Page last updated: 2024-09-03

safinamide and istradefylline

safinamide has been researched along with istradefylline in 3 studies

Compound Research Comparison

Studies (safinamide)	Trials (safinamide)	Recent Studies (post-2010) (safinamide)	Studies (istradefylline)	Trials (istradefylline)	Recent Studies (post-2010) (istradefylline)
199	29	159	212	18	121

Protein Interaction Comparison

Protein	Taxonomy	safinamide (IC50)	istradefylline (IC50)
Adenosine receptor A2a	Homo sapiens (human)		5.249
Adenosine receptor A2a	Rattus norvegicus (Norway rat)		0.228

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (66.67)	24.3611
2020's	1 (33.33)	2.80

Authors

Authors	Studies
Gütschow, M; Heer, J; Hinz, S; Küppers, P; Müller, CE; Schlenk, M; Stössel, A	1
Akkari, R; Borrmann, T; Brunschweiger, A; Drabczyńska, A; Hockemeyer, J; Kieć-Kononowicz, K; Koch, P; Köse, M; Küppers, P; Müller, CE; Radjainia, H; Schlenk, M	1
Bhowmick, SS; Fox, SH; Gonzalez-Latapi, P; Saranza, G	1

Reviews

1 review(s) available for safinamide and istradefylline

Article	Year
Non-Dopaminergic Treatments for Motor Control in Parkinson's Disease: An Update. CNS drugs, 2020, Volume: 34, Issue:10 Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Drug Development; Drug Repositioning; Humans; Parkinson Disease; Purines; Zonisamide	2020

Other Studies

2 other study(ies) available for safinamide and istradefylline

Article	Year
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones. Journal of medicinal chemistry, 2013, Jun-13, Volume: 56, Issue:11 Topics: Adenosine A2 Receptor Antagonists; Animals; Benzothiadiazines; Brain; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Humans; In Vitro Techniques; Isoenzymes; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenylbutyrates; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Stereoisomerism; Structure-Activity Relationship; Thiazines	2013
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases. Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23 Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; CHO Cells; Cricetulus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Purinergic P1 Receptor Antagonists; Purines; Xanthines	2013

Article

Year

Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.

Journal of medicinal chemistry, 2013, Jun-13, Volume: 56, Issue:11

Topics: Adenosine A2 Receptor Antagonists; Animals; Benzothiadiazines; Brain; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Humans; In Vitro Techniques; Isoenzymes; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenylbutyrates; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Stereoisomerism; Structure-Activity Relationship; Thiazines

2013

1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.

Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23

Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; CHO Cells; Cricetulus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Purinergic P1 Receptor Antagonists; Purines; Xanthines

2013