salicylates and chlorite

There are both anecdotal clinical and laboratory experimental data suggesting that low pH mouthrinses cause dental erosion. This evidence is particularly relevant to acidified sodium chlorite (ASC) formulations since they have plaque inhibitory properties comparable to chlorhexidine but without the well known local side effects.. Studies in situ and in vitro were planned to measure enamel erosion by low pH mouthrinses. The study in situ measured enamel erosion by ASC, essential oil and hexetidine mouthrinses over 15-day study periods. The study was a 5 treatment, single blind cross over design involving 15 healthy subjects using orange juice, as a drink, and water, as a rinse, as positive and negative controls respectively. 2 enamel specimens from unerupted human third molar teeth were placed in the palatal area of upper removable acrylic appliances which were worn from 9 a.m. to 5 p.m., Monday to Friday for 3 weeks. Rinses were used 2x daily and 250 ml volumes of orange juice were imbibed 4x daily. Enamel loss was determined by profilometry on days 5, 10 and 15. The study in vitro involved immersing specimens in the 4 test solutions together with a reduced acid ASC formulation for a period of 4 h under constant stirring; Enamel loss was measured by profilometry every hour.. Enamel loss was in situ progressive over time with the 3 rinses and orange juice but negligible with water. ASC produced similar erosion to orange juice and significantly more than the two proprietary rinses and water. The essential oil and hexetidine rinses produced similar erosion and significantly more than water. Enamel loss in vitro was progressive over time, and the order from low to high erosion was reduced acid ASC, ASC, Essential oil, and hexetidine mouthrinses and orange juice.. Based on the study in situ, it is recommended that low pH mouthrinses should not be considered for long term or continuous use and never as pre-brushing rinses. In view of the plaque inhibitory efficacy of ASC, short- to medium-term applications similar to those of chlorhexidine would be envisaged.

Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Beverages; Chlorides; Chlorine Compounds; Citrus; Cross-Over Studies; Dental Enamel; Dental Plaque; Disease Progression; Drug Combinations; Female; Follow-Up Studies; Hexetidine; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Mouthwashes; Oils, Volatile; Oxides; Salicylates; Single-Blind Method; Statistics as Topic; Statistics, Nonparametric; Terpenes; Tooth Erosion; Water

AIM, BACKGROUND: Oral malodour (halitosis) is generally ascribable to oral microbial putrefaction generating malodorous volatile sulphur compounds which predominantly comprise dihydrogen sulphide and methyl mercaptan. This study assesses the relative effectiveness of 6 oral health care products in reducing oral cavity volatile sulphur compound concentrations.. A mixed model 3-factor factorial experimental design involving 6 volunteers, 7 treatment regimens (products I-VI* and water placebo) and 5 time-points (0.00-5.29 h) was undertaken. Electron-donating volatile sulphur compound levels were determined in triplicate using a sulphide monitor (Interscan model 1170) both prior to (0.00 h) and following oral rinsing (20 ml of 5 of the products) or chewing (2 capsules of the remaining product) episodes with each product examined (0.29, 1.29, 2.29 and 5.29 h post-administration).. Results were recorded as peak and steady-state volatile sulphur compound equivalents (ppb). With the exception of one of the products, each oral health care product tested was found to reproducibly reduce volatile sulphur compound concentrations within 20 min of treatment; the mean % decreases in peak (and corresponding steady-state) levels ranging from 3.6 (0.0) to 16.8 (16.4)%. Subsequently, volatile sulphur compound concentrations returned to their zero-control (baseline) values within 5 h, the rate of this regression being in the reverse of the order observed for the magnitude of the primary 20 min reduction for both peak and steady-state measurements. As expected, the water placebo exerted no influence on oral cavity volatile sulphur compound levels. The most effective oral health care products contained admixtures of chlorite anion and chlorine dioxide (both of these agents have the ability to directly oxidise volatile sulphur compounds to non-malodorous products and the latter is also powerfully cidal towards odourigenic micro-organisms).. We therefore conclude that oral health care products containing such oxohalogen oxidants may provide a useful therapeutic strategy for the treatment of oral malodour.

Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Bacteria; Capsules; Cetylpyridinium; Chlorides; Chlorine; Chlorine Compounds; Confidence Intervals; Drug Combinations; Factor Analysis, Statistical; Halitosis; Humans; Hydrogen Sulfide; Male; Mastication; Middle Aged; Mouthwashes; Oxidants; Oxidation-Reduction; Oxides; Placebos; Quaternary Ammonium Compounds; Reproducibility of Results; Salicylates; Sulfhydryl Compounds; Sulfur Compounds; Terpenes; Time Factors; Water