salicylates has been researched along with pholedrine* in 3 studies
3 other study(ies) available for salicylates and pholedrine
| Article | Year |
|---|---|
Influence of lipophilic counter ions on the transport of ionizable hydrophilic drugs.
The influence of lipophilic counter ions on the transport of the hydrophilic drugs pholedrine and bretylium across artificial lipid membranes has been studied using a permeation model system. The transport of both drugs was markedly enhanced by hexylsalicylate and by salts of fatty acids with a maximum at decanoate. The transport of pholedrine was additionally increased by bile salts such as desoxycholate. Topics: Bretylium Compounds; Fatty Acids; Lipids; Membranes, Artificial; Methamphetamine; Permeability; Pharmaceutical Preparations; Salicylates; Spectrophotometry, Ultraviolet | 1991 |
Influence of ion-pair-formation on the pharmacokinetic properties of drugs. Part 3: Influence of hexylsalicylic acid on the pharmacokinetics of pholedrine.
Based on previous in vitro studies it could be shown that ion-pair-formation with the lipophilic hexylsalicylic acid (1) influences the pharmacokinetics of the hydrophilic drug pholedrine (2) which is ionized in all physiological media. After oral combination with 1 an increase of the AUC of 2 could be observed. This finding is due both to the increase of the absorption of 2 and to the decrease of the elimination of 2. After i.v. application the high biotransformation rate of 2 prevents an influence of 1. Topics: Administration, Oral; Animals; Injections, Intravenous; Methamphetamine; Rabbits; Salicylates; Sympathomimetics | 1988 |
[Drug transport through artificial lipoid membranes. 21. Ion pair transport with alkyl salicylic acids].
Using hexylsalicylic acid it was demonstrated that alkylated derivatives of salicylic acid are able to increase partition and transport of ionized basic drugs across lipophilic membranes. The influence of different donor concentrations on the relation of transport was studied by means of pholedrine in combination with hexylsalicylic acid. In order to explain the mechanism of the ion-pair-transport experiments were carried out which show beside the mentioned increase of transport the occurrence of a countertransport of protons and lithium-ions, respectively. The lipophilic counterion hexylsalicylate acts inside of this mechanism as a carrier for the ionized drugs. Topics: Chemical Phenomena; Chemistry; Chemistry, Physical; Hydrogen-Ion Concentration; Lipid Bilayers; Methamphetamine; Salicylates | 1987 |