salicylates and aloxiprin

Two young patients with unimpaired renal and hepatic function were found to have developed metabolic acidosis after treatment for glaucoma and joint pain with a combination of salicylates and carbonic anhydrase inhibitors in normal doses. Carbonic anhydrase inhibitors appear to interact with salicylates to produce serious metabolic acidosis in patients without the predisposing factors generally considered to constitute risks. It is recommended that treatment combining salicylates and carbonic anhydrase inhibitors is either kept to a minimum or avoided.

Topics: Acetazolamide; Acidosis; Adult; Arthritis; Aspirin; Carbonic Anhydrase Inhibitors; Child; Dichlorphenamide; Drug Interactions; Drug Therapy, Combination; Female; Glaucoma; Humans; Male; Salicylates

A simple, rapid fluorometric method for the determination of salicylic acid in aluminium acetylsalicylate is presented. The method is based on the dissolution of aluminium acetylsalicylate in sodium fluoride-hydrochloric acid solution, filtration and dilution with buffer solution pH = 4 followed by the fluorometric determination of the liberated salicylic acid. The method was applied successfully to the determination of salicylic acid in aluminium acetylsalicylate tablets.

Topics: Aspirin; Hydrogen-Ion Concentration; Salicylates; Salicylic Acid; Spectrometry, Fluorescence; Tablets