salicylates and isoamyl-salicylate

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Topics: Animals; Consumer Product Safety; DNA Damage; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endpoint Determination; Humans; No-Observed-Adverse-Effect Level; Perfume; Rats; Risk Assessment; Salicylates; Toxicity Tests

A toxicologic and dermatologic review of isoamyl salicylate when used as a fragrance ingredient is presented.

Topics: Animals; Consumer Product Safety; Dose-Response Relationship, Drug; Humans; Irritants; Perfume; Risk Assessment; Salicylates; Skin; Skin Absorption; Skin Irritancy Tests; Skin Tests; Toxicity Tests

Topics: Air Pollution; Animals; Blood; Flavoring Agents; Guinea Pigs; Hygiene; Immune System; Lethal Dose 50; Male; Maximum Allowable Concentration; Nervous System; Rats; Salicylates

A system for the evaluation of antifungal activity of volatile compounds has been developed that is based on dynamic growth of a single hypha. The newly developed system is composed of a reaction vessel under a microscope, automatic stage, charge coupled device (CCD) camera, TV monitor, video tape recorder (VTR), and a microcomputer. A fungus was inoculated in the reaction vessel containing agar medium and then was treated with an antifungal reagent in the gas phase either in batch or flow reaction manner. The apex of a growing hypha displayed on a TV monitor was followed automatically. From the ratio of the growth rate under exposure of a reagent (UEXPO) to the growth rate before the exposure (UPRE), the antifungal activity was expressed quantitatively.

Topics: Antifungal Agents; Aspergillus niger; Fungi; Microcomputers; Salicylates; Television; Videotape Recording

A novel method is proposed for the evaluation of the activity of an antifungal agent administered as a gas. This system is composed of a batch-flow type reaction vessel, a gas flow system, and a microscopic observation system. The agar plate was prepared on the ceiling of the reaction vessel, and the mycelium of a fungus (Aspergillus niger or Rhizoctonia solani) was inoculated onto it. After preincubation at 25 degrees C for 24 h, the reaction vessel was connected to the gas flow system. An appropriate hypha was selected, and its elongation rate was measured. Then a sample holder containing an antifungal compound was inserted into the reaction vessel from the side hole to saturate the atmosphere inside with its vapor. The retardation or inhibition of the hypha elongation was observed on a television monitor and recorded on a video tape recorder. The antifungal compound was then removed, and the reaction vessel was flushed with air. If the hypha lived, it began to elongate again. By this method, antifungal activity of seven odor compounds could be evaluated quantitatively within several hours.

Topics: Acrolein; Acyclic Monoterpenes; Antifungal Agents; Aspergillus niger; Benzaldehydes; Cyclohexanols; Cyclohexenes; Eucalyptol; Limonene; Menthol; Microbial Sensitivity Tests; Monoterpenes; Rhizoctonia; Salicylates; Terpenes; Volatilization