s-farnesylcysteine has been researched along with prenylcysteine* in 1 studies
1 other study(ies) available for s-farnesylcysteine and prenylcysteine
Article | Year |
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Solid-phase synthesis of prenylcysteine analogs.
Prenylcysteine derivatives are of interest for a variety of different biological reasons, including probing the CaaX protein processing pathway. A solid-phase synthesis protocol for the preparation of prenylcysteines using 2-chlorotrityl chloride resin as a solid support has been developed. A series of novel amide-modified farnesylcysteine analogs were synthesized in both high purity and yield under mild conditions. The farnesylcysteine analogs were evaluated using human isoprenylcysteine carboxyl methyltransferase as a biological target, and several new inhibitors, one with significantly enhanced potency, were identified. Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cysteine; Humans; Molecular Structure; Protein Methyltransferases; Solid Phase Extraction; Trityl Compounds | 2009 |