salicylates has been researched along with 4-aminophenol* in 2 studies
2 other study(ies) available for salicylates and 4-aminophenol
| Article | Year |
|---|---|
Design and evaluation of 4-aminophenol and salicylate derivatives as free-radical scavenger.
This theoretical and experimental study describes the design and evaluation of the free-radical scavenging effect for the molecular association of 4-aminophenol and salicylate derivatives. For this purpose, we employed theoretical methods for the selection of antioxidant drugs and the rapid methods of evaluation: the 1,1-diphenyl-2-picrylhydrazyl radical and the thiobarbituric acid reactive substances in the lipid peroxidation initiated by Fe(2+) and ascorbic acid in human erythrocytes. The associate derivatives exhibited a more potent inhibition than the salicylic acid, while the benzoyl compound exhibited a more potent inhibition than paracetamol. The molecular parameters related to the electron distribution and structure (ionization potential and energy of the highest occupied molecular orbital) correlated very well with the antioxidant action of the compounds studied here in different tests. Topics: Aminophenols; Computer-Aided Design; Drug Design; Drug Evaluation, Preclinical; Erythrocytes; Free Radical Scavengers; Humans; Lipid Peroxidation; Quantum Theory; Salicylates; Structure-Activity Relationship | 2013 |
Comparison of high-performance capillary electrophoresis and liquid chromatography on analysis of zinc 5-aminosalicylate dihydrate and related materials.
Separation and determination of zinc 5-aminosalicylate dihydrate (ZASA) and related materials by high-performance capillary electrophoresis (HPCE) and liquid chromatography (HPLC) have been studied systematically. The R.S.D. of peak time and area and detection limits of materials were lower in HPLC compared to HPCE. HPCE and HPLC were used for determining ZASA and related materials in crude and treated ZASA using acid and heat, and similar results with both techniques showed the principal impurities in the crude ZASA were 5-aminosalicylic acid (ASA) and salicylic acid (SA), the compounds from ZASA decomposing under conditions of acid and heat were ASA, p-aminophenol and 5-benzeneazosalicylic acid. Topics: Aminophenols; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Chromatography, High Pressure Liquid; Drug Stability; Electrophoresis, Capillary; Hot Temperature; Mesalamine; Reproducibility of Results; Salicylates; Salicylic Acid; Sulfuric Acids; Zinc Compounds | 1998 |