salicylates has been researched along with acetyl-4-aminosalicylic-acid* in 1 studies
1 other study(ies) available for salicylates and acetyl-4-aminosalicylic-acid
| Article | Year |
|---|---|
Determination of p-aminosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity.
A capillary zone electrophoresis method has been developed for the determination of p-aminosalicylic acid (PAS) and its metabolite, N-acetyl-p-aminosalicylic acid (N-acetyl-PAS), in urine. A linear relationship was observed between time-normalized peak area and the concentration of the parent and metabolite with correlation coefficients greater than 0.9990. The method could be applied to the determination of PAS and N-acetyl-PAS in human urine without any sample pretreatment. A good separation of the analytes is achieved in a run time of 12 min (15 min total, including capillary wash). Using PAS as a probe for N-acetyltransferase 1 activity, 20 healthy volunteers were phenotyped after oral administration of a 1 g dose. The preliminary results seem to indicate a bimodal distribution of N-acetyl-PAS/PAS molar ratios. Topics: Acetamides; Adolescent; Adult; Aminosalicylic Acid; Aminosalicylic Acids; Arylamine N-Acetyltransferase; Electrophoresis, Capillary; Female; Humans; Male; Middle Aged; Phenotype; Salicylates | 1997 |