safrole has been researched along with 1'-hydroxysafrole in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Borchert, P; Miller, EC; Miller, JA; Wislocki, PG | 1 |
| McCoy, EC; Miller, EC; Miller, JA; Rosenkranz, HS; Wislocki, PG | 1 |
| Boberg, EW; Liem, A; Miller, EC; Miller, JA | 1 |
| Disher, RM; Lu, LJ; Randerath, K | 1 |
| Miller, EC; Miller, JA | 1 |
| Boberg, EW; Delclos, KB; Fennell, TR; Lai, CC; Liem, A; Miller, EC; Miller, JA; Wiseman, RW | 1 |
| Fennell, TR; Miller, EC; Miller, JA; Wiseman, RW | 1 |
| Boberg, EW; Liem, A; Miller, EC; Miller, JA; Poland, A | 1 |
| Fennell, TR; Miller, EC; Miller, JA | 1 |
| Adams, B; Miller, EC; Miller, JA; Phillips, DH | 1 |
| Hanawalt, PC; Miller, EC; Miller, JA; Phillips, DH | 1 |
| Alink, GM; Awad, HM; Boersma, MG; Bogaards, JJ; Brand, W; Cnubben, NH; Fiamegos, YC; Jeurissen, SM; Rietjens, IM; Sudhölter, EJ; van Beek, TA | 1 |
| Chen, IH; Chi, CW; Chung, YT; Hsieh, LL; Liao, CT; Liou, SH; Liu, TY; Ueng, YF | 1 |
| Boersma, MG; Khadka, DB; Martati, E; Punt, A; Rietjens, IM; Spenkelink, A; van Bladeren, PJ; Vervoort, J | 1 |
| Kawai, T; Rietjens, IMCM; Wesseling, S; Yang, S | 1 |
1 review(s) available for safrole and 1'-hydroxysafrole
| Article | Year |
|---|---|
Sulfuric acid esters as ultimate electrophilic and carcinogenic metabolites of some alkenylbenzenes and aromatic amines in mouse liver.
Topics: 2-Acetylaminofluorene; Animals; Azo Compounds; Biotransformation; Carcinogens; Chemical Phenomena; Chemistry; Dioxoles; DNA, Neoplasm; Hydroxyacetylaminofluorene; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; p-Aminoazobenzene; Phosphoadenosine Phosphosulfate; Safrole; Sulfates; Sulfurtransferases | 1985 |
14 other study(ies) available for safrole and 1'-hydroxysafrole
| Article | Year |
|---|---|
The metabolic activation of the carcinogen 1'-hydroxysafrole in vivo and in vitro and the electrophilic reactivities of possible ultimate carcinogens.
Topics: Acetyltransferases; Animals; Carcinogens; Cricetinae; Cytosol; Dioxoles; DNA; Guanosine; In Vitro Techniques; Liver; Mice; Microsomes, Liver; NADP; Nucleosides; Oxidation-Reduction; Phosphoadenosine Phosphosulfate; Proteins; Rats; RNA, Ribosomal; Safrole; Sulfurtransferases | 1976 |
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Neoplasms; Mice; Mutagens; Mutation; Neoplasms, Experimental; Papilloma; Phenobarbital; Rats; Safrole; Salmonella typhimurium; Sarcoma, Experimental; Skin Neoplasms; Structure-Activity Relationship | 1977 |
Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.
Topics: Animals; Chick Embryo; Chlorophenols; Cocarcinogenesis; Diethylnitrosamine; Dioxoles; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Pentachlorophenol; Precancerous Conditions; Rats; Rats, Inbred Strains; Safrole | 1987 |
Differences in the covalent binding of benzo[a]pyrene, safrole, 1'-hydroxysafrole, and 4-aminobiphenyl to DNA of pregnant and non-pregnant mice.
Topics: Aminobiphenyl Compounds; Animals; Benzo(a)pyrene; Carcinogens; DNA; Female; Kidney; Liver; Lung; Mice; Mice, Inbred ICR; Pregnancy; Pregnancy, Animal; Safrole | 1986 |
Electrophilic sulfuric acid ester metabolites as ultimate carcinogens.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; DNA; Liver; Liver Neoplasms, Experimental; Male; Mice; Rats; Safrole; Structure-Activity Relationship; Sulfates | 1986 |
Further characterization of the DNA adducts formed by electrophilic esters of the hepatocarcinogens 1'-hydroxysafrole and 1'-hydroxyestragole in vitro and in mouse liver in vivo, including new adducts at C-8 and N-7 of guanine residues.
Topics: Animals; Anisoles; Carcinogens; Chromatography, High Pressure Liquid; Dioxoles; DNA; Guanine; In Vitro Techniques; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Safrole | 1985 |
Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver.
Topics: Animals; Carcinogens; Chlorophenols; Cytosol; Dioxoles; Female; Kinetics; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Pentachlorophenol; Phenotype; Rats; Safrole; Species Specificity; Sulfurtransferases | 1983 |
Characterization of the biliary and urinary glutathione and N-acetylcysteine metabolites of the hepatic carcinogen 1'-hydroxysafrole and its 1'-oxo metabolite in rats and mice.
Topics: Acetylcysteine; Animals; Bile; Chromatography, High Pressure Liquid; Dioxoles; Female; Glutathione; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry | 1984 |
N2 atom of guanine and N6 atom of adenine residues as sites for covalent binding of metabolically activated 1'-hydroxysafrole to mouse liver DNA in vivo.
Topics: Animals; Binding Sites; Biotransformation; Carcinogens; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Countercurrent Distribution; Dioxoles; DNA; Female; Injections, Intraperitoneal; Liver; Magnetic Resonance Spectroscopy; Mice; Proteins; RNA, Ribosomal; Safrole | 1981 |
The in vivo formation and repair of DNA adducts from 1'-hydroxysafrole.
Topics: Animals; Cell Line; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Dioxoles; DNA; DNA Repair; Female; Glioma; Humans; Magnetic Resonance Spectroscopy; Mice; Molecular Weight; Safrole | 1981 |
Human cytochrome p450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1'-hydroxysafrole.
Topics: Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Microsomes, Liver; Risk Assessment; Safrole; Statistics, Nonparametric; Substrate Specificity | 2004 |
Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Animals; Arylsulfotransferase; Carcinoma, Squamous Cell; Case-Control Studies; Chlorocebus aethiops; COS Cells; Genetic Predisposition to Disease; Haplotypes; Humans; Isoenzymes; Male; Middle Aged; Mouth Neoplasms; Naphthols; Polymorphism, Single Nucleotide; Risk Factors; Safrole; Smoking; Taiwan; Young Adult | 2009 |
Physiologically based biokinetic (PBBK) model for safrole bioactivation and detoxification in rats.
Topics: Allyl Compounds; Allylbenzene Derivatives; Animals; Anisoles; Benzene Derivatives; Cytochrome P-450 Enzyme System; Eugenol; Food Additives; Glucuronides; Kinetics; Male; Models, Biological; Mutagens; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Safrole | 2011 |
In vitro and in silico study on consequences of combined exposure to the food-borne alkenylbenzenes estragole and safrole.
Topics: Allylbenzene Derivatives; Anisoles; Carcinogens; DNA Adducts; Hep G2 Cells; Humans; Risk Assessment; Safrole | 2022 |