Compounds > s-methyl diethylthiocarbamate
Page last updated: 2024-09-03

s-methyl diethylthiocarbamate and disulfiram

s-methyl diethylthiocarbamate has been researched along with disulfiram in 6 studies

Compound Research Comparison

Studies
(s-methyl diethylthiocarbamate)		Trials
(s-methyl diethylthiocarbamate)		Recent Studies (post-2010)
(s-methyl diethylthiocarbamate)		Studies
(disulfiram)		Trials
(disulfiram)		Recent Studies (post-2010) (disulfiram)
11133,776175723

Protein Interaction Comparison

ProteinTaxonomys-methyl diethylthiocarbamate (IC50)disulfiram (IC50)
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium berghei10.1
Spike glycoproteinBetacoronavirus England 19.35
Replicase polyprotein 1abBetacoronavirus England 19.35
type-1 angiotensin II receptorHomo sapiens (human)6.637
perilipin-5Homo sapiens (human)1.622
perilipin-1Homo sapiens (human)6.959
apelin receptorHomo sapiens (human)2.63
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)4.2905
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferaseMycobacterium tuberculosis H37Rv85.03
Transmembrane protease serine 2Homo sapiens (human)9.35
Bile salt export pumpHomo sapiens (human)10
Carbamate kinaseGiardia intestinalis0.6
Retinal dehydrogenase 1Homo sapiens (human)0.13
Aldehyde dehydrogenase, mitochondrialHomo sapiens (human)3.4
Cytochrome P450 1A2Homo sapiens (human)4
Procathepsin LHomo sapiens (human)9.35
Alpha-2A adrenergic receptorHomo sapiens (human)4.904
Fructose-1,6-bisphosphatase 1Homo sapiens (human)1.3756
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus9.35
Replicase polyprotein 1abHuman coronavirus 229E9.35
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus9.35
Adenosine receptor A3Homo sapiens (human)0.356
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 26.9171
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.356
Alpha-2B adrenergic receptorHomo sapiens (human)3.218
D(1A) dopamine receptorHomo sapiens (human)2.158
D(4) dopamine receptorHomo sapiens (human)3.15
C-X-C chemokine receptor type 2Homo sapiens (human)6.013
Mitogen-activated protein kinase 3 Homo sapiens (human)1.51
Protein-lysine 6-oxidaseHomo sapiens (human)0.32
Lysine-specific demethylase 5AHomo sapiens (human)10
Caspase-1Homo sapiens (human)1.8
Mu-type opioid receptorHomo sapiens (human)3.511
D(3) dopamine receptorHomo sapiens (human)1.084
Kappa-type opioid receptorHomo sapiens (human)6.103
C-C chemokine receptor type 2Homo sapiens (human)2.468
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.356
C-C chemokine receptor type 4Homo sapiens (human)8.395
Gasdermin-DHomo sapiens (human)0.4
Lysyl oxidase homolog 3Homo sapiens (human)0.093
Spike glycoproteinSevere acute respiratory syndrome-related coronavirus9.35
Sodium-dependent dopamine transporter Homo sapiens (human)4.637
NACHT, LRR and PYD domains-containing protein 3 Mus musculus (house mouse)3
Lysyl oxidase homolog 4Homo sapiens (human)0.059
Histone-lysine N-methyltransferase EHMT2Homo sapiens (human)0.6
Monoglyceride lipaseHomo sapiens (human)0.8095
Angiotensin-converting enzyme 2 Homo sapiens (human)9.35
Gasdermin-DMus musculus (house mouse)0.4
Histone-lysine N-methyltransferase EHMT1Homo sapiens (human)1.6
Lysyl oxidase homolog 2Homo sapiens (human)0.15
large T antigenBetapolyomavirus macacae10.73

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (83.33)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kitson, TM1
Fauq, AH; Lipsky, JJ; Mays, DC; Naylor, S; Nelson, AN; Shriver, ZH; Veverka, KA1
Faiman, MD; Madan, A; Nagendra, SN1
Faiman, MD; Madan, A; Parkinson, A2
Hochreiter, J; Lapham, J; Ma, Q; McCance-Katz, EF; Morse, GD1

Other Studies

6 other study(ies) available for s-methyl diethylthiocarbamate and disulfiram

ArticleYear
Effect of some thiocarbamate compounds on aldehyde dehydrogenase and implications for the disulfiram ethanol reaction.
    The Biochemical journal, 1991, Aug-15, Volume: 278 ( Pt 1)

    Topics: Aldehyde Dehydrogenase; Animals; Carbamates; Disulfides; Disulfiram; Ditiocarb; Kinetics; Liver; Sheep; Thiocarbamates

1991
S-methyl N,N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low Km mitochondrial aldehyde dehydrogenase.
    Biochemical pharmacology, 1995, Mar-01, Volume: 49, Issue:5

    Topics: Aldehyde Dehydrogenase; Animals; Disulfiram; Dithiothreitol; Enzyme Reactivators; Glutathione; Kinetics; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Sulfones; Thiocarbamates

1995
S-methyl N,N-diethylthiolcarbamate sulfone, an in vitro and in vivo inhibitor of rat liver mitochondrial low Km aldehyde dehydrogenase.
    Biochemical pharmacology, 1994, Apr-20, Volume: 47, Issue:8

    Topics: Aldehyde Dehydrogenase; Animals; Disulfiram; Ditiocarb; Male; Mitochondria, Liver; Oxidation-Reduction; Rats; Thiocarbamates

1994
Role of flavin-dependent monooxygenases and cytochrome P450 enzymes in the sulfoxidation of S-methyl N,N-diethylthiolcarbamate.
    Biochemical pharmacology, 1993, Dec-14, Volume: 46, Issue:12

    Topics: Animals; Antibodies; Biotransformation; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Male; Microsomes, Liver; Oxygenases; Rats; Rats, Sprague-Dawley; Sulfoxides; Thiocarbamates

1993
Identification of the human and rat P450 enzymes responsible for the sulfoxidation of S-methyl N,N-diethylthiolcarbamate (DETC-ME). The terminal step in the bioactivation of disulfiram.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:10

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Humans; Male; Microsomes, Liver; Rabbits; Rats; Thiocarbamates

1995
Disulfiram metabolite S-methyl-N,N-diethylthiocarbamate quantitation in human plasma with reverse phase ultra performance liquid chromatography and mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, May-15, Volume: 897

    Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Disulfiram; Drug Stability; Humans; Mass Spectrometry; Reproducibility of Results; Thiocarbamates

2012