analgesia; Aspirin; Biomedical Research; Blood; Body Weight; Delayed-Action Preparations; Drug Therapy; Pain Management; Rheumatic Diseases; Salicylic Acid; Tablets; Toxicology | 1964 |
SERUM SALICYLATE LEVELS IN OSTEOARTHRITIS FOLLOWING ORAL ADMINISTRATION OF A PREPARATION CONTAINING SALICYLSALICYLIC ACID.
Topics: Administration, Oral; Aspirin; Blood; Blood Chemical Analysis; Drug Therapy; Geriatrics; Humans; Osteoarthritis; Salicylates; Salicylic Acid | 1964 |
[ABSORPTION OF SOME CHEMICAL SUBSTANCES BY THE GASTROINTESTINAL TRACT OF GERM-FREE AND CONVENTIONAL RATS].
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Aspirin; Fasting; Gastrointestinal Tract; Germ-Free Life; Intestinal Absorption; Intestine, Small; Intestines; Perfusion; Phenols; Rats; Research; Salicylic Acid; Xylose | 1964 |
NARCOTIC AND NON-NARCOTIC ANALGESICS WHICH BLOCK VISCERAL PAIN EVOKED BY INTRA-ARTERIAL INJECTION OF BRADYKININ AND OTHER ALGESIC AGENTS.
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anilides; Antipyretics; Aspirin; Bradykinin; Dogs; Injections, Intra-Arterial; Levorphanol; Meperidine; Morphine; Nalorphine; Narcotics; Oxyphenbutazone; Pain; Pharmacology; Phenylbutazone; Research; Salicylic Acid; Toxicology; Visceral Pain | 1964 |
[LIGHT AND ELECTRON MICROSCOPIC STUDIES ON THE LOCAL EFFECT OF SOME SALICYLATES ON THE GASTROINTESTINAL MUCOSA].
Topics: Aspirin; Electrons; Gastrointestinal Tract; Guinea Pigs; Microscopy; Microscopy, Electron; Mucous Membrane; Pharmacology; Rats; Research; Salicylamides; Salicylates; Salicylic Acid; Toxicology | 1964 |
TERATOGENIC ACTION OF SALICYLATES RELATED TO THE INHIBITION OF MUCOPOLYSACCHARIDE SYNTHESIS.
Topics: Abnormalities, Drug-Induced; Aspirin; Blood Vessels; Carbohydrate Metabolism; Glycosaminoglycans; Mice; Pharmacology; Pregnancy; Pregnancy, Animal; Research; Ribs; Salicylates; Salicylic Acid; Spine; Teratogens; Toxicology | 1965 |
CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF ASPIRIN, CAFFEINE, AND ACETAMINOPHEN.
Topics: Acetaminophen; Aspirin; Caffeine; Chemistry, Pharmaceutical; Chromatography; Pharmacy; Research; Salicylic Acid | 1964 |
INTERACTION BETWEEN POLY-N-VINYL-5-METHYL-2-OXAZOLIDINONE AND CERTAIN PHARMACEUTICALS IN AQUEOUS SOLUTION.
Topics: Aspirin; Barbiturates; Benzoates; Chemistry, Pharmaceutical; Cimetidine; Diphenhydramine; Drug Combinations; Ibuprofen; Indoles; Ketanserin; Macromolecular Substances; Methylprednisolone; Oxazoles; Oxazolidinones; Polymers; Research; Salicylic Acid; Sulfonamides; Xanthines | 1965 |
A KINETIC STUDY OF THE ELIMINATION OF SALICYLATE IN MAN.
Topics: Aspirin; Biological Transport; Body Fluids; Fluids and Secretions; Humans; Kinetics; Male; Metabolism; Research; Salicylates; Salicylic Acid; Urine | 1965 |
DAMAGE TO THE GASTRIC MUCOSA: EFFECTS OF SALICYLATES AND STIMULATION.
Topics: Absorption; Animals; Aspirin; Bethanechol Compounds; Denervation; Dogs; Gastric Mucosa; Gastrins; Gastrointestinal Hemorrhage; Hemorrhage; Histamine; Intestinal Absorption; Ion Exchange; Pharmacology; Research; Salicylates; Salicylic Acid; Sympathomimetics; Toxicology | 1965 |
A rapid high-performance liquid chromatographic method for the simultaneous quantitation of aspirin, salicylic acid, and caffeine in effervescent tablets.
Topics: Aspirin; Caffeine; Chromatography, High Pressure Liquid; Reference Standards; Reproducibility of Results; Salicylic Acid; Sensitivity and Specificity; Tablets | 2003 |
Antioxidant effect of acetylsalicylic and salicylic acid in rat brain slices subjected to hypoxia.
Topics: Animals; Aspirin; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Glutathione; Hypoxia, Brain; In Vitro Techniques; Lipid Peroxidation; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Salicylic Acid | 2004 |
Comparative pharmacokinetics of acetyl salicylic acid and its metabolites in children suffering from autoimmune diseases.
Topics: Administration, Oral; Adolescent; Area Under Curve; Arthritis, Juvenile; Aspirin; Autoimmune Diseases; Biological Availability; Child; Chromatography, High Pressure Liquid; Female; Gentisates; Half-Life; Hippurates; Humans; Male; Mexico; Prospective Studies; Rheumatic Fever; Salicylic Acid; Tablets | 2004 |
[Study on relative bioavailability of aspirin in afenca tablet].
Topics: Administration, Oral; Adult; Area Under Curve; Aspirin; Cross-Over Studies; Humans; Male; Salicylic Acid; Tablets; Therapeutic Equivalency | 2003 |
[Aspirin and salicylates; present view of their biological effect].
Topics: Aspirin; Humans; Salicylates; Salicylic Acid | 1951 |
The synthesis of acetyl-1-C14-salicylic acid.
Topics: Aspirin; Radioisotopes; Salicylic Acid | 1951 |
Antioxidant effects of a single dose of acetylsalicylic acid and salicylic acid in rat brain slices subjected to oxygen-glucose deprivation in relation with its antiplatelet effect.
Topics: Animals; Antioxidants; Aspirin; Cell Hypoxia; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Glucose; Glutathione; Hypoxia-Ischemia, Brain; In Vitro Techniques; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Salicylic Acid | 2004 |
[Development of salicylic acid detector tube].
Topics: Acute Disease; Aspirin; Biomarkers; Humans; Poisoning; Reagent Kits, Diagnostic; Salicylic Acid; Toxicology | 2004 |
Life-history traits of standard and autochthonous cladocerans: II. Acute and chronic effects of acetylsalicylic acid metabolites.
Topics: Animals; Aspirin; Cladocera; Daphnia; Female; Fresh Water; Gentisates; Hippurates; Male; No-Observed-Adverse-Effect Level; Portugal; Reproduction; Salicylic Acid; Toxicity Tests, Acute; Toxicity Tests, Chronic; Water Pollutants, Chemical | 2004 |
MORNING STIFFNESS IN ARTHRITIS.
Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Humans; Joint Diseases; Nervous System Diseases; Placebos; Salicylic Acid | 1963 |
HucR, a novel uric acid-responsive member of the MarR family of transcriptional regulators from Deinococcus radiodurans.
Topics: Amino Acid Sequence; Aspirin; Binding Sites; Circular Dichroism; Cloning, Molecular; Deinococcus; Deoxyribonuclease I; DNA; DNA, Intergenic; Dose-Response Relationship, Drug; Edetic Acid; Escherichia coli Proteins; Gene Expression Regulation; Kinetics; Ligands; Models, Chemical; Models, Genetic; Molecular Sequence Data; Open Reading Frames; Oxidative Stress; Phenol; Promoter Regions, Genetic; Protein Binding; Reactive Oxygen Species; Repressor Proteins; RNA; RNA, Messenger; Salicylic Acid; Sequence Homology, Amino Acid; Temperature; Transcription Factors; Transcription, Genetic; Urate Oxidase; Uric Acid | 2004 |
Inhibition of cardiac mitochondrial respiration by salicylic acid and acetylsalicylate.
Topics: Animals; Aspirin; Cell Respiration; Citric Acid Cycle; Dinitrophenols; Drug Evaluation, Preclinical; Electron Transport; Ketoglutarate Dehydrogenase Complex; Mitochondria, Heart; NAD; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Salicylic Acid; Sarcolemma; Uncoupling Agents | 2004 |
Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Animal; Misoprostol; Neovascularization, Pathologic; Oxytocics; Rats; Rats, Sprague-Dawley; Salicylic Acid | 2005 |
Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Concanavalin A; Down-Regulation; Humans; Kynurenine; Leukocytes, Mononuclear; Neopterin; Phytohemagglutinins; Protein Denaturation; Salicylic Acid; Tryptophan | 2005 |
Production of antioxidant compounds by culture of Panax ginseng C.A. Meyer hairy roots: I. Enhanced production of secondary metabolite in hairy root cultures by elicitation.
Topics: Antioxidants; Aspirin; Cell Culture Techniques; Cell Proliferation; Dose-Response Relationship, Drug; Panax; Plant Roots; Rhizobium; Salicylates; Salicylic Acid; Saponins; Yeasts | 2005 |
Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Glucuronides; Glucuronosyltransferase; Humans; Microsomes, Liver; Salicylic Acid | 2006 |
Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets.
Topics: Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Salicylic Acid | 2006 |
Aspirin is a substrate for paraoxonase-like activity: implications in atherosclerosis.
Topics: Adult; Antioxidants; Aryldialkylphosphatase; Aspirin; Atherosclerosis; Binding, Competitive; Biotransformation; Humans; Hydrolysis; In Vitro Techniques; Nitrophenols; Paraoxon; Platelet Aggregation Inhibitors; Salicylic Acid | 2007 |
Influence of water-cellulose binding energy on stability of acetylsalicylic acid.
Topics: Aspirin; Calorimetry, Differential Scanning; Cellulose; Drug Stability; Excipients; Kinetics; Microscopy, Electron, Scanning; Salicylic Acid; Temperature; Thermodynamics; Water; X-Ray Diffraction | 2006 |
Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism.
Topics: Antineoplastic Agents; Aspirin; Celecoxib; Cell Line; Cell Proliferation; Cell Survival; Cyclooxygenase Inhibitors; Endothelial Cells; Humans; Neovascularization, Physiologic; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Salicylic Acid; Sulfonamides | 2006 |
Semi-micro column high-performance liquid chromatography with UV detection for quantification of aspirin and salicylic acid and its application to patients' sera administered with low-dose enteric-coated aspirin.
Topics: Aged; Aged, 80 and over; Aspirin; Chromatography, High Pressure Liquid; Female; Humans; Indicators and Reagents; Male; Middle Aged; Salicylic Acid; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Tablets, Enteric-Coated | 2007 |
Derivative-ratio spectrophotometric method for the determination of ternary mixture of aspirin, paracetamol and salicylic acid.
Topics: Acetaminophen; Aspirin; Drug Combinations; Salicylic Acid; Spectrophotometry; Spectrophotometry, Ultraviolet | 2007 |
Samuel James (c1763-1831) of Hoddesdon and the medicinal use of willow bark.
Topics: Aspirin; Chemistry, Analytic; England; History, 18th Century; History, 19th Century; Humans; Pain; Plant Bark; Plant Extracts; Salicylic Acid; Salix | 2007 |
Potentiometric response and mechanism of anionic recognition of heterocalixarene-based ion selective electrodes.
Topics: Anions; Aspirin; Binding Sites; Calixarenes; Chemistry Techniques, Analytical; Hydrogen Bonding; Hydrogen-Ion Concentration; Ion-Selective Electrodes; Ions; Models, Chemical; Polymers; Potentiometry; Salicylic Acid | 2007 |
The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.
Topics: Algorithms; Alkalies; Aspirin; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Platelet Aggregation Inhibitors; Polyethylene Glycols; Quaternary Ammonium Compounds; Salicylates; Salicylic Acid; Sodium Dodecyl Sulfate; Sodium Hydroxide; Spectrophotometry, Ultraviolet; Static Electricity; Surface-Active Agents; Water | 2007 |
Generalized regression neural networks in prediction of drug stability.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Compounding; Drug Design; Drug Stability; Drug Storage; Hardness; Neural Networks, Computer; Polymethacrylic Acids; Salicylic Acid; Tablets; Temperature | 2007 |
Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings.
Topics: Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Food-Drug Interactions; Gallic Acid; Humans; In Vitro Techniques; Platelet Aggregation; Salicylic Acid; Thromboxane B2 | 2007 |
In vitro enantioselective displacement of propranolol from protein binding sites by acetyl salicylic acid and salicylic acid.
Topics: Adrenergic beta-Antagonists; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding, Competitive; Blood Proteins; Drug Interactions; Humans; Kinetics; Propranolol; Protein Binding; Salicylic Acid; Serum Albumin; Stereoisomerism | 2007 |
Differences in the influence of the interaction between acetylsalicylic acid and salicylic acid on platelet function in whole blood and isolated platelets: influence of neutrophils.
Topics: Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Male; Neutrophils; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Salicylic Acid; Thromboxane B2 | 2007 |
[Autopsy case of aspirin intoxication: distribution of salicylic acid and salicyluric acid in body fluid and organs].
Topics: Aspirin; Autopsy; Body Fluids; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Hippurates; Humans; Kidney; Liver; Lung; Middle Aged; Myocardium; Salicylic Acid; Tissue Distribution | 2007 |
[From the willow to aspirin].
Topics: Aspirin; Chemistry; History of Pharmacy; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Molecular Structure; Salicylic Acid; Salix | 2007 |
Determination of acetylsalicylic acid and its major metabolite, salicylic acid, in human plasma using liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study of Astrix in Korean healthy volunteers.
Topics: Aspirin; Humans; Korea; Reference Standards; Reference Values; Reproducibility of Results; Salicylic Acid; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Narrow-line waveguide terahertz time-domain spectroscopy of aspirin and aspirin precursors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoic Acid; Hydroxybenzoates; Microwaves; Parabens; Radio Waves; Salicylic Acid; Spectrum Analysis | 2008 |
Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.
Topics: Acetaminophen; Antipyrine; Aspirin; Beverages; Biological Products; Caffeine; Chromatography, Micellar Electrokinetic Capillary; Codeine; Cosmetics; Food Analysis; Linear Models; Pharmaceutical Preparations; Salicylic Acid; Theobromine; Theophylline | 2008 |
Aspirin: expectations and limitations.
Topics: Asia, Western; Aspirin; Coronary Artery Disease; Cross-Sectional Studies; Cyclooxygenase Inhibitors; Developing Countries; Dose-Response Relationship, Drug; Drug Resistance; Ethnicity; Humans; India; Long-Term Care; Platelet Activation; Platelet Aggregation Inhibitors; Salicylic Acid; Tablets, Enteric-Coated; Treatment Outcome | 2008 |
Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 rats.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Drug Evaluation, Preclinical; Eicosanoids; Male; Nitric Oxide; Rats; Rats, Inbred F344; Salicylic Acid; Thromboxane B2; Time Factors | 2008 |
Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity.
Topics: Animals; Aspirin; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Humans; Phosphofructokinase-1; Protein Structure, Quaternary; Rabbits; Salicylic Acid; Structure-Activity Relationship | 2009 |
Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid.
Topics: Adult; Animals; Aspirin; Benzoic Acid; Fasting; Female; Hippurates; Humans; Male; Middle Aged; Salicylic Acid | 2008 |
A comparison of salicylic acid levels in normal subjects after rectal versus oral dosing.
Topics: Administration, Oral; Administration, Rectal; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Prospective Studies; Salicylic Acid; Suppositories | 2009 |
Effects of acetylsalicylic acid on increase of fibrin network porosity and the consequent upregulation of fibrinolysis.
Topics: Aspirin; Blood Coagulation; Blood Coagulation Tests; Blood Platelets; Fibrin; Fibrinogen; Fibrinolysis; Gels; Humans; Permeability; Porosity; Salicylic Acid; Thrombin; Up-Regulation | 2009 |
Emergent aspirin use in cardiovascular disease in the emergency department: oral dosing versus rectal suppositories.
Topics: Administration, Oral; Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Emergency Service, Hospital; Humans; Mastication; Salicylic Acid; Suppositories | 2009 |
Effect of genetic polymorphisms in UDP-glucuronosyltransferase 1A6 (UGT1A6) on acetylsalicylic acid metabolism in healthy female volunteers.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Glucuronosyltransferase; Hippurates; Homozygote; Humans; Polymorphism, Genetic; Salicylic Acid; Young Adult | 2009 |
Rapid and sensitive determination of acetylsalicylic acid and salicylic acid in plasma using liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study.
Topics: Animals; Aspirin; Calibration; Chromatography, Liquid; Dogs; Drug Stability; Linear Models; Male; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Salicylic Acid; Sensitivity and Specificity; Tandem Mass Spectrometry | 2009 |
Effect of analgesics and their derivatives on antibiotic resistance of environmental microbes.
Topics: Amino Acid Sequence; Analgesics; Anti-Bacterial Agents; Aspirin; Bacterial Proteins; Ciprofloxacin; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Lipoproteins; Membrane Transport Proteins; Microbial Sensitivity Tests; Molecular Sequence Data; Nalidixic Acid; Nitrosomonas europaea; Salicylic Acid; Salmonella enterica; Sequence Homology, Amino Acid | 2009 |
Sub-millimolar concentration of the novel phenol-based compound, 2-hydroxy benzoate zinc, induces apoptosis in human HT-1080 fibrosarcoma cells.
Topics: Antineoplastic Agents; Apoptosis; Aspirin; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Fibrosarcoma; Humans; Salicylic Acid; Tumor Suppressor Protein p53 | 2010 |
Anti-inflammatory drugs selectively target sporangium development in Mucor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Aspirin; Benzoic Acid; Ibuprofen; Indomethacin; Mitochondria; Mortierella; Mucor; Mucormycosis; Plant Diseases; Salicylic Acid | 2009 |
Development and validation of a high-performance liquid chromatography method for the simultaneous determination of aspirin and folic acid from nano-particulate systems.
Topics: Aspirin; Chromatography, High Pressure Liquid; Folic Acid; Lactic Acid; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Reproducibility of Results; Salicylic Acid | 2010 |
In search of pure liquid salt forms of aspirin: ionic liquid approaches with acetylsalicylic acid and salicylic acid.
Topics: Aspirin; Crystallography, X-Ray; Hydrogen Bonding; Hydrolysis; Ionic Liquids; Phase Transition; Salicylic Acid; Salts; Transition Temperature | 2010 |
Electrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes.
Topics: Alkalies; Aspirin; Boron; Carbon; Diamond; Electrochemistry; Electrodes; Glass; High-Throughput Screening Assays; Hydrogen-Ion Concentration; Hydrolysis; Molecular Structure; Particle Size; Salicylates; Salicylic Acid; Surface Properties; Water | 2010 |
Two cases of oral aspirin overdose.
Topics: Administration, Oral; Adult; Aspirin; Chromatography, High Pressure Liquid; Diphenhydramine; Drug Overdose; Female; Forensic Pathology; Forensic Toxicology; Gastrointestinal Contents; Humans; Hypnotics and Sedatives; Japan; Male; Platelet Aggregation Inhibitors; Salicylic Acid; Suicide | 2010 |
Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes.
Topics: Acetaminophen; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Line, Tumor; Cyclooxygenase Inhibitors; Dinoprostone; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen Peroxide; Mice; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Salicylic Acid; Thromboxane B2 | 2010 |
Para-carboxy modified amphiphilic calixarene, self-assembly and interactions with pharmaceutically-relevant molecules.
Topics: Acetaminophen; Aspirin; Calixarenes; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Molecular Structure; Nanoparticles; Particle Size; Salicylic Acid; Surface Properties; Surface-Active Agents; Unilamellar Liposomes | 2010 |
Willow species and aspirin: different mechanism of actions.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzyl Alcohols; Flavonoids; Glucosides; Humans; Plant Bark; Polyphenols; Salicylic Acid; Salix; Species Specificity | 2011 |
DNA immobilization on a polypyrrole nanofiber modified electrode and its interaction with salicylic acid/aspirin.
Topics: Animals; Aspirin; Cattle; Dielectric Spectroscopy; DNA; Electrochemical Techniques; Electrodes; Guanine; Nanofibers; Oxidation-Reduction; Polymers; Pyrroles; Salicylic Acid | 2011 |
Electrocatalytic oxidation of salicylic acid by a cobalt hydrotalcite-like compound modified Pt electrode.
Topics: Aluminum Hydroxide; Aspirin; Catalysis; Cobalt; Drug Contamination; Electrochemical Techniques; Electrodes; Magnesium Hydroxide; Oxidation-Reduction; Platinum; Salicylic Acid; Sensitivity and Specificity | 2011 |
Nitrooxyacyl derivatives of salicylic acid: aspirin-like molecules that covalently inactivate cyclooxygenase-1.
Topics: Anti-Inflammatory Agents; Aspirin; Catalytic Domain; Cell Line; Computer Simulation; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Humans; Platelet Aggregation Inhibitors; Recombinant Proteins; Salicylic Acid | 2011 |
Two novel aspirin analogues show selective cytotoxicity in primary chronic lymphocytic leukaemia cells that is associated with dual inhibition of Rel A and COX-2.
Topics: ADP-ribosyl Cyclase 1; Aged; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Caspase 3; Caspase Inhibitors; CD40 Antigens; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Membrane Glycoproteins; Mice; Oligopeptides; Parabens; Salicylic Acid; Transcription Factor RelA; Transcription, Genetic; Tumor Cells, Cultured; ZAP-70 Protein-Tyrosine Kinase | 2011 |
Method development and validation for optimised separation of salicylic, acetyl salicylic and ascorbic acid in pharmaceutical formulations by hydrophilic interaction chromatography and response surface methodology.
Topics: Acetates; Acetonitriles; Analysis of Variance; Ascorbic Acid; Aspirin; Chromatography, Liquid; Drug Contamination; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Least-Squares Analysis; Models, Chemical; Reproducibility of Results; Salicylic Acid; Sensitivity and Specificity; Tablets; Temperature | 2011 |
Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting.
Topics: Adult; Aspirin; Biological Transport; Blood Platelets; Cells, Cultured; Coronary Artery Bypass; Cyclic AMP; Cyclooxygenase 1; Dinoprostone; Drug Interactions; Drug Resistance; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Propionates; Prostaglandin-Endoperoxide Synthases; Quinolines; RNA, Small Interfering; Salicylic Acid; Thromboxane B2 | 2011 |
Nanostructured conducting molecularly imprinted polymer for selective extraction of salicylate from urine and serum samples by electrochemically controlled solid-phase micro-extraction.
Topics: Administration, Oral; Animals; Aspirin; Cattle; Electrochemistry; Humans; Molecular Imprinting; Nanostructures; Salicylic Acid; Solid Phase Extraction | 2011 |
Simultaneous determination and pharmacokinetics of protein unbound aspirin and salicylic acid in rat blood and brain by microdialysis: an application to herbal-drug interaction.
Topics: Animals; Area Under Curve; Aspirin; Bleeding Time; Brain Chemistry; Drug Stability; Drugs, Chinese Herbal; Herb-Drug Interactions; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Salicylic Acid | 2012 |
Aspirin downregulates angiotensin type 1 receptor transcription implications in capillary formation from endothelial cells.
Topics: Angiogenesis Inhibitors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Aspirin; Capillaries; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Losartan; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neovascularization, Physiologic; Receptor, Angiotensin, Type 1; RNA, Messenger; Salicylic Acid; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2012 |
Preparation of lipid aspirin sustained-release pellets by solvent-free extrusion/spheronization and an investigation of their stability.
Topics: Aspirin; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Implants; Drug Stability; Lipids; Microscopy, Electron, Scanning; Salicylic Acid; Solubility; Solvents; Technology, Pharmaceutical; Transition Temperature; X-Ray Diffraction | 2012 |
Pharmacokinetic and pharmacodynamic interaction of Danshen-Gegen extract with warfarin and aspirin.
Topics: Animals; Anticoagulants; Area Under Curve; Aspirin; Drugs, Chinese Herbal; Herb-Drug Interactions; Lactates; Male; Prothrombin Time; Rats; Rats, Sprague-Dawley; Salicylic Acid; Warfarin | 2012 |
Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Bleeding Time; Carotid Artery Thrombosis; Drug Therapy, Combination; Gastric Mucosa; Guinea Pigs; Immunoenzyme Techniques; Indicators and Reagents; Male; Mice; Phosphodiesterase Inhibitors; Photochemistry; Platelet Aggregation Inhibitors; Pyridines; Rolipram; Salicylic Acid; Stomach Diseases; Thromboxane B2 | 2012 |
Low dose aspirin estimation: an application to a human pharmacokinetic study.
Topics: Administration, Oral; Aspirin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Stability; Humans; Limit of Detection; Male; Reproducibility of Results; Salicylic Acid; Tandem Mass Spectrometry | 2013 |
Simultaneous determination of acetylsalicylic acid and salicylic acid in human plasma by isocratic high-pressure liquid chromatography with post-column hydrolysis and fluorescence detection.
Topics: Aspirin; Chromatography, High Pressure Liquid; Drug Stability; Humans; Hydrolysis; Limit of Detection; Reproducibility of Results; Salicylic Acid; Spectrometry, Fluorescence | 2013 |
Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1α genes.
Topics: Animals; Aryldialkylphosphatase; Aspirin; Cells, Cultured; Gene Expression Regulation; Heat-Shock Proteins; Hep G2 Cells; Hepatocytes; Humans; Hydrogen Peroxide; Hydroxybenzoates; Mice; Mice, Inbred C57BL; Mitochondria, Liver; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Platelet Aggregation Inhibitors; Receptors, Aryl Hydrocarbon; Salicylic Acid; Sirtuin 1; Trans-Activators; Transcription Factors | 2013 |
Synovial distribution of "systemically" administered acetylsalicylic acid in the isolated perfused equine distal limb.
Topics: Administration, Intravenous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromatography, High Pressure Liquid; Female; Hemoperfusion; Hindlimb; Horses; Male; Microdialysis; Salicylic Acid; Synovial Fluid | 2013 |
Association of plasma concentrations of salicylic acid and high on ASA platelet reactivity in type 2 diabetes patients.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Chromatography, High Pressure Liquid; Coronary Artery Disease; Cyclooxygenase 1; Diabetes Mellitus, Type 2; Drug Resistance; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Function Tests; Poland; Predictive Value of Tests; Prospective Studies; Risk Factors; Salicylic Acid; Thromboxane B2 | 2013 |
Solid-state 17O NMR of pharmaceutical compounds: salicylic acid and aspirin.
Topics: Aspirin; Dimerization; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Oxygen Isotopes; Salicylic Acid; Thermodynamics | 2013 |
Acetylsalicylic acid (aspirin) and salicylic acid interaction with the human erythrocyte membrane bilayer induce in vitro changes in the morphology of erythrocytes.
Topics: Aspirin; Cell Shape; Dimyristoylphosphatidylcholine; Erythrocyte Membrane; Humans; Lipid Bilayers; Phosphatidylethanolamines; Salicylic Acid; Unilamellar Liposomes | 2013 |
Polysaccharide arabinogalactan from larch Larix sibirica as carrier for molecules of salicylic and acetylsalicylic acid: preparation, physicochemical and pharmacological study.
Topics: Administration, Oral; Animals; Aspirin; Drug Carriers; Galactans; Larix; Male; Phase Transition; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats, Wistar; Salicylic Acid; Solubility; Solutions; Surface Properties | 2015 |
Application of time-resolved fluorescence to the determination of metabolites.
Topics: Aspirin; Gentisates; Humans; Salicylic Acid; Spectrometry, Fluorescence; Urine | 2014 |
Quality and antioxidant properties on sweet cherries as affected by preharvest salicylic and acetylsalicylic acids treatments.
Topics: Anthocyanins; Antioxidants; Aspirin; Fruit; Plant Extracts; Prunus; Salicylic Acid | 2014 |
Multiple dual mode counter-current chromatography with variable duration of alternating phase elution steps.
Topics: Aspirin; Caffeine; Coumarins; Countercurrent Distribution; Models, Theoretical; Salicylic Acid | 2014 |
The adsorption of pharmaceutically active compounds from aqueous solutions onto activated carbons.
Topics: Adsorption; Aspirin; Atenolol; Carbon; Diclofenac; Salicylic Acid; Solutions; Surface Properties; Water Pollutants, Chemical; Water Purification | 2015 |
Evaluation of the pharmaceutical characteristics of various enteric-coated aspirin tablets under different storage conditions.
Topics: Aspirin; Chemistry, Pharmaceutical; Drug Stability; Microscopy, Electron, Scanning; Salicylic Acid; Spectrum Analysis, Raman; Surface Properties; Tablets, Enteric-Coated; Temperature; Time Factors | 2014 |
Modifications of the chemical structure of phenolics differentially affect physiological activities in pulvinar cells of Mimosa pudica L. I. Multimode effect on early membrane events.
Topics: Aspirin; Cell Membrane; Mimosa; Phenols; Proton-Translocating ATPases; Pulvinar; Salicylic Acid | 2014 |
Aspirin may influence cellular energy status.
Topics: Apolipoprotein A-I; Aryldialkylphosphatase; Aspirin; DNA-Binding Proteins; Hep G2 Cells; Humans; Hydrogen Peroxide; Ion Channels; Mitochondrial Proteins; NF-E2-Related Factor 2; Nitric Oxide Synthase Type III; Salicylic Acid; Sirtuins; STAT3 Transcription Factor; Transcription Factors; Uncoupling Protein 1 | 2015 |
A Reaction of Aspirin with Ferrous Gluconate.
Topics: Aspirin; Ferrous Compounds; Gluconates; Iron; Oxidation-Reduction; Salicylic Acid; Solutions; Spectrophotometry | 2015 |
Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450.
Topics: Aspirin; Benzaldehydes; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Deferoxamine; Enzyme Inhibitors; Humans; Hydroxylation; Isoenzymes; Microsomes, Liver; NADP; Organophosphates; Oxidation-Reduction; Reactive Oxygen Species; Recombinant Proteins; Salicylic Acid | 2015 |
Preparation of acetylsalicylic acid-acylated chitosan as a novel polymeric drug for drug controlled release.
Topics: Acetylation; Aspirin; Chitosan; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Proton Magnetic Resonance Spectroscopy; Salicylic Acid; Spectroscopy, Fourier Transform Infrared | 2015 |
Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.
Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers, Pharmacological; Biotransformation; Chemistry, Pharmaceutical; Computer Simulation; Dose-Response Relationship, Drug; Drug Liberation; Hippurates; Humans; Models, Biological; Pharmacology, Clinical; Salicylic Acid; Software; Therapeutic Equivalency; Tissue Distribution | 2015 |
Isolation, Characterization of a Potential Degradation Product of Aspirin and an HPLC Method for Quantitative Estimation of Its Impurities.
Topics: Aspirin; Chromatography, High Pressure Liquid; Drug Contamination; Hot Temperature; Linear Models; Nuclear Magnetic Resonance, Biomolecular; Reproducibility of Results; Salicylic Acid; Sensitivity and Specificity | 2015 |
Novel mixed metal Ag(I)-Sb(III)-metallotherapeutics of the NSAIDs, aspirin and salicylic acid: Enhancement of their solubility and bioactivity by using the surfactant CTAB.
Topics: Antimony; Antineoplastic Agents; Aspirin; Cetrimonium; Cetrimonium Compounds; Coordination Complexes; Glutathione; Humans; Kinetics; Linoleic Acid; Lipoxygenase; MCF-7 Cells; Micelles; Proton Magnetic Resonance Spectroscopy; Receptors, Estrogen; Salicylic Acid; Silver; Solubility; Spectrometry, X-Ray Emission; Surface-Active Agents | 2015 |
Complexation induced fluorescence and acid-base properties of dapoxyl dye with γ-cyclodextrin: a drug-binding application using displacement assays.
Topics: Acetaminophen; Ampicillin; Aspirin; beta-Cyclodextrins; Binding Sites; Chloramphenicol; Drug Delivery Systems; Fluorescence; Fluorescent Dyes; Fluorometry; Hydrogen-Ion Concentration; Ibuprofen; Kanamycin; Oxazines; Oxazoles; Piroxicam; Salicylates; Salicylic Acid; Sorbic Acid; Sulfonamides; Thiamphenicol; Xanthenes | 2015 |
Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression.
Topics: 3T3 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenase 2; Epithelial-Mesenchymal Transition; Female; HMGB1 Protein; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mice; Mice, Knockout; Mice, SCID; Neoplasm Invasiveness; Salicylic Acid; Xenograft Model Antitumor Assays | 2015 |
Aspirin's Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses.
Topics: Aspirin; Cyclooxygenase 2; HMGB1 Protein; Humans; Inflammation; Mutation; Nuclear Magnetic Resonance, Biomolecular; Salicylic Acid | 2015 |
Assessment of in vitro antiovulatory activities of nonsteroidal anti-inflammatory drugs and comparison with in vivo reproductive toxicities of medaka (Oryzias latipes).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Female; Humans; Ketoprofen; Mefenamic Acid; Oryzias; Ovary; Ovulation; Ovum; Reproduction; Salicylic Acid; Water Pollutants, Chemical | 2016 |
Pharmacokinetic and pharmacodynamic interactions of aspirin with warfarin in beagle dogs.
Topics: Animals; Aspirin; Dogs; Dose-Response Relationship, Drug; Drug Interactions; International Normalized Ratio; Male; Partial Thromboplastin Time; Platelet Aggregation Inhibitors; Prothrombin Time; Reference Standards; Salicylic Acid; Warfarin | 2016 |
Human GAPDH Is a Target of Aspirin's Primary Metabolite Salicylic Acid and Its Derivatives.
Topics: Aspirin; Cell Death; Cell Line; Cell Nucleus; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Humans; Molecular Structure; Protein Binding; Protein Transport; Salicylic Acid | 2015 |
A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Behavior, Animal; Cyclic N-Oxides; Drug Synergism; Ganglia, Spinal; Hyperalgesia; Imidazoles; Low Back Pain; Male; Neurons; Radiculopathy; Rats; Rats, Sprague-Dawley; Salicylic Acid; Spin Labels; Spinal Cord Compression | 2015 |
Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention.
Topics: Aspirin; Cell Line, Tumor; Cell Proliferation; Cyclin A2; Cyclin-Dependent Kinase 2; Down-Regulation; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; MCF-7 Cells; Models, Molecular; Molecular Docking Simulation; Neoplasms; Protein Binding; Salicylic Acid | 2016 |
Simultaneous determination of salicylic, 3-methyl salicylic, 4-methyl salicylic, acetylsalicylic and benzoic acids in fruit, vegetables and derived beverages by SPME-LC-UV/DAD.
Topics: Aspirin; Benzoates; Benzoic Acid; Beverages; Chromatography, High Pressure Liquid; Dimethylpolysiloxanes; Fruit; Polyvinyls; Salicylic Acid; Solid Phase Microextraction; Ultraviolet Rays; Vegetables | 2016 |
Newly Identified Targets of Aspirin and Its Primary Metabolite, Salicylic Acid.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Drug Repositioning; Glyceraldehyde-3-Phosphate Dehydrogenases; HMGB1 Protein; Humans; Salicylic Acid | 2016 |
Preharvest salicylic acid and acetylsalicylic acid treatments preserve quality and enhance antioxidant systems during postharvest storage of sweet cherry cultivars.
Topics: Agriculture; Anthocyanins; Antioxidants; Ascorbate Peroxidases; Ascorbic Acid; Aspirin; Catalase; Color; Food Handling; Food Preservation; Food Storage; Fruit; Hardness; Humans; Oxidation-Reduction; Peroxidase; Phenols; Prunus; Salicylic Acid; Superoxide Dismutase; Taste | 2017 |
Simultaneous Determination of Aspirin, Dipyridamole and Two of Their Related Impurities in Capsules by Validated TLC-Densitometric and HPLC Methods.
Topics: Acetates; Aspirin; Capsules; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Densitometry; Dipyridamole; Hydrogen-Ion Concentration; Methanol; Reproducibility of Results; Salicylic Acid; Solvents; Tartrates; Toluene | 2016 |
EPR studies of intermolecular interactions and competitive binding of drugs in a drug-BSA binding model.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Binding, Competitive; Electron Spin Resonance Spectroscopy; Ibuprofen; Pharmaceutical Preparations; Protein Binding; Salicylic Acid; Serum Albumin, Bovine; Spin Labels | 2016 |
Aspirin for cancer is no mere antiplatelet prototype. There is potential in its ancient roots.
Topics: Animals; Aspirin; Blood Platelets; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Gastrointestinal Diseases; Humans; Neoplasms; Platelet Aggregation Inhibitors; Preventive Medicine; Risk; Salicylic Acid; Vascular Diseases | 2016 |
Ethanol oxidation and the inhibition by drugs in human liver, stomach and small intestine: Quantitative assessment with numerical organ modeling of alcohol dehydrogenase isozymes.
Topics: Acetaminophen; Alcohol Dehydrogenase; Aspirin; Cimetidine; Ethanol; Gastric Mucosa; Genotype; Humans; Intestine, Small; Isoenzymes; Kinetics; Liver; Models, Biological; Oxidation-Reduction; Pharmaceutical Preparations; Salicylic Acid; Stomach; Substrate Specificity | 2016 |
ABCC3 Polymorphisms and mRNA Expression Influence the Concentration of a Carboxylic Acid Metabolite in Patients on Clopidogrel and Aspirin Therapy.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Carboxylic Acids; Chromatography, Liquid; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Genotype; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; RNA, Messenger; Salicylic Acid; Tandem Mass Spectrometry; Ticlopidine; Up-Regulation | 2017 |
Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Chromatography, High Pressure Liquid; Dogs; Drug Interactions; Fibrinolytic Agents; Limit of Detection; Male; Panax notoginseng; Permeability; Rats; Rats, Sprague-Dawley; Salicylic Acid; Saponins; Tandem Mass Spectrometry | 2017 |
Bioavailability of aspirin in rats comparing the drug's uptake into gastrointestinal tissue and vascular and lymphatic systems: implications on aspirin's chemopreventive action.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Biological Availability; Drug Administration Routes; Intestinal Mucosa; Lymphatic System; Male; Rats; Rats, Sprague-Dawley; Salicylic Acid | 2016 |
Quantitative determination of five metabolites of aspirin by UHPLC-MS/MS coupled with enzymatic reaction and its application to evaluate the effects of aspirin dosage on the metabolic profile.
Topics: Animals; Aspirin; Chromatography, High Pressure Liquid; Glucuronates; Glucuronidase; Glucuronides; Hippurates; Male; Metabolome; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Tandem Mass Spectrometry | 2017 |
How does the multifaceted plant hormone salicylic acid combat disease in plants and are similar mechanisms utilized in humans?
Topics: Agriculture; Aspirin; Cytosol; Disease Resistance; Humans; Plant Diseases; Plant Growth Regulators; Salicylic Acid; Signal Transduction | 2017 |
Impaired liver cytochrome P450 2C11 activity after dual antiplatelet therapy with aspirin and clopidogrel in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Aspirin; Chromatography, Liquid; Clopidogrel; Cytochrome P450 Family 2; Inactivation, Metabolic; Liver; Male; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Salicylic Acid; Steroid 16-alpha-Hydroxylase; Tandem Mass Spectrometry; Ticlopidine | 2018 |
Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer.
Topics: Acetylation; Anticarcinogenic Agents; Aspirin; CDC2 Protein Kinase; Colorectal Neoplasms; Cyclin B1; HCT116 Cells; Humans; Hydroxybenzoates; Molecular Docking Simulation; Protein Kinase Inhibitors; Salicylic Acid | 2017 |
Impact of Multidrug Resistance Protein-4 Inhibitors on Modulating Platelet Function and High on-Aspirin Treatment Platelet Reactivity.
Topics: Aged; Aspirin; Blood Platelets; Cilostazol; Cohort Studies; Cyclic AMP; Female; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandins H; Salicylic Acid; Thrombosis | 2018 |
Effect of Red Ginseng Extract on the Pharmacokinetics of Aspirin Metabolite in Sprague Dawley Rats.
Topics: Animals; Aspirin; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Male; Panax; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Salicylic Acid | 2018 |
Simultaneous determination of methocarbamol and aspirin in presence of their pharmacopeial-related substances in combined tablets using novel HPLC-DAD method.
Topics: Acetic Acid; Acetonitriles; Aspirin; Calibration; Chromatography, High Pressure Liquid; Drug Combinations; Guaifenesin; Limit of Detection; Methocarbamol; Powders; Reference Standards; Reproducibility of Results; Salicylic Acid; Tablets | 2019 |
Detection and monitoring of in vitro formation of salicylic acid from aspirin using fluorescence spectroscopic technique and DFT calculations.
Topics: Aspirin; Density Functional Theory; Humans; Hydrogen-Ion Concentration; Salicylic Acid; Spectrometry, Fluorescence | 2018 |
Quantitative determination of carbasalate calcium derived metabolites, acetylsalicylic acid and salicylic acid, in six animal foods using liquid-liquid extraction method coupled with liquid chromatography-tandem mass spectrometry.
Topics: Acetonitriles; Animal Feed; Animals; Aspirin; Chromatography, Liquid; Food Analysis; Food Contamination; Limit of Detection; Liquid-Liquid Extraction; Milk; Red Meat; Salicylic Acid; Seafood; Swine; Tandem Mass Spectrometry; Urea | 2019 |
Modulating Inflammation in Monocytes Using Capillary Fiber Organic Electronic Ion Pumps.
Topics: Aspirin; Cytokines; Drug Delivery Systems; Electrolytes; Electronics; Humans; Hydrogen-Ion Concentration; Inflammation; Interleukin-6; Ions; Lipopolysaccharides; Miniaturization; Monocytes; Organic Chemicals; Salicylic Acid; Tumor Necrosis Factor-alpha | 2019 |
Role of aspirin-triggered lipoxin A4, aspirin, and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsia.
Topics: Acetylation; Adolescent; Adult; Aspirin; Cell Adhesion; Cyclooxygenase 2; Female; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipoxins; Neutrophils; NF-kappa B; Oxidative Stress; Pre-Eclampsia; Pregnancy; Protein Processing, Post-Translational; Salicylic Acid; Thiobarbituric Acid Reactive Substances; Tyrosine; U937 Cells; Young Adult | 2020 |
Salicylic acid and aspirin stimulate growth of Chlamydomonas and inhibit lipoxygenase and chloroplast desaturase pathways.
Topics: Aspirin; Chlamydomonas; Chloroplasts; Enzyme Activation; Enzyme Inhibitors; Fatty Acid Desaturases; Lipoxygenase; Salicylic Acid | 2020 |
Translation of Microbiota Short-Chain Fatty Acid Mechanisms Affords Anti-infective Acyl-Salicylic Acid Derivatives.
Topics: Acylation; Anti-Infective Agents; Aspirin; Clostridioides difficile; Drug Therapy, Combination; Esters; Fatty Acids, Volatile; Humans; Microbiota; Salicylic Acid; Salmonella typhimurium; Structure-Activity Relationship | 2020 |
Low levels of salicylic acid and salicyluric acid are present in synovial fluid of patients taking aspirin at the time of knee arthroplasty surgery.
Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; Aspirin; Drug Administration Schedule; Drug Monitoring; Female; Hippurates; Humans; Knee Prosthesis; Male; Prosthesis-Related Infections; Salicylic Acid; Synovial Fluid | 2020 |
An interim internal Threshold of Toxicologic Concern (iTTC) for chemicals in consumer products, with support from an automated assessment of ToxCast™ dose response data.
Topics: Acetic Acid; Animals; Aspirin; Automation; Dose-Response Relationship, Drug; Humans; Molecular Structure; No-Observed-Adverse-Effect Level; Receptors, Androgen; Risk Assessment; Salicylic Acid; Structure-Activity Relationship | 2020 |
Preharvest application of methyl salicylate, acetyl salicylic acid and salicylic acid alleviated disease caused by Botrytis cinerea through stimulation of antioxidant system in table grapes.
Topics: Antioxidants; Aspirin; Botrytis; Disease Resistance; Food Preservation; Phenols; Plant Diseases; Salicylates; Salicylic Acid; Vitis | 2020 |
Green analysis of newly approved binary omeprazole/aspirin mixture in presence of aspirin impurity using ultra-high-performance liquid chromatography and thin-layer chromatography methods.
Topics: Aspirin; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drug Contamination; Green Chemistry Technology; Limit of Detection; Linear Models; Omeprazole; Reproducibility of Results; Salicylic Acid | 2021 |
Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Cell Line, Tumor; Disease Models, Animal; Endoplasmic Reticulum Stress; Male; Melanoma; Mice, Inbred C57BL; Molecular Targeted Therapy; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Salicylic Acid; Skin Neoplasms; TOR Serine-Threonine Kinases; Up-Regulation | 2020 |
Spectrophotometric Determination of Aspirin and Omeprazole in the Presence of Salicylic Acid as a Degradation Product: A Comparative Evaluation of Different Univariate/Multivariate Post Processing Algorithms.
Topics: Algorithms; Aspirin; Calibration; Humans; Least-Squares Analysis; Omeprazole; Salicylic Acid; Spectrophotometry | 2022 |
Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.
Topics: Aspirin; Case-Control Studies; Colorectal Neoplasms; Diet; Female; Genome-Wide Association Study; Genotyping Techniques; Humans; Male; Mendelian Randomization Analysis; Polymorphism, Single Nucleotide; Risk Factors; Salicylic Acid | 2021 |
Micelle-Incorporated Liquid Chromatography in the Light of Green Chemistry: An Application for the Quality Control Analysis of Anti-Platelet Fixed-Dose Combinations.
Topics: Aspirin; Chromatography, High Pressure Liquid; Chromatography, Liquid; Clopidogrel; Micelles; Quality Control; Reproducibility of Results; Salicylic Acid | 2022 |
Monitoring of salicylic acid content in human saliva and its relationship with plasma concentrations.
Topics: Aspirin; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Salicylic Acid; Saliva | 2022 |
Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells.
Topics: Aspirin; Colorectal Neoplasms; Cyclin-Dependent Kinase 4; Humans; Prospective Studies; Ribosomal Proteins; RNA, Small Interfering; Salicylic Acid; Sodium Salicylate | 2022 |
Determination of milk concentrations and pharmacokinetics of salicylic acid following acetylsalicylic acid (aspirin) administration in postpartum dairy cows.
Topics: Animals; Aspirin; Cattle; Female; Lactation; Milk; Postpartum Period; Prostaglandins; Salicylic Acid | 2022 |
A photoelectron spectroscopic investigation of aspirin, paracetamol and ibuprofen in the gas phase.
Topics: Acetaminophen; Aspirin; Gases; Ibuprofen; Photoelectron Spectroscopy; Salicylic Acid | 2023 |
Low dose acetyl salicylic acid (LDA) mediates epigenetic changes in preeclampsia placental mesenchymal stem cells similar to cells from healthy pregnancy.
Topics: Aspirin; Epigenesis, Genetic; Female; Humans; Mesenchymal Stem Cells; Placenta; Pre-Eclampsia; Pregnancy; Salicylic Acid | 2023 |
A pharmacokinetics interaction study of antiplatelet agents aspirin and clopidogrel combined with dl-3-n-butylphthalide in rats by liquid chromatography-tandem mass spectrometry.
Topics: Animals; Aspirin; Chromatography, High Pressure Liquid; Chromatography, Liquid; Clopidogrel; Platelet Aggregation Inhibitors; Rats; Salicylic Acid; Tandem Mass Spectrometry | 2023 |
The Plasma Concentration of Ticagrelor and Aspirin as a Predictor of Bleeding Complications in Chinese Acute Coronary Syndrome Patients With Dual Antiplatelet Therapy: A Prospective Observational Study.
Topics: Acute Coronary Syndrome; Aspirin; East Asian People; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Salicylic Acid; ST Elevation Myocardial Infarction; Ticagrelor; Treatment Outcome | 2023 |
Voltammetric quantification of acetylsalicylic acid in pharmaceutical formulations utilizing copper wire electrode.
Topics: Aspirin; Copper; Drug Compounding; Electrodes; Pharmaceutical Preparations; Salicylic Acid | 2023 |
Association between 23 drugs and Parkinson's disease: A two-sample Mendelian randomization study.
Topics: Aspirin; Fibrinolytic Agents; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Parkinson Disease; Reproducibility of Results; Salicylic Acid | 2023 |
A classification of headache.
Topics: Antidepressive Agents; Anxiety; Arteritis; Aspirin; Depression; Ergot Alkaloids; Facial Neuralgia; Headache; Histamine Release; Humans; Inflammation; Methysergide; Microcirculation; Migraine Disorders; Muscle Contraction; Myositis; Neck; Neuralgia; Osteoarthritis; Scalp; Serotonin Antagonists; Vascular Headaches; Vasoconstrictor Agents | 1970 |
Craniofacial pain followed by scalp necrosis and stroke. An unusual presentation of the primary antiphospholipid syndrome.
Topics: Aged; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoimmune Diseases; Blood Sedimentation; Brain Ischemia; Diagnosis, Differential; Facial Pain; Giant Cell Arteritis; Headache; Humans; Magnetic Resonance Imaging; Male; Necrosis; Scalp; Thrombophilia | 1999 |
Subgaleal hematoma in a child with Sturge-Weber syndrome: to prevent stroke-like episodes, is treatment with aspirin advisable?
Topics: Aspirin; Child, Preschool; Craniocerebral Trauma; Hematoma; Humans; Male; Platelet Aggregation Inhibitors; Scalp; Stroke; Sturge-Weber Syndrome; Tomography Scanners, X-Ray Computed | 2008 |
Brooke-Spiegler syndrome: report of a case of multiple cylindromas and trichoepitheliomas.
Topics: Administration, Topical; Aspirin; Biomarkers, Tumor; Biopsy, Needle; Carcinoma, Adenoid Cystic; Carcinoma, Skin Appendage; Combined Modality Therapy; Deubiquitinating Enzyme CYLD; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lip; Male; Middle Aged; Mohs Surgery; Neoplasm Staging; Neoplastic Syndromes, Hereditary; Risk Assessment; Scalp; Skin Neoplasms; Treatment Outcome; Tumor Suppressor Proteins | 2008 |