saicar has been researched along with aminoimidazole carboxamide in 36 studies
| Studies (saicar) | Trials (saicar) | Recent Studies (post-2010) (saicar) | Studies (aminoimidazole carboxamide) | Trials (aminoimidazole carboxamide) | Recent Studies (post-2010) (aminoimidazole carboxamide) |
|---|---|---|---|---|---|
| 36 | 0 | 10 | 1,913 | 35 | 830 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.89) | 18.7374 |
| 1990's | 11 (30.56) | 18.2507 |
| 2000's | 9 (25.00) | 29.6817 |
| 2010's | 9 (25.00) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Bal, J; Pieniazek, NJ | 1 |
| Jaeken, J; Van den Bergh, F; Van den Berghe, G; Vincent, MF | 4 |
| Christopherson, RI; Harsanyi, MC; Lyons, SD; Poiner, A; Sant, ME | 1 |
| Van den Berghe, G; Vincent, MF | 1 |
| Gruber, HE; Hoffer, M; Jaeken, J; Jansen, I; Laikind, PK; Miller, L; Seegmiller, JE; Van den Berghe, G; Willis, RC | 1 |
| Gruber, HE; Laikind, PK; Seegmiller, JE | 1 |
| Krijt, J; Sebesta, I; Svehlakova, A; Zeman, J; Zumrova, A | 1 |
| Capuozzo, E; Crifò, C; Giardini, O; Salerno, C | 1 |
| Davisson, VJ; Firestine, SM; Mueller, EJ; Poon, SW; Stubbe, J | 1 |
| Dixon, JE; Stone, RL; Zalkin, H | 1 |
| Cascante, M; Curto, R; Voit, EO | 1 |
| Bosschaart, AN; Duran, M; Hageman, G; Tien Poll-The, B; van den Bergh, FA | 1 |
| Kappock, TJ; Meyer, E; Osuji, C; Stubbe, J | 1 |
| Borne, F; Daignan-Fornier, B; Desmoucelles, C; Pinson, B; Rébora, K | 1 |
| Marie, S; Race, V; Van den Berghe, G; Vincent, MF | 1 |
| Colman, RF; Palenchar, JB | 1 |
| Champion, M; Duley, JA; Fairbanks, LD; Kurian, MA; Marie, S; Marinaki, AM; Simmonds, HA; van den Berghe, G; Vincent, MF | 1 |
| Daignan-Fornier, B; Laloo, B; Rébora, K | 1 |
| Hartmannová, H; Kmoch, S; Krijt, J; Zikánová, M | 1 |
| Mitsch, RN; Rolfes, RJ; Som, I; Urbanowski, JL | 1 |
| Bahi-Buisson, N; Benoist, JF; Ceballos-Picot, I; Desguerre, I; Gitiaux, C; Marie, S; Rio, M; Valayannopoulos, V; Verrieres, S; Vincent, MF | 1 |
| Balaram, H; Bopanna, MP; Bulusu, V; Srinivasan, B | 1 |
| Brockmann, K; Dechent, P; Dreha-Kulaczewski, S; Engelke, U; Gärtner, J; Heerschap, A; Helms, G; Henneke, M; van der Graaf, M; Wevers, RA; Willemsen, MA | 1 |
| Antonopoulos, C; Colman, RF; Currier, J; De Zoysa Ariyananda, L | 1 |
| Calkins, LA; Capodagli, GC; Deaton, MK; Ghosh, K; Patterson, D; Pegan, SD; Ray, SP; Sawle, L | 1 |
| Duval, N; Ghosh, K; Patterson, D; Ray, SP; Shaheen, SE; Wilkinson, TG | 1 |
| McKnight, SL | 1 |
| Doctor, ZM; Dwyer, ZW; Keller, KE; Lee, YS | 1 |
| Bowman, GD; Chakravarthy, S; Lee, YS; Pollack, L; Tokuda, JM; Yan, M | 1 |
| Bierau, J; Garbade, SF; Haas, D; Hauke, J; Hoffmann, GF; Klinke, G; Langhans, CD; Monostori, P; Okun, JG; Richter, S | 1 |
| Göttmann, M; Helleday, T; Homan, E; Jemth, AS; Marttila, P; Škerlová, J; Stenmark, P; Unterlass, J | 1 |
| Boeckx, C; Burkhalter, MD; Dutto, I; Gerhards, J; Herrera, A; Junza, A; Lüders, J; Philipp, M; Pons, S; Škopová, V; Smak, JA; Souckova, O; Stracker, TH; Yanes, O; Zikánová, M | 1 |
36 other study(ies) available for saicar and aminoimidazole carboxamide
| Article | Year |
|---|---|
Detection of 5-amino-4-imidazole-N-succinocarboxamide ribotide and hypoxanthine accumulation. A simple method for identification of some purine auxotrophs.
Topics: Aminoimidazole Carboxamide; Aspergillus nidulans; Chromatography, Thin Layer; Hypoxanthines; Imidazoles; Mutation; Purines; Ribonucleotides | 1979 |
Adenylosuccinase activity and succinylpurine production in fibroblasts of adenylosuccinase-deficient children.
Topics: Adenosine Monophosphate; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Cells, Cultured; Child; Fibroblasts; Humans; Kinetics; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribonucleotides | 1991 |
Radiochemical assay of adenylosuccinase: demonstration of parallel loss of activity toward both adenylosuccinate and succinylaminoimidazole carboxamide ribotide in liver of patients with the enzyme defect.
Topics: Adenosine Monophosphate; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cold Temperature; Enzyme Stability; Fumarates; Humans; Liver; Male; Muscles; Rats; Rats, Inbred Strains; Ribonucleotides; Saccharomyces cerevisiae; Substrate Specificity | 1991 |
Chromatographic analysis of purine precursors in mouse L1210 leukemia.
Topics: Aminoimidazole Carboxamide; Animals; Cell Extracts; Chromatography, Ion Exchange; Leukemia L1210; Mice; Purine Nucleotides; Ribonucleotides | 1989 |
Influence of succinylpurines on the binding of adenosine to a particulate fraction of rat cerebral cortex.
Topics: Adenosine; Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Cell Membrane; Cerebral Cortex; Imidazoles; Rats; Receptors, Purinergic; Ribonucleotides | 1989 |
Purine biosynthesis in Chinese hamster cell mutants and human fibroblasts partially deficient in adenylosuccinate lyase.
Topics: 5'-Nucleotidase; Adenylosuccinate Lyase; Adenylosuccinate Synthase; Aminoimidazole Carboxamide; Animals; Cell Line; Cricetinae; Cricetulus; Humans; IMP Dehydrogenase; Nucleotidases; Purine Nucleotides; Purines; Ribonucleotides | 1986 |
Detection of 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole in urine by use of the Bratton-Marshall reaction: identification of patients deficient in adenylosuccinate lyase activity.
Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Chromatography, High Pressure Liquid; Creatinine; Ethylenediamines; Humans; Imidazoles; Lyases; Purine-Pyrimidine Metabolism, Inborn Errors; Reagent Strips; Ribonucleosides; Ribonucleotides; Spectrophotometry | 1986 |
Adenylosuccinate lyase deficiency in a Czech girl and two siblings.
Topics: Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Child; Child, Preschool; Female; Genes, Recessive; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides; S-Adenosylmethionine | 1994 |
Anomalous response to intravenous fructose tolerance test in a case of deficit of adenylosuccinate lyase.
Topics: Adenosine Triphosphate; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Blood Glucose; Child; Female; Fructose; Humans; Lymphocytes; Magnesium; Phosphates; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides; S-Adenosylmethionine; Uric Acid | 1994 |
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms.
Topics: Aminoimidazole Carboxamide; Animals; Base Sequence; Biological Evolution; Carbon Dioxide; Carboxy-Lyases; Catalysis; Chickens; Escherichia coli; Genetic Complementation Test; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nitroimidazoles; Peptide Synthases; Ribonucleotides; Substrate Specificity; Transformation, Genetic | 1994 |
Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase.
Topics: Adenylosuccinate Lyase; Amino Acid Sequence; Aminoimidazole Carboxamide; Base Sequence; Chromatography, Gel; Chromatography, Ion Exchange; Gene Expression; Humans; Hydrogen-Ion Concentration; Intellectual Disability; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Plasmids; Point Mutation; Polymerase Chain Reaction; Recombinant Proteins; Ribonucleotides; Substrate Specificity | 1993 |
Residual adenylosuccinase activities in fibroblasts of adenylosuccinase-deficient children: parallel deficiency with adenylosuccinate and succinyl-AICAR in profoundly retarded patients and non-parallel deficiency in a mildly retarded girl.
Topics: Adenosine Monophosphate; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Binding, Competitive; Cells, Cultured; Child; Chromatography, Ion Exchange; Female; Fibroblasts; Humans; Hydrogen-Ion Concentration; Intellectual Disability; Kinetics; Nucleotides; Potassium Chloride; Ribonucleotides; Substrate Specificity | 1993 |
Functional studies in fibroblasts of adenylosuccinase-deficient children.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Cells, Cultured; Child; Fibroblasts; Formates; Humans; Hypoxanthine; Hypoxanthines; Intellectual Disability; Ribonucleotides | 1993 |
Analysis of abnormalities in purine metabolism leading to gout and to neurological dysfunctions in man.
Topics: Adenylosuccinate Lyase; Aminoimidazole Carboxamide; AMP Deaminase; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Models, Biological; Models, Chemical; Purines; Ribonucleotides; Ribose-Phosphate Pyrophosphokinase; Uric Acid | 1998 |
Adenylosuccinase deficiency with neonatal onset severe epileptic seizures and sudden death.
Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Anticonvulsants; Death, Sudden; Epilepsy; Humans; Infant, Newborn; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides | 1998 |
Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase.
Topics: Aminoimidazole Carboxamide; Carbon Isotopes; Carboxy-Lyases; Catalysis; Conserved Sequence; Electron Transport; Escherichia coli; Lysine; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Ribonucleotides | 1999 |
Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate.
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Alleles; Amidophosphoribosyltransferase; Aminoimidazole Carboxamide; Epistasis, Genetic; Feedback, Physiological; Fungal Proteins; Genes, Dominant; Homeodomain Proteins; Mutation; Protein Binding; Ribonucleotides; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Trans-Activators; Two-Hybrid System Techniques | 2001 |
Adenylosuccinate lyase deficiency: from the clinics to molecular biology.
Topics: Adenosine; Adenosine Monophosphate; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Enzyme Stability; Gene Expression; Heating; Humans; Recombinant Fusion Proteins; Ribonucleotides | 2000 |
Characterization of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase deficiency: asparagine 276 plays an important structural role.
Topics: Adenosine Monophosphate; Adenylosuccinate Lyase; Amino Acid Sequence; Aminoimidazole Carboxamide; Arginine; Asparagine; Bacillus subtilis; Bacterial Proteins; Circular Dichroism; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Ribonucleotides; Substrate Specificity; Threonine | 2003 |
Adenylosuccinate lyase deficiency--first British case.
Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Catalysis; Exons; Fatal Outcome; Female; Heterozygote; Humans; Infant, Newborn; Mutation; Phenotype; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribonucleotides | 2004 |
Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; Folic Acid; Gene Expression Regulation, Fungal; Histidine; Inosine Monophosphate; Purines; Ribonucleotides; Saccharomyces cerevisiae | 2005 |
Preparation of 5-amino-4-imidazole-N-succinocarboxamide ribotide, 5-amino-4-imidazole-N-succinocarboxamide riboside and succinyladenosine, compounds usable in diagnosis and research of adenylosuccinate lyase deficiency.
Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Biochemistry; Cations; Chemistry, Clinical; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cloning, Molecular; DNA, Complementary; Humans; Mutation; Phosphorylation; Purine-Pyrimidine Metabolism, Inborn Errors; Recombinant Proteins; Ribonucleotides; Substrate Specificity; Time Factors | 2005 |
DNA-bound Bas1 recruits Pho2 to activate ADE genes in Saccharomyces cerevisiae.
Topics: Aminoimidazole Carboxamide; Binding Sites; Cell Nucleus; DNA, Fungal; Gene Expression Regulation, Fungal; Homeodomain Proteins; Promoter Regions, Genetic; Ribonucleotides; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Trans-Activators | 2005 |
Misleading behavioural phenotype with adenylosuccinate lyase deficiency.
Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Angelman Syndrome; Behavior; Child; Chromatography, High Pressure Liquid; Consanguinity; Female; Humans; Intellectual Disability; Mutation, Missense; Pedigree; Phenotype; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides; Sequence Analysis, DNA; Stereotyped Behavior | 2009 |
Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum.
Topics: Adenosine Monophosphate; Adenylosuccinate Lyase; Amino Acid Sequence; Aminoimidazole Carboxamide; Animals; Biocatalysis; Cyclic AMP; Escherichia coli; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmodium falciparum; Protozoan Proteins; Recombinant Proteins; Ribonucleotides; Sequence Alignment; Substrate Specificity; Thermodynamics | 2009 |
In vivo proton MR spectroscopy findings specific for adenylosuccinate lyase deficiency.
Topics: Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Child; Child, Preschool; Female; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides; S-Adenosylmethionine | 2010 |
In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes.
Topics: Adenylosuccinate Lyase; Amino Acid Sequence; Aminoimidazole Carboxamide; Area Under Curve; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Histidine; Humans; Kinetics; Metabolism, Inborn Errors; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins; Mutation; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Renaturation; Recombinant Fusion Proteins; Ribonucleotides; Succinic Acid; Temperature | 2011 |
Structural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation.
Topics: Adenosine Monophosphate; Adenylosuccinate Lyase; Amino Acid Sequence; Aminoimidazole Carboxamide; Autistic Disorder; Humans; Mutation, Missense; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides; Sequence Alignment | 2012 |
Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations.
Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Chromatography, High Pressure Liquid; Electrochemistry; Homozygote; Humans; Kinetics; Mutagenesis, Site-Directed; Mutation, Missense; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides; Substrate Specificity | 2013 |
Please keep me 2uned to PKM2.
Topics: Aminoimidazole Carboxamide; Animals; Carrier Proteins; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Protein Kinase Inhibitors; Ribonucleotides; Signal Transduction; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2014 |
SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells.
Topics: Adenosine Diphosphate; Aminoimidazole Carboxamide; Animals; Carrier Proteins; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Isoenzymes; Ligands; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Array Analysis; Protein Binding; Protein Kinase Inhibitors; Recombinant Proteins; Ribonucleotides; Signal Transduction; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Xenopus laevis | 2014 |
SAICAR binding activates PKM2 protein kinase activity.
Topics: Aminoimidazole Carboxamide; Carrier Proteins; Cell Cycle; Cell Proliferation; Humans; Membrane Proteins; Neoplasms; Phosphorylation; Ribonucleotides; Signal Transduction; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2014 |
Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5'-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form.
Topics: Aminoimidazole Carboxamide; Calorimetry; Chromatography, Gel; Crystallography, X-Ray; Dimerization; Enzyme Activation; Pyruvate Kinase; Ribonucleotides | 2016 |
Extended diagnosis of purine and pyrimidine disorders from urine: LC MS/MS assay development and clinical validation.
Topics: Adenine; Adolescent; Adult; Aminoimidazole Carboxamide; Biomarkers; Child; Child, Preschool; Chromatography, Liquid; Female; Humans; Infant; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Quality Control; Reference Values; Ribonucleotides; Tandem Mass Spectrometry; Urea; Uridine | 2019 |
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Catalytic Domain; Cell Line, Tumor; Crystallography, X-Ray; Gene Knockout Techniques; HEK293 Cells; Humans; Male; Models, Molecular; Peptide Synthases; Prostatic Neoplasms; Protein Conformation; Ribonucleosides; Ribonucleotides | 2020 |
Pathway-specific effects of ADSL deficiency on neurodevelopment.
Topics: Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Animals; Autism Spectrum Disorder; Autistic Disorder; Cell Cycle; Cell Cycle Proteins; Cell Line; Chickens; Ciliopathies; DNA Damage; Humans; Microcephaly; Microtubule-Associated Proteins; Neurogenesis; Phenotype; Phosphoproteins; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribonucleotides; Zebrafish | 2022 |