Page last updated: 2024-09-04

saccharopine and lysine

saccharopine has been researched along with lysine in 43 studies

Compound Research Comparison

Studies (saccharopine)	Trials (saccharopine)	Recent Studies (post-2010) (saccharopine)	Studies (lysine)	Trials (lysine)	Recent Studies (post-2010) (lysine)
44	0	21	37,449	622	11,213

Protein Interaction Comparison

Protein	Taxonomy	saccharopine (IC50)	lysine (IC50)
Cationic amino acid transporter 3	Homo sapiens (human)		158

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (18.60)	18.7374
1990's	8 (18.60)	18.2507
2000's	6 (13.95)	29.6817
2010's	15 (34.88)	24.3611
2020's	6 (13.95)	2.80

Authors

Authors	Studies
Chang, YF; Pan, X; Rao, VV	1
Divry, P; Mathieu, M; Vianey-Liaud, C	1
Broquist, HP; Harris, CM; Harris, TM; Wickwire, BM	1
Branski, D; Christensen, E; Elpeleg, ON; Hurvitz, H	1
Amrhein, N; Laber, B	1
Ameen, M; Palmer, T	2
Ameen, M; Oberholzer, VG; Palmer, T	1
Eckel, RE; Simonson, MS	1
Chang, YF	1
Alvarez, E; Esmahan, C; Martin, JF; Montenegro, E	1
Perry, D; Sim, KL	1
Higashino, K	1
Arruda, P; Cord-Neto, G; Kemper, EL; Langone, F; Papes, F	1
Galili, G; Tang, G; Tang, X; Zhu, X	1
Johansson, E; Lindqvist, Y; Schneider, G; Steffens, JJ	1
BROQUIST, HP; TRUPIN, JS	1
BROQUIST, HP; JONES, EE	1
Campoy, S; Casqueiro, J; Martín, JF; Naranjo, L; Valmaseda, EM	1
Berghuis, AM; Burk, DL; Dmitrienko, GI; Goodfellow, V; Hwang, J; Kwok, E; Marrone, L	1
Andi, B; Cook, PF; West, AH; Xu, H	1
Cook, PF; Vashishtha, AK; West, AH	1
Bobyk, KD; Cook, PF; Kim, SG; Kim, SK; Kumar, VP; West, AH	1
Chen, Z; Lan, Y; Liu, L; Liu, S; Ren, G; Shen, Y; Wan, J; Yang, C; Zhang, Y	1
Almasi, JN; Bushnell, EA; Gauld, JW	1
Arruda, P; Kiyota, E; Rezende e Silva Figueira, T; Serrano, GC; Zanata, N	1
Bland, RJ; Simpson, HV; Umair, S	1
Creamer, R; Dawe, AL; Mukherjee, S	1
Hoffmann, GF; Kölker, S; Mohr, H; Okun, JG; Opp, S; Posset, R; Sauer, SW; Struys, EA; Völkl, A	1
Fujimura, S; Kadowaki, M; Kobayashi, H; Kubota, M; Shibata, M; Watanabe, G	1
Biffoni, M; Cappellari, M; De Maria, R; Grande, S; Guidoni, L; Luciani, AM; Pallini, R; Palma, A; Ricci-Vitiani, L; Rosi, A; Runci, D; Viti, V	1
Ito, Y; Nagasawa, T; Sato, T	1
Arruda, P; Eberlin, MN; Laranjeira, ÂB; MacKenzie, A; Marques, LA; Pena, IA; Yunes, JA	1
Gabriel, I; Rychłowski, M	1
Ban, Z; Chang, Y; Gan, Q; Guo, W; Guo, Y; Jing, Y; Qian, W; Tang, R; Wang, F; Wang, G; Wang, M; Wang, X; Wu, S; Yang, C; Zhang, F; Zhang, Q; Zhao, L; Zhou, J	1
Houten, SM; Leandro, J	1
Crowther, LM; Mathis, D; Plecko, B; Poms, M	1
Aleshin, VA; Artiukhov, AV; Bunik, VI; Fernie, AR; Grabarska, A; Gumbarewicz, E; Kähne, T; Kazantsev, AV; Lukashev, NV; Obata, T; Stepulak, A	1
Baur, JA; Beier, UH; Concors, S; Denburg, MR; Gade, TP; Hancock, WW; Hartung, EA; Hernandez, PT; Levine, MH; Perry, C; Wang, Z	1
Baly, C; Gabory, A; Jammes, H; Jouin, M; Jouneau, L; Rousseau-Ralliard, D; Safi-Stibler, S; Seyer, A; Thévenot, EA	1
Gornbein, JA; Koos, BJ	1
Matthews, DE	1
Guo, W; Guo, Y; Jian, Y; Wang, M; Wang, X; Wu, J; Yang, C	1

Reviews

3 review(s) available for saccharopine and lysine

Article	Year
[Inborn errors of lysine metabolism]. Annales de biologie clinique, 1991, Volume: 49, Issue:1 Topics: 2-Aminoadipic Acid; Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Female; Glutarates; Humans; Infant; Infant, Newborn; Lysine; Male; Pipecolic Acids	1991
[Saccharopinuria (a variant form of familial hyperlysinemia)]. Ryoikibetsu shokogun shirizu, 1998, Issue:18 Pt 1 Topics: Amino Acid Metabolism, Inborn Errors; Biomarkers; Humans; Infant, Newborn; Lysine; NADP; Prognosis	1998
Review of Lysine Metabolism with a Focus on Humans. The Journal of nutrition, 2020, 10-01, Volume: 150, Issue:Suppl 1 Topics: 2-Aminoadipic Acid; Acetyl Coenzyme A; Ammonia; Animals; Bacteria; Body Weight; Deficiency Diseases; Diet; Gastrointestinal Microbiome; Humans; Lysine; Nitrogen; Nutritional Requirements; Nutritional Status; Proteins; Urea	2020

Other Studies

40 other study(ies) available for saccharopine and lysine

Article	Year
Developmental changes of L-lysine-ketoglutarate reductase in rat brain and liver. Comparative biochemistry and physiology. B, Comparative biochemistry, 1992, Volume: 103, Issue:1 Topics: Aging; Animals; Brain; Enzyme Induction; Gestational Age; Glucagon; Liver; Lysine; Rats; Rats, Sprague-Dawley; Saccharopine Dehydrogenases; Succinate Dehydrogenase	1992
Pipecolic acid biosynthesis in Rhizoctonia leguminicola. I. The lysine saccharopine, delta 1-piperideine-6-carboxylic acid pathway. The Journal of biological chemistry, 1990, Sep-05, Volume: 265, Issue:25 Topics: Lysine; Magnetic Resonance Spectroscopy; Mitosporic Fungi; Picolinic Acids; Pipecolic Acids; Rhizoctonia; Stereoisomerism	1990
Recurrent, familial Reye-like syndrome with a new complex amino and organic aciduria. European journal of pediatrics, 1990, Volume: 149, Issue:10 Topics: Adipates; Adolescent; Amino Acids; Female; Humans; Lysine; Male; Metabolism, Inborn Errors; Recurrence; Reye Syndrome	1990
A spectrophotometric assay for meso-diaminopimelate decarboxylase and L-alpha-amino-epsilon-caprolactam hydrolase. Analytical biochemistry, 1989, Volume: 181, Issue:2 Topics: Azepines; Bacterial Proteins; Caprolactam; Carbon Dioxide; Carboxy-Lyases; Lysine; NAD; Ninhydrin; Oxidation-Reduction; Saccharopine Dehydrogenases; Spectrophotometry, Ultraviolet	1989
Inhibition of urea cycle enzymes by lysine and saccharopine. Biochemistry international, 1987, Volume: 14, Issue:3 Topics: Animals; Arginase; Argininosuccinate Lyase; Argininosuccinate Synthase; Cattle; Kinetics; Ligases; Liver; Lyases; Lysine; Rats; Urea	1987
Inhibition of bovine liver lysine-ketoglutarate reductase by urea cycle metabolites and saccharopine. Biochemistry international, 1987, Volume: 14, Issue:4 Topics: Ammonia; Animals; Cattle; Citrulline; Humans; Lysine; Mitochondria, Liver; Oxidoreductases Acting on CH-NH Group Donors; Rats; Saccharopine Dehydrogenases; Species Specificity	1987
Enzymatic measurement of saccharopine with saccharopine dehydrogenase. Analytical biochemistry, 1985, May-15, Volume: 147, Issue:1 Topics: Animals; Electrophoresis, Paper; Liver; Lysine; Male; NAD; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Inbred Strains; Saccharopine Dehydrogenases	1985
Enzyme inhibition as a possible cause of secondary increases in metabolite levels in patients with inborn errors of metabolism. Journal of inherited metabolic disease, 1980, Volume: 3, Issue:3 Topics: Amino Acid Metabolism, Inborn Errors; Ammonium Chloride; Ammonium Sulfate; Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Argininosuccinic Acid; Cattle; Citrulline; Ligases; Liver; Lyases; Lysine; Rats; Swine	1980
Lysine metabolism in the human and the monkey: demonstration of pipecolic acid formation in the brain and other organs. Neurochemical research, 1982, Volume: 7, Issue:5 Topics: 2-Aminoadipic Acid; Adult; Animals; Brain; Female; Humans; Kidney; Liver; Lysine; Macaca mulatta; Pipecolic Acids; Spinal Cord	1982
Catabolism of lysine in Penicillium chrysogenum leads to formation of 2-aminoadipic acid, a precursor of penicillin biosynthesis. Applied and environmental microbiology, 1994, Volume: 60, Issue:6 Topics: 2-Aminoadipic Acid; Lysine; Penicillins; Penicillium chrysogenum; Pipecolic Acids	1994
Analysis of swainsonine and its early metabolic precursors in cultures of Metarhizium anisopliae. Glycoconjugate journal, 1997, Volume: 14, Issue:5 Topics: 2-Aminoadipic Acid; Chromatography, High Pressure Liquid; Lysine; Mitosporic Fungi; Pipecolic Acids; Swainsonine	1997
Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. The Biochemical journal, 1999, Dec-01, Volume: 344 Pt 2 Topics: Amino Acid Sequence; Animals; Gene Expression Regulation, Enzymologic; Gene Library; Kidney; Liver; Lysine; Mice; Molecular Sequence Data; Multienzyme Complexes; Saccharopine Dehydrogenases; Sequence Homology, Amino Acid; Starvation; Tissue Distribution	1999
A novel composite locus of Arabidopsis encoding two polypeptides with metabolically related but distinct functions in lysine catabolism. The Plant journal : for cell and molecular biology, 2000, Volume: 23, Issue:2 Topics: Amino Acid Sequence; Arabidopsis; Base Sequence; Genes, Plant; Lysine; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger; Saccharopine Dehydrogenases; Sequence Alignment; Sequence Homology, Nucleic Acid; TATA Box; Transcription, Genetic	2000
Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis. Structure (London, England : 1993), 2000, Oct-15, Volume: 8, Issue:10 Topics: 2-Aminoadipic Acid; Amino Acid Sequence; Binding Sites; Catalysis; Crystallography, X-Ray; Dimerization; Fungal Proteins; Hydrogen Bonding; Ligands; Lysine; Magnaporthe; Models, Molecular; Molecular Sequence Data; NADP; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Saccharopine Dehydrogenases	2000
SACCHAROPINE, AN INTERMEDIATE OF THE AMINOADIPIC ACID PATHWAY OF LYSINE BIOSYNTHESIS. I. STUDIES IN NEUROSPORA CRASSA. The Journal of biological chemistry, 1965, Volume: 240 Topics: Adipates; Aldehydes; Amino Acids; Electrophoresis; Infrared Rays; Ketoglutaric Acids; Lysine; Molecular Biology; Mutation; Neurospora; Neurospora crassa; Research; Spectrophotometry	1965
SACCHAROPINE, AN INTERMEDIATE OF THE AMINOADIPIC ACID PATHWAY OF LYSINE BIOSYNTHESIS. II. STUDIES IN SACCHAROMYCES CEREVISEAE. The Journal of biological chemistry, 1965, Volume: 240 Topics: Adipates; Aldehydes; Amino Acid Oxidoreductases; Amino Acids; Biochemical Phenomena; Biochemistry; Chromatography; Lysine; Molecular Biology; Mutation; Research; Saccharomyces; Spectrophotometry	1965
Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase. Molecular genetics and genomics : MGG, 2005, Volume: 274, Issue:3 Topics: 2-Aminoadipic Acid; Amino Acid Sequence; Base Sequence; Chromatography, High Pressure Liquid; Lysine; Molecular Sequence Data; Penicillins; Penicillium chrysogenum; Saccharopine Dehydrogenases; Sequence Analysis, DNA; Transaminases	2005
Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae. Journal of molecular biology, 2007, Oct-26, Volume: 373, Issue:3 Topics: Alanine Dehydrogenase; Amino Acid Sequence; Binding Sites; Catalysis; Crystallography, X-Ray; Lysine; Models, Molecular; Molecular Sequence Data; NAD; Protein Conformation; Saccharomyces cerevisiae; Saccharopine Dehydrogenases; Sequence Homology, Amino Acid	2007
Crystal structures of ligand-bound saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry, 2007, Nov-06, Volume: 46, Issue:44 Topics: Binding Sites; Crystallography, X-Ray; Ligands; Lysine; Models, Biological; Models, Molecular; Protein Binding; Saccharomyces cerevisiae; Saccharopine Dehydrogenases	2007
Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae. Biochemistry, 2009, Jun-30, Volume: 48, Issue:25 Topics: Deuterium Exchange Measurement; Hydrogen-Ion Concentration; Kinetics; Lysine; NADP; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Saccharopine Dehydrogenases; Solvents	2009
The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH. Archives of biochemistry and biophysics, 2011, Sep-15, Volume: 513, Issue:2 Topics: Amino Acid Substitution; Apoenzymes; Base Sequence; Catalytic Domain; Cysteine; Deuterium Exchange Measurement; DNA, Fungal; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; NAD; Oxidation-Reduction; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Saccharopine Dehydrogenases; Sulfhydryl Compounds	2011
Mutation of OsALDH7 causes a yellow-colored endosperm associated with accumulation of oryzamutaic acid A in rice. Planta, 2012, Volume: 235, Issue:2 Topics: Acids; Aldehyde Dehydrogenase; Alkaloids; Amino Acid Sequence; Chromosome Mapping; Chromosomes, Plant; Cloning, Molecular; Endosperm; Gene Expression Regulation, Plant; Genes, Plant; Genetic Vectors; Glutamic Acid; Lysine; Molecular Sequence Data; Mutation; Oryza; Pigmentation; Pigments, Biological; Transformation, Genetic; Yeasts	2012
A QM/MM-based computational investigation on the catalytic mechanism of saccharopine reductase. Molecules (Basel, Switzerland), 2011, Oct-12, Volume: 16, Issue:10 Topics: 2-Aminoadipic Acid; Catalysis; Glutamic Acid; Lysine; Magnaporthe; NADP; Saccharopine Dehydrogenases	2011
Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes. FEBS letters, 2012, Mar-23, Volume: 586, Issue:6 Topics: Amino Acid Sequence; Animals; Arabidopsis; Bacteria; Humans; Lysine; Molecular Sequence Data; Phylogeny; Protein Structure, Tertiary; Recombinant Proteins; Saccharopine Dehydrogenases; Sequence Alignment	2012
Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta. Experimental parasitology, 2012, Volume: 131, Issue:1 Topics: Animals; Cadaverine; Haemonchus; Hydrogen-Ion Concentration; Kinetics; Larva; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Pipecolic Acids; Saccharopine Dehydrogenases; Trichostrongyloidea	2012
Potential role for saccharopine reductase in swainsonine metabolism in endophytic fungus, Undifilum oxytropis. Fungal biology, 2012, Volume: 116, Issue:8 Topics: Ascomycota; Biosynthetic Pathways; Endophytes; Fungal Proteins; Lysine; Molecular Sequence Data; Mucoproteins; Oxytropis; Saccharopine Dehydrogenases; Swainsonine	2012
Understanding cerebral L-lysine metabolism: the role of L-pipecolate metabolism in Gcdh-deficient mice as a model for glutaric aciduria type I. Journal of inherited metabolic disease, 2015, Volume: 38, Issue:2 Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; Deamination; Disease Models, Animal; Genetic Predisposition to Disease; Glutaryl-CoA Dehydrogenase; Liver; Lysine; Mice, Knockout; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Peroxisomes; Phenotype; Pipecolic Acids	2015
Regulation of free glutamate content in meat by dietary lysine in broilers. Animal science journal = Nihon chikusan Gakkaiho, 2015, Volume: 86, Issue:4 Topics: 2-Aminoadipic Acid; Animal Feed; Animals; Chickens; Dietary Supplements; Female; Food Quality; Glutamic Acid; Liver; Lysine; Meat; Muscles; Pipecolic Acids; RNA, Messenger; Saccharopine Dehydrogenases	2015
(1) H NMR spectroscopy of glioblastoma stem-like cells identifies alpha-aminoadipate as a marker of tumor aggressiveness. NMR in biomedicine, 2015, Volume: 28, Issue:3 Topics: 2-Aminoadipic Acid; Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Cell Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Lysine; Male; Metabolic Networks and Pathways; Mitochondria; Multivariate Analysis; Neoplasm Invasiveness; Neoplastic Stem Cells; Proton Magnetic Resonance Spectroscopy; Signal Processing, Computer-Assisted	2015
Attenuation of autophagic-proteolysis in C2C12 cells by saccharopine. Molecular and cellular biochemistry, 2015, Volume: 410, Issue:1-2 Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy; Carrier Proteins; Cell Cycle Proteins; Cell Line; Eukaryotic Initiation Factors; Kinetics; Lysine; Methylhistidines; Mice; Microtubule-Associated Proteins; Muscle Fibers, Skeletal; Muscular Atrophy; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proteolysis; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases	2015
Mouse lysine catabolism to aminoadipate occurs primarily through the saccharopine pathway; implications for pyridoxine dependent epilepsy (PDE). Biochimica et biophysica acta. Molecular basis of disease, 2017, Volume: 1863, Issue:1 Topics: 2-Aminoadipic Acid; Animals; Epilepsy; Female; Lysine; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Picolinic Acids; Pyridoxal Phosphate	2017
Consequences of lysine auxotrophy for Candida albicans adherence and biofilm formation. Acta biochimica Polonica, 2017, Volume: 64, Issue:2 Topics: Animals; Biofilms; Candida albicans; Cell Adhesion; Epithelial Cells; Gene Expression Regulation, Fungal; Humans; Lysine; Mice; NIH 3T3 Cells	2017
The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. The Journal of cell biology, 2019, 02-04, Volume: 218, Issue:2 Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Homeostasis; Hyperlysinemias; Lysine; Mice; Mitochondria, Liver; Mutation; Saccharopine Dehydrogenases	2019
Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. The Journal of cell biology, 2019, 02-04, Volume: 218, Issue:2 Topics: Animals; Homeostasis; Lysine; Mice; Mitochondria; Saccharomyces cerevisiae	2019
New insights into human lysine degradation pathways with relevance to pyridoxine-dependent epilepsy due to antiquitin deficiency. Journal of inherited metabolic disease, 2019, Volume: 42, Issue:4 Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Epilepsy; Humans; Lysine; Metabolic Networks and Pathways; Pipecolic Acids; Vitamin B 6	2019
Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues. Scientific reports, 2020, 02-05, Volume: 10, Issue:1 Topics: Adipates; Animals; Enzyme Assays; Humans; Ketoglutarate Dehydrogenase Complex; Ketone Oxidoreductases; Lysine; Male; MCF-7 Cells; Niacin; Oxidation-Reduction; Phosphorylation; Rats; RNA-Seq	2020
Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection. Metabolomics : Official journal of the Metabolomic Society, 2020, 05-04, Volume: 16, Issue:5 Topics: Animals; Disease Models, Animal; Female; Graft Rejection; Kidney; Kidney Transplantation; Kynurenine; Lysine; Metabolomics; Mice; Mice, Inbred C57BL; Reperfusion Injury; Succinates	2020
Differential Effects of Post-Weaning Diet and Maternal Obesity on Mouse Liver and Brain Metabolomes. Nutrients, 2020, May-28, Volume: 12, Issue:6 Topics: 3-Hydroxybutyric Acid; Animals; Anserine; Brain; Deoxyglucose; Diet; Energy Metabolism; Female; Homeostasis; Liver; Lysine; Male; Maternal Nutritional Physiological Phenomena; Maternal-Fetal Exchange; Metabolome; Mice, Inbred C57BL; Obesity, Maternal; Pregnancy; Prenatal Exposure Delayed Effects; Weaning	2020
Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming. American journal of obstetrics and gynecology, 2021, Volume: 224, Issue:2 Topics: Adult; Alanine; Arginine; Carnitine; Case-Control Studies; Diabetes, Gestational; Diet Therapy; Dopamine; Early Diagnosis; Epigenesis, Genetic; Female; Fetal Development; Gestational Age; Glucose Tolerance Test; Glucuronides; Humans; Hypoglycemic Agents; Lactones; Lysine; Meglutol; Metabolomics; Neopterin; Orotic Acid; Phenols; Pregnancy; Ribonucleosides; Sulfides	2021
The Metabolite Saccharopine Impairs Neuronal Development by Inhibiting the Neurotrophic Function of Glucose-6-Phosphate Isomerase. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022, 03-30, Volume: 42, Issue:13 Topics: Animals; Female; Glucose-6-Phosphate Isomerase; Hyperlysinemias; Lysine; Male; Mice; Saccharopine Dehydrogenases	2022