salicylates has been researched along with acetylsalicylic-anhydride* in 3 studies
3 other study(ies) available for salicylates and acetylsalicylic-anhydride
| Article | Year |
|---|---|
[Determination of trace amounts of salicylic acid and acetylsalicylic acid in polopirin and other drugs containing acetylsalicylic acid].
A liquid chromatography procedure has been employed for the quantitative determination of trace amounts of salicylic acid, acetylsalicylic salicylic acid and acetylsalicylic anhydride in several Polish drugs containing aspirin. The results were compared with those obtained by other workers for analogous foreign drugs. Topics: Aspirin; Chromatography, Liquid; Salicylates; Salicylic Acid | 1993 |
Determination of related compounds in aspirin by liquid chromatography.
A rapid liquid chromatographic procedure has been validated for the determination of salicylic acid, salsalate, acetylsalicylsalicylic acid, and acetylsalicylic anhydride in aspirin. Samples are dissolved in methylene chloride and analyzed directly by adsorption chromatography in a 7-min separation using an isocratic mobile phase. Recoveries averaged 99% over a 200-10,000 ppm concentration range with standard deviations of less than 4% for the four compounds of interest. Detection limits ranged from 5 to 36 ppm. Compared to a recently published reversed-phase liquid chromatographic procedure for analyzing aspirin, this method is twice as fast, more sensitive, and avoids the use of hydroxylic solvents which lead to degradation of aspirin and acetylsalicylic anhydride. Topics: Aspirin; Chromatography, Liquid; Salicylates; Salicylic Acid; Tablets | 1982 |
Aspirin--a national survey III: Determination of impurities in bulk aspirin and aspirin formulations by high-pressure liquid chromatography and spectrophotometry.
A quantitative high-pressure liquid chromatographic method, using a reversed-phase column and an aqueous acetic acid-methanol solution as the mobile phase, was employed for the determination of O-acetyl-O-salicylsalicylic acid and O-salicylsalicylic acid in pharmaceutical aspirin preparations. The aspirin was dissolved, filtered, and injected into the chromatograph. The absorbance of the impurities was measured at 254 nm. Acetylsalicylic anhydridge was determined by a spectrophotometric method. The aspirin was dissolved in pH 11.3 buffer and extracted with benzene. An aliquot of the benzene was evaporated, and the residue was dissolved in alpha-benzamidocinnamate-pyridine reagent. The acetylsalicylic anhydride was measured using the difference between the absorbance at 362 and 372 nm. Possible interference of aspirin with the procedure is discussed. Thirty-four bulk aspirin and 172 tablet formulations were examined. Results for O-acetyl-O-salicylsalicylic acid, O-salicylsalicylic acid and acetylsalicylic anhydride are given. Topics: Aspirin; Chromatography, High Pressure Liquid; Drug Contamination; Salicylates; Spectrophotometry | 1980 |