salicylates has been researched along with hydroxyethylcellulose* in 1 studies
1 other study(ies) available for salicylates and hydroxyethylcellulose
| Article | Year |
|---|---|
Designing novel bioconjugates of hydroxyethyl cellulose and salicylates for potential pharmaceutical and pharmacological applications.
This deals with fabrication of macromolecular prodrugs (MPDs) of salicylic acid (SA) and aspirin (ASP) based on a hydrophilic cellulose ether, hydroxyethyl cellulose (HEC). Degrees of substitution (DS) of SA and ASP per HEC repeating unit (HEC-RU) were achieved ranging from 0.60 to 2.18 and 0.53 to1.50, respectively. The amphiphilic HEC-SA conjugate 2 assembled into nanowire-like structures, while HEC-ASP conjugate 6 formed nanoparticles (diameter 300-00nm) at a water/DMSO interface. After oral administration in rabbit models, conjugates 2 and 6 showed plasma half-life of 6.96 and 7.01h with maximum plasma concentration (C Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cellulose; Cytokines; Drug Design; Drug Stability; Half-Life; Hydrophobic and Hydrophilic Interactions; Kinetics; Male; Prodrugs; Rabbits; Salicylates; Temperature; Tissue Distribution | 2017 |