salicylates has been researched along with 2-methyl-6-(4-methoxyphenyl)-3-7-dihydroimidazo(1-2-alpha)pyrazin-3-one* in 1 studies
1 other study(ies) available for salicylates and 2-methyl-6-(4-methoxyphenyl)-3-7-dihydroimidazo(1-2-alpha)pyrazin-3-one
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A high involvement of O2- possibly generated in inner membranes for iron-induced microsomal lipid peroxidation.
The lipid peroxidation of and the O2- generation by rat liver microsomes in the presence of NADPH or both NADPH and Fe3+ were determined by thiobarbituric acid-reacting substance formation and by chemiluminescence intensities with a cypridina luciferin analog, 2-methyl-6-(p-methoxyphenyl)-3, 7-dihydroimidazo[1,2-a]pyrazin-3-one(MCLA), as a chemiluminescence probe. Judging from the experiments with various inhibitors on the O2- generation and the lipid peroxidation, O2- generated, at intramembranous site, by cytochrome P-450 system is considered to be highly involved in the iron-induced lipid peroxidation. Topics: Animals; Ceruloplasmin; Copper; Cytochrome P-450 Enzyme System; Erythrocytes; Free Radical Scavengers; Imidazoles; Intracellular Membranes; Iron; Lipid Peroxidation; Luminescent Measurements; Microsomes, Liver; Milk; Models, Biological; Organometallic Compounds; Pyrazines; Rats; Salicylates; Superoxide Dismutase; Superoxides; Xanthine Oxidase | 1992 |