salicylates and resorcinol

Acne and rosacea are common inflammatory processes historically classified in the same disease category, but evolving understanding of their disparate pathophysiology and exacerbating factors have generated an enormous armamentarium of therapeutic possibilities. Patients seek over-the-counter therapies first when managing cutaneous disease; therefore, this review defines ingredients considered to be effective over-the-counter acne and rosacea products, their mechanisms, and safe formulations, including botanical components, oral supplements, and other anecdotal options in this vast skin care domain.

Topics: Acne Vulgaris; Administration, Cutaneous; Astringents; Benzoyl Peroxide; Dermatologic Agents; Detergents; Evidence-Based Medicine; Global Health; Humans; Hydroxy Acids; Kinetin; Niacinamide; Nonprescription Drugs; Phototherapy; Randomized Controlled Trials as Topic; Resorcinols; Rosacea; Salicylates; Sulfur; Sunscreening Agents; Tea Tree Oil; Treatment Outcome; Tretinoin; Zinc

The drugs used in the treatment of superficial mycoses include substances with an indirect affect on the organisms such as the keratolytics as well as antifungal compounds. The antifungals include specific inhibitory compounds such as the polyene or imidazole antibiotics and substances with a wider spectrum of antiseptic activity. High cure rates (80-90%) can be achieved by most specific antifungals although this can be affected by the host response and the location of the infection. The orally active antifungals used in superficial disease, ketoconazole and griseofulvin, can be used in conditions unresponsive or inaccessible to topical therapy, such as chronic superficial candidosis and tinea capitis. However, the treatment of onychomycosis, particularly affecting toe nails, is highly unsatisfactory. There is therefore an important place for new drugs and new methods of applying them in the treatment of superficial (local) mycoses.

Topics: Administration, Oral; Administration, Topical; Amphotericin B; Antifungal Agents; Benzoates; Dermatomycoses; Drug Combinations; Etretinate; Female; Griseofulvin; Humans; Imidazoles; Ketoconazole; Nystatin; Potassium Permanganate; Resorcinols; Salicylates; Salicylic Acid; Suppositories; Tretinoin; Vagina

Topics: Acne Vulgaris; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Androgens; Anti-Bacterial Agents; Drug Therapy; Estradiol; Estrogens; Folliculitis; Halogens; Hexachlorophene; Humans; Infant; Infant, Newborn; Minor Surgical Procedures; Neomycin; Penicillins; Resorcinols; Salicylates; Sebaceous Glands; Sulfur; Tetracycline; Toxicology; Triamcinolone

Topics: Acetanilides; Antipyrine; Aspirin; Benzene; Benzoates; Caffeine; Chemical Phenomena; Chemistry, Physical; Chloral Hydrate; Cinnamates; Research; Resorcinols; Salicylamides; Salicylates; Surface Tension; Urethane

Topics: Acetanilides; Antipyrine; Benzene; Camphor; Chemical Phenomena; Chemistry, Physical; Chloral Hydrate; Phenacetin; Research; Resorcinols; Salicylates; Surface Tension; Urethane

Some substituted dihydroxybenzenes have been examined for suppression of the yeast-induced inflammatory reaction in the rat paw. This anti-inflammatory activity is greatest in those compounds derived from resorcinol and in particular the halogenated 5-methylresorcinols. The significance of the internuclear distance between the hydroxyl groups in the meta-position to each other in resorcinol and the importance of the enhanced activity due to the halogen atom(s) is discussed. In this series the toxicity and activity could not be divorced.

Topics: Anti-Inflammatory Agents; Benzene; Bromine; Inflammation; Mycoses; Pharmacology; Phenols; Rats; Research; Resorcinols; Salicylates

Topics: Animals; Fumarates; Liver; Mitochondria; Mitochondria, Liver; Oxidoreductases; Rats; Resorcinols; Salicylates; Succinates; Succinic Acid