safrole has been researched along with isosafrole in 110 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 56 (50.91) | 18.7374 |
1990's | 39 (35.45) | 18.2507 |
2000's | 10 (9.09) | 29.6817 |
2010's | 5 (4.55) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kubo, A; Kubo, I; Muroi, H | 1 |
Himejima, M; Kubo, I; Muroi, H | 1 |
Bridges, JW; Dickins, M; Elcombe, CR; Netter, KJ | 1 |
Guengerich, FP; Mimura, M; Shimada, T; Yamazaki, H | 1 |
Horbach, GJ; Kremers, P; Rietjens, IM; Van Asten, JG; Van Bezooijen, CF | 1 |
Albores, A; Bach, PH; Bridges, JW; Cebrian, ME; Connelly, JC | 1 |
Hsieh, CY; Huang, JD | 1 |
Balvers, WG; Boersma, MG; Rietjens, IM; Veeger, C | 1 |
Devichensky, VM; Dubrov, YN; Korneva, EN; Molchanova, LD; Shcherbakov, VM | 1 |
Hanioka, N; Ishida, C; Koga, N; Saeki, HK; Yoshimura, H | 1 |
Guengerich, FP; Shimada, T | 1 |
Chui, YC; Hodgson, E; Levi, P; Lewandowski, M | 1 |
Bélanger, PM; St-Hilaire, S | 1 |
Kim, SG; Novak, RF | 1 |
Chui, YC; Hodgson, E; Levi, PE; Lewandowski, M | 1 |
Barton, HA; Costantini, MG; Forkert, PG; Marletta, MA | 1 |
Jacobs, JM; Jacobs, NJ; Lambrecht, RW; Sinclair, JF; Sinclair, PR | 1 |
Boobis, AR; Davies, DS; Edwards, RJ; Levin, W; Sesardic, D; Thomas, PE | 1 |
Boobis, AR; Cole, KJ; Davies, DS; Edwards, RJ; Levin, W; Sesardic, D; Thomas, PE | 1 |
Clement, B; Kunze, T | 1 |
Fernandes, G; Horbach, GJ; Venkatraman, JT | 1 |
Kelley, M; Safe, S; Womack, J | 1 |
Horbach, GJ; van Asten, JG; van Bezooijen, CF | 1 |
Etoh, H; Misawa, S; Tanaka, E | 1 |
Bars, RG; Elcombe, CR; Mitchell, AM; Wolf, CR | 1 |
Aust, SD; Voorman, R | 1 |
Aust, SD; Morehouse, LA | 1 |
Cook, JC; Hodgson, E | 2 |
Kammerer, RC; Lampe, MA | 1 |
Bachmann, KA; Jahn, D; Schwartz, J; Yang, C | 1 |
Gessner, T; Olson, JR; Wroblewski, VJ | 1 |
Batt, AM; Delatour, P; Masson, C; Mothe, O; Siest, G; Souhaili-El Amri, H; Totis, M | 1 |
Campanile, C; Haniu, M; Levin, W; Maines, SL; Mendez-Picon, G; Parker, G; Shively, JE; Thomas, PE; Watkins, PB; Wrighton, SA | 1 |
Francis, JE; Smith, AG | 1 |
Currò, P; Lanuzza, F; Micali, G | 1 |
Smith, AG; Stewart, FP | 1 |
Degawa, M; Hashimoto, Y; Kojima, M; Sato, Y | 1 |
Adang, A; Müller, F; van Bladeren, PJ; van Ommen, B | 1 |
Bresnick, E; Houser, WH; Zielinski, R | 1 |
Farrell, GC; Murray, M; Zaluzny, L | 1 |
Chen, YT; Ding, JH; Kato, T | 1 |
Coon, MJ; Holm, KA; Koop, DR; Kupfer, D; Theoharides, AD | 1 |
Gonzalez, FJ; Nebert, DW; Tuteja, N | 2 |
Brezinski, DA; Dahl, AR | 1 |
Juchau, MR; Namkung, MJ; Nelson, SD; Porubek, DJ | 1 |
Delaforge, M; Ioannides, C; Parke, DV | 2 |
Elcombe, CR; Houston, JB; Taylor, G | 1 |
Balfour, C; Dunbar, D; Halpert, J; Kaminsky, LS; Miller, NE; Morgan, ET | 1 |
Paterson, P; Skett, P | 1 |
Bark, DH; Greenaway, JC; Juchau, MR; Shewey, LM | 1 |
Goldstein, JA; Hodgson, E; Linko, P; Yeowell, HN | 1 |
Bast, A; Kroes, BH; Savenije-Chapel, EM | 1 |
Nebert, DW; Negishi, M | 1 |
Koop, DR; Levin, W; Reidy, J; Reik, LM; Ryan, DE; Thomas, PE | 1 |
Levin, W; Reik, LM; Ryan, DE; Thomas, PE | 1 |
Parkinson, A; Robertson, LW; Safe, SH | 1 |
Nebert, DW; Negishi, M; Ohyama, T | 1 |
Haier, RJ; Keitner, GI; Sabaawi, M | 1 |
Kimura, R; Watanabe, K; Yoshizawa, I | 1 |
Haniu, M; Levin, W; Ryan, DE; Shively, JE | 1 |
Cho, AK; Hwa, JJ; Kammerer, RC; Schmitz, DA | 1 |
Jollow, DJ; Longacre, S; Price, V; Roberts, S; Smith, C | 1 |
Levin, W; Ryan, DE; Thomas, PE | 1 |
Fisher, GJ; Fukushima, H; Gaylor, JL | 1 |
Billheimer, JT; Bowen, WD; Fisher, GJ; Gaylor, JL; Trzaskos, JM | 1 |
Sekizawa, J; Shibamoto, T | 1 |
Elcombe, CR; Hook, JB; Lock, EA; Rose, MS | 1 |
Coon, MJ; Delaforge, M; Koop, DR | 1 |
Altieri, M; Chen, YT; Ikeda, T; Nakamura, M; Nebert, DW; Negishi, M; Tukey, RH | 1 |
Coon, MJ; Gorsky, LD; Oprian, DD | 1 |
Botelho, LH; Kutny, R; Levin, W; Ryan, DE; Shively, JE; Yuan, PM | 1 |
Bornheim, LM; Franklin, MR | 1 |
Klungsøyr, J; Scheline, RR | 1 |
Levin, W; Ryan, DE; Thomas, PE; Vlasuk, GP; Walz, FG | 1 |
Bridges, JW; Fennell, TR; Sweatman, BC | 1 |
Castell, JV; Donato, MT; Gómez-Lechón, MJ | 1 |
Boersma, MG; Cnubben, NH; Rietjens, IM; Vervoort, J | 1 |
George, SG; Leaver, MJ; Pirrit, L | 1 |
Andersen, ME; Birnbaum, LS; Kedderis, LB | 1 |
Bradlow, HL; Jellinck, PH; Makin, HL; Sepkovic, DW | 1 |
Adams, NH; Hodgson, E; Levi, PE | 1 |
Nemoto, N; Sakurai, J | 1 |
Hodgson, AV; Strobel, HW; White, JW; White, TB | 1 |
Alexander, J; Ingebrigtsen, K; Klungsøyr, L; Vikse, R | 1 |
Franklin, MR; Moody, DE; Slawson, MH | 1 |
O'Brien, PJ; Zhao, ZS | 1 |
Buhler, DR; Henderson, MC; Miranda, CL; Williams, DE | 1 |
Kalow, W; Pastrakuljic, A; Roberts, EA; Tang, BK | 1 |
Khan, S; O'Brien, PJ; Zhao, ZS | 1 |
Périn, F; Périn-Roussel, O; Plessis, MJ; Taras-Valéro, D | 1 |
Förlin, L; Ronisz, D | 1 |
Law, MY; Moody, DE; Slawson, MH | 1 |
Chen, TT; Lipsky, MM; Råbergh, CM; Vrolijk, NH | 1 |
Chiba, K; Higuchi, S; Mera, A; Noguchi, K; Watanabe, T | 1 |
Buhler, DR; Deinzer, ML; Stevens, JF; Yilmazer, M | 1 |
Asztemborska, M; Nowakowski, R; Sybilska, D | 1 |
Badger, TM; Hakkak, R; Ronis, MJ; Rowlands, JC | 1 |
Giesy, JP; Stegeman, JJ; Verbrugge, DA; Verbrugge, LA; Woodin, BR | 1 |
Allis, JW; Anderson, BP; Pegram, RA; Ross, TM; Zhao, G | 1 |
Antunes, OA; da Silva, II; Pereira, NP; Santos, AS; Sarquis, MI | 1 |
CAUJOLLE, F; MEYNIER, D | 1 |
Kataoka, H; Oka, Y; Omura, M; Touhara, K | 1 |
Gröger, T; Pütz, M; Schäffer, M; Zimmermann, R | 1 |
Scharfman, HE | 1 |
Inoue, T; Katsu, T; Lee, S; Otsuki, T; Sada, N | 1 |
Rho, JM | 1 |
Chen, P; Fu, Y; Liu, S; Wen, P; Wu, D; Zheng, P | 1 |
3 review(s) available for safrole and isosafrole
Article | Year |
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Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution.
Topics: Animals; Biological Evolution; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Phenobarbital; Polycyclic Compounds; Pregnenolone Carbonitrile; Safrole; Species Specificity | 1982 |
Pharmacokinetic considerations in toxicity testing.
Topics: Acetaminophen; Animals; Cricetinae; Drug Interactions; Kinetics; Liver; Methylcholanthrene; Pharmaceutical Preparations; Rats; Receptors, Drug; Safrole; Toxicology | 1982 |
Safrole: its metabolism, carcinogenicity and interactions with cytochrome P-450.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Dioxoles; Hemeproteins; Ligands; Mixed Function Oxygenases; Oxidation-Reduction; Safrole | 1981 |
107 other study(ies) available for safrole and isosafrole
Article | Year |
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Naturally occurring antiacne agents.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Fatty Alcohols; Membrane Fluidity; Microbial Sensitivity Tests; Plants, Medicinal; Propionibacterium acnes; Structure-Activity Relationship | 1994 |
Combination effects of antifungal nagilactones against Candida albicans and two other fungi with phenylpropanoids.
Topics: Amphotericin B; Anisoles; Antifungal Agents; Candida albicans; Culture Media; Diterpenes; Malassezia; Microbial Sensitivity Tests; Saccharomyces cerevisiae | 1993 |
A novel haemoprotein induced by isosafrole pretreatment in the rat.
Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Safrole; Spectrum Analysis | 1978 |
Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens.
Topics: Aflatoxins; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carcinogenicity Tests; Carcinogens; Cytochrome P-450 Enzyme System; DNA; DNA Damage; In Vitro Techniques; Lung; Male; Microsomes; Microsomes, Liver; Phenobarbital; Pregnenolone; Rats; Rats, Sprague-Dawley; Safrole; SOS Response, Genetics; Sterigmatocystin | 1992 |
The effect of age on inducibility of various types of rat liver cytochrome P-450.
Topics: Aging; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methylcholanthrene; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred BN; RNA, Messenger; Safrole | 1992 |
Effects of arsenite on hepatic mixed-function oxidase activity in rats.
Topics: Animals; Arsenic; Arsenites; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Wistar; Safrole | 1992 |
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism.
Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole | 1992 |
Differential cumene hydroperoxide sensitivity of cytochrome P-450 enzymes IA1 and IIB1 determined by their way of membrane incorporation.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Electrophoresis, Polyacrylamide Gel; Kinetics; Lipid Peroxidation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1992 |
NADPH-dependent reduction of amaranch in liver microsomes characterized the quantity of low spin forms of cytochrome P-450.
Topics: Amaranth Dye; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fomepizole; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Safrole | 1991 |
Metabolism in vitro of 3,4,3',4'- and 2,5,2',5'-tetrachlorobiphenyl by rat liver microsomes and highly purified cytochrome P-450.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Pentobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Safrole; Sulfhydryl Compounds | 1991 |
Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.
Topics: Aflatoxin B1; Animals; Aroclors; Benzoflavones; beta-Galactosidase; Carbolines; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; DNA; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Mutagens; Nicotiana; Plants, Toxic; Quinidine; Rats; Rats, Inbred Strains; Safrole; Smoke; SOS Response, Genetics | 1991 |
Acetanilide 4-hydroxylase and acetanilide 2-hydroxylase activity in hepatic microsomes from induced mice.
Topics: Acetanilides; Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, Thin Layer; Male; Mice; Mice, Inbred DBA; Microsomes, Liver; Safrole | 1991 |
The characteristics of the microsomal hydroxylation of tolbutamide.
Topics: Animals; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Hemeproteins; Hydroxylation; In Vitro Techniques; Isoenzymes; Kinetics; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Safrole; Species Specificity; Tolbutamide | 1991 |
Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke: redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine.
Topics: Animals; Biotransformation; Catalase; Cytochrome P-450 Enzyme System; DNA Damage; Glutathione; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyridines; Rabbits; Safrole; Smoke; Superoxide Dismutase; Superoxides | 1990 |
Differences in induction of hepatic cytochrome P450 isozymes by mice in eight methylenedioxyphenyl compounds.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isoenzymes; Liver; Male; Mice; Mice, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug; Safrole | 1990 |
The 4S polycyclic aromatic hydrocarbon-binding protein: immunohistochemical localization in mice.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carcinogens; Carrier Proteins; Cytochrome P-450 Enzyme System; Cytosol; Glycine N-Methyltransferase; Immunoenzyme Techniques; Kidney; Kinetics; Liver; Lung; Male; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polycyclic Compounds; Safrole | 1990 |
Role of inducer binding in cytochrome P-450 IA2-mediated uroporphyrinogen oxidation.
Topics: Animals; Butanols; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Oxidation-Reduction; Polychlorinated Dibenzodioxins; Protein Binding; Rats; Rats, Inbred F344; Safrole; Species Specificity; Uroporphyrinogens | 1990 |
High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cyclohexanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxidoreductases; Phenacetin; Rats; Rats, Inbred Strains; Safrole; Substrate Specificity | 1990 |
The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases; Rats; Rats, Inbred Strains; Safrole; Tissue Distribution | 1990 |
Hepatic microsomal N-hydroxylation of adenine to 6-N-hydroxylaminopurine.
Topics: Adenine; Animals; Catalase; Chromatography, High Pressure Liquid; Female; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Safrole; Superoxide Dismutase | 1990 |
Food restriction prevents the loss of isosafrole inducible cytochrome P-450 mRNA and enzyme levels in aging rats.
Topics: Aging; Animals; Blotting, Western; Body Weight; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Food Deprivation; Liver; Male; Microsomes, Liver; Organ Size; Rats; Rats, Inbred F344; RNA, Messenger; Safrole | 1990 |
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone | 1990 |
The influence of ageing on the induction of the mRNAs of rat liver cytochromes P450IIB1 and P450IIB2.
Topics: Aging; Animals; Base Sequence; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Liver; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Phenobarbital; Rats; RNA Probes; RNA, Messenger; Safrole | 1990 |
The effects of selective cytochrome P-450 inducing agents on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in rats.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Liver; Male; Methylcholanthrene; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Trimethadione | 1990 |
Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Isoenzymes; Isomerism; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1989 |
Inducers of cytochrome P-450d: influence on microsomal catalytic activities and differential regulation by enzyme stabilization.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Half-Life; Microsomes, Liver; Polybrominated Biphenyls; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1988 |
Generation of superoxide by the microsomal mixed-function oxidase system.
Topics: Animals; Butanols; Cytochrome P-450 Enzyme System; Isoenzymes; Isomerism; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polybrominated Biphenyls; Rats; Rats, Inbred Strains; Safrole; Superoxides | 1988 |
Induction of cytochrome P-450 in congenic C57BL/6J mice by isosafrole: lack of correlation with the Ah locus.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Ethylmorphine-N-Demethylase; Genetic Linkage; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxygenases; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug; Safrole | 1986 |
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole | 1987 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II.
Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin | 1988 |
Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Species Specificity | 1988 |
Albendazole sulfonation by rat liver cytochrome P-450c.
Topics: Albendazole; Animals; Anthelmintics; Aroclors; Benzimidazoles; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Safrole | 1988 |
Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.
Topics: Adult; Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Humans; Immunosorbent Techniques; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Rats; Safrole | 1986 |
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Iron; Male; Mice; Mice, Inbred C57BL; Oxidoreductases; Phenobarbital; Polycyclic Compounds; Porphyrias; Safrole; Uroporphyrinogen Decarboxylase | 1987 |
Determination of beta-asarone, safrole, isosafrole and anethole in alcoholic drinks by high-performance liquid chromatography.
Topics: Alcoholic Beverages; Allylbenzene Derivatives; Anisoles; Chromatography, High Pressure Liquid; Dioxoles; Indicators and Reagents; Oils, Volatile; Safrole | 1987 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
Induction of a high spin form of microsomal cytochrome P-448 in rat liver by 4-aminoazobenzene derivatives.
Topics: Animals; Azo Compounds; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochromes; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; p-Aminoazobenzene; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole | 1986 |
The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA.
Topics: Animals; Carbon Radioisotopes; Chlorophenols; DNA; Female; Hexachlorobenzene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Pentachlorophenol; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Safrole | 1986 |
Further characterization of the polycyclic aromatic hydrocarbon binding properties of the 4S protein.
Topics: Age Factors; Animals; Benzo(a)pyrene; Benzofurans; Binding, Competitive; Carrier Proteins; Cytosol; Enzyme Induction; Female; Liver; Macromolecular Substances; Male; Molybdenum; Phenobarbital; Polycyclic Compounds; Rats; Safrole | 1986 |
Selective reactivation of steroid hydroxylases following dissociation of the isosafrole metabolite complex with rat hepatic cytochrome P-450.
Topics: Androstenedione; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dioxoles; Enzyme Activation; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Oxygenases; Protein Binding; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1986 |
Identification and quantification of a messenger ribonucleic acid induced by polynuclear aromatic hydrocarbons--using a cloned human cytochrome P-450 gene.
Topics: Animals; Benz(a)Anthracenes; Benzopyrene Hydroxylase; Carcinogens; Cell Line; Cloning, Molecular; Cytochrome P-450 Enzyme System; Diazonium Compounds; DNA; Electrophoresis, Agar Gel; Genes; Humans; Hydrolases; Lymphocytes; Macaca fascicularis; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Polycyclic Compounds; Protein Biosynthesis; Rabbits; Reticulocytes; RNA, Messenger; Safrole | 1985 |
omega-1 and omega-2 hydroxylation of prostaglandins by rabbit hepatic microsomal cytochrome P-450 isozyme 6.
Topics: Alprostadil; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dinoprostone; Ethanol; Hydroxylation; Imidazoles; Isoenzymes; Kinetics; Miconazole; Microsomes, Liver; NADP; Proadifen; Prostaglandins; Prostaglandins E; Rabbits; Safrole | 1985 |
An example of P-450 catalytic activities not correlated with corresponding P-450 mRNA concentrations.
Topics: Animals; Catalysis; Cytochrome P-450 Enzyme System; Female; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; RNA, Messenger; Safrole | 1986 |
Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds.
Topics: Animals; Benzaldehydes; Benzodioxoles; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Dealkylation; Dioxoles; Liver; Male; Nose; Oxidoreductases, N-Demethylating; Phenols; Piperonyl Butoxide; Rabbits; Safrole | 1985 |
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Estradiol; Ethanol; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1985 |
Interactions of safrole and isosafrole and their metabolites with cytochromes P-450.
Topics: Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Dioxoles; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Safrole; Structure-Activity Relationship; Substrate Specificity | 1985 |
Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Dioxoles; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Organ Size; Oxygenases; Phenobarbital; Promethazine; Rats; Rats, Inbred Strains; Safrole | 1985 |
Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chloramphenicol; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Substrate Specificity; Testosterone; Warfarin | 1985 |
Sex differences in the effects of microsomal enzyme inducers on hepatic phase I drug metabolism in the rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Ethanol; Female; Imipramine; Lidocaine; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Sex Characteristics | 1985 |
Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromosome Mapping; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxins; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Induction; Female; Gene Expression Regulation; Genes; Liver; Methylcholanthrene; Mice; Polychlorinated Dibenzodioxins; Pregnancy; Safrole; Steroid Hydroxylases | 1985 |
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Embryo, Mammalian; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Safrole | 1985 |
Induction of specific cytochrome P-450 isozymes by methylenedioxyphenyl compounds and antagonism by 3-methylcholanthrene.
Topics: Animals; Cell-Free System; Collodion; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Immunochemistry; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Polyribosomes; Radioimmunoassay; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry | 1985 |
Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers.
Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Ranitidine; Rats; Rats, Inbred Strains; Safrole | 1984 |
Use of monoclonal antibody probes against rat hepatic cytochromes P-450c and P-450d to detect immunochemically related isozymes in liver microsomes from different species.
Topics: Animals; Antibodies, Monoclonal; Cricetinae; Cross Reactions; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Epitopes; Guinea Pigs; Immunodiffusion; Isoenzymes; Male; Mice; Microsomes, Liver; Rabbits; Safrole; Species Specificity | 1984 |
Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Immune Sera; Immunodiffusion; Isomerism; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Radioimmunoassay; Rats; Safrole | 1983 |
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry | 1983 |
Isosafrole-induced cytochrome P2-450 in DBA/2N mouse liver. Characterization and genetic control of induction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Dioxoles; Immunodiffusion; Isomerism; Kinetics; Mice; Mice, Inbred Strains; Microsomes, Liver; Molecular Weight; Safrole | 1984 |
Isosafrole and schizophrenia-like psychosis.
Topics: Adult; Amphetamine; Dioxoles; Humans; Lysergic Acid Diethylamide; Male; Psychoses, Substance-Induced; Safrole; Schizophrenia; Substance-Related Disorders | 1984 |
An induction effect of phenobarbital on rat liver microsomal 4-hydroxylation of estradiol 17-sulfate.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Estradiol; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1984 |
Structures of cysteine-containing peptides in isosafrole-inducible rat hepatic microsomal cytochrome P-450d: sequence homology with 3-methylcholanthrene-induced cytochrome P-450c.
Topics: Amino Acid Sequence; Animals; Cysteine; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Peptide Fragments; Rats; Safrole; Trypsin | 1984 |
Induction of phencyclidine metabolism by phencyclidine, ketamine, ethanol, phenobarbital and isosafrole.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Ethanol; In Vitro Techniques; Ketamine; Male; Microsomes, Liver; Phencyclidine; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1984 |
Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.
Topics: Animals; Catalysis; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epoxide Hydrolases; Immunodiffusion; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Peptide Fragments; Phenobarbital; Rats; Safrole; Spectrophotometry | 1980 |
Isolation, purification, and properties of a unique form of cytochrome P-450 in microsomes of isosafrole-treated rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Isomerism; Male; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Rats; Safrole; Spectrophotometry | 1981 |
Microsomal enzymes of cholesterol biosynthesis from lanosterol: a progress report.
Topics: Animals; Chemical Phenomena; Chemistry; Cholesterol; Cytochrome P-450 Enzyme System; Electron Transport; Glutathione; Hemin; Immunodiffusion; Isoenzymes; Lanosterol; Microsomes; Multienzyme Complexes; Oxidation-Reduction; Rats; Safrole | 1982 |
Genotoxicity of safrole-related chemicals in microbial test systems.
Topics: 1-Propanol; Allylbenzene Derivatives; Animals; Anisoles; Bacillus subtilis; Benzaldehydes; Benzodioxoles; Dioxoles; DNA Repair; Escherichia coli; Eugenol; Mutagenicity Tests; Oils, Volatile; Propanols; Rats; Safrole; Salmonella typhimurium | 1982 |
Characterization of the effects of known hepatic monooxygenase inducers on male and female rat and mouse kidneys.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Enzyme Induction; Kidney; Mice; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxygenases; Polychlorinated Biphenyls; Rats; Safrole | 1982 |
Role of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Safrole | 1982 |
Induction of cytochrome P-450 by methylenedioxyphenyl compounds: importance of the methylene carbon.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Ethylmorphine-N-Demethylase; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Nitriles; Oxidoreductases; Phenobarbital; Safrole; Structure-Activity Relationship | 1983 |
Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole.
Topics: Animals; Cloning, Molecular; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Female; Gene Expression Regulation; Kidney; Liver; Male; Methylcholanthrene; Mice; Nucleic Acid Hybridization; Phenobarbital; Polychlorinated Dibenzodioxins; RNA, Messenger; Safrole | 1983 |
Properties of the oxygenated form of liver microsomal cytochrome P-450.
Topics: Anaerobiosis; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Isomerism; Kinetics; Microsomes, Liver; Oxidation-Reduction; Rabbits; Safrole; Spectrophotometry | 1983 |
Amino-terminal and carboxy-terminal sequence of hepatic microsomal cytochrome P-450d, a unique hemoprotein from rats treated with isosafrole.
Topics: Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Dioxoles; Hemeproteins; Microsomes, Liver; Rats; Safrole | 1982 |
Metabolic-intermediate complex formation reveals major changes in rat hepatic cytochrome P-450 subpopulations in addition to those forms previously purified after phenobarbital, beta-naphthoflavone, and isosafrole induction.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dioxoles; Flavonoids; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1982 |
Metabolism of isosafrole and dihydrosafrole in the rat.
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, Gas; Dioxoles; Gas Chromatography-Mass Spectrometry; Male; Rats; Rats, Inbred Strains; Safrole | 1982 |
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics.
Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes | 1982 |
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Safrole | 1980 |
Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture.
Topics: Adult; Aged; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Female; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Nitrophenols; Oxazines; Oxidation-Reduction; Phenobarbital; Safrole; Substrate Specificity; Testosterone | 1995 |
The effect of varying halogen substituent patterns on the cytochrome P450 catalysed dehalogenation of 4-halogenated anilines to 4-aminophenol metabolites.
Topics: Aminophenols; Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Halogens; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Wistar; Safrole | 1995 |
Cytochrome P450 1A1 cDNA from plaice (Pleuronectes platessa) and induction of P450 1A1 mRNA in various tissues by 3-methylcholanthrene and isosafrole.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Flounder; Humans; Liver; Methylcholanthrene; Molecular Sequence Data; Organ Specificity; Restriction Mapping; RNA, Messenger; Safrole; Sequence Homology, Amino Acid | 1993 |
Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.
Topics: Animals; Bile; Corn Oil; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Liver; Male; Oxidoreductases, N-Demethylating; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred F344; Safrole; Time Factors; Tissue Distribution | 1993 |
Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomes.
Topics: Administration, Oral; Androstenedione; Animals; Anticarcinogenic Agents; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Growth Hormone; Indoles; Injections, Intraperitoneal; Kinetics; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Safrole; Sex Factors; Structure-Activity Relationship | 1993 |
Regulation of cytochrome P-450 isozymes by methylenedioxyphenyl compounds.
Topics: Animals; Base Sequence; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression; Isoenzymes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Sequence Data; Oligodeoxyribonucleotides; Oxidoreductases; Piperonyl Butoxide; Receptors, Aryl Hydrocarbon; Receptors, Drug; RNA, Messenger; Safrole | 1993 |
Cell-density-dependent expression of Cyp1a2 gene in monolayer-cultured adult mouse hepatocytes.
Topics: Animals; Blotting, Northern; Cell Count; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Liver; Methylcholanthrene; Mice; Mice, Inbred C57BL; Oxidoreductases; Polychlorinated Dibenzodioxins; RNA, Messenger; Safrole; Time Factors | 1993 |
Expression analysis of the mixed function oxidase system in rat brain by the polymerase chain reaction.
Topics: Amitriptyline; Animals; Base Sequence; Benzoflavones; beta-Naphthoflavone; Brain; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Imipramine; Isoenzymes; Male; Mixed Function Oxygenases; Molecular Sequence Data; Nerve Tissue Proteins; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Safrole | 1993 |
Effects of enzyme induction on the distribution of the food carcinogen 2-amino-3,8-dimethyl-imidazo[4,5-ss]-quinoxaline (MeIQx) in Ah-receptor- responsive- and Ah-receptor-non-responsive mice.
Topics: Animals; Carcinogens; Enzyme Induction; Hydroxylation; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Quinoxalines; Safrole; Species Specificity; Spleen; Tissue Distribution | 1995 |
Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Epoxide Hydrolases; Ethanol; Glucuronosyltransferase; Glutathione Transferase; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Safrole | 1996 |
The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Liver; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Necrosis; Plants; Safrole | 1996 |
In vitro metabolism of 7,12-dimethylbenz[a]anthracene by rainbow trout liver microsomes and trout P450 isoforms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta-Naphthoflavone; Biotransformation; Clofibrate; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Adducts; Drug Synergism; Ellipticines; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Microsomes, Liver; Oncorhynchus mykiss; Proteins; Safrole | 1997 |
Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole.
Topics: Cell Line; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Fluvoxamine; Humans; Liver; Safrole | 1997 |
The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dioxoles; Ferric Compounds; Kidney; Kidney Diseases; Lipid Peroxidation; Liver; Liver Diseases; Male; Mice; Microsomes, Liver; Necrosis; Nitrilotriacetic Acid; Rats; Rats, Sprague-Dawley; Safrole | 1997 |
Inhibition of 5,9-dimethyldibenzo[c,g]carbazole-DNA adduct formation in mouse liver by pretreatment with cytochrome P4501A inducers in vivo.
Topics: Animals; beta-Naphthoflavone; Carbazoles; Carcinogens; Cell Nucleus; Cytochrome P-450 Enzyme System; DNA Adducts; Enzyme Induction; Female; Glucuronosyltransferase; Glutathione Transferase; Liver; Mice; Mice, Inbred Strains; Polychlorinated Dibenzodioxins; Safrole | 1998 |
Interaction of isosafrole, beta-naphthoflavone and other CYP1A inducers in liver of rainbow trout (Oncorhynchus mykiss) and eelpout (Zoarces viviparus).
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Female; Fishes; Liver; Male; Safrole | 1998 |
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat.
Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole | 2000 |
Differential expression of two CYP1A genes in rainbow trout (Oncorhynchys mykiss).
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Blotting, Northern; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Induction; Female; Gene Expression Regulation; Liver; Male; Methylcholanthrene; Oncorhynchus mykiss; Polychlorinated Dibenzodioxins; Polymerase Chain Reaction; RNA, Messenger; Safrole; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid | 2000 |
Identification of cytochrome P450 isoform involved in the metabolism of YM992, a novel selective serotonin re-uptake inhibitor, in human liver microsomes.
Topics: Benzoflavones; Chromatography; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Kinetics; Microsomes, Liver; Models, Biological; Morpholines; Protein Binding; Protein Isoforms; Recombinant Proteins; Safrole; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists | 2000 |
In vitro biotransformation of xanthohumol, a flavonoid from hops (Humulus lupulus), by rat liver microsomes.
Topics: Animals; Beer; beta-Naphthoflavone; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Flavonoids; Kinetics; Magnetic Resonance Spectroscopy; Magnoliopsida; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Propiophenones; Rats; Safrole | 2001 |
Separation ability and stoichiometry of cyclodextrin complexes.
Topics: Allylbenzene Derivatives; Anisoles; Chromatography, Gas; Cyclodextrins; Naphthalenes; Safrole; Stereoisomerism | 2000 |
Inducibility of hepatic CYP1A enzymes by 3-methylcholanthrene and isosafrole differs in male rats fed diets containing casein, soy protein isolate or whey from conception to adulthood.
Topics: Aging; Animals; Blotting, Northern; Blotting, Western; Caseins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytosol; Dietary Proteins; Enzyme Induction; Female; Fertilization; Liver; Male; Methylcholanthrene; Milk Proteins; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Safrole; Soybean Proteins; Whey Proteins | 2001 |
Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole.
Topics: Animals; Antibodies; beta-Naphthoflavone; Catalysis; Chickens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Ellipticines; Enzyme Induction; Enzyme Inhibitors; Hepatocytes; Immunoblotting; Immunochemistry; Safrole; Species Specificity | 2001 |
Evidence for the involvement of CYP1A2 in the metabolism of bromodichloromethane in rat liver.
Topics: Alanine Transaminase; Animals; Blotting, Western; Bromides; Carcinogens; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Induction; Isoenzymes; L-Iditol 2-Dehydrogenase; Liver; Male; Microsomes, Liver; Models, Biological; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred F344; Safrole; Trihalomethanes | 2002 |
Microbiologic oxidation of isosafrole into piperonal.
Topics: Benzaldehydes; Benzodioxoles; Biotransformation; Chromatography, Gas; Cladosporium; Gas Chromatography-Mass Spectrometry; Isomerism; Oxidation-Reduction; Safrole | 2003 |
[Toxicity of cis-isosafrol & trans-isosafrol for the mouse].
Topics: Animals; Mice; Oils; Safrole | 1958 |
Olfactory receptor antagonism between odorants.
Topics: Animals; Animals, Newborn; Anisoles; Calcium; Cell Line; Dose-Response Relationship, Drug; Electrophysiology; Eugenol; Fluorescent Dyes; Humans; Isoproterenol; Mice; Mice, Inbred BALB C; Models, Biological; Odorants; Olfactory Mucosa; Olfactory Receptor Neurons; Receptors, Odorant; Reverse Transcriptase Polymerase Chain Reaction; Safrole; Smell; Structure-Activity Relationship | 2004 |
Forensic profiling of sassafras oils based on comprehensive two-dimensional gas chromatography.
Topics: Allylbenzene Derivatives; Benzaldehydes; Benzodioxoles; Benzyl Compounds; Cyclohexane Monoterpenes; Dioxolanes; Eugenol; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hallucinogens; Illicit Drugs; Molecular Structure; Monoterpenes; N-Methyl-3,4-methylenedioxyamphetamine; Phenols; Plant Oils; Pyrogallol; Safrole; Sassafras | 2013 |
Neuroscience. Metabolic control of epilepsy.
Topics: Animals; Anticonvulsants; Dioxolanes; Enzyme Inhibitors; L-Lactate Dehydrogenase; Safrole; Seizures | 2015 |
Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy.
Topics: Animals; Anticonvulsants; Dioxolanes; Disease Models, Animal; Enzyme Inhibitors; L-Lactate Dehydrogenase; Membrane Potentials; Mice; Mice, Inbred ICR; Neurons; Patch-Clamp Techniques; Safrole; Seizures; Subthalamic Nucleus | 2015 |
Inhibition of Lactate Dehydrogenase to Treat Epilepsy.
Topics: Animals; Anticonvulsants; Dioxolanes; Enzyme Inhibitors; Epilepsy; Humans; L-Lactate Dehydrogenase; Safrole | 2015 |
Highly Efficient Biosynthesis of Heliotropin by Engineered
Topics: Benzaldehydes; Benzodioxoles; Candida; Escherichia coli; Formate Dehydrogenases; Fungal Proteins; Metabolic Engineering; NAD; Oxygenases; Safrole | 2019 |