safrole has been researched along with phenobarbital in 54 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 38 (70.37) | 18.7374 |
1990's | 15 (27.78) | 18.2507 |
2000's | 1 (1.85) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Cameron, RG; Farber, E; Joly, JG; Murray, RK; Sharma, RN | 1 |
Cameron, RG; Farber, E; Griffin, MJ; Joly, JG; Murray, RK; Sharma, RN | 1 |
McCoy, EC; Miller, EC; Miller, JA; Rosenkranz, HS; Wislocki, PG | 1 |
Bridges, JW; Dickins, M; Fennell, TR | 1 |
Bridges, JW; Dickins, M; Elcombe, CR; Netter, KJ | 1 |
Bridges, JW; McPherson, FJ; Parke, DV | 1 |
Ioannides, C; Parke, DV; Tong, S | 1 |
Bridges, JW; Hartman, GC; Markham, A; McPherson, FJ; Parke, DV | 1 |
Guengerich, FP; Mimura, M; Shimada, T; Yamazaki, H | 1 |
Horbach, GJ; Kremers, P; Rietjens, IM; Van Asten, JG; Van Bezooijen, CF | 1 |
Albores, A; Bach, PH; Bridges, JW; Cebrian, ME; Connelly, JC | 1 |
Hsieh, CY; Huang, JD | 1 |
Balvers, WG; Boersma, MG; Rietjens, IM; Veeger, C | 1 |
Devichensky, VM; Dubrov, YN; Korneva, EN; Molchanova, LD; Shcherbakov, VM | 1 |
Bélanger, PM; St-Hilaire, S | 1 |
Kim, SG; Novak, RF | 1 |
Kelley, M; Safe, S; Womack, J | 1 |
Horbach, GJ; van Asten, JG; van Bezooijen, CF | 1 |
Etoh, H; Misawa, S; Tanaka, E | 1 |
Bars, RG; Elcombe, CR; Mitchell, AM; Wolf, CR | 1 |
Aust, SD; Morehouse, LA | 1 |
Kammerer, RC; Lampe, MA | 1 |
Bachmann, KA; Jahn, D; Schwartz, J; Yang, C | 1 |
Gessner, T; Olson, JR; Wroblewski, VJ | 1 |
Francis, JE; Smith, AG | 1 |
Smith, AG; Stewart, FP | 1 |
Degawa, M; Hashimoto, Y; Kojima, M; Sato, Y | 1 |
Adang, A; Müller, F; van Bladeren, PJ; van Ommen, B | 1 |
Bresnick, E; Houser, WH; Zielinski, R | 1 |
Juchau, MR; Namkung, MJ; Nelson, SD; Porubek, DJ | 1 |
Elcombe, CR; Houston, JB; Taylor, G | 1 |
Balfour, C; Dunbar, D; Halpert, J; Kaminsky, LS; Miller, NE; Morgan, ET | 1 |
Paterson, P; Skett, P | 1 |
Bark, DH; Greenaway, JC; Juchau, MR; Shewey, LM | 1 |
Bast, A; Kroes, BH; Savenije-Chapel, EM | 1 |
Nebert, DW; Negishi, M | 1 |
Parkinson, A; Robertson, LW; Safe, SH | 1 |
Kimura, R; Watanabe, K; Yoshizawa, I | 1 |
Cho, AK; Hwa, JJ; Kammerer, RC; Schmitz, DA | 1 |
Levin, W; Ryan, DE; Thomas, PE | 1 |
Batt, AM; Martin, N; Siest, G | 1 |
Coon, MJ; Delaforge, M; Koop, DR | 1 |
Cook, JC; Hodgson, E | 1 |
Dubé, CE; Murray, M; Wilkinson, CF | 1 |
Altieri, M; Chen, YT; Ikeda, T; Nakamura, M; Nebert, DW; Negishi, M; Tukey, RH | 1 |
Bornheim, LM; Franklin, MR | 1 |
Levin, W; Ryan, DE; Thomas, PE; Vlasuk, GP; Walz, FG | 1 |
Delaforge, M; Ioannides, C; Parke, DV; Phillipson, CE | 1 |
Bridges, JW; Fennell, TR; Sweatman, BC | 1 |
Carls, N; Schiestl, RH | 1 |
Castell, JV; Donato, MT; Gómez-Lechón, MJ | 1 |
Hodgson, AV; Strobel, HW; White, JW; White, TB | 1 |
Franklin, MR; Moody, DE; Slawson, MH | 1 |
Law, MY; Moody, DE; Slawson, MH | 1 |
1 review(s) available for safrole and phenobarbital
Article | Year |
---|---|
Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution.
Topics: Animals; Biological Evolution; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Phenobarbital; Polycyclic Compounds; Pregnenolone Carbonitrile; Safrole; Species Specificity | 1982 |
53 other study(ies) available for safrole and phenobarbital
Article | Year |
---|---|
Multiple patterns of induction of rat liver microsomal mono-oxygenases and other polypeptides by xenobiotics [proceedings].
Topics: 2-Acetylaminofluorene; Animals; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone; Rats; Safrole | 1979 |
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics.
Topics: 2-Acetylaminofluorene; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Peptide Biosynthesis; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Safrole | 1979 |
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Neoplasms; Mice; Mutagens; Mutation; Neoplasms, Experimental; Papilloma; Phenobarbital; Rats; Safrole; Salmonella typhimurium; Sarcoma, Experimental; Skin Neoplasms; Structure-Activity Relationship | 1977 |
Interaction of isosafrole in vivo with rat hepatic microsomal cytochrome P-450 following treatment with phenobarbitone or 20-methylcholanthrene.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Drug Interactions; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Safrole | 1979 |
A novel haemoprotein induced by isosafrole pretreatment in the rat.
Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Safrole; Spectrum Analysis | 1978 |
The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes.
Topics: Acetone; Aniline Hydroxylase; Animals; Benzopyrene Hydroxylase; Benzopyrenes; Catechol Oxidase; Cricetinae; Cytochromes; Dactinomycin; Dioxoles; Male; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nikethamide; Phenobarbital; Rats; Safrole | 1976 |
Possible pitfalls of the biphenyl test for chemical carcinogens [proceedings].
Topics: Animals; Biphenyl Compounds; Carbon Monoxide; Dioxoles; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Safrole; Spectrometry, Fluorescence | 1977 |
A comparison of the properties in vitro of biphenyl 2- and 4-hydroxylase in the mesocarp from avocado pear (Persea americana) and Syrian-hamster hepatic tissue.
Topics: Animals; Benzopyrenes; Biphenyl Compounds; Cricetinae; Fruit; Liver; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Safrole | 1975 |
Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens.
Topics: Aflatoxins; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carcinogenicity Tests; Carcinogens; Cytochrome P-450 Enzyme System; DNA; DNA Damage; In Vitro Techniques; Lung; Male; Microsomes; Microsomes, Liver; Phenobarbital; Pregnenolone; Rats; Rats, Sprague-Dawley; Safrole; SOS Response, Genetics; Sterigmatocystin | 1992 |
The effect of age on inducibility of various types of rat liver cytochrome P-450.
Topics: Aging; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methylcholanthrene; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred BN; RNA, Messenger; Safrole | 1992 |
Effects of arsenite on hepatic mixed-function oxidase activity in rats.
Topics: Animals; Arsenic; Arsenites; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Wistar; Safrole | 1992 |
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism.
Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole | 1992 |
Differential cumene hydroperoxide sensitivity of cytochrome P-450 enzymes IA1 and IIB1 determined by their way of membrane incorporation.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Electrophoresis, Polyacrylamide Gel; Kinetics; Lipid Peroxidation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1992 |
NADPH-dependent reduction of amaranch in liver microsomes characterized the quantity of low spin forms of cytochrome P-450.
Topics: Amaranth Dye; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fomepizole; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Safrole | 1991 |
The characteristics of the microsomal hydroxylation of tolbutamide.
Topics: Animals; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Hemeproteins; Hydroxylation; In Vitro Techniques; Isoenzymes; Kinetics; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Safrole; Species Specificity; Tolbutamide | 1991 |
Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke: redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine.
Topics: Animals; Biotransformation; Catalase; Cytochrome P-450 Enzyme System; DNA Damage; Glutathione; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyridines; Rabbits; Safrole; Smoke; Superoxide Dismutase; Superoxides | 1990 |
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone | 1990 |
The influence of ageing on the induction of the mRNAs of rat liver cytochromes P450IIB1 and P450IIB2.
Topics: Aging; Animals; Base Sequence; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Liver; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Phenobarbital; Rats; RNA Probes; RNA, Messenger; Safrole | 1990 |
The effects of selective cytochrome P-450 inducing agents on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in rats.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Liver; Male; Methylcholanthrene; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Trimethadione | 1990 |
Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Isoenzymes; Isomerism; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1989 |
Generation of superoxide by the microsomal mixed-function oxidase system.
Topics: Animals; Butanols; Cytochrome P-450 Enzyme System; Isoenzymes; Isomerism; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polybrominated Biphenyls; Rats; Rats, Inbred Strains; Safrole; Superoxides | 1988 |
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole | 1987 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II.
Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin | 1988 |
Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Species Specificity | 1988 |
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Iron; Male; Mice; Mice, Inbred C57BL; Oxidoreductases; Phenobarbital; Polycyclic Compounds; Porphyrias; Safrole; Uroporphyrinogen Decarboxylase | 1987 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
Induction of a high spin form of microsomal cytochrome P-448 in rat liver by 4-aminoazobenzene derivatives.
Topics: Animals; Azo Compounds; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochromes; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; p-Aminoazobenzene; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole | 1986 |
The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA.
Topics: Animals; Carbon Radioisotopes; Chlorophenols; DNA; Female; Hexachlorobenzene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Pentachlorophenol; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Safrole | 1986 |
Further characterization of the polycyclic aromatic hydrocarbon binding properties of the 4S protein.
Topics: Age Factors; Animals; Benzo(a)pyrene; Benzofurans; Binding, Competitive; Carrier Proteins; Cytosol; Enzyme Induction; Female; Liver; Macromolecular Substances; Male; Molybdenum; Phenobarbital; Polycyclic Compounds; Rats; Safrole | 1986 |
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Estradiol; Ethanol; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1985 |
Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Dioxoles; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Organ Size; Oxygenases; Phenobarbital; Promethazine; Rats; Rats, Inbred Strains; Safrole | 1985 |
Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chloramphenicol; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Substrate Specificity; Testosterone; Warfarin | 1985 |
Sex differences in the effects of microsomal enzyme inducers on hepatic phase I drug metabolism in the rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Ethanol; Female; Imipramine; Lidocaine; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Sex Characteristics | 1985 |
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Embryo, Mammalian; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Safrole | 1985 |
Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers.
Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Ranitidine; Rats; Rats, Inbred Strains; Safrole | 1984 |
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry | 1983 |
An induction effect of phenobarbital on rat liver microsomal 4-hydroxylation of estradiol 17-sulfate.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Estradiol; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1984 |
Induction of phencyclidine metabolism by phencyclidine, ketamine, ethanol, phenobarbital and isosafrole.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Ethanol; In Vitro Techniques; Ketamine; Male; Microsomes, Liver; Phencyclidine; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1984 |
Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.
Topics: Animals; Catalysis; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epoxide Hydrolases; Immunodiffusion; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Peptide Fragments; Phenobarbital; Rats; Safrole; Spectrophotometry | 1980 |
Induction of group-1 and group-2 UDP-glucuronosyltransferase in microsomes from the livers of C57 Bl/6 mice.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Safrole; Substrate Specificity | 1981 |
Role of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Safrole | 1982 |
Induction of cytochrome P-450 by methylenedioxyphenyl compounds: importance of the methylene carbon.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Ethylmorphine-N-Demethylase; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Nitriles; Oxidoreductases; Phenobarbital; Safrole; Structure-Activity Relationship | 1983 |
Effects of dihydrosafrole on cytochromes P-450 and drug oxidation in hepatic microsomes from control and induced rats.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1983 |
Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole.
Topics: Animals; Cloning, Molecular; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Female; Gene Expression Regulation; Kidney; Liver; Male; Methylcholanthrene; Mice; Nucleic Acid Hybridization; Phenobarbital; Polychlorinated Dibenzodioxins; RNA, Messenger; Safrole | 1983 |
Metabolic-intermediate complex formation reveals major changes in rat hepatic cytochrome P-450 subpopulations in addition to those forms previously purified after phenobarbital, beta-naphthoflavone, and isosafrole induction.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dioxoles; Flavonoids; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1982 |
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics.
Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes | 1982 |
Studies on the substrate-binding sites of liver microsomal cytochrome P-448.
Topics: Animals; Benzphetamine; Binding Sites; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Ellipticines; Fluorenes; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry; Substrate Specificity | 1982 |
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Safrole | 1980 |
Evaluation of the yeast DEL assay with 10 compounds selected by the International Program on Chemical Safety for the evaluation of short-term tests for carcinogens.
Topics: Acrylonitrile; Benzene; Carcinogens; Chromosome Deletion; Diethylhexyl Phthalate; Diethylstilbestrol; Hempa; Mutagenicity Tests; Phenobarbital; Saccharomyces cerevisiae; Safrole; Toluidines | 1994 |
Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture.
Topics: Adult; Aged; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Female; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Nitrophenols; Oxazines; Oxidation-Reduction; Phenobarbital; Safrole; Substrate Specificity; Testosterone | 1995 |
Expression analysis of the mixed function oxidase system in rat brain by the polymerase chain reaction.
Topics: Amitriptyline; Animals; Base Sequence; Benzoflavones; beta-Naphthoflavone; Brain; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Imipramine; Isoenzymes; Male; Mixed Function Oxygenases; Molecular Sequence Data; Nerve Tissue Proteins; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Safrole | 1993 |
Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Epoxide Hydrolases; Ethanol; Glucuronosyltransferase; Glutathione Transferase; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Safrole | 1996 |
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat.
Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole | 2000 |