salicylates and flumethasone-pivalate

Test results are reported of the effect of salicylic acid on the vasoconstrictive effect of flumethasone pivalate. In specific, the depigmentation of the skin (identical with increase in lightness of the skin) following topical application of flumethasone pivalate was investigated with the aid of an improved spectrophotometric method. Using numeric lightness evaluation it was possible to demonstrate that salicylic acid increases the vasoconstriction.

Topics: Adult; Flumethasone; Humans; Male; Salicylates; Salicylic Acid; Skin; Skin Pigmentation; Vasoconstriction