salicylates and urushiol

salicylates has been researched along with urushiol* in 2 studies

Other Studies

2 other study(ies) available for salicylates and urushiol

Article	Year
Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols. Toxicology letters, 2014, Sep-02, Volume: 229, Issue:2 Ginkgolic acids and urushiols are natural alkylphenols known for their mutagenic, carcinogenic and genotoxic potential. However, the mechanism of toxicity of these compounds has not been thoroughly elucidated so far. Considering that the SIRT inhibitory potential of anacardic acids has been hypothesized by in silico techniques, we herein demonstrated through both in vitro and computational methods that structurally related compounds such as ginkgolic acids and urushiols are able to modulate SIRT activity. Moreover, their SIRT inhibitory profile and cytotoxicity were comparable to sirtinol, a non-specific SIRT inhibitor (SIRT1 and SIRT2), and different from EX-527, a SIRT1 specific inhibitor. This is the first report on the SIRT inhibition of ginkgolic acids and urushiols. The results reported here are in line with previously observed effects on the induction of apoptosis by this class of compounds, and the non-specific SIRT inhibition is suggested as a new mechanism for their in vitro cytotoxicity. Topics: Catalytic Domain; Catechols; HEK293 Cells; HeLa Cells; Humans; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Salicylates; Sirtuin 1; Sirtuin 2	2014
The separation and synthesis of lipidic 1,2- and 1,3-diols from natural phenolic lipids for the complexation and recovery of boron. Chemistry and physics of lipids, 2003, Volume: 126, Issue:2 A study has been made of the semi-synthesis of 1,3-diols (anacardic alcohols) from natural phenolic lipid resources from Anacardium occidentale and Anacardium giganteum which have given C15 and C11 derivatives, respectively. An isomeric 1,3-diol (isoanacardic alcohol) has been obtained from cardanol separated from technical cashew nut-shell liquid. Homologous 1,3-diols have been synthesised from a range of synthetic 2-alkyl-, 3-alkyl- and 4-alkylphenols and from 6-alkylsalicylic acids. The natural 1,2-diol, urushiol, from Rhus vernicifera has been purified. All these lipidic compounds have been studied for their complexation and the potential recovery of boron as boric acid. Topics: Anacardium; Boron; Catechols; Chromatography; Fatty Alcohols; Isomerism; Lipids; Mass Spectrometry; Molecular Structure; Phenols; Rhus; Salicylates; Spectrophotometry, Infrared	2003

Article

Year

Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols.

Toxicology letters, 2014, Sep-02, Volume: 229, Issue:2

Ginkgolic acids and urushiols are natural alkylphenols known for their mutagenic, carcinogenic and genotoxic potential. However, the mechanism of toxicity of these compounds has not been thoroughly elucidated so far. Considering that the SIRT inhibitory potential of anacardic acids has been hypothesized by in silico techniques, we herein demonstrated through both in vitro and computational methods that structurally related compounds such as ginkgolic acids and urushiols are able to modulate SIRT activity. Moreover, their SIRT inhibitory profile and cytotoxicity were comparable to sirtinol, a non-specific SIRT inhibitor (SIRT1 and SIRT2), and different from EX-527, a SIRT1 specific inhibitor. This is the first report on the SIRT inhibition of ginkgolic acids and urushiols. The results reported here are in line with previously observed effects on the induction of apoptosis by this class of compounds, and the non-specific SIRT inhibition is suggested as a new mechanism for their in vitro cytotoxicity.

Topics: Catalytic Domain; Catechols; HEK293 Cells; HeLa Cells; Humans; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Salicylates; Sirtuin 1; Sirtuin 2

2014

The separation and synthesis of lipidic 1,2- and 1,3-diols from natural phenolic lipids for the complexation and recovery of boron.

Chemistry and physics of lipids, 2003, Volume: 126, Issue:2

A study has been made of the semi-synthesis of 1,3-diols (anacardic alcohols) from natural phenolic lipid resources from Anacardium occidentale and Anacardium giganteum which have given C15 and C11 derivatives, respectively. An isomeric 1,3-diol (isoanacardic alcohol) has been obtained from cardanol separated from technical cashew nut-shell liquid. Homologous 1,3-diols have been synthesised from a range of synthetic 2-alkyl-, 3-alkyl- and 4-alkylphenols and from 6-alkylsalicylic acids. The natural 1,2-diol, urushiol, from Rhus vernicifera has been purified. All these lipidic compounds have been studied for their complexation and the potential recovery of boron as boric acid.

Topics: Anacardium; Boron; Catechols; Chromatography; Fatty Alcohols; Isomerism; Lipids; Mass Spectrometry; Molecular Structure; Phenols; Rhus; Salicylates; Spectrophotometry, Infrared

2003