s-benzyl-phenylmethanethiosulfinate has been researched along with allicin* in 1 studies
1 other study(ies) available for s-benzyl-phenylmethanethiosulfinate and allicin
| Article | Year |
|---|---|
Allicin and derivates are cysteine protease inhibitors with antiparasitic activity.
Allicin and derivatives thereof inhibit the CAC1 cysteine proteases falcipain 2, rhodesain, cathepsin B and L in the low micromolar range. The structure-activity relationship revealed that only derivatives with primary carbon atom in vicinity to the thiosulfinate sulfur atom attacked by the active-site Cys residue are active against the target enzymes. Some compounds also show potent antiparasitic activity against Plasmodium falciparum and Trypanosoma brucei brucei. Topics: Animals; Antiparasitic Agents; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disulfides; Garlic; Humans; Malaria, Falciparum; Plasmodium falciparum; Sulfinic Acids; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |