salicylates and danthron

salicylates has been researched along with danthron* in 2 studies

Other Studies

2 other study(ies) available for salicylates and danthron

Article	Year
[Stability of cignolin (dithranol) in ointments containing tar with and without the addition of salicylic acid. Oxidation to danthron and dithranol dimer]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1987, Volume: 38, Issue:2 The stability of dithranol in white petrolatum was investigated over a period of 10 weeks in dithranol ointments containing liquor carbonis detergens (LCD) and/or coal tar, in the presence and absence of salicylic acid. Qualitative and semiquantitative analysis using high-pressure liquid chromatography (HPLC) showed that dithranol (0.1%, 0.5%, 1.0%) remained rather stable in white petrolatum for 10 weeks, regardless of the presence or absence of salicylic acid. The addition of 5% LCD or 5% crude coal tar resulted, however, in the rather rapid oxidation of dithranol into its products, danthron and dithranol dimer. The addition of 2% salicylic acid to these combined ointments did not stabilize the dithranol: rather, it reduced the amount of danthron but resulted in a considerable increase in the amount of dithranol dimer. The oxidation of dithranol into its products danthron and dithranol-dimer was almost complete in 0.1% ointments and ranged between 16.3% and 53.8% in 0.5% white petrolatum after 10 weeks. These findings may explain why the addition of tar minimizes dithranol-induced erythema, as reported in clinical studies. Such combinations may have an important influence on the antipsoriatic activity of dithranol and the appearance of brownish discoloration. Topics: Anthralin; Anthraquinones; Chromatography, High Pressure Liquid; Coal Tar; Drug Stability; Humans; Ointments; Oxidation-Reduction; Salicylates; Structure-Activity Relationship	1987
Anthralin stability in various vehicles. Journal of the American Academy of Dermatology, 1987, Volume: 16, Issue:5 Pt 1 The stability of anthralin in white soft paraffin, Lassar's paste, and Unguentum Merck was assessed using a sensitive assay for degradation products, over a 1-year period. The stability was found to vary with concentration, weaker preparations being less stable. Significant degradation was observed in Unguentum Merck, and this increased when salicylic acid was present. Preparations with Unguentum Merck could be stabilized with ascorbic or oxalic acid. Salicylic acid stabilized anthralin in Lassar's paste but had a negligible effect in white soft paraffin. Preparations with white soft paraffin were relatively stable. Topics: Anthralin; Anthraquinones; Chromatography, High Pressure Liquid; Drug Stability; Drug Storage; Ointments; Pharmaceutic Aids; Salicylates; Salicylic Acid; Time Factors	1987

Article

Year

[Stability of cignolin (dithranol) in ointments containing tar with and without the addition of salicylic acid. Oxidation to danthron and dithranol dimer].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1987, Volume: 38, Issue:2

The stability of dithranol in white petrolatum was investigated over a period of 10 weeks in dithranol ointments containing liquor carbonis detergens (LCD) and/or coal tar, in the presence and absence of salicylic acid. Qualitative and semiquantitative analysis using high-pressure liquid chromatography (HPLC) showed that dithranol (0.1%, 0.5%, 1.0%) remained rather stable in white petrolatum for 10 weeks, regardless of the presence or absence of salicylic acid. The addition of 5% LCD or 5% crude coal tar resulted, however, in the rather rapid oxidation of dithranol into its products, danthron and dithranol dimer. The addition of 2% salicylic acid to these combined ointments did not stabilize the dithranol: rather, it reduced the amount of danthron but resulted in a considerable increase in the amount of dithranol dimer. The oxidation of dithranol into its products danthron and dithranol-dimer was almost complete in 0.1% ointments and ranged between 16.3% and 53.8% in 0.5% white petrolatum after 10 weeks. These findings may explain why the addition of tar minimizes dithranol-induced erythema, as reported in clinical studies. Such combinations may have an important influence on the antipsoriatic activity of dithranol and the appearance of brownish discoloration.

Topics: Anthralin; Anthraquinones; Chromatography, High Pressure Liquid; Coal Tar; Drug Stability; Humans; Ointments; Oxidation-Reduction; Salicylates; Structure-Activity Relationship

1987

Anthralin stability in various vehicles.

Journal of the American Academy of Dermatology, 1987, Volume: 16, Issue:5 Pt 1

The stability of anthralin in white soft paraffin, Lassar's paste, and Unguentum Merck was assessed using a sensitive assay for degradation products, over a 1-year period. The stability was found to vary with concentration, weaker preparations being less stable. Significant degradation was observed in Unguentum Merck, and this increased when salicylic acid was present. Preparations with Unguentum Merck could be stabilized with ascorbic or oxalic acid. Salicylic acid stabilized anthralin in Lassar's paste but had a negligible effect in white soft paraffin. Preparations with white soft paraffin were relatively stable.

Topics: Anthralin; Anthraquinones; Chromatography, High Pressure Liquid; Drug Stability; Drug Storage; Ointments; Pharmaceutic Aids; Salicylates; Salicylic Acid; Time Factors

1987