salicylates has been researched along with tenocyclidine* in 1 studies
1 other study(ies) available for salicylates and tenocyclidine
| Article | Year |
|---|---|
Modulation of glutamate neurotoxicity on mesencephalic dopaminergic neurons in primary cultures by the presence of striatal target cells.
Glutamate toxicity was compared in substantia nigra (SN)/striatum (STR) and SN/cerebellum (CRB) co-cultures on both the entire neuronal population (neuron specific enolase (NSE) immunopositive cells) and dopaminergic neurons (tyrosine hydroxylase (TH) immunopositive cells). In SN/CRB co-cultures NSE- and TH-positive cells were more sensitive to glutamate-induced toxicity than in SN/STR co-cultures. Moreover, in SN/STR co-cultures as compared to SN/CRB and SN cultures, glutamate toxicity was prevented to a larger extent by TCP, a non-competitive NMDA antagonist. These results suggest that target cells induce a differential expression of the different glutamate receptor subtypes in mesencephalic dopaminergic cells. Alternatively, the presence of target cells may induce the selective development of a subpopulation of dopaminergic neurons expressing predominantly NMDA receptors. Topics: Animals; Cell Count; Cells, Cultured; Cerebellum; Chlorine; Coculture Techniques; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Combinations; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; Iodine; Lethal Dose 50; Mesencephalon; Neurons; Neuroprotective Agents; Phencyclidine; Phenols; Phosphopyruvate Hydratase; Rats; Salicylates; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |