salacinol has been researched along with morpholine* in 1 studies
1 other study(ies) available for salacinol and morpholine
| Article | Year |
|---|---|
Synthesis of new nitrogen analogues of salacinol and deoxynojirimycin and their evaluation as glycosidase inhibitors.
The synthesis of two enantiomerically pure iminosugars, analogues of 1-L-deoxynojirimycin (l-DNJ) and 1-D-deoxymannojirimycin (DMJ), was achieved using cyclic sulfate substituted isoxazoline derivatives. The piperidine ring was formed via the reduction of an isoxazoline into an amine which underwent a spontaneous intramolecular cyclization by reaction with the cyclic sulfate moiety. The nucleophilic attack of these two trisubstituted piperidines and morpholine on L- and D-erythritol-1,3-cyclic sulfates gave six new nitrogen analogues of salacinol. The inhibitory properties of the synthesized salacinol analogues were evaluated on several commercial glycosidases. Topics: 1-Deoxynojirimycin; Alkylation; Enzyme Inhibitors; Glycoside Hydrolases; Hydroxylation; Molecular Structure; Morpholines; Nitrogen; Sugar Alcohols; Sulfates | 2006 |