salicylates and talipexole

The effect of protection of dopaminergic neurons by talipexole, a dopamine (DA) agonist, is investigated on a methamphetamine (MA)-induced parkinsonism model of mice (C57BL/6N). The reduction of tyrosine hydroxylase activity in the striatum 72 h after MA (5 mg/kg every 2 h, four times) treatment was attenuated by the administration of talipexole (0.25 mg/kg or 1.0 mg/kg) prior to the administration of MA. In an in vitro experiment, talipexole inhibited the adduction reaction of hydroxyl radicals to salicylate. Taken together, these data suggest that the protective effect of talipexole on DA neurons is, in part, caused by the hydroxyl radical-scavenging action of the drug.

Topics: Animals; Azepines; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agonists; Enzyme Induction; Free Radical Scavengers; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Parkinson Disease, Secondary; Receptors, Dopamine D2; Salicylates; Salicylic Acid; Tyrosine 3-Monooxygenase