safrole has been researched along with estragole in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (45.45) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Caldwell, J; Chan, VS | 1 |
| Liem, A; Miller, EC; Miller, JA; Wiseman, RW | 1 |
| Miller, EC; Miller, JA | 2 |
| Haglund, RE; Phillips, DH; Randerath, K; Reddy, MV | 1 |
| Phillips, DH; Randerath, K; Reddy, MV | 1 |
| Sekizawa, J; Shibamoto, T | 1 |
| Fletcher, TL; Liem, A; Miller, EC; Miller, JA; Phillips, DH; Swanson, AB | 1 |
| Andersen, ME; Hunt, TP; To, LP | 1 |
| Miller, EC; Miller, JA; Swanson, AB | 1 |
| Delaforge, M; Janiaud, P; Levi, P; Morizot, JP | 1 |
| Phillips, DH | 1 |
| Alink, GM; Boersma, MG; Jeurissen, SM; Rietjens, IM; Schutte, ME; van der Woude, H | 1 |
| Boersma, MG; Bogaards, JJ; Cnubben, NH; Fiamegos, YC; Jeurissen, SM; Punt, A; Rietjens, IM; Schilter, B; van Bladeren, PJ | 1 |
| Delatour, T; Punt, A; Rietjens, IM; Schilter, B; Scholz, G; van Bladeren, PJ | 1 |
| Boersma, MG; Khadka, DB; Martati, E; Punt, A; Rietjens, IM; Spenkelink, A; van Bladeren, PJ; Vervoort, J | 1 |
| Bishop, ME; Davis, KJ; Ding, W; Duan, JD; Jeffrey, AM; Levy, DD; Lyn-Cook, LE; Manjanatha, MG; Pearce, MG; White, GA; Williams, GM | 1 |
| Galli, CL; La Fauci, P; Marabini, L; Marinovich, M | 1 |
| Garrido Frenich, A; López-Ruiz, R; Rivera-Pérez, A; Romero-González, R | 1 |
| Cohen, SM; Davidsen, JM; Eisenbrand, G; Fukushima, S; Gooderham, NJ; Guengerich, FP; Harman, CL; Hecht, SS; Murray, IJ; Rietjens, IMCM; Rosol, TJ; Taylor, SV | 1 |
| Kawai, T; Rietjens, IMCM; Wesseling, S; Yang, S | 1 |
| Dang, HNP; Quirino, JP | 1 |
3 review(s) available for safrole and estragole
| Article | Year |
|---|---|
The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole.
Topics: Adenine; Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Carcinogens, Environmental; Cricetinae; Cytidine; Dioxoles; DNA; Female; Flavoring Agents; Humans; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Rats; RNA; Safrole; Time Factors; Urethane | 1983 |
DNA adducts derived from safrole, estragole and related compounds, and from benzene and its metabolites.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Benzene; Carcinogens; DNA; DNA Adducts; Female; Flavoring Agents; Humans; Pregnancy; Safrole | 1994 |
Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk.
Topics: Allyl Compounds; Allylbenzene Derivatives; Animals; Anisoles; Carcinogens; Eugenol; Flavonoids; Mutagens; Quercetin; Rats; Safrole | 2005 |
19 other study(ies) available for safrole and estragole
| Article | Year |
|---|---|
Comparative induction of unscheduled DNA synthesis in cultured rat hepatocytes by allylbenzenes and their 1'-hydroxy metabolites.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Carcinogens; Cell Death; Cells, Cultured; DNA; Eugenol; Flavoring Agents; Hydroxylation; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Inbred F344; Safrole | 1992 |
Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice.
Topics: Age Factors; Allylbenzene Derivatives; Animals; Animals, Suckling; Anisoles; Chromatography, High Pressure Liquid; Dioxoles; Disease Susceptibility; Female; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Safrole; Sex Factors; Species Specificity; Structure-Activity Relationship | 1987 |
32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Benzene Derivatives; Biotransformation; Carcinogens; Dioxoles; DNA; Female; Liver; Mice; Mice, Inbred Strains; Pentachlorophenol; Phosphorus Radioisotopes; Safrole; Structure-Activity Relationship | 1984 |
32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F1 mice.
Topics: Allylbenzene Derivatives; Animals; Animals, Newborn; Anisoles; Benzene Derivatives; Carcinogens; Dioxoles; DNA; Female; Liver; Male; Mice; Mice, Inbred Strains; Phosphorus Radioisotopes; Safrole; Structure-Activity Relationship | 1984 |
Genotoxicity of safrole-related chemicals in microbial test systems.
Topics: 1-Propanol; Allylbenzene Derivatives; Animals; Anisoles; Bacillus subtilis; Benzaldehydes; Benzodioxoles; Dioxoles; DNA Repair; Escherichia coli; Eugenol; Mutagenicity Tests; Oils, Volatile; Propanols; Rats; Safrole; Salmonella typhimurium | 1982 |
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
Topics: Administration, Oral; Allylbenzene Derivatives; Animals; Anisoles; Dioxoles; Female; Injections, Intraperitoneal; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Rats; Rats, Inbred F344; Safrole; Structure-Activity Relationship | 1983 |
Mutagenicity of trans-anethole, estragole, eugenol, and safrole in the Ames Salmonella typhimurium assay.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Dioxoles; Eugenol; Mutagenicity Tests; Mutagens; Phosphoadenosine Phosphosulfate; Rats; Safrole; Salmonella typhimurium | 1982 |
The side-chain epoxidation and hydroxylation of the hepatocarcinogens safrole and estragole and some related compounds by rat and mouse liver microsomes.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Dioxoles; Epoxy Compounds; Flavoring Agents; Hydroxylation; Mice; Microsomes, Liver; Rats; Safrole; Species Specificity; Structure-Activity Relationship | 1981 |
Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules.
Topics: 2-Acetylaminofluorene; Aflatoxins; Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Carcinogens; Chemical Phenomena; Chemistry; Cocarcinogenesis; DNA; Humans; Liver; Macromolecular Substances; Neoplasms; Rats; Safrole | 1981 |
Biotransformation of allylbenzene analogues in vivo and in vitro through the epoxide-diol pathway.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Epoxy Compounds; Ethers, Cyclic; Eugenol; Gas Chromatography-Mass Spectrometry; Glycols; In Vitro Techniques; Liver; Male; Microsomes, Liver; Rats; Safrole | 1980 |
Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes.
Topics: Allylbenzene Derivatives; Anisoles; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Eugenol; Flavoring Agents; Humans; Hydroxylation; Microsomes, Liver; Safrole; Substrate Specificity | 2007 |
Tandem mass spectrometry analysis of N2-(trans-Isoestragol-3'-yl)-2'-deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1'-hydroxyestragole.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; Carcinogens; Chromatography, Liquid; Deoxyguanosine; Female; Humans; Kinetics; Liver; Male; Mice; Molecular Structure; Rats; Rats, Sprague-Dawley; Risk Factors; Safrole; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Subcellular Fractions; Sulfonic Acids; Sulfotransferases; Tandem Mass Spectrometry | 2007 |
Physiologically based biokinetic (PBBK) model for safrole bioactivation and detoxification in rats.
Topics: Allyl Compounds; Allylbenzene Derivatives; Animals; Anisoles; Benzene Derivatives; Cytochrome P-450 Enzyme System; Eugenol; Food Additives; Glucuronides; Kinetics; Male; Models, Biological; Mutagens; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Safrole | 2011 |
In vivo genotoxicity of estragole in male F344 rats.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Comet Assay; DNA Adducts; DNA Damage; DNA Glycosylases; Kidney; Liver; Male; Micronucleus Tests; Mutagenicity Tests; Rats, Inbred F344; Safrole; Stomach | 2015 |
Effect of plant extracts on the genotoxicity of 1'-hydroxy alkenylbenzenes.
Topics: Allylbenzene Derivatives; Anisoles; Benzene Derivatives; Comet Assay; Hep G2 Cells; Humans; Micronucleus Tests; Mutagens; Plant Extracts; Safrole | 2019 |
A new strategy based on gas chromatography-high resolution mass spectrometry (GC-HRMS-Q-Orbitrap) for the determination of alkenylbenzenes in pepper and its varieties.
Topics: Allylbenzene Derivatives; Anisoles; Benzene Derivatives; Benzyl Compounds; Chemical Fractionation; Dioxolanes; Eugenol; Food Analysis; Gas Chromatography-Mass Spectrometry; Piper nigrum; Pyrogallol; Safrole; Ultrasonics | 2020 |
FEMA GRAS assessment of natural flavor complexes: Clove, cinnamon leaf and West Indian bay leaf-derived flavoring ingredients.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Cinnamomum zeylanicum; Consumer Product Safety; Escherichia coli; Eugenol; Female; Flavoring Agents; Humans; Laurus; Male; Mice; Mutagenicity Tests; No-Observed-Adverse-Effect Level; Plant Oils; Rats; Safrole; Salmonella typhimurium; Syzygium | 2020 |
In vitro and in silico study on consequences of combined exposure to the food-borne alkenylbenzenes estragole and safrole.
Topics: Allylbenzene Derivatives; Anisoles; Carcinogens; DNA Adducts; Hep G2 Cells; Humans; Risk Assessment; Safrole | 2022 |
High Performance Liquid Chromatography versus Stacking-Micellar Electrokinetic Chromatography for the Determination of Potentially Toxic Alkenylbenzenes in Food Flavouring Ingredients.
Topics: Allylbenzene Derivatives; Anisoles; Chromatography, High Pressure Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Dioxolanes; Eugenol; Flavoring Agents; Food Ingredients; Safrole | 2021 |