Page last updated: 2024-08-16

safrole and phenobarbital

safrole has been researched along with phenobarbital in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (70.37)	18.7374
1990's	15 (27.78)	18.2507
2000's	1 (1.85)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cameron, RG; Farber, E; Joly, JG; Murray, RK; Sharma, RN	1
Cameron, RG; Farber, E; Griffin, MJ; Joly, JG; Murray, RK; Sharma, RN	1
McCoy, EC; Miller, EC; Miller, JA; Rosenkranz, HS; Wislocki, PG	1
Bridges, JW; Dickins, M; Fennell, TR	1
Bridges, JW; Dickins, M; Elcombe, CR; Netter, KJ	1
Bridges, JW; McPherson, FJ; Parke, DV	1
Ioannides, C; Parke, DV; Tong, S	1
Bridges, JW; Hartman, GC; Markham, A; McPherson, FJ; Parke, DV	1
Guengerich, FP; Mimura, M; Shimada, T; Yamazaki, H	1
Horbach, GJ; Kremers, P; Rietjens, IM; Van Asten, JG; Van Bezooijen, CF	1
Albores, A; Bach, PH; Bridges, JW; Cebrian, ME; Connelly, JC	1
Hsieh, CY; Huang, JD	1
Balvers, WG; Boersma, MG; Rietjens, IM; Veeger, C	1
Devichensky, VM; Dubrov, YN; Korneva, EN; Molchanova, LD; Shcherbakov, VM	1
Bélanger, PM; St-Hilaire, S	1
Kim, SG; Novak, RF	1
Kelley, M; Safe, S; Womack, J	1
Horbach, GJ; van Asten, JG; van Bezooijen, CF	1
Etoh, H; Misawa, S; Tanaka, E	1
Bars, RG; Elcombe, CR; Mitchell, AM; Wolf, CR	1
Aust, SD; Morehouse, LA	1
Kammerer, RC; Lampe, MA	1
Bachmann, KA; Jahn, D; Schwartz, J; Yang, C	1
Gessner, T; Olson, JR; Wroblewski, VJ	1
Francis, JE; Smith, AG	1
Smith, AG; Stewart, FP	1
Degawa, M; Hashimoto, Y; Kojima, M; Sato, Y	1
Adang, A; Müller, F; van Bladeren, PJ; van Ommen, B	1
Bresnick, E; Houser, WH; Zielinski, R	1
Juchau, MR; Namkung, MJ; Nelson, SD; Porubek, DJ	1
Elcombe, CR; Houston, JB; Taylor, G	1
Balfour, C; Dunbar, D; Halpert, J; Kaminsky, LS; Miller, NE; Morgan, ET	1
Paterson, P; Skett, P	1
Bark, DH; Greenaway, JC; Juchau, MR; Shewey, LM	1
Bast, A; Kroes, BH; Savenije-Chapel, EM	1
Nebert, DW; Negishi, M	1
Parkinson, A; Robertson, LW; Safe, SH	1
Kimura, R; Watanabe, K; Yoshizawa, I	1
Cho, AK; Hwa, JJ; Kammerer, RC; Schmitz, DA	1
Levin, W; Ryan, DE; Thomas, PE	1
Batt, AM; Martin, N; Siest, G	1
Coon, MJ; Delaforge, M; Koop, DR	1
Cook, JC; Hodgson, E	1
Dubé, CE; Murray, M; Wilkinson, CF	1
Altieri, M; Chen, YT; Ikeda, T; Nakamura, M; Nebert, DW; Negishi, M; Tukey, RH	1
Bornheim, LM; Franklin, MR	1
Levin, W; Ryan, DE; Thomas, PE; Vlasuk, GP; Walz, FG	1
Delaforge, M; Ioannides, C; Parke, DV; Phillipson, CE	1
Bridges, JW; Fennell, TR; Sweatman, BC	1
Carls, N; Schiestl, RH	1
Castell, JV; Donato, MT; Gómez-Lechón, MJ	1
Hodgson, AV; Strobel, HW; White, JW; White, TB	1
Franklin, MR; Moody, DE; Slawson, MH	1
Law, MY; Moody, DE; Slawson, MH	1

Reviews

1 review(s) available for safrole and phenobarbital

Article	Year
Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution. Biochemical pharmacology, 1982, Jul-15, Volume: 31, Issue:14 Topics: Animals; Biological Evolution; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Phenobarbital; Polycyclic Compounds; Pregnenolone Carbonitrile; Safrole; Species Specificity	1982

Other Studies

53 other study(ies) available for safrole and phenobarbital

Article	Year
Multiple patterns of induction of rat liver microsomal mono-oxygenases and other polypeptides by xenobiotics [proceedings]. Biochemical Society transactions, 1979, Volume: 7, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone; Rats; Safrole	1979
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics. The Biochemical journal, 1979, Aug-15, Volume: 182, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Peptide Biosynthesis; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Safrole	1979
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites. Cancer research, 1977, Volume: 37, Issue:6 Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Neoplasms; Mice; Mutagens; Mutation; Neoplasms, Experimental; Papilloma; Phenobarbital; Rats; Safrole; Salmonella typhimurium; Sarcoma, Experimental; Skin Neoplasms; Structure-Activity Relationship	1977
Interaction of isosafrole in vivo with rat hepatic microsomal cytochrome P-450 following treatment with phenobarbitone or 20-methylcholanthrene. Biochemical pharmacology, 1979, Apr-15, Volume: 28, Issue:8 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Drug Interactions; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Safrole	1979
A novel haemoprotein induced by isosafrole pretreatment in the rat. Biochemical and biophysical research communications, 1978, Jan-13, Volume: 80, Issue:1 Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Safrole; Spectrum Analysis	1978
The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes. The Biochemical journal, 1976, Mar-15, Volume: 154, Issue:3 Topics: Acetone; Aniline Hydroxylase; Animals; Benzopyrene Hydroxylase; Benzopyrenes; Catechol Oxidase; Cricetinae; Cytochromes; Dactinomycin; Dioxoles; Male; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nikethamide; Phenobarbital; Rats; Safrole	1976
Possible pitfalls of the biphenyl test for chemical carcinogens [proceedings]. Biochemical Society transactions, 1977, Volume: 5, Issue:5 Topics: Animals; Biphenyl Compounds; Carbon Monoxide; Dioxoles; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Safrole; Spectrometry, Fluorescence	1977
A comparison of the properties in vitro of biphenyl 2- and 4-hydroxylase in the mesocarp from avocado pear (Persea americana) and Syrian-hamster hepatic tissue. Biochemical Society transactions, 1975, Volume: 3, Issue:2 Topics: Animals; Benzopyrenes; Biphenyl Compounds; Cricetinae; Fruit; Liver; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Safrole	1975
Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens. Mutation research, 1992, Dec-16, Volume: 284, Issue:2 Topics: Aflatoxins; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carcinogenicity Tests; Carcinogens; Cytochrome P-450 Enzyme System; DNA; DNA Damage; In Vitro Techniques; Lung; Male; Microsomes; Microsomes, Liver; Phenobarbital; Pregnenolone; Rats; Rats, Sprague-Dawley; Safrole; SOS Response, Genetics; Sterigmatocystin	1992
The effect of age on inducibility of various types of rat liver cytochrome P-450. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:5 Topics: Aging; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methylcholanthrene; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred BN; RNA, Messenger; Safrole	1992
Effects of arsenite on hepatic mixed-function oxidase activity in rats. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:5 Topics: Animals; Arsenic; Arsenites; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Wistar; Safrole	1992
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism. Journal of chromatography, 1992, Mar-13, Volume: 575, Issue:1 Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole	1992
Differential cumene hydroperoxide sensitivity of cytochrome P-450 enzymes IA1 and IIB1 determined by their way of membrane incorporation. Biochimica et biophysica acta, 1992, Sep-15, Volume: 1117, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Electrophoresis, Polyacrylamide Gel; Kinetics; Lipid Peroxidation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases	1992
NADPH-dependent reduction of amaranch in liver microsomes characterized the quantity of low spin forms of cytochrome P-450. Biochemical and biophysical research communications, 1991, Sep-16, Volume: 179, Issue:2 Topics: Amaranth Dye; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fomepizole; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Safrole	1991
The characteristics of the microsomal hydroxylation of tolbutamide. Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:3 Topics: Animals; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Hemeproteins; Hydroxylation; In Vitro Techniques; Isoenzymes; Kinetics; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Safrole; Species Specificity; Tolbutamide	1991
Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke: redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine. Cancer research, 1990, Sep-01, Volume: 50, Issue:17 Topics: Animals; Biotransformation; Catalase; Cytochrome P-450 Enzyme System; DNA Damage; Glutathione; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyridines; Rabbits; Safrole; Smoke; Superoxide Dismutase; Superoxides	1990
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins. Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12 Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone	1990
The influence of ageing on the induction of the mRNAs of rat liver cytochromes P450IIB1 and P450IIB2. Biochemical pharmacology, 1990, Aug-01, Volume: 40, Issue:3 Topics: Aging; Animals; Base Sequence; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Liver; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Phenobarbital; Rats; RNA Probes; RNA, Messenger; Safrole	1990
The effects of selective cytochrome P-450 inducing agents on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in rats. Research communications in chemical pathology and pharmacology, 1990, Volume: 68, Issue:3 Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Liver; Male; Methylcholanthrene; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Trimethadione	1990
Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry. The Biochemical journal, 1989, Aug-15, Volume: 262, Issue:1 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Isoenzymes; Isomerism; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole	1989
Generation of superoxide by the microsomal mixed-function oxidase system. Basic life sciences, 1988, Volume: 49 Topics: Animals; Butanols; Cytochrome P-450 Enzyme System; Isoenzymes; Isomerism; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polybrominated Biphenyls; Rats; Rats, Inbred Strains; Safrole; Superoxides	1988
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro. Carcinogenesis, 1987, Volume: 8, Issue:10 Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole	1987
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:2 Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin	1988
Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster. Biochemical pharmacology, 1988, Apr-15, Volume: 37, Issue:8 Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Species Specificity	1988
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. Biochemical and biophysical research communications, 1987, Jul-15, Volume: 146, Issue:1 Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Iron; Male; Mice; Mice, Inbred C57BL; Oxidoreductases; Phenobarbital; Polycyclic Compounds; Porphyrias; Safrole; Uroporphyrinogen Decarboxylase	1987
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes. Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13 Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole	1986
Induction of a high spin form of microsomal cytochrome P-448 in rat liver by 4-aminoazobenzene derivatives. Biochemical pharmacology, 1986, Oct-15, Volume: 35, Issue:20 Topics: Animals; Azo Compounds; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochromes; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; p-Aminoazobenzene; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole	1986
The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA. Chemico-biological interactions, 1986, Oct-15, Volume: 60, Issue:1 Topics: Animals; Carbon Radioisotopes; Chlorophenols; DNA; Female; Hexachlorobenzene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Pentachlorophenol; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Safrole	1986
Further characterization of the polycyclic aromatic hydrocarbon binding properties of the 4S protein. Archives of biochemistry and biophysics, 1986, Nov-15, Volume: 251, Issue:1 Topics: Age Factors; Animals; Benzo(a)pyrene; Benzofurans; Binding, Competitive; Carrier Proteins; Cytosol; Enzyme Induction; Female; Liver; Macromolecular Substances; Male; Molybdenum; Phenobarbital; Polycyclic Compounds; Rats; Safrole	1986
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents. Journal of steroid biochemistry, 1985, Volume: 22, Issue:4 Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Estradiol; Ethanol; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases	1985
Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone. Xenobiotica; the fate of foreign compounds in biological systems, 1985, Volume: 15, Issue:3 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Dioxoles; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Organ Size; Oxygenases; Phenobarbital; Promethazine; Rats; Rats, Inbred Strains; Safrole	1985
Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo. Molecular pharmacology, 1985, Volume: 28, Issue:3 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chloramphenicol; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Substrate Specificity; Testosterone; Warfarin	1985
Sex differences in the effects of microsomal enzyme inducers on hepatic phase I drug metabolism in the rat. Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Ethanol; Female; Imipramine; Lidocaine; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Sex Characteristics	1985
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers. Toxicology and applied pharmacology, 1985, Volume: 81, Issue:3 Pt 1 Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Embryo, Mammalian; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Safrole	1985
Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers. Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:5 Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Ranitidine; Rats; Rats, Inbred Strains; Safrole	1984
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl. Biochemical pharmacology, 1983, Jul-15, Volume: 32, Issue:14 Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry	1983
An induction effect of phenobarbital on rat liver microsomal 4-hydroxylation of estradiol 17-sulfate. Journal of pharmacobio-dynamics, 1984, Volume: 7, Issue:9 Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Estradiol; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole	1984
Induction of phencyclidine metabolism by phencyclidine, ketamine, ethanol, phenobarbital and isosafrole. Biochemical pharmacology, 1984, Feb-15, Volume: 33, Issue:4 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Ethanol; In Vitro Techniques; Ketamine; Male; Microsomes, Liver; Phencyclidine; Phenobarbital; Rats; Rats, Inbred Strains; Safrole	1984
Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms. The Journal of biological chemistry, 1980, Aug-25, Volume: 255, Issue:16 Topics: Animals; Catalysis; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epoxide Hydrolases; Immunodiffusion; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Peptide Fragments; Phenobarbital; Rats; Safrole; Spectrophotometry	1980
Induction of group-1 and group-2 UDP-glucuronosyltransferase in microsomes from the livers of C57 Bl/6 mice. Toxicology letters, 1981, Volume: 9, Issue:4 Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Safrole; Substrate Specificity	1981
Role of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomes. Biochemical and biophysical research communications, 1982, Sep-16, Volume: 108, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Safrole	1982
Induction of cytochrome P-450 by methylenedioxyphenyl compounds: importance of the methylene carbon. Toxicology and applied pharmacology, 1983, Mar-30, Volume: 68, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Ethylmorphine-N-Demethylase; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Nitriles; Oxidoreductases; Phenobarbital; Safrole; Structure-Activity Relationship	1983
Effects of dihydrosafrole on cytochromes P-450 and drug oxidation in hepatic microsomes from control and induced rats. Toxicology and applied pharmacology, 1983, Mar-30, Volume: 68, Issue:1 Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole	1983
Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole. European journal of biochemistry, 1983, Jul-15, Volume: 134, Issue:1 Topics: Animals; Cloning, Molecular; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Female; Gene Expression Regulation; Kidney; Liver; Male; Methylcholanthrene; Mice; Nucleic Acid Hybridization; Phenobarbital; Polychlorinated Dibenzodioxins; RNA, Messenger; Safrole	1983
Metabolic-intermediate complex formation reveals major changes in rat hepatic cytochrome P-450 subpopulations in addition to those forms previously purified after phenobarbital, beta-naphthoflavone, and isosafrole induction. Molecular pharmacology, 1982, Volume: 21, Issue:2 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dioxoles; Flavonoids; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains; Safrole	1982
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics. Biochemistry, 1982, Nov-23, Volume: 21, Issue:24 Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes	1982
Studies on the substrate-binding sites of liver microsomal cytochrome P-448. The Biochemical journal, 1982, Oct-01, Volume: 207, Issue:1 Topics: Animals; Benzphetamine; Binding Sites; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Ellipticines; Fluorenes; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry; Substrate Specificity	1982
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents. Chemico-biological interactions, 1980, Volume: 31, Issue:2 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Safrole	1980
Evaluation of the yeast DEL assay with 10 compounds selected by the International Program on Chemical Safety for the evaluation of short-term tests for carcinogens. Mutation research, 1994, Volume: 320, Issue:4 Topics: Acrylonitrile; Benzene; Carcinogens; Chromosome Deletion; Diethylhexyl Phthalate; Diethylstilbestrol; Hempa; Mutagenicity Tests; Phenobarbital; Saccharomyces cerevisiae; Safrole; Toluidines	1994
Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:5 Topics: Adult; Aged; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Female; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Nitrophenols; Oxazines; Oxidation-Reduction; Phenobarbital; Safrole; Substrate Specificity; Testosterone	1995
Expression analysis of the mixed function oxidase system in rat brain by the polymerase chain reaction. Molecular and cellular biochemistry, 1993, Mar-24, Volume: 120, Issue:2 Topics: Amitriptyline; Animals; Base Sequence; Benzoflavones; beta-Naphthoflavone; Brain; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Imipramine; Isoenzymes; Male; Mixed Function Oxygenases; Molecular Sequence Data; Nerve Tissue Proteins; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Safrole	1993
Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver. Toxicology letters, 1996, Volume: 85, Issue:1 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Epoxide Hydrolases; Ethanol; Glucuronosyltransferase; Glutathione Transferase; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Safrole	1996
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:3 Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole	2000