salicylates and monoperoxysulfate

The aim of this study is to identify common household disinfectants that combine significant activity against the type orthopoxvirus, vaccinia virus with minimal impact in terms of potential toxicity and/or damage to household or personal items.. Laboratory scale experiments assessed common disinfectants containing anionic and nonionic detergents, oxygen-based bleach, potassium peroxomonosulfate, chloroxylenol or halogenated phenols. Disinfectants were assessed for their ability to inactivate the virus on contact or after a short incubation period in the presence and absence of foetal bovine serum as a potential interferant. Significant differences were observed ranging from negligible effect of detergents to complete inactivation on contact with chloroxylenol.. At least one chloroxylenol-based household disinfectant is available, which inactivates vaccinia virus on contact.. In the event of a release or major outbreak of a pathogenic orthopoxvirus there is likely to be significant public demand for disinfectants with activity against these viruses. The identification of common household disinfectants with such activity obviates any requirement to stockpile or distribute laboratory/industrial disinfectants for this purpose.

Topics: Chlorine; Culture Media; Detergents; Disinfectants; Drug Combinations; Household Products; Iodine; Oxidants; Peroxides; Phenols; Salicylates; Sulfuric Acids; Surface-Active Agents; Vaccinia virus; Virus Inactivation; Xylenes

Twenty toothbrushes used by healthy subjects were screened for the presence of microorganisms. Microbes were dislodged from the brushes by vortexing, and an average of 4 x 10(3) CFU/mL were recovered from the suspending fluid. Bristles removed from the vortexed brushes still yielded confluent bacterial growth on brain-heart infusion agar medium. Virkon (one per cent), Listerine, Cepacol, Scope, and Plax were tested for their bactericidal effects on microorganisms sedimented from the suspending fluid, on toothbrush bristles and proxabrushes, and on various test species including Candida albicans, Mycobacterium smegmatis, M. bovis, and Streptococcus mitis. Virkon and Listerine killed all the test species and virtually all the microorganisms on the toothbrush bristles and proxabrushes. Six volunteers tested the efficacy of a Listerine soaking regime to prevent the bacterial contamination of toothbrushes. Soaking the toothbrush head (bristles) in Listerine for 20 minutes after brushing was sufficient to eliminate bacterial contamination.

Topics: Bacteria; Benzoates; Candida albicans; Cetylpyridinium; Disinfectants; Drug Combinations; Equipment Contamination; Humans; Mouthwashes; Peroxides; Quaternary Ammonium Compounds; Salicylates; Sodium Chloride; Sodium Dodecyl Sulfate; Sulfuric Acids; Terpenes; Toothbrushing