salicylates has been researched along with bryostatin-1* in 2 studies
2 other study(ies) available for salicylates and bryostatin-1
| Article | Year |
|---|---|
Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.
Bryostatin 1 is in clinical trials for the treatment of cancer and Alzheimer's disease and is a candidate for a first-in-class approach to HIV/AIDS eradication. It is neither readily available nor optimally suited for clinical use. Using a function oriented synthesis strategy, a new class of bryostatin-inspired analogs was designed with a simplified salicylate-derived subunit, enabling step-economical synthesis (23 total steps) of agents exhibiting bryostatin-like affinity to protein kinase C (PKC). Topics: Bryostatins; Humans; Molecular Structure; Protein Kinase C; Salicylates | 2014 |
Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold.
Bryostatin 1, in clinical trials or preclinical development for cancer, Alzheimer's disease, and a first-of-its-kind strategy for HIV/AIDS eradication, is neither readily available nor optimally suited for clinical use. In preceding work, we disclosed a new class of simplified bryostatin analogs designed for ease of access and tunable activity. Here we describe a final step diversification strategy that provides, in only 25 synthetic steps, simplified and tunable analogs with bryostatin-like PKC modulatory activities. Topics: Bryostatins; Humans; Molecular Structure; Protein Kinase C; Salicylates | 2014 |