salicylates and boric-acid

The objective of the present study was to estimate the therapeutic efficacy and safety of the topically applied otinum ear drops. The authors present the results of the combined treatment of acute catarrhal otitis in the children with the use of choline salicilate (otinum). The study included 50 patients randomized into two identical groups. The children of group 1 received systemic therapy supplemented by the topical application of otinum, those in group 2 were prescribed a 3% alcoholic solution of boric acid. The study has demonstrated a significantly more pronounced positive dynamics of clinical conditions in the patients of group 1 compared with those of the control group. The total duration of therapy in the first group was 37.5% shorter than in the second. The results of the study confirmed the strong anti-inflammatory and analgesic action of choline salicilate. The pain was relieved within 7 minutes on the average after the application of this agent. It is concluded that otinum can be recommended for the introduction into combined therapy of acute catarrhal otitis media as an efficacious anti-inflammatory and analgetic drug.

Topics: Administration, Topical; Adolescent; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Boric Acids; Child; Child, Preschool; Choline; Drug Combinations; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Otitis Media; Salicylates

This study evaluated the in vitro virucidal activity of soluble components of a topical film-forming medication, Zilactin, against Herpes simplex virus type 1 (HSV-1). Using a standard plaque reduction assay, a 1:10 dilution of the experimental liquid resulted in total destruction of infectious HSV-1. The phenomenon could not be explained by ethanol concentration or lowering of pH, both of which had no effect on control samples. As employed in this assay, Zilactin diluted 1:10 did not demonstrate cyctotoxicity to the cell monolayer system. The implications of these findings on the design and implementation of clinical trials are discussed, with special reference made to the restrictions imposed by the natural history of clinical lesions caused by HSV-1.

Topics: Animals; Antiviral Agents; Boric Acids; Cellulose; Ethanol; Hydrolyzable Tannins; Salicylates; Salicylic Acid; Simplexvirus; Vero Cells; Viral Plaque Assay

Through clinical observations and known chemical properties, this series of studies delineates properties of a new bioadhesive agent available commercially (Zilactin). Using a previously published protocol, we determined that the duration of the film formed on mucosa was not altered after exposure to extremes in temperatures encountered in drinking hot and cold liquids. In addition, through dissection of the agent into several component parts, we were able to determine a specific role for each of the acidic ingredients. It is clear that the solubility of hydroxypropyl cellulose (Klucel) is altered by esterification of the polymer by tannic and salicylic acids and that boric acid effectively crosslinks these to form Zilactin's characteristic clinical film. Other fine points of the chemical reactions are detailed. These studies are intended to serve as a foundation for the future manipulation and application of this agent in oral mucosal diseases.

Topics: Adhesiveness; Adhesives; Biocompatible Materials; Boric Acids; Cellulose; Chemical Phenomena; Chemistry, Physical; Humans; Hydrolyzable Tannins; Materials Testing; Mouth Mucosa; Pharmaceutical Vehicles; Salicylates; Solubility; Time Factors

Topics: Bandages; Boric Acids; Female; Humans; Leg Ulcer; Middle Aged; Ointments; Pharmaceutical Vehicles; Salicylates; Salicylic Acid; Zinc Oxide