salicylates and glipalamide

salicylates has been researched along with glipalamide* in 1 studies

Other Studies

1 other study(ies) available for salicylates and glipalamide

Article	Year
Influence of some salicylates and sulfonamides on binding by albumin of SPC-703 and tolbutamide. Polish journal of pharmacology and pharmacy, 1976, Volume: 28, Issue:2 Bovine serum albumin has two different binding sites for sulfonylurea. The sites at high affinity can bind up to 2 moles of a new hypoglycemic sulfonylurea SPC-703 (k1=6.8.10(3) M(-1)) or tolbutamide K1=19.3.10(3) M(-1)). The sites of lower affinity can bind 4 mole of SPC-703 (K2=1.6.10(3) M(-1)) or 8 moles of tolbutamide (k2=1.3.10(3) M(-1)). Binding of SPC-703 and tolbutamide was decreased mostly in the presence of sulfadimetoxine, but this sulfonamide increased the concentration of free tolbutamide more than that of SPC-703. Topics: Animals; Cattle; Depression, Chemical; Hypoglycemic Agents; Protein Binding; Pyrazoles; Salicylates; Serum Albumin, Bovine; Sulfonamides; Sulfonylurea Compounds; Tolbutamide	1976

Article

Year

Influence of some salicylates and sulfonamides on binding by albumin of SPC-703 and tolbutamide.

Polish journal of pharmacology and pharmacy, 1976, Volume: 28, Issue:2

Bovine serum albumin has two different binding sites for sulfonylurea. The sites at high affinity can bind up to 2 moles of a new hypoglycemic sulfonylurea SPC-703 (k1=6.8.10(3) M(-1)) or tolbutamide K1=19.3.10(3) M(-1)). The sites of lower affinity can bind 4 mole of SPC-703 (K2=1.6.10(3) M(-1)) or 8 moles of tolbutamide (k2=1.3.10(3) M(-1)). Binding of SPC-703 and tolbutamide was decreased mostly in the presence of sulfadimetoxine, but this sulfonamide increased the concentration of free tolbutamide more than that of SPC-703.

Topics: Animals; Cattle; Depression, Chemical; Hypoglycemic Agents; Protein Binding; Pyrazoles; Salicylates; Serum Albumin, Bovine; Sulfonamides; Sulfonylurea Compounds; Tolbutamide

1976