s-farnesylcysteine and prenylcysteine

s-farnesylcysteine has been researched along with prenylcysteine* in 1 studies

Other Studies

1 other study(ies) available for s-farnesylcysteine and prenylcysteine

ArticleYear
Solid-phase synthesis of prenylcysteine analogs.
    The Journal of organic chemistry, 2009, Apr-17, Volume: 74, Issue:8

    Prenylcysteine derivatives are of interest for a variety of different biological reasons, including probing the CaaX protein processing pathway. A solid-phase synthesis protocol for the preparation of prenylcysteines using 2-chlorotrityl chloride resin as a solid support has been developed. A series of novel amide-modified farnesylcysteine analogs were synthesized in both high purity and yield under mild conditions. The farnesylcysteine analogs were evaluated using human isoprenylcysteine carboxyl methyltransferase as a biological target, and several new inhibitors, one with significantly enhanced potency, were identified.

    Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cysteine; Humans; Molecular Structure; Protein Methyltransferases; Solid Phase Extraction; Trityl Compounds

2009