salicylates has been researched along with diflunisal-glucuronide-ester* in 2 studies
2 other study(ies) available for salicylates and diflunisal-glucuronide-ester
| Article | Year |
|---|---|
Assay methodology for quantification of the ester and ether glucuronide conjugates of diflunisal in human urine.
Diflunisal is a salicylate derivative with analgesic and anti-inflammatory properties. It is excreted in the urine as an ether glucuronide, a 1-O-acyl glucuronide and as unchanged drug. The 1-O-acyl glucuronide rearranges to isomeric esters of glucuronic acid under neutral to alkaline pH conditions. The development of a urine assay for the conjugates enables the elucidation of diflunisal non-linear pharmacokinetics. The assay quantitates the ether and ester glucuronides and free diflunisal in urine at 0.5-1.0 micrograms/ml. Analysis of the glucuronides does not require authentic standards. Topics: Chromatography, High Pressure Liquid; Diflunisal; Drug Stability; Humans; Hydrogen-Ion Concentration; Salicylates; Solvents; Spectrophotometry, Ultraviolet | 1985 |
Direct analysis of diflunisal ester and ether glucuronides by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Diflunisal; Glucuronidase; Humans; Salicylates; Sodium Hydroxide | 1984 |