Page last updated: 2024-08-16

safrole and isosafrole

safrole has been researched along with isosafrole in 110 studies

Research

Studies (110)

Timeframe	Studies, this research(%)	All Research%
pre-1990	56 (50.91)	18.7374
1990's	39 (35.45)	18.2507
2000's	10 (9.09)	29.6817
2010's	5 (4.55)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kubo, A; Kubo, I; Muroi, H	1
Himejima, M; Kubo, I; Muroi, H	1
Bridges, JW; Dickins, M; Elcombe, CR; Netter, KJ	1
Guengerich, FP; Mimura, M; Shimada, T; Yamazaki, H	1
Horbach, GJ; Kremers, P; Rietjens, IM; Van Asten, JG; Van Bezooijen, CF	1
Albores, A; Bach, PH; Bridges, JW; Cebrian, ME; Connelly, JC	1
Hsieh, CY; Huang, JD	1
Balvers, WG; Boersma, MG; Rietjens, IM; Veeger, C	1
Devichensky, VM; Dubrov, YN; Korneva, EN; Molchanova, LD; Shcherbakov, VM	1
Hanioka, N; Ishida, C; Koga, N; Saeki, HK; Yoshimura, H	1
Guengerich, FP; Shimada, T	1
Chui, YC; Hodgson, E; Levi, P; Lewandowski, M	1
Bélanger, PM; St-Hilaire, S	1
Kim, SG; Novak, RF	1
Chui, YC; Hodgson, E; Levi, PE; Lewandowski, M	1
Barton, HA; Costantini, MG; Forkert, PG; Marletta, MA	1
Jacobs, JM; Jacobs, NJ; Lambrecht, RW; Sinclair, JF; Sinclair, PR	1
Boobis, AR; Davies, DS; Edwards, RJ; Levin, W; Sesardic, D; Thomas, PE	1
Boobis, AR; Cole, KJ; Davies, DS; Edwards, RJ; Levin, W; Sesardic, D; Thomas, PE	1
Clement, B; Kunze, T	1
Fernandes, G; Horbach, GJ; Venkatraman, JT	1
Kelley, M; Safe, S; Womack, J	1
Horbach, GJ; van Asten, JG; van Bezooijen, CF	1
Etoh, H; Misawa, S; Tanaka, E	1
Bars, RG; Elcombe, CR; Mitchell, AM; Wolf, CR	1
Aust, SD; Voorman, R	1
Aust, SD; Morehouse, LA	1
Cook, JC; Hodgson, E	2
Kammerer, RC; Lampe, MA	1
Bachmann, KA; Jahn, D; Schwartz, J; Yang, C	1
Gessner, T; Olson, JR; Wroblewski, VJ	1
Batt, AM; Delatour, P; Masson, C; Mothe, O; Siest, G; Souhaili-El Amri, H; Totis, M	1
Campanile, C; Haniu, M; Levin, W; Maines, SL; Mendez-Picon, G; Parker, G; Shively, JE; Thomas, PE; Watkins, PB; Wrighton, SA	1
Francis, JE; Smith, AG	1
Currò, P; Lanuzza, F; Micali, G	1
Smith, AG; Stewart, FP	1
Degawa, M; Hashimoto, Y; Kojima, M; Sato, Y	1
Adang, A; Müller, F; van Bladeren, PJ; van Ommen, B	1
Bresnick, E; Houser, WH; Zielinski, R	1
Farrell, GC; Murray, M; Zaluzny, L	1
Chen, YT; Ding, JH; Kato, T	1
Coon, MJ; Holm, KA; Koop, DR; Kupfer, D; Theoharides, AD	1
Gonzalez, FJ; Nebert, DW; Tuteja, N	2
Brezinski, DA; Dahl, AR	1
Juchau, MR; Namkung, MJ; Nelson, SD; Porubek, DJ	1
Delaforge, M; Ioannides, C; Parke, DV	2
Elcombe, CR; Houston, JB; Taylor, G	1
Balfour, C; Dunbar, D; Halpert, J; Kaminsky, LS; Miller, NE; Morgan, ET	1
Paterson, P; Skett, P	1
Bark, DH; Greenaway, JC; Juchau, MR; Shewey, LM	1
Goldstein, JA; Hodgson, E; Linko, P; Yeowell, HN	1
Bast, A; Kroes, BH; Savenije-Chapel, EM	1
Nebert, DW; Negishi, M	1
Koop, DR; Levin, W; Reidy, J; Reik, LM; Ryan, DE; Thomas, PE	1
Levin, W; Reik, LM; Ryan, DE; Thomas, PE	1
Parkinson, A; Robertson, LW; Safe, SH	1
Nebert, DW; Negishi, M; Ohyama, T	1
Haier, RJ; Keitner, GI; Sabaawi, M	1
Kimura, R; Watanabe, K; Yoshizawa, I	1
Haniu, M; Levin, W; Ryan, DE; Shively, JE	1
Cho, AK; Hwa, JJ; Kammerer, RC; Schmitz, DA	1
Jollow, DJ; Longacre, S; Price, V; Roberts, S; Smith, C	1
Levin, W; Ryan, DE; Thomas, PE	1
Fisher, GJ; Fukushima, H; Gaylor, JL	1
Billheimer, JT; Bowen, WD; Fisher, GJ; Gaylor, JL; Trzaskos, JM	1
Sekizawa, J; Shibamoto, T	1
Elcombe, CR; Hook, JB; Lock, EA; Rose, MS	1
Coon, MJ; Delaforge, M; Koop, DR	1
Altieri, M; Chen, YT; Ikeda, T; Nakamura, M; Nebert, DW; Negishi, M; Tukey, RH	1
Coon, MJ; Gorsky, LD; Oprian, DD	1
Botelho, LH; Kutny, R; Levin, W; Ryan, DE; Shively, JE; Yuan, PM	1
Bornheim, LM; Franklin, MR	1
Klungsøyr, J; Scheline, RR	1
Levin, W; Ryan, DE; Thomas, PE; Vlasuk, GP; Walz, FG	1
Bridges, JW; Fennell, TR; Sweatman, BC	1
Castell, JV; Donato, MT; Gómez-Lechón, MJ	1
Boersma, MG; Cnubben, NH; Rietjens, IM; Vervoort, J	1
George, SG; Leaver, MJ; Pirrit, L	1
Andersen, ME; Birnbaum, LS; Kedderis, LB	1
Bradlow, HL; Jellinck, PH; Makin, HL; Sepkovic, DW	1
Adams, NH; Hodgson, E; Levi, PE	1
Nemoto, N; Sakurai, J	1
Hodgson, AV; Strobel, HW; White, JW; White, TB	1
Alexander, J; Ingebrigtsen, K; Klungsøyr, L; Vikse, R	1
Franklin, MR; Moody, DE; Slawson, MH	1
O'Brien, PJ; Zhao, ZS	1
Buhler, DR; Henderson, MC; Miranda, CL; Williams, DE	1
Kalow, W; Pastrakuljic, A; Roberts, EA; Tang, BK	1
Khan, S; O'Brien, PJ; Zhao, ZS	1
Périn, F; Périn-Roussel, O; Plessis, MJ; Taras-Valéro, D	1
Förlin, L; Ronisz, D	1
Law, MY; Moody, DE; Slawson, MH	1
Chen, TT; Lipsky, MM; Råbergh, CM; Vrolijk, NH	1
Chiba, K; Higuchi, S; Mera, A; Noguchi, K; Watanabe, T	1
Buhler, DR; Deinzer, ML; Stevens, JF; Yilmazer, M	1
Asztemborska, M; Nowakowski, R; Sybilska, D	1
Badger, TM; Hakkak, R; Ronis, MJ; Rowlands, JC	1
Giesy, JP; Stegeman, JJ; Verbrugge, DA; Verbrugge, LA; Woodin, BR	1
Allis, JW; Anderson, BP; Pegram, RA; Ross, TM; Zhao, G	1
Antunes, OA; da Silva, II; Pereira, NP; Santos, AS; Sarquis, MI	1
CAUJOLLE, F; MEYNIER, D	1
Kataoka, H; Oka, Y; Omura, M; Touhara, K	1
Gröger, T; Pütz, M; Schäffer, M; Zimmermann, R	1
Scharfman, HE	1
Inoue, T; Katsu, T; Lee, S; Otsuki, T; Sada, N	1
Rho, JM	1
Chen, P; Fu, Y; Liu, S; Wen, P; Wu, D; Zheng, P	1

Reviews

3 review(s) available for safrole and isosafrole

Article	Year
Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution. Biochemical pharmacology, 1982, Jul-15, Volume: 31, Issue:14 Topics: Animals; Biological Evolution; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Phenobarbital; Polycyclic Compounds; Pregnenolone Carbonitrile; Safrole; Species Specificity	1982
Pharmacokinetic considerations in toxicity testing. Drug metabolism reviews, 1982, Volume: 13, Issue:6 Topics: Acetaminophen; Animals; Cricetinae; Drug Interactions; Kinetics; Liver; Methylcholanthrene; Pharmaceutical Preparations; Rats; Receptors, Drug; Safrole; Toxicology	1982
Safrole: its metabolism, carcinogenicity and interactions with cytochrome P-450. Food and cosmetics toxicology, 1981, Volume: 19, Issue:5 Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Dioxoles; Hemeproteins; Ligands; Mixed Function Oxygenases; Oxidation-Reduction; Safrole	1981

Other Studies

107 other study(ies) available for safrole and isosafrole

Article	Year
Naturally occurring antiacne agents. Journal of natural products, 1994, Volume: 57, Issue:1 Topics: Acne Vulgaris; Anti-Bacterial Agents; Fatty Alcohols; Membrane Fluidity; Microbial Sensitivity Tests; Plants, Medicinal; Propionibacterium acnes; Structure-Activity Relationship	1994
Combination effects of antifungal nagilactones against Candida albicans and two other fungi with phenylpropanoids. Journal of natural products, 1993, Volume: 56, Issue:2 Topics: Amphotericin B; Anisoles; Antifungal Agents; Candida albicans; Culture Media; Diterpenes; Malassezia; Microbial Sensitivity Tests; Saccharomyces cerevisiae	1993
A novel haemoprotein induced by isosafrole pretreatment in the rat. Biochemical and biophysical research communications, 1978, Jan-13, Volume: 80, Issue:1 Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Safrole; Spectrum Analysis	1978
Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens. Mutation research, 1992, Dec-16, Volume: 284, Issue:2 Topics: Aflatoxins; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carcinogenicity Tests; Carcinogens; Cytochrome P-450 Enzyme System; DNA; DNA Damage; In Vitro Techniques; Lung; Male; Microsomes; Microsomes, Liver; Phenobarbital; Pregnenolone; Rats; Rats, Sprague-Dawley; Safrole; SOS Response, Genetics; Sterigmatocystin	1992
The effect of age on inducibility of various types of rat liver cytochrome P-450. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:5 Topics: Aging; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methylcholanthrene; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred BN; RNA, Messenger; Safrole	1992
Effects of arsenite on hepatic mixed-function oxidase activity in rats. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:5 Topics: Animals; Arsenic; Arsenites; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Wistar; Safrole	1992
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism. Journal of chromatography, 1992, Mar-13, Volume: 575, Issue:1 Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole	1992
Differential cumene hydroperoxide sensitivity of cytochrome P-450 enzymes IA1 and IIB1 determined by their way of membrane incorporation. Biochimica et biophysica acta, 1992, Sep-15, Volume: 1117, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Electrophoresis, Polyacrylamide Gel; Kinetics; Lipid Peroxidation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases	1992
NADPH-dependent reduction of amaranch in liver microsomes characterized the quantity of low spin forms of cytochrome P-450. Biochemical and biophysical research communications, 1991, Sep-16, Volume: 179, Issue:2 Topics: Amaranth Dye; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fomepizole; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Safrole	1991
Metabolism in vitro of 3,4,3',4'- and 2,5,2',5'-tetrachlorobiphenyl by rat liver microsomes and highly purified cytochrome P-450. Journal of pharmacobio-dynamics, 1991, Volume: 14, Issue:5 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Pentobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Safrole; Sulfhydryl Compounds	1991
Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. Cancer research, 1991, Oct-01, Volume: 51, Issue:19 Topics: Aflatoxin B1; Animals; Aroclors; Benzoflavones; beta-Galactosidase; Carbolines; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; DNA; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Mutagens; Nicotiana; Plants, Toxic; Quinidine; Rats; Rats, Inbred Strains; Safrole; Smoke; SOS Response, Genetics	1991
Acetanilide 4-hydroxylase and acetanilide 2-hydroxylase activity in hepatic microsomes from induced mice. Toxicology letters, 1991, Volume: 55, Issue:2 Topics: Acetanilides; Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, Thin Layer; Male; Mice; Mice, Inbred DBA; Microsomes, Liver; Safrole	1991
The characteristics of the microsomal hydroxylation of tolbutamide. Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:3 Topics: Animals; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Hemeproteins; Hydroxylation; In Vitro Techniques; Isoenzymes; Kinetics; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Safrole; Species Specificity; Tolbutamide	1991
Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke: redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine. Cancer research, 1990, Sep-01, Volume: 50, Issue:17 Topics: Animals; Biotransformation; Catalase; Cytochrome P-450 Enzyme System; DNA Damage; Glutathione; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyridines; Rabbits; Safrole; Smoke; Superoxide Dismutase; Superoxides	1990
Differences in induction of hepatic cytochrome P450 isozymes by mice in eight methylenedioxyphenyl compounds. Journal of biochemical toxicology, 1990,Spring, Volume: 5, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isoenzymes; Liver; Male; Mice; Mice, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug; Safrole	1990
The 4S polycyclic aromatic hydrocarbon-binding protein: immunohistochemical localization in mice. Carcinogenesis, 1990, Volume: 11, Issue:10 Topics: Animals; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carcinogens; Carrier Proteins; Cytochrome P-450 Enzyme System; Cytosol; Glycine N-Methyltransferase; Immunoenzyme Techniques; Kidney; Kinetics; Liver; Lung; Male; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polycyclic Compounds; Safrole	1990
Role of inducer binding in cytochrome P-450 IA2-mediated uroporphyrinogen oxidation. Journal of biochemical toxicology, 1990,Fall, Volume: 5, Issue:3 Topics: Animals; Butanols; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Oxidation-Reduction; Polychlorinated Dibenzodioxins; Protein Binding; Rats; Rats, Inbred F344; Safrole; Species Specificity; Uroporphyrinogens	1990
High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat. Biochemical pharmacology, 1990, Feb-01, Volume: 39, Issue:3 Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cyclohexanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxidoreductases; Phenacetin; Rats; Rats, Inbred Strains; Safrole; Substrate Specificity	1990
The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues. Biochemical pharmacology, 1990, Feb-01, Volume: 39, Issue:3 Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases; Rats; Rats, Inbred Strains; Safrole; Tissue Distribution	1990
Hepatic microsomal N-hydroxylation of adenine to 6-N-hydroxylaminopurine. Biochemical pharmacology, 1990, Mar-01, Volume: 39, Issue:5 Topics: Adenine; Animals; Catalase; Chromatography, High Pressure Liquid; Female; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Safrole; Superoxide Dismutase	1990
Food restriction prevents the loss of isosafrole inducible cytochrome P-450 mRNA and enzyme levels in aging rats. Biochemistry international, 1990, Volume: 20, Issue:4 Topics: Aging; Animals; Blotting, Western; Body Weight; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Food Deprivation; Liver; Male; Microsomes, Liver; Organ Size; Rats; Rats, Inbred F344; RNA, Messenger; Safrole	1990
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins. Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12 Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone	1990
The influence of ageing on the induction of the mRNAs of rat liver cytochromes P450IIB1 and P450IIB2. Biochemical pharmacology, 1990, Aug-01, Volume: 40, Issue:3 Topics: Aging; Animals; Base Sequence; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Liver; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Phenobarbital; Rats; RNA Probes; RNA, Messenger; Safrole	1990
The effects of selective cytochrome P-450 inducing agents on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in rats. Research communications in chemical pathology and pharmacology, 1990, Volume: 68, Issue:3 Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Liver; Male; Methylcholanthrene; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Trimethadione	1990
Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry. The Biochemical journal, 1989, Aug-15, Volume: 262, Issue:1 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Isoenzymes; Isomerism; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole	1989
Inducers of cytochrome P-450d: influence on microsomal catalytic activities and differential regulation by enzyme stabilization. Archives of biochemistry and biophysics, 1988, Volume: 262, Issue:1 Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Half-Life; Microsomes, Liver; Polybrominated Biphenyls; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases	1988
Generation of superoxide by the microsomal mixed-function oxidase system. Basic life sciences, 1988, Volume: 49 Topics: Animals; Butanols; Cytochrome P-450 Enzyme System; Isoenzymes; Isomerism; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polybrominated Biphenyls; Rats; Rats, Inbred Strains; Safrole; Superoxides	1988
Induction of cytochrome P-450 in congenic C57BL/6J mice by isosafrole: lack of correlation with the Ah locus. Chemico-biological interactions, 1986, Volume: 58, Issue:2 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Ethylmorphine-N-Demethylase; Genetic Linkage; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxygenases; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug; Safrole	1986
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro. Carcinogenesis, 1987, Volume: 8, Issue:10 Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole	1987
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:2 Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin	1988
Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster. Biochemical pharmacology, 1988, Apr-15, Volume: 37, Issue:8 Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Species Specificity	1988
Albendazole sulfonation by rat liver cytochrome P-450c. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2 Topics: Albendazole; Animals; Anthelmintics; Aroclors; Benzimidazoles; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Safrole	1988
Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat. Molecular pharmacology, 1986, Volume: 29, Issue:4 Topics: Adult; Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Humans; Immunosorbent Techniques; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Rats; Safrole	1986
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. Biochemical and biophysical research communications, 1987, Jul-15, Volume: 146, Issue:1 Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Iron; Male; Mice; Mice, Inbred C57BL; Oxidoreductases; Phenobarbital; Polycyclic Compounds; Porphyrias; Safrole; Uroporphyrinogen Decarboxylase	1987
Determination of beta-asarone, safrole, isosafrole and anethole in alcoholic drinks by high-performance liquid chromatography. Journal of chromatography, 1987, Aug-28, Volume: 404, Issue:1 Topics: Alcoholic Beverages; Allylbenzene Derivatives; Anisoles; Chromatography, High Pressure Liquid; Dioxoles; Indicators and Reagents; Oils, Volatile; Safrole	1987
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes. Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13 Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole	1986
Induction of a high spin form of microsomal cytochrome P-448 in rat liver by 4-aminoazobenzene derivatives. Biochemical pharmacology, 1986, Oct-15, Volume: 35, Issue:20 Topics: Animals; Azo Compounds; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochromes; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; p-Aminoazobenzene; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole	1986
The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA. Chemico-biological interactions, 1986, Oct-15, Volume: 60, Issue:1 Topics: Animals; Carbon Radioisotopes; Chlorophenols; DNA; Female; Hexachlorobenzene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Pentachlorophenol; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Safrole	1986
Further characterization of the polycyclic aromatic hydrocarbon binding properties of the 4S protein. Archives of biochemistry and biophysics, 1986, Nov-15, Volume: 251, Issue:1 Topics: Age Factors; Animals; Benzo(a)pyrene; Benzofurans; Binding, Competitive; Carrier Proteins; Cytosol; Enzyme Induction; Female; Liver; Macromolecular Substances; Male; Molybdenum; Phenobarbital; Polycyclic Compounds; Rats; Safrole	1986
Selective reactivation of steroid hydroxylases following dissociation of the isosafrole metabolite complex with rat hepatic cytochrome P-450. Archives of biochemistry and biophysics, 1986, Volume: 251, Issue:2 Topics: Androstenedione; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dioxoles; Enzyme Activation; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Oxygenases; Protein Binding; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1986
Identification and quantification of a messenger ribonucleic acid induced by polynuclear aromatic hydrocarbons--using a cloned human cytochrome P-450 gene. European journal of biochemistry, 1985, Sep-16, Volume: 151, Issue:3 Topics: Animals; Benz(a)Anthracenes; Benzopyrene Hydroxylase; Carcinogens; Cell Line; Cloning, Molecular; Cytochrome P-450 Enzyme System; Diazonium Compounds; DNA; Electrophoresis, Agar Gel; Genes; Humans; Hydrolases; Lymphocytes; Macaca fascicularis; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Polycyclic Compounds; Protein Biosynthesis; Rabbits; Reticulocytes; RNA, Messenger; Safrole	1985
omega-1 and omega-2 hydroxylation of prostaglandins by rabbit hepatic microsomal cytochrome P-450 isozyme 6. Archives of biochemistry and biophysics, 1985, Nov-15, Volume: 243, Issue:1 Topics: Alprostadil; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dinoprostone; Ethanol; Hydroxylation; Imidazoles; Isoenzymes; Kinetics; Miconazole; Microsomes, Liver; NADP; Proadifen; Prostaglandins; Prostaglandins E; Rabbits; Safrole	1985
An example of P-450 catalytic activities not correlated with corresponding P-450 mRNA concentrations. Biochemical pharmacology, 1986, Feb-15, Volume: 35, Issue:4 Topics: Animals; Catalysis; Cytochrome P-450 Enzyme System; Female; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; RNA, Messenger; Safrole	1986
Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds. Biochemical pharmacology, 1985, Mar-01, Volume: 34, Issue:5 Topics: Animals; Benzaldehydes; Benzodioxoles; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Dealkylation; Dioxoles; Liver; Male; Nose; Oxidoreductases, N-Demethylating; Phenols; Piperonyl Butoxide; Rabbits; Safrole	1985
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents. Journal of steroid biochemistry, 1985, Volume: 22, Issue:4 Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Estradiol; Ethanol; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases	1985
Interactions of safrole and isosafrole and their metabolites with cytochromes P-450. Chemico-biological interactions, 1985, Volume: 53, Issue:3 Topics: Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Dioxoles; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Safrole; Structure-Activity Relationship; Substrate Specificity	1985
Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone. Xenobiotica; the fate of foreign compounds in biological systems, 1985, Volume: 15, Issue:3 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Dioxoles; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Organ Size; Oxygenases; Phenobarbital; Promethazine; Rats; Rats, Inbred Strains; Safrole	1985
Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo. Molecular pharmacology, 1985, Volume: 28, Issue:3 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chloramphenicol; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Substrate Specificity; Testosterone; Warfarin	1985
Sex differences in the effects of microsomal enzyme inducers on hepatic phase I drug metabolism in the rat. Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Ethanol; Female; Imipramine; Lidocaine; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Sex Characteristics	1985
Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes. Developmental biology, 1985, Volume: 112, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromosome Mapping; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxins; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Induction; Female; Gene Expression Regulation; Genes; Liver; Methylcholanthrene; Mice; Polychlorinated Dibenzodioxins; Pregnancy; Safrole; Steroid Hydroxylases	1985
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers. Toxicology and applied pharmacology, 1985, Volume: 81, Issue:3 Pt 1 Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Embryo, Mammalian; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Safrole	1985
Induction of specific cytochrome P-450 isozymes by methylenedioxyphenyl compounds and antagonism by 3-methylcholanthrene. Archives of biochemistry and biophysics, 1985, Volume: 243, Issue:2 Topics: Animals; Cell-Free System; Collodion; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Immunochemistry; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Polyribosomes; Radioimmunoassay; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry	1985
Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers. Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:5 Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Ranitidine; Rats; Rats, Inbred Strains; Safrole	1984
Use of monoclonal antibody probes against rat hepatic cytochromes P-450c and P-450d to detect immunochemically related isozymes in liver microsomes from different species. Archives of biochemistry and biophysics, 1984, Nov-15, Volume: 235, Issue:1 Topics: Animals; Antibodies, Monoclonal; Cricetinae; Cross Reactions; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Epitopes; Guinea Pigs; Immunodiffusion; Isoenzymes; Male; Mice; Microsomes, Liver; Rabbits; Safrole; Species Specificity	1984
Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics. The Journal of biological chemistry, 1983, Apr-10, Volume: 258, Issue:7 Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Immune Sera; Immunodiffusion; Isomerism; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Radioimmunoassay; Rats; Safrole	1983
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl. Biochemical pharmacology, 1983, Jul-15, Volume: 32, Issue:14 Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry	1983
Isosafrole-induced cytochrome P2-450 in DBA/2N mouse liver. Characterization and genetic control of induction. The Journal of biological chemistry, 1984, Feb-25, Volume: 259, Issue:4 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Dioxoles; Immunodiffusion; Isomerism; Kinetics; Mice; Mice, Inbred Strains; Microsomes, Liver; Molecular Weight; Safrole	1984
Isosafrole and schizophrenia-like psychosis. The American journal of psychiatry, 1984, Volume: 141, Issue:8 Topics: Adult; Amphetamine; Dioxoles; Humans; Lysergic Acid Diethylamide; Male; Psychoses, Substance-Induced; Safrole; Schizophrenia; Substance-Related Disorders	1984
An induction effect of phenobarbital on rat liver microsomal 4-hydroxylation of estradiol 17-sulfate. Journal of pharmacobio-dynamics, 1984, Volume: 7, Issue:9 Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Estradiol; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole	1984
Structures of cysteine-containing peptides in isosafrole-inducible rat hepatic microsomal cytochrome P-450d: sequence homology with 3-methylcholanthrene-induced cytochrome P-450c. Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:14 Topics: Amino Acid Sequence; Animals; Cysteine; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Peptide Fragments; Rats; Safrole; Trypsin	1984
Induction of phencyclidine metabolism by phencyclidine, ketamine, ethanol, phenobarbital and isosafrole. Biochemical pharmacology, 1984, Feb-15, Volume: 33, Issue:4 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Ethanol; In Vitro Techniques; Ketamine; Male; Microsomes, Liver; Phencyclidine; Phenobarbital; Rats; Rats, Inbred Strains; Safrole	1984
Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms. The Journal of biological chemistry, 1980, Aug-25, Volume: 255, Issue:16 Topics: Animals; Catalysis; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epoxide Hydrolases; Immunodiffusion; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Peptide Fragments; Phenobarbital; Rats; Safrole; Spectrophotometry	1980
Isolation, purification, and properties of a unique form of cytochrome P-450 in microsomes of isosafrole-treated rats. The Journal of biological chemistry, 1981, May-10, Volume: 256, Issue:9 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Isomerism; Male; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Rats; Safrole; Spectrophotometry	1981
Microsomal enzymes of cholesterol biosynthesis from lanosterol: a progress report. Lipids, 1982, Volume: 17, Issue:3 Topics: Animals; Chemical Phenomena; Chemistry; Cholesterol; Cytochrome P-450 Enzyme System; Electron Transport; Glutathione; Hemin; Immunodiffusion; Isoenzymes; Lanosterol; Microsomes; Multienzyme Complexes; Oxidation-Reduction; Rats; Safrole	1982
Genotoxicity of safrole-related chemicals in microbial test systems. Mutation research, 1982, Volume: 101, Issue:2 Topics: 1-Propanol; Allylbenzene Derivatives; Animals; Anisoles; Bacillus subtilis; Benzaldehydes; Benzodioxoles; Dioxoles; DNA Repair; Escherichia coli; Eugenol; Mutagenicity Tests; Oils, Volatile; Propanols; Rats; Safrole; Salmonella typhimurium	1982
Characterization of the effects of known hepatic monooxygenase inducers on male and female rat and mouse kidneys. Life sciences, 1982, Sep-13, Volume: 31, Issue:11 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Enzyme Induction; Kidney; Mice; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxygenases; Polychlorinated Biphenyls; Rats; Safrole	1982
Role of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomes. Biochemical and biophysical research communications, 1982, Sep-16, Volume: 108, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Safrole	1982
Induction of cytochrome P-450 by methylenedioxyphenyl compounds: importance of the methylene carbon. Toxicology and applied pharmacology, 1983, Mar-30, Volume: 68, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Ethylmorphine-N-Demethylase; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Nitriles; Oxidoreductases; Phenobarbital; Safrole; Structure-Activity Relationship	1983
Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole. European journal of biochemistry, 1983, Jul-15, Volume: 134, Issue:1 Topics: Animals; Cloning, Molecular; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Female; Gene Expression Regulation; Kidney; Liver; Male; Methylcholanthrene; Mice; Nucleic Acid Hybridization; Phenobarbital; Polychlorinated Dibenzodioxins; RNA, Messenger; Safrole	1983
Properties of the oxygenated form of liver microsomal cytochrome P-450. The Journal of biological chemistry, 1983, Jul-25, Volume: 258, Issue:14 Topics: Anaerobiosis; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Isomerism; Kinetics; Microsomes, Liver; Oxidation-Reduction; Rabbits; Safrole; Spectrophotometry	1983
Amino-terminal and carboxy-terminal sequence of hepatic microsomal cytochrome P-450d, a unique hemoprotein from rats treated with isosafrole. Biochemistry, 1982, Mar-16, Volume: 21, Issue:6 Topics: Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Dioxoles; Hemeproteins; Microsomes, Liver; Rats; Safrole	1982
Metabolic-intermediate complex formation reveals major changes in rat hepatic cytochrome P-450 subpopulations in addition to those forms previously purified after phenobarbital, beta-naphthoflavone, and isosafrole induction. Molecular pharmacology, 1982, Volume: 21, Issue:2 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dioxoles; Flavonoids; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains; Safrole	1982
Metabolism of isosafrole and dihydrosafrole in the rat. Biomedical mass spectrometry, 1982, Volume: 9, Issue:8 Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, Gas; Dioxoles; Gas Chromatography-Mass Spectrometry; Male; Rats; Rats, Inbred Strains; Safrole	1982
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics. Biochemistry, 1982, Nov-23, Volume: 21, Issue:24 Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes	1982
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents. Chemico-biological interactions, 1980, Volume: 31, Issue:2 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Safrole	1980
Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:5 Topics: Adult; Aged; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Female; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Nitrophenols; Oxazines; Oxidation-Reduction; Phenobarbital; Safrole; Substrate Specificity; Testosterone	1995
The effect of varying halogen substituent patterns on the cytochrome P450 catalysed dehalogenation of 4-halogenated anilines to 4-aminophenol metabolites. Biochemical pharmacology, 1995, May-11, Volume: 49, Issue:9 Topics: Aminophenols; Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Halogens; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Wistar; Safrole	1995
Cytochrome P450 1A1 cDNA from plaice (Pleuronectes platessa) and induction of P450 1A1 mRNA in various tissues by 3-methylcholanthrene and isosafrole. Molecular marine biology and biotechnology, 1993, Volume: 2, Issue:6 Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Flounder; Humans; Liver; Methylcholanthrene; Molecular Sequence Data; Organ Specificity; Restriction Mapping; RNA, Messenger; Safrole; Sequence Homology, Amino Acid	1993
Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1993, Volume: 21, Issue:4 Topics: Animals; Bile; Corn Oil; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Liver; Male; Oxidoreductases, N-Demethylating; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred F344; Safrole; Time Factors; Tissue Distribution	1993
Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomes. The Journal of steroid biochemistry and molecular biology, 1993, Volume: 46, Issue:6 Topics: Administration, Oral; Androstenedione; Animals; Anticarcinogenic Agents; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Growth Hormone; Indoles; Injections, Intraperitoneal; Kinetics; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Safrole; Sex Factors; Structure-Activity Relationship	1993
Regulation of cytochrome P-450 isozymes by methylenedioxyphenyl compounds. Chemico-biological interactions, 1993, Volume: 86, Issue:3 Topics: Animals; Base Sequence; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression; Isoenzymes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Sequence Data; Oligodeoxyribonucleotides; Oxidoreductases; Piperonyl Butoxide; Receptors, Aryl Hydrocarbon; Receptors, Drug; RNA, Messenger; Safrole	1993
Cell-density-dependent expression of Cyp1a2 gene in monolayer-cultured adult mouse hepatocytes. Japanese journal of cancer research : Gann, 1993, Volume: 84, Issue:3 Topics: Animals; Blotting, Northern; Cell Count; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Liver; Methylcholanthrene; Mice; Mice, Inbred C57BL; Oxidoreductases; Polychlorinated Dibenzodioxins; RNA, Messenger; Safrole; Time Factors	1993
Expression analysis of the mixed function oxidase system in rat brain by the polymerase chain reaction. Molecular and cellular biochemistry, 1993, Mar-24, Volume: 120, Issue:2 Topics: Amitriptyline; Animals; Base Sequence; Benzoflavones; beta-Naphthoflavone; Brain; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Imipramine; Isoenzymes; Male; Mixed Function Oxygenases; Molecular Sequence Data; Nerve Tissue Proteins; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Safrole	1993
Effects of enzyme induction on the distribution of the food carcinogen 2-amino-3,8-dimethyl-imidazo[4,5-ss]-quinoxaline (MeIQx) in Ah-receptor- responsive- and Ah-receptor-non-responsive mice. Pharmacology & toxicology, 1995, Volume: 77, Issue:1 Topics: Animals; Carcinogens; Enzyme Induction; Hydroxylation; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Quinoxalines; Safrole; Species Specificity; Spleen; Tissue Distribution	1995
Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver. Toxicology letters, 1996, Volume: 85, Issue:1 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Epoxide Hydrolases; Ethanol; Glucuronosyltransferase; Glutathione Transferase; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Safrole	1996
The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes. Toxicology and applied pharmacology, 1996, Volume: 140, Issue:2 Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Liver; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Necrosis; Plants; Safrole	1996
In vitro metabolism of 7,12-dimethylbenz[a]anthracene by rainbow trout liver microsomes and trout P450 isoforms. Toxicology and applied pharmacology, 1997, Volume: 142, Issue:1 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta-Naphthoflavone; Biotransformation; Clofibrate; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Adducts; Drug Synergism; Ellipticines; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Microsomes, Liver; Oncorhynchus mykiss; Proteins; Safrole	1997
Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole. Biochemical pharmacology, 1997, Feb-21, Volume: 53, Issue:4 Topics: Cell Line; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Fluvoxamine; Humans; Liver; Safrole	1997
The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants. Chemico-biological interactions, 1997, Dec-12, Volume: 108, Issue:1-2 Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dioxoles; Ferric Compounds; Kidney; Kidney Diseases; Lipid Peroxidation; Liver; Liver Diseases; Male; Mice; Microsomes, Liver; Necrosis; Nitrilotriacetic Acid; Rats; Rats, Sprague-Dawley; Safrole	1997
Inhibition of 5,9-dimethyldibenzo[c,g]carbazole-DNA adduct formation in mouse liver by pretreatment with cytochrome P4501A inducers in vivo. Environmental and molecular mutagenesis, 1998, Volume: 32, Issue:4 Topics: Animals; beta-Naphthoflavone; Carbazoles; Carcinogens; Cell Nucleus; Cytochrome P-450 Enzyme System; DNA Adducts; Enzyme Induction; Female; Glucuronosyltransferase; Glutathione Transferase; Liver; Mice; Mice, Inbred Strains; Polychlorinated Dibenzodioxins; Safrole	1998
Interaction of isosafrole, beta-naphthoflavone and other CYP1A inducers in liver of rainbow trout (Oncorhynchus mykiss) and eelpout (Zoarces viviparus). Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1998, Volume: 121, Issue:1-3 Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Female; Fishes; Liver; Male; Safrole	1998
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:3 Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole	2000
Differential expression of two CYP1A genes in rainbow trout (Oncorhynchys mykiss). Toxicology and applied pharmacology, 2000, Jun-15, Volume: 165, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Blotting, Northern; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Induction; Female; Gene Expression Regulation; Liver; Male; Methylcholanthrene; Oncorhynchus mykiss; Polychlorinated Dibenzodioxins; Polymerase Chain Reaction; RNA, Messenger; Safrole; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid	2000
Identification of cytochrome P450 isoform involved in the metabolism of YM992, a novel selective serotonin re-uptake inhibitor, in human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:5 Topics: Benzoflavones; Chromatography; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Kinetics; Microsomes, Liver; Models, Biological; Morpholines; Protein Binding; Protein Isoforms; Recombinant Proteins; Safrole; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists	2000
In vitro biotransformation of xanthohumol, a flavonoid from hops (Humulus lupulus), by rat liver microsomes. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:3 Topics: Animals; Beer; beta-Naphthoflavone; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Flavonoids; Kinetics; Magnetic Resonance Spectroscopy; Magnoliopsida; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Propiophenones; Rats; Safrole	2001
Separation ability and stoichiometry of cyclodextrin complexes. Journal of chromatography. A, 2000, Dec-15, Volume: 902, Issue:2 Topics: Allylbenzene Derivatives; Anisoles; Chromatography, Gas; Cyclodextrins; Naphthalenes; Safrole; Stereoisomerism	2000
Inducibility of hepatic CYP1A enzymes by 3-methylcholanthrene and isosafrole differs in male rats fed diets containing casein, soy protein isolate or whey from conception to adulthood. The Journal of nutrition, 2001, Volume: 131, Issue:4 Topics: Aging; Animals; Blotting, Northern; Blotting, Western; Caseins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytosol; Dietary Proteins; Enzyme Induction; Female; Fertilization; Liver; Male; Methylcholanthrene; Milk Proteins; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Safrole; Soybean Proteins; Whey Proteins	2001
Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2001, Volume: 130, Issue:1 Topics: Animals; Antibodies; beta-Naphthoflavone; Catalysis; Chickens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Ellipticines; Enzyme Induction; Enzyme Inhibitors; Hepatocytes; Immunoblotting; Immunochemistry; Safrole; Species Specificity	2001
Evidence for the involvement of CYP1A2 in the metabolism of bromodichloromethane in rat liver. Toxicology, 2002, Jul-01, Volume: 176, Issue:1-2 Topics: Alanine Transaminase; Animals; Blotting, Western; Bromides; Carcinogens; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Induction; Isoenzymes; L-Iditol 2-Dehydrogenase; Liver; Male; Microsomes, Liver; Models, Biological; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred F344; Safrole; Trihalomethanes	2002
Microbiologic oxidation of isosafrole into piperonal. Applied biochemistry and biotechnology, 2003,Spring, Volume: 105 -108 Topics: Benzaldehydes; Benzodioxoles; Biotransformation; Chromatography, Gas; Cladosporium; Gas Chromatography-Mass Spectrometry; Isomerism; Oxidation-Reduction; Safrole	2003
[Toxicity of cis-isosafrol & trans-isosafrol for the mouse]. Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1958, Oct-27, Volume: 247, Issue:17 Topics: Animals; Mice; Oils; Safrole	1958
Olfactory receptor antagonism between odorants. The EMBO journal, 2004, Jan-14, Volume: 23, Issue:1 Topics: Animals; Animals, Newborn; Anisoles; Calcium; Cell Line; Dose-Response Relationship, Drug; Electrophysiology; Eugenol; Fluorescent Dyes; Humans; Isoproterenol; Mice; Mice, Inbred BALB C; Models, Biological; Odorants; Olfactory Mucosa; Olfactory Receptor Neurons; Receptors, Odorant; Reverse Transcriptase Polymerase Chain Reaction; Safrole; Smell; Structure-Activity Relationship	2004
Forensic profiling of sassafras oils based on comprehensive two-dimensional gas chromatography. Forensic science international, 2013, Jun-10, Volume: 229, Issue:1-3 Topics: Allylbenzene Derivatives; Benzaldehydes; Benzodioxoles; Benzyl Compounds; Cyclohexane Monoterpenes; Dioxolanes; Eugenol; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hallucinogens; Illicit Drugs; Molecular Structure; Monoterpenes; N-Methyl-3,4-methylenedioxyamphetamine; Phenols; Plant Oils; Pyrogallol; Safrole; Sassafras	2013
Neuroscience. Metabolic control of epilepsy. Science (New York, N.Y.), 2015, Mar-20, Volume: 347, Issue:6228 Topics: Animals; Anticonvulsants; Dioxolanes; Enzyme Inhibitors; L-Lactate Dehydrogenase; Safrole; Seizures	2015
Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science (New York, N.Y.), 2015, Mar-20, Volume: 347, Issue:6228 Topics: Animals; Anticonvulsants; Dioxolanes; Disease Models, Animal; Enzyme Inhibitors; L-Lactate Dehydrogenase; Membrane Potentials; Mice; Mice, Inbred ICR; Neurons; Patch-Clamp Techniques; Safrole; Seizures; Subthalamic Nucleus	2015
Inhibition of Lactate Dehydrogenase to Treat Epilepsy. The New England journal of medicine, 2015, Jul-09, Volume: 373, Issue:2 Topics: Animals; Anticonvulsants; Dioxolanes; Enzyme Inhibitors; Epilepsy; Humans; L-Lactate Dehydrogenase; Safrole	2015
Highly Efficient Biosynthesis of Heliotropin by Engineered Journal of agricultural and food chemistry, 2019, Dec-26, Volume: 67, Issue:51 Topics: Benzaldehydes; Benzodioxoles; Candida; Escherichia coli; Formate Dehydrogenases; Fungal Proteins; Metabolic Engineering; NAD; Oxygenases; Safrole	2019