safinamide has been researched along with clorgyline in 19 studies
| Studies (safinamide) | Trials (safinamide) | Recent Studies (post-2010) (safinamide) | Studies (clorgyline) | Trials (clorgyline) | Recent Studies (post-2010) (clorgyline) |
|---|---|---|---|---|---|
| 199 | 29 | 159 | 1,075 | 23 | 170 |
| Protein | Taxonomy | safinamide (IC50) | clorgyline (IC50) |
|---|---|---|---|
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | 0.8602 | |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | 0.5688 | |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | 0.2574 | |
| Amine oxidase [flavin-containing] A | Bos taurus (cattle) | 0.0032 | |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | 3.6869 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 10 (52.63) | 2.80 |
| Authors | Studies |
|---|---|
| Almos, T; Edmondson, DE; Massari, ME; Rojas, RJ; Scott, R | 1 |
| Cho, NC; Choi, JW; Han, G; Jang, BK; Ju, EJ; Kim, DJ; Lee, YS; Pae, AN; Park, JH; Park, KD; Yeon, SK | 1 |
| Alcaro, S; Borges, F; Cagide, F; Chavarria, D; Fernandes, C; Gaspar, A; Ortuso, F; Reis, J; Remião, F; Silva, T; Uriarte, E | 1 |
| Alcaro, S; Bagetta, D; Borges, F; Fonseca, A; Matos, MJ; Ortuso, F; Reis, J; Silva, T; Uriarte, E | 1 |
| Bahn, YS; Choi, JW; Han, G; Jang, BK; Kim, HJ; Kim, S; Lee, YR; Lee, YS; Pae, AN; Park, JH; Park, KD; Shin, SJ; Yeon, SK | 1 |
| Buchwalder, C; Devineau, A; Dullaghan, EM; Gealageas, R; Goebeler, V; Grierson, DS; Heller, M; Kim, CMJ; Putnins, EE; So, PPL; Surendradoss, J | 1 |
| Alcaro, S; Bagetta, D; Borges, F; Cagide, F; Oliveira, PJ; Ortuso, F; Pérez, C; Reis, J; Rodríguez-Franco, MI; Teixeira, J; Uriarte, E; Valencia, ME | 1 |
| Altomare, CD; Catto, M; Cellamare, S; Denora, N; Farina, R; Iacobazzi, RM; Pisani, L; Rullo, M | 1 |
| Cheng, K; Duan, Y; Han, J; Huang, X; Kong, H; Li, S; Liao, C; Lv, X; Tian, Y; Xie, Z | 1 |
| Borges, F; Chavarria, D; Fernandes, C; Gil-Martins, E; Oliveira, PJ; Remião, F; Silva, C; Silva, R; Silva, T; Silva, V; Soares, P | 1 |
| Abarbri, M; El Qami, A; Frlan, R; Gobec, S; Jismy, B; Knez, D; Kos, J; Pišlar, A | 1 |
| Chen, KZ; Hao, GF; Jin, CF; Wang, ZZ; Xu, TF | 1 |
| Acar Çevik, U; Kaplancıklı, ZA; Kaya Çavuşoğlu, B; Levent, S; Osmaniye, D; Özkay, Y; Sağlık, BN | 1 |
| Alcaro, S; Borges, F; Fernandes, C; Gaspar, A; Maruca, A; Mesiti, F; Remião, F; Rocca, R; Silva, V; Uriarte, E | 1 |
| Duan, Y; Han, J; Hou, R; Kong, H; Liao, C; Meng, X; Xie, Z; Yang, X | 1 |
| Hoshi, K; Kamauchi, H; Mabashi, R; Nagai, J; Sugita, Y; Takao, K; Takemura, Y; Uesawa, Y | 1 |
| Alcaro, S; Barreiro, S; Borges, F; Chavarria, D; Fernandes, C; Gaspar, A; Gil Martins, E; Gul, S; Keminer, O; Maruca, A; Mesiti, F; Rocca, R; Silva, R | 1 |
| Brandão, P; Burke, AJ; Fernández-Bolaños, JG; Leitzbach, L; López, Ó; Pineiro, M; Stark, H | 1 |
| Alcaro, S; Bagetta, D; Burke, AJ; Carreiro, EP; Fernández-Bolaños, JG; Hagenow, S; Leitzbach, L; López, Ó; Marques, C; Moutayakine, A; Stark, H | 1 |
19 other study(ies) available for safinamide and clorgyline
| Article | Year |
|---|---|
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
Topics: Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Small Molecule Libraries; Thermodynamics | 2015 |
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.
Topics: Binding Sites; Free Radical Scavengers; Humans; Hydrogen Peroxide; Ketones; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship | 2015 |
Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.
Topics: Cell Survival; Chromones; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured | 2016 |
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?
Topics: Alanine; Benzylamines; Chromones; Clorgyline; Coumarins; Humans; Indans; Kinetics; Ligands; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Selegiline; Structure-Activity Relationship | 2017 |
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzene Derivatives; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Structure-Activity Relationship | 2018 |
Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Dogs; Drug Development; Humans; Madin Darby Canine Kidney Cells; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nervous System Diseases | 2018 |
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.
Topics: Alzheimer Disease; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Chromones; Drug Design; Hep G2 Cells; Humans; Ligands; Molecular Docking Simulation; Molecular Targeted Therapy; Monoamine Oxidase; Monoamine Oxidase Inhibitors | 2018 |
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.
Topics: Acetylcholinesterase; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Molecular Conformation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Nitrates; Nitric Oxide; Rotenone; Structure-Activity Relationship | 2019 |
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Drug Design; Humans; Isatin; Molecular Dynamics Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Isoforms; Structure-Activity Relationship | 2019 |
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.
Topics: Alkaloids; Benzodioxoles; Caco-2 Cells; Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.
Topics: Antiparkinson Agents; Bromides; Coordination Complexes; Humans; Indazoles; Metals; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Neuroprotective Agents; Protein Binding; Small Molecule Libraries; Structure-Activity Relationship; Tyramine | 2021 |
Computational Fragment-Based Design Facilitates Discovery of Potent and Selective Monoamine Oxidase-B (MAO-B) Inhibitor.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alanine; Amides; Animals; Benzylamines; Binding Sites; Dopaminergic Neurons; Drug Design; Humans; Male; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease, Secondary; Protein Binding; Structure-Activity Relationship | 2020 |
Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors - design, synthesis, biological evaluation and molecular modelling.
Topics: | 2020 |
4-Oxoquinolines and monoamine oxidase: When tautomerism matters.
Topics: 4-Quinolones; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation.
Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Indenes; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship; Sulfhydryl Compounds | 2021 |
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.
Topics: Chromones; Dose-Response Relationship, Drug; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship; Recombinant Proteins | 2021 |
Mapping Chromone-3-Phenylcarboxamide Pharmacophore:
Topics: Cell Line; Chromones; Dose-Response Relationship, Drug; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2021 |
Ugi Reaction Synthesis of Oxindole-Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors.
Topics: | 2021 |
Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Horses; Kinetics; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2022 |