s-adenosylmethionine has been researched along with s-adenosylhomocysteine in 741 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 198 (26.72) | 18.7374 |
| 1990's | 133 (17.95) | 18.2507 |
| 2000's | 194 (26.18) | 29.6817 |
| 2010's | 190 (25.64) | 24.3611 |
| 2020's | 26 (3.51) | 2.80 |
| Authors | Studies |
|---|---|
| Butt, VS; Poulton, JE | 2 |
| Cook, DE; Dang, AQ | 1 |
| Casellas, P; Jeanteur, P | 1 |
| Barailler, J; Cronenberger, L; Fonlupt, P; Pacheco, H; Roche, M | 1 |
| Ghosh, HP; Toneguzzo, F | 1 |
| Kuchino, Y; Nishimura, S; Yasuda, T | 1 |
| Busch, H; Gupta, KK; Hirsch, F; Rao, M; Spohn, W; Wu, BC | 1 |
| Banerjee, AK; Testa, D | 1 |
| Duncan, GS; Wolberg, G; Zimmerman, TP | 1 |
| Lawrence, F; Lederer, E; Robert-Gero, M; Vedel, M | 1 |
| Kredich, NM; Pike, MC; Snyderman, R | 2 |
| Pegg, AE | 1 |
| Furuichi, Y | 1 |
| Mertens, PP; Payne, CC | 2 |
| Cornatzer, WE; Duerre, JA; Hoffman, DR | 1 |
| Johnston, JM; Kredich, NM | 1 |
| Cantoni, GL; Chiang, PK | 1 |
| Brown, GE; Desrosiers, RC; Lebleu, B; Lengyel, P; Sen, GC; Shaila, S | 1 |
| Acierno, P; Errera, M; Giudice, G; Pirrone, AM; Spinelli, G | 1 |
| Mitsuda, H; Nadamoto, T; Nakajima, K | 1 |
| Nishimura, S; Tanaka, Y; Taya, Y | 1 |
| Eloranta, TO | 1 |
| Eloranta, TO; Raina, AM | 1 |
| Fuller, RW; Lee, HS; Schulz, AR | 1 |
| Reilly, MA; Schayer, RW | 1 |
| Mack, JP; Slaytor, MB | 1 |
| Borchardt, RT; Wu, BS; Wu, YS | 3 |
| Farrugia, G; Lederer, E; Legreverend, M; Michelot, R | 1 |
| Hoffman, JL | 1 |
| Cantoni, GL; Chiang, PK; Richards, HH | 1 |
| Farris, DA; Levin, KH; Samuel, CE | 1 |
| Kerr, SJ; Trewyn, RW | 1 |
| Ito, S; Nicol, JA | 1 |
| Altman, NH; Brada, Z; Bulba, S | 1 |
| Legraverend, M; Michelot, R | 1 |
| Borchardt, RT; Huber, JA; Wu, YS | 1 |
| Borchardt, RT; Huber, JA; Shiong, Y; Wycpalek, AF | 1 |
| Samuel, CE | 1 |
| Eloranta, TO; Kajander, EO; Raina, AM | 2 |
| Colonno, RJ; Stone, HO | 1 |
| Chargaff, E; Gambino-Giuffrida, A; Stavrianopoulos, JG | 1 |
| Cotton, RC; Danks, DM; Goldsmith, D; Patrick, MG | 1 |
| Schatz, RA; Sellinger, OZ | 1 |
| Both, GW; Furuichi, Y; Muthukrishnan, S; Shatkin, AJ | 1 |
| Pearson, AG; Turner, AJ | 1 |
| Martin, SA; Moss, B | 1 |
| Both, GW; Filipowicz, W; Muthukrishnan, S; Ochoa, S; Shatkin, AJ; Sierra, JM | 1 |
| Hoffman, J | 1 |
| Keating, JN; Kennedy, DG; Kennedy, S; Molloy, AM; Scott, JM; Weir, DG; Young, PB | 1 |
| Kiss, A; Szilák, L; Venetianer, P | 1 |
| Aarbakke, J; Andersen, A; Loennechen, T; Moens, U; Nilsen, IW | 1 |
| Kennedy, DG; Kennedy, S; Molloy, AM; Orsi, B; Scott, JM; Weir, DG | 1 |
| Andriamampandry, C; Kanfer, JN; Massarelli, R | 1 |
| Ballinger, MD; Eliasson, R; Harder, J; Pontis, E; Reichard, P | 1 |
| Szumlanski, CL; Van Loon, JA; Weinshilboum, RM | 1 |
| Poirier, LA; Wainfan, E | 1 |
| Follmann, H; Hogenkamp, HP; McFarlan, SC; Spormann, A; Sze, IS | 1 |
| Chmurzynska, W; Grzelakowska-Sztabert, B; Manteuffel-Cymborowska, M | 1 |
| Schalinske, KL; Steele, RD | 2 |
| Balaghi, M; Wagner, C | 1 |
| Fullerton, FR; Hathcock, JN; Poirier, LA; Reicks, MM; Whittaker, P | 1 |
| Keating, JN; Mulcahy, F; Scott, JM; Trimble, KC; Weir, DG | 1 |
| Daino, L; Feo, F; Lai, P; Pascale, R; Ruggiu, ME; Satta, G; Seddaiu, MA; Sequenza, MJ; Simile, MM; Vannini, MG | 1 |
| Chagoya de Sánchez, V; Hernández-Muñoz, R; Sánchez, L; Suárez, J; Vidrio, S; Yáñez, L | 1 |
| Carl, GF; Eto, I; Furman, GM; Krumdieck, CL; Schatz, RA; Smith, ML | 1 |
| Dixon, RA; Edwards, R | 1 |
| Cañada, FJ; Pérez-Sala, D; Rando, RR; Tan, EW | 1 |
| Guattari, B | 1 |
| Isobe, R; Kang, D; Minakami, S; Takeshige, K | 1 |
| Balzarini, J; Cools, M; De Clercq, E | 1 |
| Edelstein, SR; Gross, LA; Johnson, MA; Richardson, BC; Scheinbart, LS | 1 |
| Fell, D; Selhub, J | 1 |
| Dubnau, D; Su, SL | 1 |
| Cordier, G; Fonlupt, P; Gormand, F; Pacheco, Y; Revillard, JP | 1 |
| Bergerat, A; Guschlbauer, W | 1 |
| Cumaraswamy, A; Henney, H | 1 |
| Cools, M; De Clercq, E | 1 |
| Bottiglieri, T | 1 |
| Kennedy, G; Kennedy, S; Molloy, AM; Scott, JM; Weir, DG | 1 |
| Borchardt, RT; Cools, M; De Clercq, E; Hasobe, M | 1 |
| Bottiglieri, T; Chanarin, I; Metz, J; Van der Westhuyzen, J; Vieira-Makings, E | 1 |
| Borchardt, RT; Hasobe, M; Holý, A; Votruba, I | 1 |
| Borchardt, RT; Kramer, DL; Porter, CW; Sufrin, JR | 1 |
| Friedman, S; Som, S | 1 |
| Colombatto, S; Grillo, MA | 2 |
| Cohen, SS | 1 |
| Bjorndahl, JM; Rutledge, CO | 1 |
| Borchardt, RT; Borcherding, DR; Hasobe, M; Keller, BT; Mckee, JG | 1 |
| Daino, L; Feo, F; Garcea, R; Pascale, R; Puddu, M; Ruggiu, ME; Satta, G; Seddaiu, MA; Sequenza, MJ; Simile, MM | 1 |
| Ellis, M; Frost, P; Judde, JG | 1 |
| Henning, SM; McKee, RW; Swendseid, ME | 1 |
| LeBel, CP; Schatz, RA | 1 |
| Gharib, A; Reynaud, D; Sarda, N | 1 |
| Barten, DM; O'Dea, RF | 1 |
| Cook, RJ; Horne, DW; Wagner, C | 1 |
| Bottiglieri, T; Chanarin, I; Deacon, R; Lumb, M; Perry, J | 1 |
| Bjur, RA; Greenhouse, AH; Mead, DJ; Reitz, RC; Welch, WH | 1 |
| Eglsaer, SJ; Richards, WR; Yee, WC | 1 |
| Borchardt, RT; Cools, M; De Clercq, E; Hasobe, M; Ishii, H; McKee, JG | 1 |
| Horne, DW | 1 |
| Borchardt, RT; De Gunzburg, J; Guitton, MC; Keller, BT; Part, D; Véron, M | 1 |
| Fell, D; Steele, RD | 2 |
| Ozawa, K; Segawa, T | 1 |
| Allen, PT; Hernandez, L; Lijinsky, W; Poirier, LA | 1 |
| Dyer, JR; Greenwood, CE | 1 |
| Arnaud, M; Dante, R; Niveleau, A | 1 |
| Martínez del Pozo, A; Mato, JM; Mérida, I; Pajares, MA; Varela, I; Villalba, M | 1 |
| Carreau, S; Drosdowsky, MA; Kamtchouing, P; Papadopoulos, V | 1 |
| Finkelstein, JD; Martin, JJ | 2 |
| Borchardt, RT; Decedue, CJ; Fisher, EW; Keller, BT | 1 |
| Blanchflower, J; Keating, S; Kennedy, DG; Kennedy, S; McPartlin, J; Molloy, A; Rice, D; Scott, JM; Weir, DG | 1 |
| Hardy, LW; Santi, DV | 1 |
| Djurhuus, R; Lillehaug, JR; Male, R; Svardal, AM; Ueland, PM | 1 |
| Hariyama, H; Moriguchi, K; Sato, H | 1 |
| Liteplo, RG | 1 |
| Ibrahim, RK; Khouri, HE; Tahara, S | 1 |
| Aarsaether, N; Aarsland, A; Berge, RK; Lønning, PE; Refsum, H; Svardal, AM; Ueland, PM | 1 |
| Liteplo, RG; Munro, S | 1 |
| Chiba, P; Kaiser, E; Wallner, C | 1 |
| Brasitus, TA; Dudeja, PK; Halline, AG | 1 |
| Creasia, D; Hoover, KL; Mikol, YB; Poirier, LA; Shivapurkar, N; Wilson, MJ | 1 |
| Lillehaug, JR; Male, R; Refsum, H; Ueland, PM | 1 |
| Aarbakke, J; Bessesen, A; Chiang, PK; Gordon, RK; Miura, GA; Prytz, PS; Slørdal, L | 1 |
| Chiang, PK; Gordon, RK; Miura, GA; Montgomery, JA | 1 |
| Carson, DA; Kajander, EO; Kubota, M; Willis, EH | 1 |
| Harrap, KR; Renshaw, J | 1 |
| Stipanuk, MH | 1 |
| Balemans, MG; Ebels, I | 1 |
| Santi, DV; Wu, JC | 1 |
| Matos, JR; Raushel, FM; Wong, CH | 1 |
| Hoffman, JL; McConnell, KP | 1 |
| Carl, GF; Gill, MW; Schatz, RA | 1 |
| Veser, J | 1 |
| Lawrence, F; Nolan, LL; Paolantonacci, P; Robert-Géro, M | 1 |
| Feldtrauer, JJ; Waldmeier, PC | 1 |
| Boss, GR; Pilz, RB; Van den Berghe, G | 1 |
| Duerre, JA; Wallwork, JC | 2 |
| Carrera, CJ; Carson, DA; Kajander, EO; Kubota, M; Montgomery, JA | 1 |
| Crooks, PA; Godin, CS | 1 |
| Djurhuus, R; Svardal, A; Ueland, PM | 1 |
| Snoswell, AM; Xue, GP | 2 |
| Bélanger, L; Gourdeau, H; Grose, JH; Lavoie, R | 1 |
| Goodman, PJ; Hill, KA; Loo, G; Smith, JT | 1 |
| Kufe, DW; Shafman, TD; Sherman, ML; Spriggs, DR | 1 |
| Pastuszko, A; Rafałowska, U | 1 |
| Brasitus, TA; Dudeja, PK; Foster, ES | 1 |
| Chan, VL; Ho, HJ | 1 |
| Loo, G; Smith, JT | 1 |
| Fonlupt, P; Gharib, A; Pacheco, H; Rey, C; Sarda, N | 1 |
| Fraki, JE; Harvima, IT; Harvima, RJ; Kajander, EO | 1 |
| Chaffee, S; Greenberg, ML; Hershfield, MS; Kurtzberg, J | 1 |
| Cantoni, GL | 1 |
| Gill, MW; Schatz, RA | 1 |
| Benjamin, LE; Fell, D; Steele, RD | 1 |
| Adler, M; Cantoni, GL; Chiang, PK; de Blas, A; Nirenberg, M; Shih, M | 1 |
| Diliberto, EJ; O'Dea, RF; Viveros, OH | 1 |
| Hill, MW; Mann, SP | 1 |
| Fuller, RW; Hemrick-Leucke, SK; Perry, KW | 1 |
| Glazer, RI; Hartman, KD | 1 |
| Morita, Y; Siraganian, RP | 1 |
| Ahl, R | 1 |
| Billingsley, ML; Roth, RH | 1 |
| Baglioni, C; de Ferra, F | 2 |
| Dev, VG; Mixon, JC | 1 |
| Biot, N; Fonlupt, P; Macovschi, O; Pacheco, H; Pacheco, Y; Perrin-Fayolle, M | 1 |
| Hoffman, RM | 1 |
| Cuatrecasas, P; Deeprose, RD; Duncan, GS; Elion, GB; Schmitges, CJ; Wolberg, G; Zimmerman, TP | 1 |
| Cornatzer, WE; Haning, JA; Hoffman, DR | 4 |
| Ven Murthy, MR | 1 |
| Coalson, DW; Hoffman, RM; Mecham, JO; Stern, PH | 1 |
| Tudball, N | 1 |
| Ozawa, Y; Shishiba, Y | 1 |
| Hoffman, RM; Mecham, JO; Stern, PH; Wallace, CD | 1 |
| Kraus-Friedmann, N; Zimniak, P | 1 |
| Aksamit, RR; Backlund, PS | 1 |
| DeFranco, AL; Koshland, DE | 1 |
| Chiang, PK; Johnson, GS | 1 |
| Burg, M; Chiang, PK; Johnson, JP; Sariban-Sohraby, S; Wiesmann, WP | 1 |
| Montgomery, JA; Schanche, JS; Schanche, T; Ueland, PM | 1 |
| Dhalla, NS; Ganguly, PK; Panagia, V; Rice, KM | 1 |
| Hoffman, RM; Stern, PH | 1 |
| Porta, R; Schatz, RA; Sellinger, OZ; Wilens, TE | 1 |
| Barber, JR; Clarke, S | 1 |
| Cedar, H; Gruenbaum, Y; Razin, A; Szyf, M | 1 |
| Godburn, KE; Nazar, RN; Sitz, TO; Somers, KD | 1 |
| Helland, S; Ueland, PM | 2 |
| Hilton, MA; Hoffman, JL; Sparks, MK | 1 |
| Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Galletti, P; Zappia, V | 1 |
| Jaiswal, RK; Landon, EJ; Sastry, BV | 1 |
| Hoffman, RM; Stern, PH; Wallace, CD | 1 |
| Borchardt, RT; Keller, BT | 1 |
| Poirier, LA; Shivapurkar, N; Wilson, MJ | 1 |
| Claverie, N; Danzin, C; Huot-Olivier, S; Palfreyman, MG; Wagner, J | 1 |
| DiMaria, P; Kim, S; Ro, JY | 1 |
| Clarke, S; Oden, KL | 1 |
| Poirier, LA; Shivapurkar, N | 1 |
| Chun, BG; Kim, S; Paik, WK | 1 |
| Hershfield, MS; Kredich, NM | 1 |
| Ferro, AJ; Law, RE | 1 |
| Borchardt, RT; Eiden, LE; Rutledge, CO | 1 |
| Chabannes, B; Cronenberger, L; Gharib, A; Pacheco, H; Sarda, N | 1 |
| Chiang, PK; Montgomery, JA; Shattil, SJ | 1 |
| Finkelstein, JD; Harris, BJ; Kyle, WE; Martin, JJ | 1 |
| Rivett, AJ; Roth, JA | 1 |
| Ciaranello, RD; Wong, DL; Zager, EL | 1 |
| Fuller, RW; Hemrick-Luecke, SK; Perry, KW | 1 |
| Schatz, RA; Sellinger, OZ; Wilens, TE | 2 |
| Gupta, KC; Roy, P | 1 |
| Doyle, RL; Porta, R; Schatz, RA; Sellinger, OZ; Tatter, SB; Wilens, TE | 1 |
| Fonlupt, P; Pacheco, H; Rey, C | 1 |
| Della Ragione, F; Galletti, P; Manna, C; Porcelli, M; Romeo, G | 1 |
| Borchardt, RT; Chen, SY; Coward, JK; Hibasami, H; Pegg, AE | 1 |
| Arrang, JM; Bidart, JM; Bohuon, C; Christa, L | 1 |
| Cornatzer, WE; Duerre, JA; Hoffman, DR; Marion, DW | 1 |
| Branno, M | 1 |
| Denisova, NA; Kelly, JF; Kowatch, MA; Roth, GS | 1 |
| Alonso-Aperte, E; Alvarez, L; Caballería, J; Deulofeu, R; Gassó, M; Mato, JM; Rodés, J; Rubio, M; Varela-Moreiras, G | 1 |
| De Abreu, R; Lambooy, L; Stet, E; Van den Heuvel, L; Vogels-Mentink, T | 1 |
| Adams, P; Bohnert, HJ; Jensen, RG; Pichorner, H; Rammesmayer, G | 1 |
| Kikuchi, S; Nishitani, H; Okumura, K; Taguchi, H | 1 |
| Buc-Calderon, P; Tinton, S | 1 |
| Bhagwat, AS; Yebra, MJ | 1 |
| Finta, C; Kiss, A; Sulima, U; Venetianer, P | 1 |
| Gillis, RA; Kellar, KJ; Travagli, RA | 1 |
| Kennedy, DG; Kennedy, S; McKeever, M; Molloy, A; Scott, JM; Weir, DG; Young, PB | 1 |
| Blom, HJ; Copius Peereboom-Stegeman, JH; Deabreu, RA; Eskes, TK; Noordhoek, J; Trijbels, FJ; Vanaerts, LA | 1 |
| De Santo, NG; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V | 1 |
| Murray, NE; Powell, LM | 1 |
| D'Angelo, S; Galletti, P; Ingrosso, D; Iolascon, A; Miraglia del Giudice, E; Perna, AF; Perrotta, S; Zappia, V | 1 |
| Klimasauskas, S; Roberts, RJ | 1 |
| Hayakawa, T; She, QB; Tsuge, H | 1 |
| Kennedy, DG; Kennedy, S; McKeever, M; Molloy, A; Scott, JM; Weir, DG; Young, P | 1 |
| Hayakawa, T; Nagao, I; She, QB; Tsuge, H | 1 |
| García-Cuevas, M; Pérez-Olleros, L; Ruiz-Roso, B; Varela-Moreiras, G | 1 |
| Löfberg, C; Oreland, L; Trolin, CG; Trolin, G | 1 |
| Giner, JL; Rando, RR | 1 |
| Christen, L; Higman, MA; Niles, EG | 1 |
| Finta, C; Kiss, A; Patthy, A; Szilák, L; Venetianer, P | 1 |
| Phillips, K; Phillips, SE | 1 |
| Bhagwat, AS; Gabbara, S; Wyszynski, M | 1 |
| Arredondo-Vega, F; Barsh, GS; Duhl, DM; Epstein, CJ; Hershfield, MS; Miller, MW; Saxon, PJ; Winkes, BM; Wolff, GL | 1 |
| Ragel, C; Ruiz-Roso, B; Varela-Moreiras, G | 1 |
| Franks, JJ; Janson, VE; Sastry, BV; Vidaver, PS | 1 |
| Ault-Riché, DB; Borchardt, RT; Borcherding, DR; Hasobe, M; Lee, Y; Wolfe, MS; Yuan, CS | 1 |
| Balaghi, M; Horne, DW; Wagner, C; Woodward, SC | 1 |
| Adams, RL; Macnab, JC; Seivwright, C | 1 |
| Da Prada, M; Dingemanse, J; Zürcher, G | 1 |
| Avila, JL; Polegre, MA | 1 |
| Aswad, DW; Johnson, BA | 1 |
| Balaghi, M; Horne, DW; Wagner, C | 1 |
| Fullerton, FR; Hansen, DK; Knowles, BJ; Poirier, LA | 1 |
| Blaydes, BS; Fullerton, FR; Greenman, DL; Poirier, LA | 1 |
| Capasso, G; De Santo, NG; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V | 1 |
| Alleman, MM; Bacchi, CJ; Dwyer, DM; Gottlieb, M; Mann, VH; Yarlett, N | 1 |
| Clifford, AJ; Ellis, WG; Gietzen, DW; Gospe, SM; Lunetta, JM; Miller, JW; Selhub, J; Summers, PJ | 1 |
| Tsiftsoglou, AS; Vizirianakis, IS | 2 |
| Allen, RH; Chandler, CJ; Halsted, CH; James, SJ; Muskhelishvili, L; Poirier, L; Stabler, SP; Villanueva, J | 1 |
| Delnomdedieu, M; Styblo, M; Thomas, DJ | 1 |
| Beart, RW; Jones, PA; Nguyen, TT; Schmutte, C; Yang, AS | 1 |
| Abadjieva, A; Firman, K; Janscak, P | 1 |
| Mao, X; Shuman, S | 1 |
| Dehal, SS; Kupfer, D | 1 |
| Blom, HJ; Bökkerink, JP; De Abreu, RA; Keuzenkamp-Jansen, CW; Trijbels, JM | 1 |
| Chawla, RK; Jones, DP; Watson, WH | 1 |
| Charlton, CG; Crowell, B | 1 |
| Kish, SJ; Morrison, LD; Smith, DD | 1 |
| Dröge, W; Fischbach, T; Germer, M; Krammer, PH; Lehmann, V; Peter, ME; Ratter, F; Schulze-Osthoff, K | 1 |
| Angst, CP; Browne, G; Fowler, B; Frick, G; Haefeli, WE; Loehrer, FM | 1 |
| Jones, PA; Rapoport, H; Shen, JC; Yang, AS; Zingg, JM | 1 |
| Aarbakke, J; Endresen, PC; Kildalsen, H; Loennechen, T | 1 |
| Orgacka, H; Scheller, T; Szumlanski, CL; Weinshilboum, RM | 1 |
| Clark, SH; Hamre, MR; Mirkin, BL | 1 |
| Alvarez, L; Farber, JL; García, C; Mato, JM; Pajares, MA; Pastorino, JG; Sánchez-Góngora, E; Viña, JR | 1 |
| Basnakian, AG; James, SJ; Kim, YI; Mason, JB; Miller, JW; Pogribny, IP; Selhub, J | 1 |
| Bleimling, N; Kozak, M; Saenger, W; Schluckebier, G; Weinhold, E | 1 |
| Choi, SW; Dallal, GE; Graeme-Cook, F; Kim, YI; Mason, JB; Salomon, RN; Smith, DE | 1 |
| Collins, MA; Gearhart, DA; Neafsey, EJ | 1 |
| Joseph, JA; Miller, JW; Nadeau, MR; Selhub, J; Shukitt-Hale, B; Villalobos-Molina, R | 1 |
| Djordjevic, S; Stock, AM | 1 |
| Béliveau, R; Boivin, D; Lin, W | 1 |
| Aquilonius, SM; Cheng, H; Ekblom, J; Gomes-Trolin, C; Löfberg, C; Oreland, L; Steinberg, A | 1 |
| Holloway, RS; Horne, DW; Wagner, C | 1 |
| Angst, CP; Fowler, B; Haefeli, WE; Loehrer, FM; Schwab, R | 1 |
| Borchardt, RT; Capdevila, A; Decha-Umphai, W; Song, KH; Wagner, C | 1 |
| Janulaitis, A; Maneliene, Z; Petrusyte, M; Vitkute, J | 1 |
| Bontemps, F; Van Den Berghe, G | 1 |
| Brunone, M; De Santo, NG; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V | 1 |
| Díaz, LE; Giorgieri, SA; Pañak, KC; Ruiz, OA | 1 |
| Cheng, H; Ekblom, J; Oreland, L; Yassin, MS | 1 |
| Hüttermann, J; Kappl, R; Knappe, J; Külzer, R; Pils, T | 1 |
| Beinert, H; Booker, S; Frey, PA; Lieder, KW; Reed, GH; Ruzicka, FJ | 1 |
| Kelm, A; Reuter, G; Schauer, R; Shaw, L | 1 |
| Fojtová, M; Holý, A; Kovarík, A; Votruba, I | 1 |
| Angst, CP; Brunner, FP; Fowler, B; Haefeli, WE; Loehrer, FM | 1 |
| Jones, PA; Shen, JC; Zingg, JM | 1 |
| Borchardt, RT; Hershfield, MS; Howell, PL; Smith, GD; Turner, MA; Yuan, CS | 1 |
| Cai, J; Huang, ZZ; Lu, SC; Mao, Z | 1 |
| Glazer, RI; Peale, AL | 1 |
| Flynn, J; Reich, N | 1 |
| Ekblom, J; Löfberg, C; Oreland, L; Yassin, MS | 1 |
| Capdevila, A; Wagner, C | 1 |
| Kim, SK; Kim, SY; Kim, YC | 1 |
| Huang, ZZ; Kanel, G; Lu, SC; Mato, JM | 1 |
| Delabar, U; Kloor, D; Luippold, G; Mühlbauer, B | 1 |
| Gassner, C; Lehmann, V; Ratter, F; Shatrov, V | 1 |
| Abad-Zapatero, C; Kavanaugh, TJ; Schluckebier, G; Stewart, KD; Zhong, P | 1 |
| Han, JW; Hong, SY; Lee, HW; Paik, WK; Seo, DW | 1 |
| Goggins, M; Scott, JM; Weir, DG | 1 |
| Bacolla, A; Pradhan, S; Roberts, RJ; Wells, RD | 1 |
| James, SJ; Melnyk, S; Pogribna, M; Pogribny, IP; Yi, P | 1 |
| Ekblom, J; Gottfries, CG; Oreland, L; Xilinas, M; Yassin, MS | 1 |
| Balaña-Fouce, R; Cubría, JC; Ordóñez, C; Ordóñez, D; Pérez-Pertejo, Y; Reguera, RM; Tekwani, BL | 1 |
| Fujioka, M; Gomi, T; Huang, Y; Komoto, J; Konishi, K; Ogawa, H; Takata, Y; Takusagawa, F | 1 |
| Dudman, NP; Fu, W; Perry, MA; Wang, XL; Young, K | 1 |
| Babaie, E; Gebhardt, K; Lindqvist, BH; Shokraei, A | 1 |
| Charlton, CG; Liu, XX; Wilson, K | 1 |
| Aswad, DW; Schurter, BT | 1 |
| D'angelo, S; di Carlo, E; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V | 1 |
| Kishi, T; Tanaka, Y; Ueda, K | 1 |
| Finkelstein, JD | 2 |
| de Meer, K; Jakobs, C; Jansen, EE; Struys, EA | 1 |
| Gowher, H; Jeltsch, A | 1 |
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| Zeisel, S | 1 |
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| Geisel, J; Grune, T; Hesse, D; Hiller, F; Kipp, AP; Kleuser, B; Obeid, R; Schulz, S; Schumacher, F; Speckmann, B | 1 |
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| Auta, J; Bhaumik, DK; Gatta, E; Gavin, DP; Grayson, DR; Guidotti, A; Pandey, SC | 1 |
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| Cella, PS; da Silva, LECM; Deminice, R; Jordao, AA; Riberio, DF | 1 |
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| Coalson, DW; Douglas Wallace, C; Erbe, RW; Hoffman, RM; Stern, PH | 1 |
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| Andrade, J; Blaženović, I; Chang, JW; Chryplewicz, A; Coscia, F; Curtis, M; Eckert, MA; Fiehn, O; Hernandez, KM; Lastra, RR; Lengyel, E; Li, G; Mann, M; McGregor, SM; Moellering, RE; Nahotko, DA; Pan, S; Perets, R; Tienda, SM; Yamada, SD | 1 |
| Chang, S; Li, B; Li, R; Liang, L; Liu, C; Niu, B; Qin, C; Wang, L; Wang, X; Zhang, L; Zhang, M; Zhang, T | 1 |
| Bulgakova, PO; Fedoseev, AN; Grachev, SV; Ivanov, AV; Kruglova, MP; Kubatiev, AA; Nikiforova, KA; Savina, GD; Virus, ED | 1 |
| Amara, CS; Ambati, CR; Ambs, S; Bollag, R; Castro, PD; Coarfa, C; Donepudi, SR; Estecio, MR; Ittmann, MM; Kornberg, MD; Lerner, SP; Lotan, Y; Piyarathna, DWB; Putluri, N; Putluri, V; Rajapakshe, K; Sreekumar, A; Tang, W; Terris, MK; Vantaku, V; Williams, SB | 1 |
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| Bulgakova, PO; Ivanov, AV; Kruglova, MP; Kubatiev, AA; Virus, ED; Vital'evich Grachev, S | 1 |
| de Rijke, YB; Griffioen, PH; Heil, SG; Herzog, EM; Steegers, EAP; Steegers-Theunissen, RPM; van Zelst, B; Willemsen, SP | 1 |
| Battaglia-Hsu, SF; Chen, B; Feng, J; Gong, C; Guo, D; Guo, T; Li, Z; Liu, P; Liu, Z; Wang, H; Wu, P; Xiao, Y; Yao, Y | 1 |
| Chang, CF; Dontsova, OA; Efimov, SV; Kechko, OI; Klochkov, VV; Mariasina, SS; Mitkevich, VA; Petrova, OA; Polshakov, VI; Sergiev, PV | 1 |
| Ha, T; Huang, L; Liao, TW; Lilley, DMJ; Wang, J | 1 |
| Bulgakova, PO; Fedoseev, AN; Grachev, SV; Ivanov, AV; Kruglova, MP; Kubatiev, AA; Samokhin, AS; Virus, ED | 1 |
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| Guo, Y; Liao, L; Peng, T; Zeng, Z; Zhao, Y; Zhou, Y | 1 |
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| Alhanti, B; Cheema, AK; Giczewska, A; Givertz, MM; Handy, DE; Joseph, J; Loscalzo, J; Mann, DL | 1 |
| Chard, R; Foster, IT; Jedrzejczak, R; Joachimiak, A; Kim, Y; Lavens, A; Maltseva, N; Michalska, K; Minasov, G; Rosas-Lemus, M; Saint, N; Satchell, KJF; Sherrell, DA; Shuvalova, L; Wilamowski, M | 1 |
| Dai, X; Guo, H; Liao, R; Ling, W; Liu, S; Wang, D; Xia, M; Xiao, Y | 1 |
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| Albanese, KI; Houk, KN; Kuhlman, B; Leaver-Fay, A; Park, R; Treacy, JW; Waters, ML | 1 |
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| Fischer, TR; Helm, M; Hoba, SN; Jung, N; Kersten, C; Koch, J; Lyko, F; Meidner, JL; Schirmeister, T; Schwickert, M; Stark, MM; Weber, M; Windbergs, M; Zimmermann, RA | 1 |
| Chen, S; Hata, J; Honda, T; Isa, A; Katakura, Y; Kitazono, T; Mihara, A; Nakao, T; Ninomiya, T; Ohara, T; Shimizu, K; Tamrakar, S; Wang, D; Yonemoto, K | 1 |
| Leisinger, F; Leopold, V; Seebeck, FP; Wen, X | 1 |
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27 review(s) available for s-adenosylmethionine and s-adenosylhomocysteine
| Article | Year |
|---|---|
Structural and functional studies on the "5'-cap": a survey method for mRNA.
Topics: Aged; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Nucleus; Cytoplasm; Humans; Kinetics; Liver; Liver Neoplasms; Models, Biological; Neoplasms, Experimental; Ovalbumin; Oxidation-Reduction; Polyribosomes; Protein Biosynthesis; Rats; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 1976 |
Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents.
Topics: Alkylating Agents; Animals; Base Sequence; Carcinogens; DNA; DNA Restriction Enzymes; Ethionine; Methylation; Mutation; Nitroso Compounds; Nucleosides; Protein Biosynthesis; RNA; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; tRNA Methyltransferases | 1977 |
Inhibitors of adenosine deaminase and the development of antiviral agents.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Antiviral Agents; Cytarabine; Deoxyadenosines; Drug Synergism; Herpes Simplex; Humans; Interferons; Mice; Nucleoside Deaminases; S-Adenosylhomocysteine; S-Adenosylmethionine | 1985 |
Metabolism of sulfur-containing amino acids.
Topics: Adenosylhomocysteinase; Animals; Carboxy-Lyases; Cysteine; Female; Homocysteine; Humans; Hydrolases; Isoenzymes; Liver; Male; Methionine; Methionine Adenosyltransferase; Methylation; Polyamines; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Taurine; Transaminases | 1986 |
Physiological aspects of pineal functions in mammals.
Topics: Acetylserotonin O-Methyltransferase; Animals; Biopterins; Cell Transformation, Neoplastic; Female; gamma-Aminobutyric Acid; Gonads; Indoles; Male; Mammals; Melatonin; Models, Biological; Neopterin; Neurophysins; Norepinephrine; Pineal Gland; Pituitary Hormones, Anterior; S-Adenosylhomocysteine; S-Adenosylmethionine; Seasons; Vasotocin | 1986 |
[Protein carboxymethylation and its role in the regulation of neurosecretion].
Topics: Adenosine Triphosphate; Endocrine Glands; Hormones; Humans; Methylation; Neurosecretory Systems; Protein Methyltransferases; Protein O-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine | 1985 |
Protein carboxymethylation: role in the regulation of cell functions.
Topics: Calmodulin; Cell Division; Chemical Phenomena; Chemistry; Membrane Lipids; Membrane Proteins; Neurotransmitter Agents; Protein Methyltransferases; Protein O-Methyltransferase; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Nitrous oxide, vitamin B12 deficiency and the methyl folate trap.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Humans; Liver; Macaca fascicularis; Methionine; Methylmalonyl-CoA Mutase; Nervous System Diseases; Nitrous Oxide; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 Deficiency | 1982 |
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Choline; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Ethionine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylation; Methyltransferases; Neoplasms; Oncogenes; Oncogenic Viruses; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1984 |
Chemotaxis and methylation in a macrophage cell line.
Topics: Adenine; Adenosine; Animals; Blood Proteins; Cell Line; Chemotaxis, Leukocyte; Guinea Pigs; Humans; Macrophages; Methylation; Mice; Phosphatidylethanolamines; Rabbits; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1983 |
Pathways and regulation of homocysteine metabolism in mammals.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Heme; Homocysteine; Isoenzymes; Kinetics; Mammals; Methionine; Methionine Adenosyltransferase; Organ Specificity; Oxidation-Reduction; Pyridoxal Phosphate; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Tetrahydrofolates | 2000 |
Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism.
Topics: Biomarkers; Carbon; Diet; DNA Methylation; Folic Acid; Homocysteine; Humans; Methylation; Nutritional Status; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B Complex | 2003 |
Involvement of gene-diet/drug interaction in DNA methylation and its contribution to complex diseases: from cancer to schizophrenia.
Topics: Diet; DNA Methylation; Female; Food-Drug Interactions; Gene Expression Regulation; Humans; Maternal Nutritional Physiological Phenomena; Neoplasms; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Schizophrenia | 2003 |
Assessing the effects of high methionine intake on DNA methylation.
Topics: Animals; Diet; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Methionine; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Interactions of cytokines, S-Adenosylmethionine, and S-Adenosylhomocysteine in alcohol-induced liver disease and immune suppression.
Topics: Animals; Cytokines; Liver Diseases, Alcoholic; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
S-adenosylmethionine and its products.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Glycine N-Methyltransferase; Homocysteine; Humans; Liver; Methionine Adenosyltransferase; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
The many flavors of hyperhomocyst(e)inemia: insights from transgenic and inhibitor-based mouse models of disrupted one-carbon metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Ferredoxin-NADP Reductase; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Transgenic; Models, Biological; Molecular Structure; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur | 2007 |
Riboswitches that sense S-adenosylmethionine and S-adenosylhomocysteine.
Topics: 5' Untranslated Regions; Base Sequence; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; RNA, Bacterial; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Alcoholic liver disease and methionine metabolism.
Topics: Alcohol Drinking; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Ethanol; Homocysteine; Humans; Liver; Liver Diseases, Alcoholic; Methionine; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine | 2009 |
Nutritional influences on epigenetics and age-related disease.
Topics: Aging; Animals; Cardiovascular Diseases; Diet; DNA Methylation; Epigenesis, Genetic; Epigenomics; Humans; Micronutrients; Neoplasms; Neurodegenerative Diseases; S-Adenosylhomocysteine; S-Adenosylmethionine | 2012 |
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Topics: Animals; Carcinoma, Hepatocellular; Disease Progression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Methionine Adenosyltransferase; Mice; Prognosis; Prohibitins; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction | 2013 |
Role of S-adenosylhomocysteine in cardiovascular disease and its potential epigenetic mechanism.
Topics: Atherosclerosis; Diabetes Mellitus; Endothelium, Vascular; Epigenesis, Genetic; Humans; Hyperhomocysteinemia; Kidney Diseases; Obesity; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases.
Topics: Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Humans; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
Topics: Consensus; Homocysteine; Humans; Infant, Newborn; Metabolism, Inborn Errors; Methionine; Methionine Adenosyltransferase; Methylation; Neonatal Screening; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
Choline, Other Methyl-Donors and Epigenetics.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cyclin-Dependent Kinase Inhibitor Proteins; Diet; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histones; Humans; Liver Neoplasms; Meta-Analysis as Topic; Mice; Models, Animal; Phenotype; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
Trans-methylation reactions in plants: focus on the activated methyl cycle.
Topics: Amino Acid Sequence; Arabidopsis; Methylation; Methyltransferases; Models, Biological; Plant Proteins; Plants; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine | 2018 |
15 trial(s) available for s-adenosylmethionine and s-adenosylhomocysteine
| Article | Year |
|---|---|
Metabolic consequences of folate-induced reduction of hyperhomocysteinemia in uremia.
Topics: Erythrocyte Membrane; Homocysteine; Humans; Membrane Proteins; Methionine; Methylation; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uremia | 1997 |
Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5'-phosphate concentrations.
Topics: Adult; Chromatography, High Pressure Liquid; Electrochemistry; Female; Homocysteine; Humans; Indicators and Reagents; Liver; Lymphocytes; Middle Aged; Pyridoxal Phosphate; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Trichloroacetic Acid | 2000 |
Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy.
Topics: Adult; Albuminuria; Creatinine; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Disease Progression; Erythrocytes; Female; Homocysteine; Humans; Lymphocytes; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Reference Values; Regression Analysis; Renal Dialysis; S-Adenosylhomocysteine; S-Adenosylmethionine | 2001 |
Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia.
Topics: Acetylcysteine; Adult; Arginine; Blood Flow Velocity; Brachial Artery; Cross-Over Studies; Cystathionine; Cysteine; Dipeptides; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kinetics; Male; Methionine; Placebos; S-Adenosylhomocysteine; S-Adenosylmethionine; Vasodilation | 2005 |
Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gas Chromatography-Mass Spectrometry; Humans; Kidney; Linear Models; Male; Middle Aged; Nutrition Assessment; S-Adenosylhomocysteine; S-Adenosylmethionine; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2006 |
Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Placebos; S-Adenosylhomocysteine; S-Adenosylmethionine; Vascular Diseases; Vitamin B 12; Vitamin B 6; Vitamins | 2010 |
Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans.
Topics: Adolescent; Adult; Aged; Biomarkers; Cholesterol, Dietary; Choline; Choline Deficiency; Docosahexaenoic Acids; Female; Genetic Association Studies; Humans; Liver; Male; Menopause; Middle Aged; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Polymorphism, Single Nucleotide; S-Adenosylhomocysteine; S-Adenosylmethionine; Young Adult | 2011 |
Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia.
Topics: Adult; Aged; Dietary Supplements; DNA Methylation; Folic Acid; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B Complex | 2011 |
Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder.
Topics: Biological Availability; Depressive Disorder, Major; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Psychiatric Status Rating Scales; S-Adenosylhomocysteine; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates | 2012 |
One year B and D vitamins supplementation improves metabolic bone markers.
Topics: Acid Phosphatase; Aged; Aged, 80 and over; Alkaline Phosphatase; Biomarkers; Bone and Bones; Cholecalciferol; Dietary Supplements; Double-Blind Method; Drug Administration Schedule; Female; Humans; Isoenzymes; Male; Middle Aged; Osteoporosis; Parathyroid Hormone; S-Adenosylhomocysteine; S-Adenosylmethionine; Tartrate-Resistant Acid Phosphatase; Vitamin B Complex; Vitamin D | 2013 |
Effect of 1 year B and D vitamin supplementation on LINE-1 repetitive element methylation in older subjects.
Topics: Aged; Aged, 80 and over; Calcium Carbonate; Cholecalciferol; Dietary Supplements; DNA Methylation; Drug Administration Schedule; Female; Homocysteine; Humans; Long Interspersed Nucleotide Elements; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B Complex | 2013 |
S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid in Rett syndrome and the effect of folinic acid supplementation.
Topics: Adolescent; Adult; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Humans; Infant; Rett Syndrome; S-Adenosylhomocysteine; S-Adenosylmethionine; Young Adult | 2013 |
Effect of adjunctive L-methylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results from a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Aldehydes; Biomarkers; C-Reactive Protein; Depressive Disorder, Treatment-Resistant; Drug Therapy, Combination; Female; Genotype; Humans; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates; Young Adult | 2014 |
Low-Dose Creatine Supplementation Lowers Plasma Guanidinoacetate, but Not Plasma Homocysteine, in a Double-Blind, Randomized, Placebo-Controlled Trial.
Topics: Adult; Bangladesh; Biomarkers; Cohort Studies; Creatine; Dietary Supplements; Double-Blind Method; Down-Regulation; Female; Folic Acid; Glycine; Homocysteine; Humans; Hyperhomocysteinemia; Intention to Treat Analysis; Male; Middle Aged; Patient Dropouts; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure.
Topics: Aged; Allopurinol; Female; Free Radical Scavengers; Heart Failure; Humans; Hyperuricemia; Male; Methylation; Middle Aged; Oxidation-Reduction; Precision Medicine; S-Adenosylhomocysteine; S-Adenosylmethionine; Stroke Volume; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2021 |
699 other study(ies) available for s-adenosylmethionine and s-adenosylhomocysteine
| Article | Year |
|---|---|
Purification and properties of S-adenosyl-L-homocysteine hydrolase from leaves of spinach beet.
Topics: Adenine; Cysteine; Deoxyadenosines; Homocysteine; Hydrogen-Ion Concentration; Hydrolases; Kinetics; Methionine; Plants; S-Adenosylhomocysteine; S-Adenosylmethionine | 1976 |
The transsulfuration pathway in Tetrahymena pyriformis.
Topics: Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Hydrogen-Ion Concentration; Hydrolases; Liver; Male; Methionine; Methionine Adenosyltransferase; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Temperature; Tetrahymena pyriformis | 1977 |
Protein methylation in animal cells. I. Purification and properties of S-adenosyl-L-methionine:protein (arginine) N-methyltransferase from Krebs II ascites cells.
Topics: Animals; Chromatography; Ethylmaleimide; Hydrogen-Ion Concentration; Kinetics; Mice; Molecular Weight; Neoplasms, Experimental; Protein Methyltransferases; Protein-Arginine N-Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 1978 |
[Effects of S-adenosylmethionine and S-adenosylhomocysteine on in vivo synthesis of noradrenaline and serotonin in different parts of the rat brain].
Topics: Animals; Brain; Homocysteine; Norepinephrine; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Serotonin | 1979 |
Characterization and translation of methylated and unmethylated vesicular stomatitis virus mRNA synthesized in vitro by ribonucleoprotein particles from vesicular stomatitis virus-infected L cells.
Topics: Base Sequence; Cell-Free System; Methylation; Peptide Biosynthesis; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Vesicular stomatitis Indiana virus; Viral Proteins | 1976 |
Deficiency of S-adenosylmethionine-homocysteine methyltransferase activity in hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Female; Homocysteine; Hydrolases; Liver; Liver Neoplasms; Methyltransferases; Neoplasms, Experimental; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1977 |
Two methyltransferase activities in the purified virions of vesicular stomatitis virus.
Topics: Kinetics; Methylation; Methyltransferases; Protein Biosynthesis; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Vesicular stomatitis Indiana virus; Virion | 1977 |
Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: evidence for a methylation reaction essential to cytolysis.
Topics: Cyclic AMP; Cytotoxicity, Immunologic; Homocysteine; Immunity, Cellular; Isomerism; Methyltransferases; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine; T-Lymphocytes; Tubercidin | 1978 |
The antifungal antibiotic sinefungin as a very active inhibitor of methyltransferases and of the transformation of chick embryo fibroblasts by Rous sarcoma virus.
Topics: Adenosine; Animals; Antifungal Agents; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; Chick Embryo; Fibroblasts; Kinetics; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1978 |
Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L).
Topics: Adenosine; Caffeic Acids; Hydrogen-Ion Concentration; Hydrolases; Kinetics; Methyltransferases; N-Glycosyl Hydrolases; Plants; S-Adenosylhomocysteine; S-Adenosylmethionine | 1975 |
Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis.
Topics: Adenosine Deaminase Inhibitors; Blood Proteins; Chemotaxis, Leukocyte; Humans; Methylation; Monocytes; Phagocytosis; S-Adenosylhomocysteine; S-Adenosylmethionine | 1978 |
"Pretranscriptional capping" in the biosynthesis of cytoplasmic polyhedrosis virus mRNA.
Topics: Adenylyl Imidodiphosphate; Base Sequence; Guanine Nucleotides; Homocysteine; Insect Viruses; Methylation; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcription, Genetic | 1978 |
S-adenosyl-L-homocysteine as a stimulator of viral RNA synthesis by two distinct cytoplasmic polyhedrosis viruses.
Topics: Adenosine; Cell-Free System; Homocysteine; Insect Viruses; Methylation; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Stimulation, Chemical | 1978 |
Relationship between tissue levels of S-adenosylmethionine, S-adenylhomocysteine, and transmethylation reactions.
Topics: Aging; Animals; Female; Homocysteine; Liver; Methylation; Methyltransferases; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1979 |
Inhibition of methylation by adenosine in adenosine deaminase-inhibited, phytohemagglutinin-stimulated human lymphocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; DNA; Homocysteine; Humans; Lymphocyte Activation; Methylation; Nucleoside Deaminases; Phytohemagglutinins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1979 |
Perturbation of biochemical transmethylations by 3-deazaadenosine in vivo.
Topics: Animals; Creatine; Cricetinae; Female; Lipid Metabolism; Liver; Male; Mesocricetus; Methyltransferases; Rats; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin; Vanilmandelic Acid | 1979 |
Impairment of reovirus mRNA methylation in extracts of interferon-treated Ehrilich ascites tumor cells: further characteristics of the phenomenon.
Topics: Animals; Carcinoma, Ehrlich Tumor; Culture Techniques; Humans; Interferons; Methylation; Methyltransferases; Mice; Poly I-C; Reoviridae; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine | 1977 |
The RNA of unfertilized sea urchin eggs is "capped".
Topics: Animals; Cell-Free System; Female; Methylation; Ovum; Protein Biosynthesis; RNA; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Sea Urchins; Zygote | 1977 |
The relation between purine metabolism and flavinogenesis in Eremothecium ashbyii. The identification of S-adenosylmethionine and S-adenosylhomocysteine accumulated in non-growing cells of E. ashbyii.
Topics: Adenine; Ascomycota; Culture Media; Dose-Response Relationship, Drug; Homocysteine; Riboflavin; S-Adenosylhomocysteine; S-Adenosylmethionine; Saccharomycetales | 1977 |
Cell-free biosynthesis of discadenine, a spore germination inhibitor of Dictyostelium discoideum.
Topics: Adenine; Cell Differentiation; Cell-Free System; Dictyostelium; Myxomycetes; S-Adenosylhomocysteine; S-Adenosylmethionine; Spores, Fungal; Transferases | 1978 |
Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines.
Topics: Age Factors; Animals; Brain; Glycine; Homocysteine; Hydrolases; Kidney; Liver; Methionine; Methionine Adenosyltransferase; Polyamines; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Factors | 1977 |
S-adenosylmethionine metabolism and its relation to polyamine synthesis in rat liver. Effect of nutritional state, adrenal function, some drugs and partial hepatectomy.
Topics: Adenosylmethionine Decarboxylase; Adrenalectomy; Animals; Female; Hepatectomy; Hydrocortisone; Liver; Methionine; Mitoguazone; Polyamines; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Starvation; Thioacetamide | 1977 |
Product inhibition studies and the reaction sequence of rabbit adrenal norepinephrine N-methyl transferase isozymes.
Topics: Adrenal Glands; Animals; Binding, Competitive; Isoenzymes; Kinetics; Norepinephrine; Phenylethanolamine N-Methyltransferase; Rabbits; S-Adenosylhomocysteine; S-Adenosylmethionine | 1978 |
Effects of various S-adenosylmethionine preparations on histamine methylation in vitro and in vivo.
Topics: Animals; Female; Guinea Pigs; Histamine; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Methylation; Mice; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1978 |
Affinity chromatography of an S-adenosylmethionine-dependent methyltransferase using immobilized S-adenosylhomocysteine. Purification of the indolethylamine N-methyltransferases of phalaris tuberosa.
Topics: Australia; Chromatography, Affinity; Methyltransferases; Poaceae; S-Adenosylhomocysteine; S-Adenosylmethionine; Serotonin; Tryptamines | 1978 |
Affinity labeling of histamine N-methyltransferase by 2',3'-dialdehyde derivatives of S-adenosylhomocysteine and S-adenosylmethionine. Kinetics of inactivation.
Topics: Affinity Labels; Chemical Phenomena; Chemistry; Histamine N-Methyltransferase; Homocysteine; Kinetics; Magnetic Resonance Spectroscopy; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Infrared; Structure-Activity Relationship | 1978 |
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 7. Role of the ribosyl moiety in enzymatic binding of S-adenosyl-L-homocysteine and S-adenosyl-L-methionine.
Topics: Animals; Cattle; Guinea Pigs; Homocysteine; In Vitro Techniques; Male; Methods; Methyltransferases; Oxidation-Reduction; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1978 |
[New studies on inhibition of tRNA N2 guanine methyltransferase by S-adenosyl-homocysteine and S-adenosyl-methionine analogs].
Topics: Animals; Escherichia coli; Guanine; Homocysteine; Kinetics; Liver; Rabbits; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; tRNA Methyltransferases | 1976 |
Selenite toxicity, depletion of liver S-adenosylmethionine, and inactivation of methionine adenosyltransferase.
Topics: Animals; Ethionine; Female; Kinetics; Liver; Male; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenium; Sex Factors; Transferases | 1977 |
S-Adenosyl-L-homocysteine hydrolase: analogues of S-adenosyl-L-homocysteine as potential inhibitors.
Topics: Animals; Cattle; Homocysteine; Hydrolases; In Vitro Techniques; Liver; Male; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1977 |
Biosynthesis of reovirus-specified polypeptides. System-dependent effect of reovirus mRNA methylation on translation in vitro catalyzed by ascites tumor and wheat embryo cell-free extracts.
Topics: Cell Line; Cell-Free System; Guanine Nucleotides; Methylation; Protein Biosynthesis; Reoviridae; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Viral Proteins | 1977 |
The enzymatic synthesis of S-adenosyl-L-[2(n)-3H]homocysteine.
Topics: Animals; Glycine; Homocysteine; Hydrolases; Liver; Methyltransferases; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1977 |
S-adenosyl-L-homocysteine dialdehyde: an affinity labeling reagent for histamine-N-methyltransferase.
Topics: Affinity Labels; Animals; Binding Sites; Brain; Guinea Pigs; Histamine N-Methyltransferase; Homocysteine; Kinetics; Mathematics; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1977 |
Isolation of S-adenosyl-3-thiopropylamine from the eye of the sea catfish (Arius felis).
Topics: Adenosine; Animals; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Eye; Fishes; Propylamines; S-Adenosylhomocysteine; S-Adenosylmethionine | 1976 |
The influence of DL-methionine on the metabolism of S-adenosylethionine in rats chronically treated with DL-ethionine.
Topics: Adenosine; Adenosine Triphosphate; Animals; Body Weight; Circadian Rhythm; Ethionine; Feeding Behavior; Female; Liver; Liver Neoplasms; Methionine; Neoplasms, Experimental; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1976 |
[New syntheses of S-adenosylhomocysteine and S-adenosylmethionine analogs].
Topics: Homocysteine; Methods; S-Adenosylhomocysteine; S-Adenosylmethionine | 1976 |
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 4. Further modifications of the amino and base portions of S-adenosyl-L-homocysteine.
Topics: Animals; Binding Sites; Cattle; Guinea Pigs; Homocysteine; In Vitro Techniques; Male; Methyltransferases; Rabbits; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1976 |
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 6. Structural modifications of S-adenosylmethionine.
Topics: Animals; Binding Sites; Cattle; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Methyltransferases; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1976 |
Mechanism of interferon action. Studies on the mechanism of interferon-mediated inhibition of reovirus messenger RNA translation in cell-free protein synthesis systems from mouse ascites tumor cells.
Topics: Cell Line; Cell-Free System; Interferons; Mammalian orthoreovirus 3; Peptide Chain Initiation, Translational; Protein Biosynthesis; Reoviridae; RNA, Messenger; RNA, Transfer; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine | 1976 |
A new method for the assay of tissue. S-adenosylhomocysteine and S-adenosylmethione. Effect of pyridoxine deficiency on the metabolism of S-adenosylhomocysteine, S-adenosylmethionine and polyamines in rat liver.
Topics: Adenosylmethionine Decarboxylase; Animals; Chromatography; Homocysteine; Liver; Male; Polyamines; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Vitamin B 6 Deficiency | 1976 |
Methylation of messenger RNA of Newcastle disease virus in vitro by a virion-associated enzyme.
Topics: Chromatography, DEAE-Cellulose; Dithiothreitol; Guanine Nucleotides; Kinetics; Manganese; Methyltransferases; Newcastle disease virus; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Viral Plaque Assay | 1975 |
Ribonuclease H of calf thymus: substrate specificity, activation, inhibition.
Topics: Animals; Cations, Divalent; Cattle; DNA, Viral; Enzyme Activation; Kinetics; Poly A; Poly T; Polydeoxyribonucleotides; Ribonucleases; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Thymus Gland | 1976 |
A screening test for sulphur-containing metabolites in urine using auxotrophic mutants of Escherichia coli K12.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Biological Assay; Cystathionine; Cystinuria; Escherichia coli; Homocystinuria; Humans; Infant, Newborn; Methods; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur | 1975 |
The elevation of cerebral histamine-N-and catechol-O-methyl transferase activities by L-methionine-dl-sulfoximine.
Topics: Animals; Basal Ganglia; Brain; Brain Stem; Catechol O-Methyltransferase; Cerebellum; Cerebral Cortex; Guinea Pigs; Hippocampus; Histamine N-Methyltransferase; Hypothalamus; Kinetics; Male; Mesencephalon; Methionine; Methionine Sulfoximine; Methylation; Methyltransferases; Mice; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1975 |
Ribosome binding to reovirus mRNA in protein synthesis requires 5' terminal 7-methylguanosine.
Topics: Aurintricarboxylic Acid; Base Sequence; Binding Sites; Guanosine; Mammalian orthoreovirus 3; Methylation; Polyribosomes; Protein Biosynthesis; Reoviridae; Ribonucleases; Ribosomes; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Subcellular Fractions; Triticum; tRNA Methyltransferases; Viral Proteins | 1975 |
Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Dopamine; Enzyme Activation; Flavin-Adenine Dinucleotide; Folic Acid; Liver; Methylenetetrahydrofolate Dehydrogenase (NADP); Methyltransferases; Oxidoreductases; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine | 1975 |
Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions.
Topics: Cations, Divalent; Guanine Nucleotides; Kinetics; Magnesium; Methyltransferases; Nucleotidyltransferases; Poly A; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Vaccinia virus | 1975 |
mRNA methylation and protein synthesis in extracts from embryos of brine shrimp, Artemia salina.
Topics: Animals; Decapoda; Embryo, Nonmammalian; Kinetics; Polyribosomes; Protein Biosynthesis; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Seeds; Triticum | 1975 |
A rapid liquid chromatographic determination of S-adenosylhomocysteine in subgram amounts of tissue.
Topics: Animals; Chromatography, High Pressure Liquid; Ethionine; Female; Homocysteine; Liver; Mice; Mice, Inbred C57BL; Microchemistry; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1975 |
Correlation of the ratio of S-adenosyl-L-methionine to S-adenosyl-L-homocysteine in the brain and cerebrospinal fluid of the pig: implications for the determination of this methylation ratio in human brain.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Humans; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Spinal Cord; Swine | 1992 |
Purification and biochemical characterization of the EcaI DNA methyltransferase.
Topics: Adenosine; Base Sequence; Binding, Competitive; Catalysis; Chemical Phenomena; Chemistry, Physical; DNA; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Methylation; Molecular Sequence Data; Plasmids; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Temperature | 1992 |
Is there an association between an increase in c-myc RNA steady state levels and c-myc methylation in HL-60 cells treated with 3-deaza-(+/-)-aristeromycin, an indirect inhibitor of methylation?
Topics: Adenosine; Cell Nucleus; DNA; Genes, myc; Humans; Methylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Restriction Mapping; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1992 |
The relationship between the activity of methionine synthase and the ratio of S-adenosylmethionine to S-adenosylhomocysteine in the brain and other tissues of the pig.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Air; Animals; Brain; Cerebral Cortex; Nitrous Oxide; S-Adenosylhomocysteine; S-Adenosylmethionine; Spinal Cord; Swine | 1992 |
Properties of a partially purified phosphodimethylethanolamine methyltransferase from rat brain cytosol.
Topics: Ammonium Sulfate; Animals; Brain; Calcium; Cytosol; Ethanolamines; Fractional Precipitation; Hydrogen-Ion Concentration; Male; Methylation; Methyltransferases; Phosphorylcholine; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 1992 |
Activation of the anaerobic ribonucleotide reductase from Escherichia coli by S-adenosylmethionine.
Topics: Anaerobiosis; Cytidine Triphosphate; Deoxyadenosines; Enzyme Activation; Escherichia coli; Kinetics; Methionine; Models, Biological; Oxidation-Reduction; Ribonucleotide Reductases; S-Adenosylhomocysteine; S-Adenosylmethionine | 1992 |
Human kidney thiopurine methyltransferase. Photoaffinity labeling with S-adenosyl-L-methionine.
Topics: Adenosine; Affinity Labels; Autoradiography; Chromatography, Ion Exchange; Gallic Acid; Humans; Isoenzymes; Kidney; Mercaptopurine; Methyltransferases; Photolysis; Polymorphism, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine | 1992 |
Methyl groups in carcinogenesis: effects on DNA methylation and gene expression.
Topics: Animals; Choline; DNA; Folic Acid; Food, Formulated; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, myc; Genes, ras; Liver; Male; Methionine; Methylation; Rats; Rats, Inbred F344; RNA, Messenger; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 1992 |
A possible new class of ribonucleotide reductase from Methanobacterium thermoautotrophicum.
Topics: Adenosine; Azides; Chromatography, Ion Exchange; Ethionine; Hydroxyurea; Kinetics; Methanobacterium; Ribonucleotide Reductases; S-Adenosylhomocysteine; S-Adenosylmethionine; Sodium Azide | 1992 |
Tissue-specific effects of testosterone on S-adenosylmethionine formation and utilization in the mouse.
Topics: Animals; Cystathionine beta-Synthase; Female; Kidney; Kinetics; Liver; Methionine Adenosyltransferase; Mice; Organ Size; Ornithine Decarboxylase; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine; Testosterone | 1992 |
Variations in S-adenosylmethionine, S-adenosylhomocysteine and adenosine concentrations in rat liver.
Topics: Adenosine; Animals; Circadian Rhythm; Fasting; Liver; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1992 |
Methyl group metabolism in the pancreas of folate-deficient rats.
Topics: Animals; Body Weight; Diet; Folic Acid; Folic Acid Deficiency; Male; Organ Size; Pancreas; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1992 |
Prolonged acetaminophen ingestion by mice fed a methionine-limited diet does not affect iron-induced liver lipid peroxidation or S-adenosylmethionine.
Topics: Acetaminophen; Animals; Cysteine; Glutathione; Glutathione Peroxidase; Iron; Lipid Peroxidation; Liver; Male; Methionine; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase | 1992 |
Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patients.
Topics: Adult; Brain; Female; HIV Seropositivity; Humans; Male; Methylation; Methyltransferases; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine | 1991 |
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis.
Topics: Adenosine; Animals; Azacitidine; Biomarkers, Tumor; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1991 |
Twenty-four-hour changes of S-adenosylmethionine, S-adenosylhomocysteine adenosine and their metabolizing enzymes in rat liver; possible physiological significance in phospholipid methylation.
Topics: Adenosine; Animals; In Vitro Techniques; Kinetics; Liver; Male; Methylation; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1991 |
Phenytoin treatment and folate supplementation affect folate concentrations and methylation capacity in rats.
Topics: Animals; Brain; Drug Interactions; Folic Acid; Liver; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Phenytoin; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Weight Gain | 1991 |
Purification and characterization of S-adenosyl-L-methionine: caffeic acid 3-O-methyltransferase from suspension cultures of alfalfa (Medicago sativa L.).
Topics: Affinity Labels; Caffeic Acids; Cells, Cultured; Chromatography; Enzyme Activation; Enzyme Stability; Hydrogen-Ion Concentration; Immunosorbent Techniques; Kinetics; Medicago sativa; Methyltransferases; Molecular Weight; Peptide Mapping; Photochemistry; S-Adenosylhomocysteine; S-Adenosylmethionine; Saccharomyces cerevisiae; Substrate Specificity | 1991 |
Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments.
Topics: Acetylcysteine; Adenosine; Animals; Cattle; Cysteine; GTP-Binding Proteins; In Vitro Techniques; Methylation; Molecular Weight; Rod Cell Outer Segment; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; Transducin | 1991 |
High-performance liquid chromatographic determination, with ultraviolet detection, of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in rat tissues and simultaneously of normetanephrine and metanephrine for phenylethanolamine-N-methyltransferase or
Topics: Adrenal Glands; Animals; Brain Chemistry; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Male; Metanephrine; Normetanephrine; Phenylethanolamine N-Methyltransferase; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet | 1991 |
Evidence that the decarboxylation reaction occurs before the first methylation in ubiquinone biosynthesis in rat liver mitochondria.
Topics: Anaerobiosis; Animals; Chromatography, High Pressure Liquid; Kinetics; Mass Spectrometry; Methylation; Mitochondria, Liver; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Ubiquinone | 1991 |
Mechanism of antiviral and cytotoxic action of (+/-)-6' beta-fluoroaristeromycin, a potent inhibitor of S-adenosylhomocysteine hydrolase.
Topics: Adenine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Division; Homocysteine; Hydrolases; Mice; Nucleic Acids; Phosphorylation; Protein Biosynthesis; S-Adenosylhomocysteine; S-Adenosylmethionine | 1991 |
Procainamide inhibits DNA methyltransferase in a human T cell line.
Topics: Animals; Cell Line; DNA (Cytosine-5-)-Methyltransferases; Methylation; Phospholipids; Procainamide; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; T-Lymphocytes | 1991 |
Disruption of thymidylate synthesis and glycine-serine interconversion by L-methionine and L-homocystine in Raji cells.
Topics: Amino Acids; Burkitt Lymphoma; Glycine; Glycine Hydroxymethyltransferase; Homocystine; Humans; Methionine; S-Adenosylhomocysteine; S-Adenosylmethionine; Serine; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1990 |
Binding of Bacillus subtilis ermC' methyltransferase to 23S rRNA.
Topics: Autoradiography; Bacillus subtilis; Bacterial Proteins; Base Sequence; Binding, Competitive; Collodion; Densitometry; Filtration; Kinetics; Methyltransferases; Molecular Sequence Data; Osmolar Concentration; Potassium Chloride; Protein Binding; RNA, Ribosomal; RNA, Ribosomal, 23S; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Temperature; Thermodynamics; Transcription, Genetic | 1990 |
Alteration of membrane phospholipid methylation by adenosine analogs does not affect T lymphocyte activation.
Topics: Adenosine; Antigens; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cell Membrane; Cells, Cultured; Humans; Leukocytes, Mononuclear; Lipids; Lymphocyte Activation; Major Histocompatibility Complex; Methylation; Phospholipids; Receptors, Antigen, T-Cell; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tritium | 1990 |
The double role of methyl donor and allosteric effector of S-adenosyl-methionine for Dam methylase of E. coli.
Topics: Adenosine; Allosteric Regulation; Base Sequence; Binding Sites; Binding, Competitive; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Kinetics; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Sodium Chloride; Temperature; Thermodynamics | 1990 |
S-adenosylmethionine and S-adenosylhomocysteine transitions in encysting Physarum flavicomum amoebae.
Topics: Chromatography, High Pressure Liquid; Methionine; Physarum; S-Adenosylhomocysteine; S-Adenosylmethionine | 1990 |
Influence of S-adenosylhomocysteine hydrolase inhibitors on S-adenosylhomocysteine and S-adenosylmethionine pool levels in L929 cells.
Topics: Adenine; Adenosylhomocysteinase; Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Hydrolases; L Cells; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Vaccinia virus | 1990 |
Isocratic high performance liquid chromatographic analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues: the effect of exposure to nitrous oxide.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Liver; Methylation; Nitrous Oxide; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet | 1990 |
A new high performance liquid chromatographic method for the simultaneous measurement of S-adenosylmethionine and S-adenosylhomocysteine. Concentrations in pig tissues after inactivation of methionine synthase by nitrous oxide.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Chromatography, High Pressure Liquid; Nitrous Oxide; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Swine; Tissue Distribution | 1990 |
Mechanism of the synergistic antiviral and cytostatic activity of (RS)-3-(adenin-9-yl)-2-hydroxypropanoic acid isobutyl ester and D,L-homocysteine.
Topics: Adenine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Line; Drug Synergism; Homocysteine; Hydrolases; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Vaccinia virus | 1990 |
Cobalamin neuropathy. Is S-adenosylhomocysteine toxicity a factor?
Topics: Animals; Brain Chemistry; Chiroptera; Chromatography, High Pressure Liquid; Homocysteine; Liver; Methionine; Neuromuscular Diseases; S-Adenosylhomocysteine; S-Adenosylmethionine; Valine; Vitamin B 12 Deficiency | 1990 |
2-Methylpropyl ester of 3-(adenin-9-yl)-2-hydroxypropanoic acid. Mechanism of antiviral action in vaccinia virus-infected L929 cells.
Topics: Adenine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Line; Chromatography, High Pressure Liquid; Hydrolases; L Cells; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Vaccinia; Vaccinia virus; Virus Replication | 1990 |
Combined modulation of S-adenosylmethionine biosynthesis and S-adenosylhomocysteine metabolism enhances inhibition of nucleic acid methylation and L1210 cell growth.
Topics: Adenosine; Animals; Cell Division; DNA, Neoplasm; Homocysteine; Leukemia L1210; Methylation; Polyamines; RNA, Neoplasm; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 1990 |
Direct photolabeling of the EcoRII methyltransferase with S-adenosyl-L-methionine.
Topics: Adenosine; Affinity Labels; Azides; Base Sequence; Chemical Precipitation; Dithiothreitol; DNA-Cytosine Methylases; DNA, Bacterial; Escherichia coli; Kinetics; Mercaptoethanol; Methylation; Photochemistry; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Trichloroacetic Acid; Ultraviolet Rays | 1990 |
Effect of vanadate and pyridoxal phosphate on S-adenosylmethionine.
Topics: Animals; Bleomycin; Chickens; Copper; Decarboxylation; In Vitro Techniques; Liver; Male; Pyridoxal Phosphate; S-Adenosylhomocysteine; S-Adenosylmethionine; Vanadates; Vanadium; Vanadium Compounds | 1985 |
Effects of secretagogues on ATP levels and protein carboxyl methylation in rat brain synaptosomes.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Calcimycin; Calcium; Chlorides; Egtazic Acid; Female; In Vitro Techniques; Manganese; Manganese Compounds; Methylation; Ouabain; Potassium; Protein Methyltransferases; Protein O-Methyltransferase; Proteins; Rats; Rats, Inbred Strains; Ruthenium Red; S-Adenosylhomocysteine; S-Adenosylmethionine; Sodium Cyanide; Synaptosomes; Tritium; Veratridine | 1986 |
Effects of 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine on the metabolism of S-adenosylhomocysteine in mouse L929 cells.
Topics: Adenosine; Adenosine Kinase; Adenosylhomocysteinase; Animals; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Homocysteine; Hydrolases; Mice; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1988 |
Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio.
Topics: Animals; Diethylnitrosamine; Genes, ras; Homocysteine; Immunoblotting; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Methylation; Precancerous Conditions; Proto-Oncogenes; Rats; Rats, Inbred F344; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 1989 |
Biochemical analysis of the role of transmethylation in the methionine dependence of tumor cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Biogenic Polyamines; Cell Division; Culture Media; Cystathionine beta-Synthase; Homocysteine; Humans; Methionine; Methionine Adenosyltransferase; Methylation; Phenotype; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1989 |
Hepatic content of S-adenosylmethionine, S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability.
Topics: Animals; Biomarkers; Choline Deficiency; Cysteine; Diet; Fatty Liver; Folic Acid Deficiency; Glutathione; Homocysteine; Lipids; Liver; Male; Methionine; Methylation; Niacinamide; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1989 |
Effect of toluene on rat synaptosomal phospholipid methylation and membrane fluidity.
Topics: Animals; Brain; Male; Membrane Fluidity; Methionine; Methionine Adenosyltransferase; Methylation; Norepinephrine; Phosphatidylethanolamines; Phospholipids; Propranolol; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Synaptosomes; Toluene | 1989 |
S-adenosylmethionine, S-adenosylhomocysteine and adenosine system. Age-dependent availability in rat brain.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Brain; Homocysteine; In Vitro Techniques; Kinetics; Male; Membranes; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1989 |
Protein carboxylmethyltransferase activity in intact, differentiated neuroblastoma cells: quantitation by S-[3H]adenosylmethionine prelabeling.
Topics: Animals; Cell Differentiation; Cell Line; Electrophoresis, Polyacrylamide Gel; Mice; Neuroblastoma; Protein Methyltransferases; Protein O-Methyltransferase; Proteins; Radioisotope Dilution Technique; S-Adenosylhomocysteine; S-Adenosylmethionine; Tritium | 1989 |
Effect of dietary methyl group deficiency on one-carbon metabolism in rats.
Topics: Amino Acids; Animals; Carbon; Choline Deficiency; Diet; Glycine N-Methyltransferase; Liver; Male; Methionine; Methylation; Methyltransferases; Organ Size; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine; Weight Gain | 1989 |
Regulation of 5-methyltetrahydrofolate synthesis.
Topics: Animals; Liver; Methionine; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1989 |
Phosphatidylethanolamine N-methyltransferase in human red blood cell membrane preparations. Kinetic mechanism.
Topics: Adult; Erythrocyte Membrane; Humans; Kinetics; Male; Methylation; Methyltransferases; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; S-Adenosylhomocysteine; S-Adenosylmethionine | 1989 |
Confirmation of a ping-pong mechanism for S-adenosyl-L-methionine:magnesium protoporphyrin methyltransferase of etiolated wheat by an exchange reaction.
Topics: Chromatography, Affinity; Chromatography, Ion Exchange; Kinetics; Methyltransferases; Oxygenases; S-Adenosylhomocysteine; S-Adenosylmethionine; Triticum | 1989 |
Elucidation of the mechanism by which homocysteine potentiates the anti-vaccinia virus effects of the S-adenosylhomocysteine hydrolase inhibitor 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Drug Synergism; Homocysteine; Hydrolases; L Cells; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Vaccinia virus | 1989 |
Effects of nitrous oxide inactivation of vitamin B12 and of methionine on folate coenzyme metabolism in rat liver, kidney, brain, small intestine and bone marrow.
Topics: Animals; Bone Marrow; Brain; Folic Acid; Intestine, Small; Kidney; Liver; Male; Methionine; Nitrous Oxide; Organ Specificity; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 1989 |
S-adenosylmethionine, S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase variations during differentiation of Dictyostelium discoideum.
Topics: Adenosylhomocysteinase; Cell Differentiation; Cyclic AMP; Dictyostelium; Genetic Variation; Homocysteine; Hydrolases; S-Adenosylhomocysteine; S-Adenosylmethionine | 1988 |
The effects of vitamin A deficiency on hepatic folate metabolism in rats.
Topics: Animals; Diterpenes; Folic Acid; Formiminoglutamic Acid; Histidine; Histidine Ammonia-Lyase; Liver; Male; Rats; Rats, Inbred Strains; Retinyl Esters; S-Adenosylhomocysteine; S-Adenosylmethionine; Urocanate Hydratase; Vitamin A; Vitamin A Deficiency | 1985 |
Histamine increases phospholipid methylation and H2-receptor-adenylate cyclase coupling in rat brain.
Topics: Adenylyl Cyclases; Animals; Brain; Cyclic AMP; Enzyme Activation; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Methylation; Methyltransferases; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Phospholipids; Rats; Rats, Inbred Strains; Receptors, Histamine H2; S-Adenosylhomocysteine; S-Adenosylmethionine; Synaptic Membranes; Tissue Distribution | 1988 |
S-adenosylmethionine, S-adenosylhomocysteine and DNA methylation levels in the liver of rats fed methapyrilene and analogs.
Topics: Aminopyridines; Animals; Carcinogens; Deoxycytidine; DNA; Homocysteine; Liver; Male; Methapyrilene; Methylation; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine | 1989 |
Evidence for altered methionine methyl-group utilization in the diabetic rat's brain.
Topics: Administration, Oral; Animals; Brain; Caseins; Diabetes Mellitus, Experimental; Diet; Female; Homocysteine; Male; Methionine; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Streptozocin; Time Factors | 1988 |
DNA methyltransferases in normal and avian sarcoma virus-transformed rat cells. Quantitation of 5-methyldeoxycytidine in DNA and enzyme kinetics study.
Topics: Animals; Avian Sarcoma Viruses; Cell Nucleus; Cell Transformation, Viral; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxycytidine; DNA; DNA (Cytosine-5-)-Methyltransferases; Fibroblasts; Kidney; Kinetics; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1985 |
Modulation by the ratio S-adenosylmethionine/S-adenosylhomocysteine of cyclic AMP-dependent phosphorylation of the 50 kDa protein of rat liver phospholipid methyltransferase.
Topics: Animals; Cyclic AMP; Fluorides; Homocysteine; Kinetics; Liver; Methyltransferases; Molecular Weight; Phosphatidyl-N-Methylethanolamine N-Methyltransferase; Phosphatidylethanolamine N-Methyltransferase; Phosphorylation; Protein Kinases; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1985 |
Effects of the transmethylation inhibitor S-adenosyl-homocysteine and of the methyl donor S-adenosyl-methionine on rat Leydig cell function in vitro.
Topics: Animals; Bucladesine; Cell Membrane; Chorionic Gonadotropin; Cyclic AMP; Dose-Response Relationship, Drug; Homocysteine; Leydig Cells; Luteinizing Hormone; Male; Methylation; Rats; Receptors, LH; S-Adenosylhomocysteine; S-Adenosylmethionine; Testosterone | 1987 |
Methionine metabolism in mammals. Adaptation to methionine excess.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Glutathione; Liver; Male; Methionine; Methionine Adenosyltransferase; Methyltransferases; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Serine | 1986 |
Modification of hepatic folate metabolism in rats fed excess retinol.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Dioxide; Folic Acid; Formates; Histidine; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Vitamin A | 1986 |
Neplanocin A inhibition of S-adenosylhomocysteine hydrolase in Alcaligenes faecalis has no effect on growth of the microorganism.
Topics: Adenosine; Adenosylhomocysteinase; Alcaligenes; Bacillus subtilis; Hydrolases; N-Glycosyl Hydrolases; S-Adenosylhomocysteine; S-Adenosylmethionine | 1987 |
Methylation deficiency causes vitamin B12-associated neuropathy in the pig.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Homocysteine; Methylation; Nervous System Diseases; Nitrous Oxide; S-Adenosylhomocysteine; S-Adenosylmethionine; Spinal Cord; Swine; Vitamin B 12 | 1988 |
Catalytic mechanism and inhibition of tRNA (uracil-5-)methyltransferase: evidence for covalent catalysis.
Topics: Aminobutyrates; Escherichia coli; Fluorouracil; Kinetics; Methylation; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; Tritium; tRNA Methyltransferases | 1987 |
Growth support and toxicity of homocysteine and its effects on methionine metabolism in non-transformed and chemically transformed C3H/10T1/2 cells.
Topics: Animals; Cell Division; Cell Line; Cysteine; Dose-Response Relationship, Drug; Glutathione; Homocysteine; Homocystine; Methionine; Mice; Mice, Inbred C3H; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1988 |
S-adenosyl-L-methionine protects the hippocampal CA1 neurons from the ischemic neuronal death in rat.
Topics: Animals; Cell Membrane; Cell Survival; Cytidine Diphosphate Choline; Hippocampus; Ischemic Attack, Transient; Male; Methionine; Methylation; Necrosis; Nerve Degeneration; Neurons; Phosphatidylcholines; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1988 |
DNA (cytosine) methylation in murine and human tumor cell lines treated with S-adenosylhomocysteine hydrolase inhibitors.
Topics: Adenosine; Adenosylhomocysteinase; Animals; DNA, Neoplasm; Humans; Hydrolases; Methylation; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin; Tumor Cells, Cultured | 1988 |
Partial purification, characterization, and kinetic analysis of isoflavone 5-O-methyltransferase from yellow lupin roots.
Topics: Cations, Divalent; Methylation; Methyltransferases; Plant Proteins; Plants; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfhydryl Reagents | 1988 |
Effect of methotrexate on homocysteine and other sulfur compounds in tissues of rats fed a normal or a defined, choline-deficient diet.
Topics: Analysis of Variance; Animals; Choline Deficiency; Diet; Glutathione; Homocysteine; Kidney; Liver; Male; Methotrexate; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 1988 |
DNA methylating capacity in metastatic variants of a human melanoma cell line.
Topics: Cell Line; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Genetic Variation; Humans; Melanoma; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine | 1988 |
S-adenosylmethionine metabolism in HL-60 cells: effect of cell cycle and differentiation.
Topics: Cell Cycle; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Humans; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine | 1988 |
1,2-Dimethylhydrazine-induced premalignant alterations in the S-adenosylmethionine/S-adenosylhomocysteine ratio and membrane lipid lateral diffusion of the rat distal colon.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Decanoic Acids; Diffusion; Dimethylhydrazines; Homocysteine; Membrane Lipids; Methionine Adenosyltransferase; Methylhydrazines; Precancerous Conditions; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1988 |
Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets.
Topics: Animals; Body Weight; Choline; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Liver Neoplasms; Male; Methionine; Methylation; Mice; Mice, Inbred C3H; Organ Size; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 1986 |
Disposition of endogenous homocysteine by mouse fibroblast C3H/10T1/2 Cl 8 and the chemically transformed C3H/10T1/2 MCA Cl 16 cells following methotrexate exposure.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromatography, Ion Exchange; Culture Media; Fibroblasts; Homocysteine; Methotrexate; Methylcholanthrene; Mice; Mice, Inbred C3H; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
Induction of HL-60 cell differentiation by 3-deaza-(+/-)-aristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Cell Cycle; Cell Differentiation; Cell Line; Cell Survival; Humans; Hydrolases; Leukemia, Myeloid, Acute; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
4'-Thioadenosine as a novel inhibitor of S-adenosylhomocysteine hydrolase and an inducer for the differentiation of HL-60 human leukemia cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Differentiation; Cell Line; Chromatography, High Pressure Liquid; Homocysteine; Humans; Hydrolases; Leukemia, Myeloid, Acute; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1986 |
S-adenosylmethionine metabolism as a target for adenosine toxicity.
Topics: Adenosine; Adenosine Kinase; Animals; Cell Line; Coformycin; Drug Resistance; Lymphoma; Methionine Adenosyltransferase; Mice; Pentostatin; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
In vivo inhibition of mouse liver methyltransferase enzymes following treatment with 2'-deoxycoformycin and 2'-deoxyadenosine.
Topics: Adenosylhomocysteinase; Animals; Coformycin; Creatinine; Deoxyadenosines; Hydrolases; Liver; Male; Methyltransferases; Mice; Pentostatin; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
Kinetic and catalytic mechanism of HhaI methyltransferase.
Topics: Binding Sites; Catalysis; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA-Cytosine Methylases; Kinetics; Methylation; Nucleic Acid Conformation; Polydeoxyribonucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine; Tritium | 1987 |
S-adenosylmethionine: studies on chemical and enzymatic synthesis.
Topics: Adenosylhomocysteinase; Enzymes, Immobilized; Hydrolases; Kinetics; Magnetic Resonance Spectroscopy; Methionine; S-Adenosylhomocysteine; S-Adenosylmethionine | 1987 |
Periodate-oxidized adenosine inhibits the formation of dimethylselenide and trimethylselenonium ion in mice treated with selenite.
Topics: Adenosine; Animals; Inactivation, Metabolic; Kinetics; Liver; Methylation; Mice; Organometallic Compounds; Organoselenium Compounds; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenious Acid; Selenium; Selenium Compounds | 1987 |
Effect of chronic primidone treatment on folate-dependent one-carbon metabolism in the rat.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Animals; Brain; Folic Acid; Glycine Hydroxymethyltransferase; Liver; Male; Methionine Adenosyltransferase; Oxidoreductases; Primidone; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1987 |
Kinetics and inhibition studies of catechol O-methyltransferase from the yeast Candida tropicalis.
Topics: Benzocycloheptenes; Candida; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Enzyme Activation; Kinetics; Magnesium; Manganese; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfhydryl Reagents; Umbelliferones; Zinc | 1987 |
Inhibition of leishmanial DNA synthesis by sinefungin.
Topics: Adenosine; Animals; Cell Line; DNA Replication; Leishmania; Macrophages; Mice; Phosphorylation; Protein Biosynthesis; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity; Thymidine; Transcription, Genetic | 1987 |
On the role of O-methylation in the metabolism of S-adenosylmethionine in rat brain.
Topics: Animals; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Cerebral Cortex; Corpus Striatum; Cycloheptanes; Dose-Response Relationship, Drug; Female; Methylation; Mice; Psychotropic Drugs; Pyrogallol; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Tropolone | 1987 |
Adenosine dialdehyde and nitrous oxide induce HL-60 differentiation.
Topics: Adenosine; Adenosylhomocysteinase; Cell Differentiation; Cell Division; Cell Line; Cycloleucine; Humans; Hydrolases; Nitrous Oxide; Osmolar Concentration; S-Adenosylhomocysteine; S-Adenosylmethionine | 1987 |
Methionine metabolism in isolated perfused livers from rats fed on zinc-deficient and restricted diets.
Topics: Animals; Butyrates; Cystathionine; Diet; Homocysteine; In Vitro Techniques; Liver; Male; Methionine; Perfusion; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Zinc | 1986 |
Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged S-adenosylmethionine pools.
Topics: Adenosine; Animals; Cells, Cultured; Drug Resistance; Homocysteine; Kinetics; Lymphoma; Methionine; Methionine Adenosyltransferase; Mice; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
In vivo depletion of S-adenosyl-L-homocysteine and S-adenosyl-L-methionine in guinea pig lung after chronic S-(-)-nicotine administration.
Topics: Animals; Chromatography, High Pressure Liquid; Guinea Pigs; Homocysteine; Injections, Subcutaneous; Liver; Lung; Male; Nicotine; S-Adenosylhomocysteine; S-Adenosylmethionine; Stereoisomerism | 1986 |
Disposition of homocysteine and S-3-deazaadenosylhomocysteine in cells exposed to 3-deazaadenosine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Fibroblasts; Homocysteine; Hydrolases; Liver; Mice; Neoplasms, Experimental; Protein Binding; Rats; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1986 |
Quantitative evaluation and regulation of S-adenosylmethionine-dependent transmethylation in sheep tissues.
Topics: Animals; Female; Homeostasis; Hydrolysis; Kinetics; Methylation; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Sheep; Tissue Distribution | 1986 |
Measurement of liver adenine nucleotides and S-adenosyl amino acids by one-step high-performance liquid chromatography.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acids, Sulfur; Animals; Chromatography, High Pressure Liquid; Guinea Pigs; Humans; Liver; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
Creatine metabolism in the pyridoxine-deficient rat.
Topics: Amidinotransferases; Animals; Creatine; Guanidinoacetate N-Methyltransferase; Kidney; Liver; Male; Methyltransferases; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 6 Deficiency | 1986 |
Inhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Differentiation; Cell Line; Deoxyadenosines; Dimethyl Sulfoxide; DNA; Leukemia, Erythroblastic, Acute; Methylation; Mice; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Tubercidin | 1985 |
Synthesis of phosphatidylcholine by two distinct methyltransferases in rat colonic brush-border membranes: evidence for extrinsic and intrinsic membrane activities.
Topics: Adenosine Triphosphate; Animals; Cations, Divalent; Colon; In Vitro Techniques; Intestinal Mucosa; Male; Methylation; Methyltransferases; Microvilli; Octoxynol; Phosphatidylcholines; Phospholipids; Polyethylene Glycols; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Subcellular Fractions; Temperature; Time Factors | 1986 |
Effect of zinc deficiency on methionine metabolism, methylation reactions and protein synthesis in isolated perfused rat liver.
Topics: Amino Acids, Sulfur; Animals; Chromatography; DNA; In Vitro Techniques; Liver; Male; Methionine; Methylation; Microsomes, Liver; Perfusion; Phospholipids; Protein Biosynthesis; Rats; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; Zinc | 1985 |
Multiple mechanisms of adenosine toxicity in an adenosine sensitive mutant of baby hamster kidney (BHK) cells.
Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cell Line; Cricetinae; Cytidine Triphosphate; Deoxyadenosines; Drug Resistance; Guanosine Triphosphate; Kidney; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Uridine Triphosphate; Vidarabine | 1985 |
Effect of S-adenosylhomocysteine on sulfhydryl xenobiotic transmethylases in rat liver.
Topics: Animals; Homocysteine; Liver; Male; Methyltransferases; Microsomes, Liver; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1985 |
Phospholipid methylase activity, [3H]S-adenosyl-L-homocysteine binding, and S-adenosyl-L-methionine and S-adenosyl-L-homocysteine levels in rat brain during maturation.
Topics: Animals; Animals, Newborn; Brain; Cell Membrane; Cerebral Cortex; Homocysteine; Male; Methyltransferases; Phosphatidyl-N-Methylethanolamine N-Methyltransferase; Phosphatidylethanolamine N-Methyltransferase; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1985 |
Comparative studies on the methionine synthesis in sheep and rat tissues.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine-Homocysteine S-Methyltransferase; Female; Kidney; Liver; Methionine; Methyltransferases; Muscles; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Sheep; Tissue Distribution | 1985 |
Purification and partial characterization of rat kidney histamine-N-methyltransferase.
Topics: Adenosine; Animals; Chromatography, DEAE-Cellulose; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Histamine N-Methyltransferase; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Iodoacetamide; Kidney; Kinetics; Male; Methylhistamines; Methyltransferases; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1985 |
Altered regulation of S-adenosylmethionine dependent methylation in adenosine deaminase deficiency.
Topics: Adenosine Deaminase; Animals; Cell Line; Child; Homeostasis; Humans; Kinetics; Methylation; Nucleoside Deaminases; S-Adenosylhomocysteine; S-Adenosylmethionine | 1985 |
The role of S-adenosylhomocysteine in the biological utilization of S-adenosylmethionine.
Topics: Alcaligenes; Animals; Dictyostelium; Homocysteine; Humans; Kinetics; Methylation; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine | 1985 |
The effect of diazepam on brain levels of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine: possible correlation with protection from methionine sulfoximine seizures.
Topics: Animals; Brain Chemistry; Diazepam; Dose-Response Relationship, Drug; Homocysteine; Male; Methionine Sulfoximine; Methylation; Mice; Reaction Time; S-Adenosylhomocysteine; S-Adenosylmethionine; Seizures | 1985 |
Determination of adenosine and S-adenosyl derivatives of sulfur amino acids in rat liver by high-performance liquid chromatography.
Topics: Adenosine; Amino Acids, Sulfur; Animals; Chromatography, High Pressure Liquid; Liver; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet | 1985 |
Inhibitors of CDP-choline synthesis, action potential calcium channels, and stimulus-secretion coupling.
Topics: Acetylcholine; Action Potentials; Animals; Calcium; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Deoxyadenosines; Hybrid Cells; Ion Channels; Mice; Motor Endplate; Nucleotidyltransferases; Phosphatidylcholines; Rats; Receptors, Nicotinic; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Tubercidin | 1984 |
Activation and inactivation of striatal tyrosine hydroxylase: the effects of pH, ATP and cyclic AMP, S-adenosylmethionine and S-adenosylhomocysteine.
Topics: Adenosine Triphosphate; Animals; Corpus Striatum; Cyclic AMP; Enzyme Activation; Haloperidol; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tyrosine 3-Monooxygenase | 1983 |
Tropolone antagonism of the L-dopa-induced elevation of S-adenosylhomocysteine: S-adenosylmethionine ratio but not depletion of adrenaline in rat hypothalamus.
Topics: Animals; Catechol O-Methyltransferase Inhibitors; Epinephrine; Homocysteine; Hypothalamus; Levodopa; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tropolone | 1984 |
Evidence that the inhibitory effect of adenosine, but not cordycepin, on the methylation of nuclear RNA is mediated by S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Adult; Animals; Cell Nucleus; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Leukemia L1210; Methylation; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.
Topics: Adenine; Adenosine; Animals; Basophils; Female; Histamine Release; Homocysteine; Immunoglobulin E; Leukemia; Mast Cells; Methylation; Mice; Rabbits; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1981 |
Effect of inhibitors of methylation on early and late interferon synthesis in bovine kidney cell cultures.
Topics: Adenine; Adenosine; Animals; Cattle; Cells, Cultured; Cycloheximide; Cycloleucine; Homocysteine; Interferons; Methylation; Newcastle disease virus; Poly I-C; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Dopamine agonists stimulate protein carboxylmethylation in striatal synaptosomes.
Topics: Animals; Apomorphine; Butaclamol; Corpus Striatum; Dopamine; Hydroxydopamines; In Vitro Techniques; Male; Nerve Tissue Proteins; Piperidines; Potassium; Protein Methyltransferases; Protein O-Methyltransferase; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Synaptosomes | 1982 |
Increase in S-adenosylhomocysteine concentration in interferon-treated HeLa cells and inhibition of methylation of vesicular stomatitis virus mRNA.
Topics: Chromatography, High Pressure Liquid; HeLa Cells; Homocysteine; Humans; Interferons; Methylation; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Vesicular stomatitis Indiana virus | 1983 |
Fragile X expression is decreased by 5-azacytidine and S-adenosylhomocysteine.
Topics: Azacitidine; Cell Line; Culture Media; DNA; Dose-Response Relationship, Drug; Floxuridine; Fragile X Syndrome; Homocysteine; Humans; Karyotyping; Methionine; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Chromosome Aberrations | 1983 |
Modulation by S-adenosyl-methionine and S-adenosyl-homocysteine of the human leucocytes histamine release.
Topics: Allergens; Cromolyn Sodium; Histamine Release; Homocysteine; Humans; Leukocytes; S-Adenosylhomocysteine; S-Adenosylmethionine; Theophylline | 1984 |
Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenylyl Cyclases; Animals; Cyclic AMP; Enzyme Activation; Guanosine; Lymphocytes; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Microsomal phosphatidylethanolamine methyltransferase: effect of altered S-adenosylmethionine-S-adenosylhomocysteine ratios in rat liver.
Topics: Animals; Bromobenzenes; Diacylglycerol Cholinephosphotransferase; Female; Homocysteine; Liver; Methyltransferases; Microsomes, Liver; Phosphatidylethanolamine N-Methyltransferase; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Starvation | 1981 |
Effects of a methyl-deficient diet on rat liver phosphatidylcholine biosynthesis.
Topics: Animals; Choline Deficiency; Diacylglycerol Cholinephosphotransferase; Diet; Female; Liver; Methionine; Methylation; Methyltransferases; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Effects of cap analogue or cap removal on the translation of rat brain mRNA in vitro.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Periodic Acid; Protein Biosynthesis; Rabbits; Rats; Rats, Inbred Strains; RNA Cap Analogs; RNA Caps; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 1982 |
Reduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells.
Topics: Cell Division; Cell Line; Cell Transformation, Viral; Homocysteine; Humans; Methionine; Neoplasms, Experimental; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1982 |
The effects of S-adenosylhomocysteine and S-adenosylmethionine on some purine- and pyrimidine-metabolizing systems.
Topics: 5'-Nucleotidase; Adenosine Deaminase Inhibitors; Adenylate Kinase; AMP Deaminase; Homocysteine; Nucleoside-Phosphate Kinase; Nucleotidases; Purine-Nucleoside Phosphorylase; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine | 1982 |
The effect of S-adenosyl methionine on the TSH receptor function in human thyroid tissue: increase in binding of TSH and decrease in adenylate cyclase coupling.
Topics: Adenylyl Cyclases; Humans; In Vitro Techniques; Receptors, Cell Surface; S-Adenosylhomocysteine; S-Adenosylmethionine; Thyroid Gland; Thyrotropin | 1982 |
Reduced free-methionine in methionine-dependent SV40-transformed human fibroblasts synthesizing apparently normal amounts of methionine.
Topics: Cell Line; Cell Transformation, Viral; Cells, Cultured; Humans; Methionine; Protein Biosynthesis; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1983 |
Effect of Friend virus infection on the biosynthetic enzymes of phosphatidylcholine biosynthesis in spleen microsomes.
Topics: Animals; Diacylglycerol Cholinephosphotransferase; Friend murine leukemia virus; Leukemia, Experimental; Male; Methylation; Mice; Mice, Inbred BALB C; Microsomes; Phosphatidylcholines; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 1984 |
45Ca2+ uptake and phospholipid methylation in isolated rat liver microsomes.
Topics: Animals; Calcium; Calcium Radioisotopes; Epinephrine; Glucagon; Insulin; Male; Methylation; Microsomes; Microsomes, Liver; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1983 |
The effects of S-adenosyl methionine (AdoMet) and its analogues on the control of transcription and translation in vitro of the mRNA products of two cytoplasmic polyhedrosis viruses.
Topics: Adenosine; Cell-Free System; DNA-Directed RNA Polymerases; Ethionine; Homocysteine; Insect Viruses; Kinetics; Plants; Protein Biosynthesis; Ribonucleotides; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity; Transcription, Genetic; Triticum | 1983 |
Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon.
Topics: Adenosine; Adenosylhomocysteinase; Burkitt Lymphoma; Cell Division; Cell Line; Deoxyadenosines; HeLa Cells; Humans; Hydrolases; Interferon Type I; Kinetics; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1984 |
Multiple methylation in processing of sensory signals during bacterial chemotaxis.
Topics: Bacterial Proteins; Bacteriophage lambda; Chemotaxis; DNA, Recombinant; Escherichia coli; Hydrolysis; Methylation; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
1-methylnicotinamide and NAD metabolism in normal and transformed normal rat kidney cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Kidney; NAD; Niacinamide; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1981 |
Methylation increases sodium transport into A6 apical membrane vesicles: possible mode of aldosterone action.
Topics: Aldosterone; Amiloride; Amphibians; Animals; Biological Transport, Active; Cell Line; Cell Membrane; Kidney; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sodium; Tubercidin | 1984 |
Inactivation and reactivation of intracellular S-adenosylhomocysteinase in the presence of nucleoside analogues in rat hepatocytes.
Topics: Adenosylhomocysteinase; Animals; Hydrolases; In Vitro Techniques; Kinetics; Liver; Nucleosides; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Vidarabine | 1984 |
Sarcolemmal phosphatidylethanolamine N-methylation in diabetic cardiomyopathy.
Topics: Animals; Cardiomyopathies; Diabetes Mellitus, Experimental; Kinetics; Male; Methylation; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcolemma | 1984 |
Elevated overall rates of transmethylation in cell lines from diverse human tumors.
Topics: Adenosylhomocysteinase; Cell Line; Homocysteine; Humans; Hydrolases; Methionine; Methylation; Neoplasms, Experimental; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1984 |
Brain methylation and epileptogenesis: the case of methionine sulfoximine.
Topics: Adenosine; Animals; Brain; Epilepsy; Histamine; Homocysteine; Methionine; Methionine Sulfoximine; Methylation; Methylhistamines; Mice; Nerve Tissue Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences.
Topics: Adenosine; Aspartic Acid; Erythrocyte Membrane; Erythrocytes; Homocysteine; Humans; Membrane Proteins; Methionine; Methylation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Methylation of replicating and post-replicated mouse L-cell DNA.
Topics: Animals; Deoxyguanine Nucleotides; DNA; DNA Replication; Kinetics; L Cells; Methylation; Mice; Phosphorus Radioisotopes; S-Adenosylhomocysteine; S-Adenosylmethionine | 1983 |
Significance of S-adenosylmethionine pools in the hypomethylation of ribosomal RNA during the propagation of tissue culture cells and oncogenesis.
Topics: Animals; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Child; Fibroblasts; HeLa Cells; Humans; Kidney; Kinetics; Liver; Liver Regeneration; Male; Methylation; Osteosarcoma; Rats; Rats, Inbred Strains; RNA, Ribosomal; S-Adenosylhomocysteine; S-Adenosylmethionine | 1983 |
Effect of 2'-deoxycoformycin infusion on S-adenosylhomocysteine hydrolase and the amount of S-adenosylhomocysteine and related compounds in tissues of mice.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosylhomocysteinase; Animals; Coformycin; Deoxyadenosines; Homocysteine; Hydrolases; Infusions, Parenteral; Jejunum; Kidney; Kinetics; Liver; Mice; Nucleoside Deaminases; Organ Specificity; Pentostatin; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1983 |
Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids.
Topics: Animals; Diet; Homocysteine; Homocystine; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Liver; Male; Methotrexate; Mice; Mice, Inbred DBA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1983 |
High-performance liquid chromatographic analysis of adenosyl-sulfur compounds related to polyamine biosynthesis.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Polyamines; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1983 |
Methylation of phospholipids in microsomes of the rat aorta.
Topics: Animals; Aorta, Thoracic; Chromatography, Thin Layer; Fluorescence Polarization; Homocysteine; Male; Methylation; Microsomes; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Trypsin; Type C Phospholipases | 1983 |
Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines.
Topics: Cell Line; Homocysteine; Humans; Methionine; Models, Biological; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Metabolic conversion of neplanocin A to S-neplanocylmethionine by mouse L 929 cells.
Topics: Adenosine; Animals; Biotransformation; L Cells; Methionine; Methyltransferases; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 1984 |
Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet.
Topics: Animals; Cell Nucleus; Choline Deficiency; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Liver Neoplasms; Male; Methionine; Methylation; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
High-performance liquid chromatographic analysis of S-adenosylmethionine and its metabolites in rat tissues: interrelationship with changes in biogenic catechol levels following treatment with L-dopa.
Topics: Adrenal Glands; Animals; Brain Chemistry; Catechols; Chromatography, High Pressure Liquid; Chromatography, Liquid; Levodopa; Male; Myocardium; Pancreas; Polyamines; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Differential membrane protein carboxyl-methylation of intact human erythrocytes by exogenous methyl donors.
Topics: Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Humans; Hydrolysis; Membrane Proteins; Methionine; Methylation; Protein O-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosine Deaminase; Adenosylhomocysteinase; Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Homocysteine; Hydrolases; In Vitro Techniques; Liver; Male; Methionine; Methyltransferases; Models, Biological; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
S-adenosyl-L-methionine synthetase from human erythrocytes: role in the regulation of cellular S-adenosylmethionine levels.
Topics: Cytosol; Erythrocytes; Humans; Kinetics; Methionine; Methionine Adenosyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Transferases | 1983 |
Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks.
Topics: Animals; Body Weight; Choline Deficiency; Diet; Folic Acid Deficiency; Homocysteine; Kinetics; Liver; Lung; Male; Methionine; Methylation; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine; Testis; Tissue Distribution; Vitamin B 12 Deficiency | 1983 |
Simple separation of adenine and adenosyl-sulfur compounds by high-performance liquid chromatography.
Topics: Adenine; Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1983 |
Perturbations in S-adenosylhomocysteine and S-adenosylmethionine metabolism: effects on transmethylation.
Topics: Adenosine; Adenosylhomocysteinase; Cell Line; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Lymphocytes; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 1980 |
Inhibition of leucine transport in Saccharomyces by S-adenosylmethionine.
Topics: Adenosine; Binding, Competitive; Biological Transport; Ethionine; Kinetics; Leucine; S-Adenosylhomocysteine; S-Adenosylmethionine; Saccharomyces cerevisiae | 1980 |
Characteristics of protein carboxyl methylation in the rat hypothalamus.
Topics: Animals; Hypothalamus; Kinetics; Male; Methionine; Methylation; Nerve Tissue Proteins; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Synaptosomes; Tritium | 1982 |
The regional concentrations of S-adenosyl-L-methionine, S-adenosyl-L-homocysteine, and adenosine in rat brain.
Topics: Adenosine; Aging; Animals; Brain; Brain Chemistry; Homocysteine; Male; Pineal Gland; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tissue Distribution | 1982 |
Inactivation of S-adenosylhomocysteine hydrolase by 9-beta-D-arabinofuranosyladenine in intact cells.
Topics: Adenosylhomocysteinase; Animals; Biological Transport; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Activation; Homocysteine; Humans; Hydrolases; Kinetics; Leukemia, Experimental; Liver; Mice; Plasmacytoma; S-Adenosylhomocysteine; S-Adenosylmethionine; Vidarabine | 1982 |
The effect of pharmacologic inhibition of phospholipid methylation on human platelet function.
Topics: Adenosine; Adenosylhomocysteinase; Blood Platelets; Humans; Hydrolases; Methylation; Phosphatidylethanolamines; Phospholipids; Platelet Aggregation; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1982 |
Methionine metabolism in mammals: concentration of metabolites in rat tissues.
Topics: Amino Acids, Sulfur; Animals; Cysteine; Cystine; Dietary Proteins; Homeostasis; Homocysteine; Male; Methionine; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfhydryl Compounds; Tissue Distribution | 1982 |
Kinetic studies on the O-methylation of dopamine by human brain membrane-bound catechol O-methyltransferase.
Topics: Brain; Catechol O-Methyltransferase; Cell Membrane; Dopamine; Humans; Kinetics; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Tropolone | 1982 |
Effects of hypophysectomy and dexamethasone administration on central and peripheral S-adenosylmethionine levels.
Topics: Adrenal Glands; Animals; Biological Assay; Brain Chemistry; Dexamethasone; Endocrine Glands; Hypophysectomy; Male; Pineal Gland; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1982 |
Effects of L-dopa on epinephrine concentration in rat brain: possible role of inhibition of norepinephrine N-methyltransferase by S-adenosylhomocysteine.
Topics: Animals; Epinephrine; Hypothalamus; Levodopa; Male; Monoamine Oxidase Inhibitors; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1982 |
Effect of 9-beta-D-arabinofuranosyladenine and erythro-9-(2-hydroxy-3-nonyl) adenine on the metabolism of S-adenosylhomocysteine, S-adenosylmethionine, and adenosine in rat liver.
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Animals; Female; Homocysteine; Hydrolases; Liver; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Vidarabine | 1982 |
Role of transmethylation reactions in cellular motility and phagocytosis.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adult; Animals; Cell Movement; Chemotaxis, Leukocyte; Depression, Chemical; Guinea Pigs; Humans; In Vitro Techniques; Lactones; Macrophages; Methylation; Models, Biological; Monocytes; Peptides; Phagocytosis; Phospholipids; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Decreased in vivo protein and phospholipid methylation after in vivo elevation of brain S-adenosyl-homocysteine.
Topics: Adenosine; Animals; Brain; Homocysteine; Male; Methylation; Mice; Nerve Tissue Proteins; Phospholipids; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Decreased transmethylation of biogenic amines after in vivo elevation of brain S-adenosyl-l-homocysteine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Biogenic Amines; Brain; Catechol O-Methyltransferase Inhibitors; Histamine; Histamine N-Methyltransferase; Homocysteine; Hydrolases; Liver; Male; Methylation; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Stimulation of transcription by S-adenosyl-L-homocysteine and virion-encapsidated methyl donor in spring viraemia of carp virus.
Topics: Animals; Capsid; Carps; Homocysteine; Kinetics; Methylation; Rhabdoviridae; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcription, Genetic; Virion | 1981 |
The biosynthesis of polyamines in the brain of audiogenic seizure-susceptible and -resistant deermice.
Topics: Acoustic Stimulation; Animals; Brain; Chromatography, High Pressure Liquid; Methionine; Peromyscus; Polyamines; Putrescine; S-Adenosylhomocysteine; S-Adenosylmethionine; Seizures; Spermidine; Spermine | 1981 |
Microsomal phosphatidylethanolamine methyltransferase: inhibition by S-adenosylhomocysteine.
Topics: Animals; Female; Guinea Pigs; Homocysteine; Kinetics; Methyltransferases; Mice; Microsomes, Liver; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Rabbits; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Phosphatidylethanolamine methylation in membranes from rat cerebral cortex : effect of exogenous phospholipids and S-adenosylhomocysteine.
Topics: Animals; Cerebral Cortex; Homocysteine; In Vitro Techniques; Membranes; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Phospholipids; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
[A new method for determination of adenosylmethionine, adenosyl-homocysteine and decarboxylated adenosylmethionine].
Topics: Animals; Chromatography, High Pressure Liquid; Homocysteine; Liver; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Studies of inhibition of rat spermidine synthase and spermine synthase.
Topics: Adenosine; Animals; Deoxyadenosines; Male; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Spermidine Synthase; Spermine Synthase; Thionucleosides; Transferases | 1980 |
Inhibition by S-adenosyl-L-homocysteine of dopamine dependent adenylate cyclase in rat retina.
Topics: Adenylyl Cyclase Inhibitors; Animals; Dopamine; Homocysteine; Male; Rats; Retina; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of L-methionine, L-homocystein, and adenosine.
Topics: Adenosine; Animals; DNA; Female; Histones; Homocysteine; Kinetics; Liver; Methionine; Perfusion; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Determination of S-adenosylmethionine and S-adenosylhomocysteine in nuclei isolated from sea urchin embryos during early development.
Topics: Animals; Cell Nucleus; Embryo, Nonmammalian; Homocysteine; S-Adenosylhomocysteine; S-Adenosylmethionine; Sea Urchins | 1980 |
Partial restoration of impaired alpha 1-adrenergic responsiveness in parotid cells of aged rats by S-adenosylmethionine treatment.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Aging; Animals; Fluorescence Polarization; Inositol 1,4,5-Trisphosphate; Male; Membrane Fluidity; Membrane Lipids; Methylation; Parotid Gland; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; Viscosity | 1995 |
Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment.
Topics: Animals; Carbon Tetrachloride; Cystathionine; DNA; Folic Acid; Homocysteine; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1995 |
Thiopurine induced disturbance of DNA methylation in human malignant cells.
Topics: Antimetabolites, Antineoplastic; Cell Death; DNA, Neoplasm; Humans; Mercaptopurine; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Thioinosine; Thionucleotides; Tumor Cells, Cultured | 1995 |
Characterization of IMT1, myo-inositol O-methyltransferase, from Mesembryanthemum crystallinum.
Topics: Amino Acid Sequence; DNA, Plant; Escherichia coli; Inositol; Kinetics; Methyltransferases; Molecular Sequence Data; Molecular Weight; Plants; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Stereoisomerism; Substrate Specificity | 1995 |
Finding of a homarine-synthesizing enzyme in turban shell and some properties of the enzyme.
Topics: Adenosine; Alkaloids; Animals; Cations, Divalent; Enzyme Inhibitors; Glycine; Invertebrates; Methyltransferases; Picolinic Acids; S-Adenosylhomocysteine; S-Adenosylmethionine; Snails; Species Specificity | 1995 |
Homocysteine enhances the inhibitory effect of extracellular adenosine on the synthesis of proteins in isolated rat hepatocytes.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cell Survival; Cells, Cultured; Drug Synergism; Homocysteine; Hydrolases; Inosine; Kinetics; Liver; Male; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 1995 |
A cytosine methyltransferase converts 5-methylcytosine in DNA to thymine.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA-Cytosine Methylases; Escherichia coli; Humans; Methylation; Molecular Structure; Mutagenesis; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine; Thymine | 1995 |
Purification of the KpnI DNA methyltransferase and photolabeling of the enzyme with S-adenosyl-L-methionine.
Topics: Adenosine; Cloning, Molecular; Escherichia coli; Molecular Sequence Data; Protein Binding; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Ultraviolet Rays | 1995 |
S-adenosyl-L-methionine modulates firing rate of dorsal motor nucleus of the vagus neurones in vitro.
Topics: Action Potentials; Alkanesulfonates; Animals; Dose-Response Relationship, Drug; Electrophysiology; Female; Male; Methylation; Motor Neurons; Patch-Clamp Techniques; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; Theobromine; Vagus Nerve; Xanthines | 1994 |
An abnormal methylation ratio induces hypomethylation in vitro in the brain of pig and man, but not in rat.
Topics: Animals; Brain; Death; Female; Humans; Methylation; Methyltransferases; Nitrous Oxide; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity; Swine; Time Factors; Vitamin B 12 Deficiency | 1995 |
Prevention of neural tube defects by and toxicity of L-homocysteine in cultured postimplantation rat embryos.
Topics: Adenosylhomocysteinase; Animals; Catalase; Copper; Copper Sulfate; Culture Techniques; Drug Interactions; Embryonic and Fetal Development; Embryonic Development; Female; Homocysteine; Homocystine; Hydrolases; Methionine; Neural Tube Defects; Oxidation-Reduction; Pregnancy; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Stereoisomerism; Teratogens; Vitamin B 12 | 1994 |
Mechanism of erythrocyte accumulation of methylation inhibitor S-adenosylhomocysteine in uremia.
Topics: Adenosine; Adenosylhomocysteinase; Adult; Aspartate Aminotransferases; Erythrocytes; Female; Homocysteine; Humans; Hydrolases; Male; Methylation; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Uremia | 1995 |
S-adenosyl methionine alters the DNA contacts of the EcoKI methyltransferase.
Topics: Base Sequence; DNA; Methylation; Molecular Sequence Data; Nucleic Acid Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Sulfuric Acid Esters; Temperature | 1995 |
Increased membrane-protein methylation in hereditary spherocytosis. A marker of cytoskeletal disarray.
Topics: Cytoskeleton; Erythrocyte Membrane; Esterification; Humans; Membrane Proteins; Methylation; Protein Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrin; Spherocytosis, Hereditary | 1995 |
M.HhaI binds tightly to substrates containing mismatches at the target base.
Topics: 5-Methylcytosine; Base Sequence; Cytosine; Dinucleoside Phosphates; DNA; DNA-Cytosine Methylases; Kinetics; Methylation; Molecular Sequence Data; Nucleic Acid Heteroduplexes; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Uracil | 1995 |
Alteration in the phosphatidylcholine biosynthesis of rat liver microsomes caused by vitamin B6 deficiency.
Topics: Animals; Caseins; Choline; Choline Kinase; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diacylglycerol Cholinephosphotransferase; Liver; Male; Methylation; Methyltransferases; Microsomes, Liver; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 6 Deficiency | 1995 |
Demonstration of hypomethylation of proteins in the brain of pigs (but not in rats) associated with chronic vitamin B12 inactivation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Brain; Female; Methylation; Nitrous Oxide; Proteins; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine; Vitamin B 12 Deficiency | 1995 |
A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of vitamin B6 deficiency on these concentrations in rat liver.
Topics: Animals; Chromatography, High Pressure Liquid; Liver; Male; Rats; Rats, Wistar; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Vitamin B 6 Deficiency | 1994 |
Effects of ageing on folate metabolism in rats fed a long-term folate deficient diet.
Topics: Aging; Animals; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1994 |
Brain ATP:L-methionine S-adenosyltransferase (MAT), S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH): regional distribution and age-related changes.
Topics: Aged; Aged, 80 and over; Aging; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Humans; Kinetics; Male; Methionine Adenosyltransferase; Middle Aged; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet | 1994 |
Novel methyltransferase activity modifying the carboxy terminal bis(geranylgeranyl)-Cys-Ala-Cys structure of small GTP-binding proteins.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cattle; Cell Membrane; GTP-Binding Proteins; Kinetics; Methylation; Methyltransferases; Molecular Sequence Data; Peptide Fragments; Protein Prenylation; S-Adenosylhomocysteine; S-Adenosylmethionine | 1994 |
Direct photolinkage of GTP to the vaccinia virus mRNA (guanine-7-) methyltransferase GTP methyl acceptor site.
Topics: Binding Sites; Binding, Competitive; Escherichia coli; Guanine; Guanosine Triphosphate; Magnesium Chloride; Methyltransferases; Photochemistry; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Ultraviolet Rays; Vaccinia virus | 1994 |
Self-methylation of BspRI DNA-methyltransferase.
Topics: Amino Acid Sequence; Binding, Competitive; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cysteine; DNA; DNA-Cytosine Methylases; Escherichia coli; Methylation; Molecular Sequence Data; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfhydryl Reagents; Tritium | 1994 |
Electrostatic activation of Escherichia coli methionine repressor.
Topics: Apoproteins; Bacterial Proteins; Base Sequence; Chemical Phenomena; Chemistry, Physical; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Hydrogen Bonding; Methionine; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Operator Regions, Genetic; Protein Binding; Protein Conformation; Repressor Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1994 |
Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coli.
Topics: Base Sequence; Cytosine; Deamination; DNA (Cytosine-5-)-Methyltransferases; DNA-Cytosine Methylases; DNA, Bacterial; Escherichia coli; Models, Biological; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Point Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine; Selection, Genetic | 1994 |
The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.
Topics: Adenosine Deaminase; Adenosylhomocysteinase; Agouti Signaling Protein; Animals; Base Sequence; Cloning, Molecular; Embryonic and Fetal Development; Genes, Lethal; Homozygote; Hydrolases; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Proteins; Restriction Mapping; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Deletion; Stem Cells; Tissue Distribution | 1994 |
Effects of prolonged aspirin or acetaminophen administration to rats on liver folate content and distribution. Relation to DNA methylation and S-adenosylmethionine.
Topics: Acetaminophen; Animals; Aspirin; DNA; Drug Administration Schedule; Folic Acid; Liver; Male; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1994 |
S-adenosyl-L-methionine-mediated enzymatic methylations in the rat retinal membranes.
Topics: Animals; Methylation; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Rats; Rats, Sprague-Dawley; Retina; S-Adenosylhomocysteine; S-Adenosylmethionine | 1994 |
Effects of 4'-modified analogs of aristeromycin on the metabolism of S-adenosyl-L-homocysteine in murine L929 cells.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Humans; Hydrolases; L Cells; Liver; Mice; Placenta; Rats; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1993 |
Pancreatic one-carbon metabolism in early folate deficiency in rats.
Topics: Analysis of Variance; Animals; Cytoplasmic Granules; Folic Acid; Folic Acid Deficiency; Glycine N-Methyltransferase; Jejunum; Male; Methyltransferases; Pancreas; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1993 |
S-adenosylmethionine metabolism in herpes simplex virus type 2-infected cells.
Topics: Animals; Biotransformation; Cell Line, Transformed; Cells, Cultured; Embryo, Mammalian; Kinetics; Methionine; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Simplexvirus; Sulfur Radioisotopes; Tritium | 1993 |
Potent COMT inhibition by Ro 40-7592 in the periphery and in the brain. Preclinical and clinical findings.
Topics: Animals; Benserazide; Benzophenones; Brain; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes; Homovanillic Acid; Humans; Levodopa; Male; Nitrophenols; Peripheral Nerves; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Tolcapone | 1993 |
Uptake and metabolism of S-adenosyl-L-methionine by Leishmania mexicana and Leishmania braziliensis promastigotes.
Topics: Amino Acids; Animals; Biological Transport; Carbohydrates; Kinetics; Leishmania braziliensis; Leishmania mexicana; Lipids; Methylation; Morphogenesis; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 1993 |
Kinetic properties of bovine brain protein L-isoaspartyl methyltransferase determined using a synthetic isoaspartyl peptide substrate.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Brain; Cattle; Chromatography, High Pressure Liquid; Kinetics; Methylation; Molecular Sequence Data; Peptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Tritium | 1993 |
Hepatic one-carbon metabolism in early folate deficiency in rats.
Topics: Animals; Cytosol; Folic Acid; Folic Acid Deficiency; Glycine N-Methyltransferase; Liver; Male; Methyltransferases; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Weaning | 1993 |
Effect of nitrous oxide exposure on maternal and embryonic S-adenosylmethionine levels and ornithine decarboxylase activity.
Topics: Animals; Embryo, Mammalian; Female; Liver; Methionine; Nitrous Oxide; Ornithine Decarboxylase; Pregnancy; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1993 |
Ethynylestradiol protection against methyl insufficiency in castrated male Wistar/Furth rats fed a methionine-choline-deficient diet.
Topics: Animals; Body Weight; Castration; Choline Deficiency; Ethinyl Estradiol; Liver; Lung; Male; Methionine; Organ Size; Pancreas; Rats; Rats, Inbred WF; S-Adenosylhomocysteine; S-Adenosylmethionine | 1993 |
Enzymatic methyl esterification of erythrocyte membrane proteins is impaired in chronic renal failure. Evidence for high levels of the natural inhibitor S-adenosylhomocysteine.
Topics: Adolescent; Adult; Aged; Child; Erythrocyte Membrane; Erythrocytes; Esterification; Female; Humans; Kidney Failure, Chronic; Male; Membrane Proteins; Methylation; Middle Aged; Models, Biological; Protein O-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Urea | 1993 |
Crithidia luciliae: effect of purine starvation on S-adenosyl-L-methionine uptake and protein methylation.
Topics: Adenosine; Animals; Crithidia; Cycloheximide; Decarboxylation; Methionine; Methylation; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Purines; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1995 |
Behavioral and neurochemical changes in folate-deficient mice.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Blood Cell Count; Body Weight; Brain; Brain Chemistry; Caudate Nucleus; Feeding Behavior; Female; Folic Acid Deficiency; Hypothalamus; Mice; Muscle, Skeletal; S-Adenosylhomocysteine; S-Adenosylmethionine; Spinal Cord | 1995 |
Carbon flow through the hepatic folate-dependent one-carbon pool is not altered in vitamin A-deficient rats.
Topics: Animals; Carbon; Carbon Radioisotopes; Diterpenes; Folic Acid; Liver; Male; Methionine; Random Allocation; Rats; Rats, Sprague-Dawley; Retinyl Esters; S-Adenosylhomocysteine; S-Adenosylmethionine; Serine; Tritium; Vitamin A; Vitamin A Deficiency | 1996 |
N6-methyladenosine inhibits murine erythroleukemia cell maturation by blocking methylation of RNA and memory via conversion to S-(N6-methyl)-adenosylhomocysteine.
Topics: Adenosine; Animals; Cell Differentiation; Cell Division; Kinetics; Leukemia, Erythroblastic, Acute; Methylation; Mice; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1995 |
Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Administration, Oral; Analysis of Variance; Animal Feed; Animals; Apoptosis; Cell Division; Deoxyuracil Nucleotides; Ethanol; Folic Acid; Homocysteine; Liver; Male; Methionine; Proliferating Cell Nuclear Antigen; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine; Swine, Miniature; Thymine Nucleotides | 1996 |
Mono- and dimethylation of arsenic in rat liver cytosol in vitro.
Topics: Animals; Arsenates; Arsenic; Arsenicals; Arsenites; Cacodylic Acid; Edetic Acid; Egtazic Acid; Glutathione; Liver; Male; Mercuric Chloride; Methylation; Methyltransferases; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine; Sodium Selenite; Vitamin B 12 | 1996 |
Mechanisms for the involvement of DNA methylation in colon carcinogenesis.
Topics: Base Sequence; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Glycosylases; DNA Repair; DNA, Complementary; DNA, Neoplasm; Escherichia coli; Humans; Intestinal Mucosa; Methylation; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; N-Glycosyl Hydrolases; Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; S-Adenosylhomocysteine; S-Adenosylmethionine; Thymidine; Uracil-DNA Glycosidase | 1996 |
The type I restriction endonuclease R.EcoR124I: over-production and biochemical properties.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Base Sequence; Chromatography, Gel; Deoxyribonucleases, Type I Site-Specific; DNA; DNA, Circular; DNA, Superhelical; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Kinetics; Magnesium; Methylation; Molecular Sequence Data; Molecular Weight; Plasmids; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Vaccinia virus mRNA (guanine-7-)methyltransferase: mutational effects on cap methylation and AdoHcy-dependent photo-cross-linking of the cap to the methyl acceptor site.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Cloning, Molecular; Cross-Linking Reagents; DNA Mutational Analysis; Escherichia coli; Guanine Nucleotides; Kinetics; Magnesium; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleotidyltransferases; Point Mutation; Polymerase Chain Reaction; Recombinant Proteins; RNA Caps; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Ultraviolet Rays; Vaccinia virus | 1996 |
Evidence that the catechol 3,4-Dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins.
Topics: Animals; Antineoplastic Agents, Hormonal; Biotransformation; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Cytochrome P-450 Enzyme System; Female; Hydroxylation; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tamoxifen | 1996 |
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Homocysteine; Humans; Mercaptopurine; Methionine; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Induction of murine erythroleukemia cell differentiation is associated with methylation and differential stability of poly(A)+ RNA transcripts.
Topics: Actins; Adenosine; Animals; Cell Differentiation; Cell Division; Cycloleucine; Dimethyl Sulfoxide; Erythrocytes; Erythropoiesis; Globins; Hemoglobins; Kinetics; Leukemia, Erythroblastic, Acute; Methylation; Mice; Neoplasm Proteins; Peroxidases; Peroxiredoxin III; Peroxiredoxins; Proto-Oncogene Proteins c-myc; Ribonucleotides; RNA Caps; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1996 |
Effect of hypoxia on hepatic DNA methylation and tRNA methyltransferase in rat: similarities to effects of methyl-deficient diets.
Topics: Animals; Blotting, Northern; DNA; Hypoxia; Liver; Male; Methionine Adenosyltransferase; Methylation; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; tRNA Methyltransferases | 1996 |
Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism.
Topics: Animals; Antiparkinson Agents; Caudate Nucleus; Dopamine; Dose-Response Relationship, Drug; Hypokinesia; Injections, Intraventricular; Levodopa; Male; Methylation; Motor Activity; Neostriatum; Parkinson Disease; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tremor | 1995 |
Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Brain Chemistry; Female; Humans; Male; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis.
Topics: Adenosine; Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Apoptosis; Cytotoxicity, Immunologic; fas Receptor; L Cells; Mice; Phospholipases A; Phospholipases A2; S-Adenosylhomocysteine; S-Adenosylmethionine; Transfection | 1996 |
Effect of methionine loading on 5-methyltetrahydrofolate, S-adenosylmethionine and S-adenosylhomocysteine in plasma of healthy humans.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Homocysteine; Humans; Kinetics; Male; Methionine; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1996 |
Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase.
Topics: Bacteria; Binding, Competitive; Deamination; DNA; DNA-Cytosine Methylases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Methylation; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1996 |
Apoptosis and transmethylation metabolites in HL-60 cells.
Topics: Adenosine; Apoptosis; DNA; DNA Fragmentation; Enzyme Inhibitors; HL-60 Cells; Homocysteine; Humans; Methylation; Methyltransferases; Nucleic Acid Synthesis Inhibitors; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1996 |
Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains.
Topics: Amodiaquine; Animals; Calcium; Chromatography, Ion Exchange; Enzyme Stability; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Magnesium; Male; Methyltransferases; Mice; Mice, Inbred Strains; Niacinamide; Nicotinamide N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Characteristics; Time Factors | 1996 |
Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Cell Division; Drug Resistance, Neoplasm; Enzyme Inhibitors; Hydrolases; Male; Methionine Adenosyltransferase; Methylation; Mice; Mice, Inbred A; Neuroblastoma; S-Adenosylhomocysteine; S-Adenosylmethionine; Tritium; Tumor Cells, Cultured | 1995 |
Increased sensitivity to oxidative injury in chinese hamster ovary cells stably transfected with rat liver S-adenosylmethionine synthetase cDNA.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Benzamides; Cell Survival; CHO Cells; Cricetinae; DNA Methylation; DNA Primers; DNA, Complementary; Enzyme Inhibitors; Hydrogen Peroxide; Liver; Methionine Adenosyltransferase; NAD; Oxidants; Phenylenediamines; Polymerase Chain Reaction; Rats; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Transfection | 1996 |
Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene.
Topics: Animals; Base Sequence; DNA; DNA Damage; DNA Methylation; Exons; Folic Acid; Folic Acid Deficiency; Genes, Suppressor; Male; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Suppressor Protein p53 | 1997 |
Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI.
Topics: Adenosine; Binding Sites; Catalysis; Crystallography, X-Ray; Electrochemistry; Enzyme Inhibitors; Escherichia coli; Hydrogen Bonding; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Spectrometry, Fluorescence | 1997 |
Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats.
Topics: Analysis of Variance; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Drug Administration Schedule; Folic Acid; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Characterization of brain beta-carboline-2-N-methyltransferase, an enzyme that may play a role in idiopathic Parkinson's disease.
Topics: Animals; Brain; Carbolines; Cattle; Cytosol; Enzyme Inhibitors; Harmine; Humans; Hydrogen-Ion Concentration; Kinetics; Methylation; Methyltransferases; Parkinson Disease; S-Adenosylhomocysteine; S-Adenosylmethionine; Zinc | 1997 |
Effect of L-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats.
Topics: Animals; Benzophenones; Brain; Catechol O-Methyltransferase Inhibitors; Cerebellum; Cerebral Cortex; Corpus Striatum; Enzyme Inhibitors; Hippocampus; Homocysteine; Kidney; Levodopa; Liver; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 1997 |
Crystal structure of the chemotaxis receptor methyltransferase CheR suggests a conserved structural motif for binding S-adenosylmethionine.
Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Crystallography, X-Ray; Macromolecular Substances; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Structure, Secondary; S-Adenosylhomocysteine; S-Adenosylmethionine; Salmonella typhimurium; Sequence Homology, Amino Acid; Software; Static Electricity | 1997 |
Essential arginine residues in isoprenylcysteine protein carboxyl methyltransferase.
Topics: Adenosine; Animals; Arginine; Cell Membrane; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kidney; Male; Methylation; Phenylglyoxal; Protein Methyltransferases; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1997 |
Levels of L-methionine S-adenosyltransferase activity in erythrocytes and concentrations of S-adenosylmethionine and S-adenosylhomocysteine in whole blood of patients with Parkinson's disease.
Topics: Antiparkinson Agents; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Levodopa; Male; Methionine Adenosyltransferase; Middle Aged; Parkinson Disease; S-Adenosylhomocysteine; S-Adenosylmethionine | 1997 |
Transport of S-adenosylmethionine in isolated rat liver mitochondria.
Topics: Animals; Biological Transport; Carrier Proteins; Kinetics; Methionine; Mitochondria, Liver; Phospholipids; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 1997 |
Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Administration, Oral; Adult; Female; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1997 |
Pancreatic exocrine secretion is blocked by inhibitors of methylation.
Topics: Acetylcysteine; Amylases; Animals; Antimetabolites; Cell Line; Enzyme Inhibitors; Ethionine; GTP-Binding Proteins; Male; Methylation; Methyltransferases; Pancreas; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Sincalide | 1997 |
BplI, a new BcgI-like restriction endonuclease, which recognizes a symmetric sequence.
Topics: Adenosine; Bacillus; Bacteriophage lambda; Binding Sites; Deoxyribonucleases, Type II Site-Specific; DNA, Viral; Magnesium; Plasmids; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 1997 |
Metabolism of exogenous S-adenosylmethionine in isolated rat hepatocyte suspensions: methylation of plasma-membrane phospholipids without intracellular uptake.
Topics: Adenosine; Animals; Cells, Cultured; Humans; Kinetics; Liver; Liver Diseases; Male; Membrane Lipids; Methylation; Phospholipids; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1997 |
Simultaneous determination of S-adenosylmethionine and S-adenosylhomocysteine by capillary zone electrophoresis.
Topics: Buffers; Electrophoresis, Capillary; Phosphates; Quality Control; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity | 1997 |
Inhibitors of catecholamine metabolizing enzymes cause changes in S-adenosylmethionine and S-adenosylhomocysteine in the rat brain.
Topics: Animals; Benzophenones; Brain; Catechol O-Methyltransferase Inhibitors; Enzyme Inhibitors; Kinetics; Male; Methionine Adenosyltransferase; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitrophenols; Phenelzine; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tolcapone | 1998 |
Reconstitution and characterization of the polynuclear iron-sulfur cluster in pyruvate formate-lyase-activating enzyme. Molecular properties of the holoenzyme form.
Topics: Acetyltransferases; Amino Acid Sequence; Apoproteins; Conserved Sequence; Cysteine; Electron Spin Resonance Spectroscopy; Enzyme Activation; Enzymes; Escherichia coli; Iron; Iron-Sulfur Proteins; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry; Sulfides | 1998 |
S-Adenosylmethionine-dependent reduction of lysine 2,3-aminomutase and observation of the catalytically functional iron-sulfur centers by electron paramagnetic resonance.
Topics: Binding Sites; Catalysis; Clostridium; Cobalt; Dithionite; Electron Spin Resonance Spectroscopy; Free Radicals; Intramolecular Transferases; Iron; Lysine; Oxidation-Reduction; Photochemistry; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur | 1998 |
The biosynthesis of 8-O-methylated sialic acids in the starfish Asterias rubens--isolation and characterisation of S-adenosyl-L-methionine:sialate-8-O-methyltransferase.
Topics: Animals; Carbohydrate Sequence; Chromatography, Affinity; Chromatography, Ion Exchange; Cobalt; Erythrocyte Membrane; Glycoconjugates; Gonads; Horses; Humans; Kinetics; Manganese; Methyltransferases; Molecular Sequence Data; Molecular Weight; S-Adenosylhomocysteine; S-Adenosylmethionine; Sialic Acids; Starfish; Substrate Specificity | 1998 |
Evaluation of the impact of S-adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome.
Topics: Adenine; Cell Line; DNA Methylation; DNA, Plant; DNA, Ribosomal; Genome, Plant; Nicotiana; Plants, Toxic; RNA, Ribosomal, 5S; S-Adenosylhomocysteine; S-Adenosylmethionine | 1998 |
Evidence for disturbed S-adenosylmethionine : S-adenosylhomocysteine ratio in patients with end-stage renal failure: a cause for disturbed methylation reactions?
Topics: Adult; Aged; Female; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methylation; Middle Aged; Models, Biological; Renal Dialysis; S-Adenosylhomocysteine; S-Adenosylmethionine | 1998 |
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI.
Topics: Adenosine; Bacterial Proteins; Cytosine; Deamination; Deoxyadenosines; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Molecular Structure; Moraxella; Mutation; Neomycin; S-Adenosylhomocysteine; S-Adenosylmethionine | 1998 |
Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
Topics: Adenosylhomocysteinase; Binding Sites; Catalysis; Crystallography, X-Ray; Humans; Hydrolases; Macromolecular Substances; Models, Molecular; NAD; S-Adenosylhomocysteine; S-Adenosylmethionine; Solutions | 1998 |
Changes in methionine adenosyltransferase during liver regeneration in the rat.
Topics: Animals; Cell Nucleus; DNA Methylation; Gene Expression Regulation, Enzymologic; Hepatectomy; Isoenzymes; Kinetics; Liver; Liver Regeneration; Male; Methionine Adenosyltransferase; Rats; Rats, Sprague-Dawley; RNA Processing, Post-Transcriptional; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Transcription, Genetic | 1998 |
Measurement of S-adenosyl-L-methionine levels by SP Sephadex chromatography.
Topics: Animals; Chromatography, Ion Exchange; In Vitro Techniques; Leukemia L1210; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 1978 |
Murine DNA (cytosine-5-)-methyltransferase: steady-state and substrate trapping analyses of the kinetic mechanism.
Topics: Animals; Binding, Competitive; Catalysis; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Isotope Labeling; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Polydeoxyribonucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured | 1998 |
Transmethylation reactions and autoradiographic distribution of vitamin B12: effects of clioquinol treatment in mice.
Topics: Animals; Anti-Infective Agents, Local; Autoradiography; Brain; Chloroform; Clioquinol; Cobalt Radioisotopes; Kidney; Liver; Male; Methionine Adenosyltransferase; Methylation; Mice; Mice, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Scintillation Counting; Solubility; Tissue Distribution; Vitamin B 12; Water | 1998 |
Measurement of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent isoindoles.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Cyanides; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Indoles; Methionine; Naphthalenes; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine; Temperature | 1998 |
Effect of betaine administration on metabolism of hepatic glutathione in rats.
Topics: Animals; Betaine; Cysteine; Female; Glutathione; Injections, Intraperitoneal; Liver; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1998 |
Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat.
Topics: Animals; Carcinogens; Cell Division; DNA; Gene Expression; Isoenzymes; Liver; Male; Methionine Adenosyltransferase; Methylation; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Thioacetamide | 1999 |
Simultaneous determination of adenosine, S-adenosylhomocysteine and S-adenosylmethionine in biological samples using solid-phase extraction and high-performance liquid chromatography.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Humans; Kidney; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet | 1999 |
Modulation of tumor necrosis factor-alpha-mediated cytotoxicity by changes of the cellular methylation state: mechanism and in vivo relevance.
Topics: Animals; Cytotoxicity, Immunologic; Female; Membrane Potentials; Methylation; Methyltransferases; Mice; Mice, Nude; Mitochondria; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
Topics: Adenosine; Amino Acid Sequence; Antifungal Agents; Bacillus subtilis; Binding Sites; Crystallography, X-Ray; Drug Resistance, Microbial; Ligands; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Structure, Secondary; RNA, Ribosomal, 23S; S-Adenosylhomocysteine; S-Adenosylmethionine | 1999 |
An endogenous proteinacious inhibitor for S-adenosyl-L-methionine-dependent transmethylation reactions; identification of S-adenosylhomocystein as an integral part.
Topics: Animals; Chromatography; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Liver; Magnetic Resonance Spectroscopy; Protein O-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrometry, Mass, Fast Atom Bombardment; Swine | 1999 |
Methylation of cortical brain proteins from patients with HIV infection.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cerebral Cortex; Encephalitis, Viral; HIV Infections; Humans; Male; Methylation; Middle Aged; Protein Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine | 1999 |
Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated dna.
Topics: Allosteric Regulation; Binding Sites; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; DNA, Superhelical; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetics; Oligodeoxyribonucleotides; Recombinant Proteins; Ribonucleoproteins, Small Nuclear; S-Adenosylhomocysteine; S-Adenosylmethionine; Trinucleotide Repeats | 1999 |
Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol.
Topics: Amebicides; Animals; Brain; Clioquinol; Male; Metals; Mice; Mice, Inbred Strains; Optic Nerve Diseases; S-Adenosylhomocysteine; S-Adenosylmethionine; Trace Elements; Vitamin B 12 | 2000 |
S-adenosylmethionine synthesis in Leishmania infantum promastigotes.
Topics: Adenosylmethionine Decarboxylase; Animals; Gene Expression Regulation; Genes, Protozoan; Leishmania infantum; Leishmaniasis, Visceral; Methionine Adenosyltransferase; Ornithine Decarboxylase; Protozoan Proteins; RNA, Messenger; RNA, Protozoan; S-Adenosylhomocysteine; S-Adenosylmethionine | 1999 |
Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
Topics: Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Catalysis; Consensus Sequence; Crystallography, X-Ray; Glycine; Glycine N-Methyltransferase; Kinetics; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 2000 |
Interrelations between plasma homocysteine and intracellular S-adenosylhomocysteine.
Topics: Adult; Aged; Animals; Case-Control Studies; Chromatography, High Pressure Liquid; Erythrocytes; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tissue Distribution; Vascular Diseases | 2000 |
RNA aptamers to S-adenosylhomocysteine: kinetic properties, divalent cation dependency, and comparison with anti-S-adenosylhomocysteine antibody.
Topics: Adenine; Antibodies, Monoclonal; Base Sequence; Binding Sites; Binding, Competitive; Biosensing Techniques; Cations, Divalent; Chromatography, Affinity; Cystathionine; Gene Library; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Oligonucleotides; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 2000 |
Effects of L-dopa treatment on methylation in mouse brain: implications for the side effects of L-dopa.
Topics: Animals; Antiparkinson Agents; Brain Chemistry; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Methionine Adenosyltransferase; Methylation; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet | 2000 |
Analysis of isoaspartate in peptides and proteins without the use of radioisotopes.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Delta Sleep-Inducing Peptide; Methylation; Peptides; Protein Methyltransferases; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Time Factors | 2000 |
Increased methyl esterification of altered aspartyl residues in erythrocyte membrane proteins in response to oxidative stress.
Topics: Anion Exchange Protein 1, Erythrocyte; Ankyrins; Antioxidants; Ascorbic Acid; Aspartic Acid; Blood Proteins; Cell Membrane; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Hydrogen Peroxide; Malondialdehyde; Membrane Proteins; Methemoglobin; Methylation; Models, Biological; Neuropeptides; Oxidants; Oxidative Stress; Oxyhemoglobins; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; tert-Butylhydroperoxide; Time Factors; Vitamin E | 2000 |
Evidence for hypomethylation in two children with acute lymphoblastic leukemia and leukoencephalopathy.
Topics: Child; Chromatography, High Pressure Liquid; Dementia, Vascular; DNA Methylation; Female; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylhomocysteine; S-Adenosylmethionine | 2000 |
Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry.
Topics: Carbon Isotopes; Child; Chromatography, Liquid; Female; Humans; Indicator Dilution Techniques; Mass Spectrometry; Premenopause; S-Adenosylhomocysteine; S-Adenosylmethionine | 2000 |
Molecular enzymology of the EcoRV DNA-(Adenine-N (6))-methyltransferase: kinetics of DNA binding and bending, kinetic mechanism and linear diffusion of the enzyme on DNA.
Topics: 2-Aminopurine; Adenine; Base Sequence; Binding, Competitive; Catalysis; Coenzymes; Diffusion; DNA; DNA Methylation; DNA-Binding Proteins; Escherichia coli; Fluorescence; Kinetics; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity; Thermodynamics | 2000 |
Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferase.
Topics: Adenine; Adenosine; Binding Sites; Buffers; Carbon Radioisotopes; Catalysis; Chromatography, High Pressure Liquid; Coenzymes; DNA; DNA Methylation; DNA-Binding Proteins; Fluorescence; Kinetics; Nucleic Acid Conformation; Protein Binding; Rhodobacter sphaeroides; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity; Thermodynamics | 2000 |
Radioenzymatic assay for reductive catalysis of N(5)N(10)-methylenetetrahydrofolate by methylenetetrahydrofolate reductase.
Topics: Animals; Carbon Radioisotopes; Catalysis; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Flavin-Adenine Dinucleotide; Humans; Kinetics; Liver; Methylenetetrahydrofolate Reductase (NADPH2); NADP; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Tetrahydrofolates; Tumor Cells, Cultured | 2000 |
Disturbed ratio of erythrocyte and plasma S-adenosylmethionine/S-adenosylhomocysteine in peripheral arterial occlusive disease.
Topics: Adult; Aged; Aged, 80 and over; Arterial Occlusive Diseases; Erythrocytes; Female; Hematocrit; Homocysteine; Humans; Kidney; Male; Middle Aged; Odds Ratio; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine | 2001 |
Characterization of BseMII, a new type IV restriction-modification system, which recognizes the pentanucleotide sequence 5'-CTCAG(N)(10/8)/.
Topics: Adenosine; Base Sequence; Binding Sites; Cloning, Molecular; Conserved Sequence; DNA Restriction Enzymes; Geobacillus stearothermophilus; Magnesium; Molecular Sequence Data; Molecular Weight; Multienzyme Complexes; Protein Subunits; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, DNA; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity | 2001 |
A dual role for substrate S-adenosyl-L-methionine in the methylation reaction with bacteriophage T4 Dam DNA-[N6-adenine]-methyltransferase.
Topics: 2-Aminopurine; Bacteriophage T4; Base Sequence; Binding Sites; Cross-Linking Reagents; DNA; DNA Methylation; Fluorescence; Glutaral; Kinetics; Nucleic Acid Conformation; Oligonucleotides; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Spectrometry, Fluorescence; Substrate Specificity; Time Factors; Viral Proteins | 2001 |
Homocysteine metabolism in children with Down syndrome: in vitro modulation.
Topics: Adenosine; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cystathionine beta-Synthase; Cysteine; DNA Methylation; Down Syndrome; Glutathione; Homocysteine; Humans; Leucovorin; Lymphocytes; Methionine; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Superoxide Dismutase; Thymidine; Vitamin B 12 | 2001 |
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Brain; Chronic Disease; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Folic Acid; Food, Fortified; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Thrombomodulin; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 2001 |
Wy-14,643-induced hypomethylation of the c-myc gene in mouse liver.
Topics: Administration, Oral; Animals; Blotting, Southern; Cell Division; Cell Nucleus; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Genes, myc; Injections, Intraperitoneal; Liver; Methionine; Mice; Mice, Inbred Strains; Peroxisome Proliferators; Proliferating Cell Nuclear Antigen; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 2001 |
Blood determinations of S-adenosylmethionine, S-adenosylhomocysteine, and homocysteine: correlations with diet.
Topics: Body Mass Index; Diet; Dietary Fats; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Neoplasms; Pyridoxine; Reference Values; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine | 2001 |
A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle.
Topics: Adenosine; Adenosylhomocysteinase; Caffeine; Carbon Dioxide; Cell Extracts; Chloroplasts; Homocysteine; Hydrolases; Methionine Adenosyltransferase; Methylation; Plant Leaves; S-Adenosylhomocysteine; S-Adenosylmethionine; Tea; Theobromine | 2001 |
Retinoid compounds activate and induce hepatic glycine N-methyltransferase in rats.
Topics: Animals; Enzyme Activation; Enzyme Induction; Glycine N-Methyltransferase; Liver; Male; Methionine; Methylation; Methyltransferases; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tretinoin | 2001 |
Increasing levels of dietary homocystine with carotid endarterectomy produced proportionate increases in plasma homocysteine and intimal hyperplasia.
Topics: Animals; Carotid Arteries; Cystathionine beta-Synthase; Endarterectomy, Carotid; Homocysteine; Homocystine; Hyperplasia; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Sprague-Dawley; Recurrence; S-Adenosylhomocysteine; S-Adenosylmethionine; Tunica Intima | 2001 |
L-dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase.
Topics: Animals; Blotting, Western; Brain; Catechol O-Methyltransferase; Dopamine; Enzyme Induction; Kidney; Levodopa; Liver; Male; Methionine Adenosyltransferase; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tyrosine; Up-Regulation | 2001 |
Effect of vitamin B6 deficiency on the synthesis and accumulation of S-adenosylhomocysteine and S-adenosylmethionine in rat tissues.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Liver; Male; Pyridoxal; Pyridoxal Phosphate; Pyridoxamine; Random Allocation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Thymus Gland; Time Factors; Vitamin B 6 Deficiency | 2001 |
DNA cleavage by type III restriction-modification enzyme EcoP15I is independent of spacer distance between two head to head oriented recognition sites.
Topics: Adenosine Triphosphate; Base Sequence; Binding Sites; Deoxyribonuclease I; Deoxyribonucleases, Type III Site-Specific; DNA; DNA Footprinting; Hydrolysis; Molecular Sequence Data; Nucleic Acid Conformation; Regulatory Sequences, Nucleic Acid; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 2001 |
Reversed-phase high-performance liquid chromatography procedure for the simultaneous determination of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in mouse liver and the effect of methionine on their concentrations.
Topics: Animals; Chromatography, High Pressure Liquid; Liver; Methionine; Mice; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet | 2001 |
Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.
Topics: Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Epinephrine; Evolution, Molecular; Humans; Ligands; Models, Molecular; Phenylethanolamine N-Methyltransferase; Protein Binding; Protein Folding; Protein Structure, Tertiary; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 2001 |
Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
Topics: Adenosine; Amino Acid Sequence; Animals; Coenzymes; Crystallography, X-Ray; Isoaspartic Acid; Isomerism; Models, Molecular; Molecular Sequence Data; Peptides; Phylogeny; Protein Conformation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Pyrococcus furiosus; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Software; Static Electricity; Substrate Specificity | 2001 |
Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine.
Topics: Adult; Aged; Cardiovascular Diseases; Case-Control Studies; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Vitamin B 12 | 2001 |
Impact of extracellular folate levels on global gene expression.
Topics: Cadherins; Carrier Proteins; CpG Islands; DNA Methylation; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation; Humans; KB Cells; Promoter Regions, Genetic; Receptors, Cell Surface; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2001 |
Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice.
Topics: Animals; Biomarkers; Choline Deficiency; Diet; DNA Methylation; Folic Acid Deficiency; Intestinal Neoplasms; Methionine; Mice; Neoplasms; Precancerous Conditions; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation.
Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Adenosylhomocysteinase; Arabidopsis; DNA, Complementary; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydrolases; Methylation; Mutation; Pectins; Phenotype; Plants, Genetically Modified; S-Adenosylhomocysteine; S-Adenosylmethionine; Seeds | 2002 |
Diethanolamine induces hepatic choline deficiency in mice.
Topics: Administration, Cutaneous; Animals; Betaine; Carcinogens; Choline Deficiency; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Ethanolamines; Glycerylphosphorylcholine; Liver; Male; Mice; Mice, Inbred C57BL; No-Observed-Adverse-Effect Level; Phosphatidylcholines; Phosphorylcholine; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity | 2002 |
Tissue levels of S-adenosylhomocysteine in the rat kidney: effects of ischemia and homocysteine.
Topics: Adenosine; Animals; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Ischemia; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice.
Topics: Adenosylhomocysteinase; Animals; Aspartic Acid; Brain; Hydrolases; Kinetics; Methionine Adenosyltransferase; Mice; Mice, Knockout; Protein D-Aspartate-L-Isoaspartate Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 2002 |
The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats.
Topics: Animals; Chromans; Cystathionine beta-Synthase; Erythrocytes; Female; Homocysteine; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Methylenetetrahydrofolate Reductase (NADPH2); Obesity; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Zucker; S-Adenosylhomocysteine; S-Adenosylmethionine; Thiazoles; Thiazolidinediones; Thinness; Troglitazone | 2002 |
S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase.
Topics: Chromatography, High Pressure Liquid; Culture Media; Cystathionine beta-Synthase; Homocysteine; Homocystinuria; Humans; S-Adenosylhomocysteine; S-Adenosylmethionine; Yeasts | 2002 |
S-adenosylmethionine conformations in solution and in protein complexes: conformational influences of the sulfonium group.
Topics: Adenosine Triphosphate; Crystallography, X-Ray; Deoxyadenosines; Macromolecular Substances; Mathematical Computing; Molecular Conformation; Monte Carlo Method; Nuclear Magnetic Resonance, Biomolecular; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Software; Solutions; Sulfonium Compounds; Sulfur; Thionucleosides; Vitamin U | 2002 |
Quantification of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent 1,N(6)-etheno derivatives: an adaptation of previously described methodology.
Topics: Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity | 2002 |
In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific.
Topics: Animals; Base Sequence; Cystathionine beta-Synthase; DNA; DNA Methylation; DNA Primers; Genotype; Homocysteine; Mice; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
S-adenosyl-methionine-induced apoptosis in PC12 cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Cell Differentiation; Culture Media, Conditioned; DNA Fragmentation; Intracellular Fluid; L-Lactate Dehydrogenase; Methionine; Neurons; Parkinsonian Disorders; PC12 Cells; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats.
Topics: Animals; Dietary Proteins; Dose-Response Relationship, Drug; Glycine N-Methyltransferase; Kidney; Liver; Male; Methionine; Methyltransferases; Pancreas; Random Allocation; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Up-Regulation; Weight Gain | 2002 |
Acute valproate administration impairs methionine metabolism in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Anticonvulsants; Betaine-Homocysteine S-Methyltransferase; Female; Folic Acid; Glutathione; Glutathione Disulfide; Homocysteine; Liver; Methionine; Methionine Adenosyltransferase; Methyltransferases; Models, Animal; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Teratogens; Valproic Acid; Vitamin B 6 | 2002 |
Remethylation and transsulfuration of methionine in cirrhosis: studies with L-[H3-methyl-1-C]methionine.
Topics: Adult; Carbon Isotopes; Homocysteine; Humans; Kinetics; Liver Cirrhosis, Alcoholic; Male; Methionine; Methylation; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Tritium | 2002 |
S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations.
Topics: Aged; Aged, 80 and over; Body Constitution; Cardiovascular Diseases; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Humans; Male; Middle Aged; Regression Analysis; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2003 |
Dose-dependent biotransformation of arsenite in rats--not S-adenosylmethionine depletion impairs arsenic methylation at high dose.
Topics: Adenosine Triphosphate; Animals; Arsenites; Bile; Biotransformation; Cacodylic Acid; Dose-Response Relationship, Drug; Glutathione; Kidney; Liver; Male; Methylation; Myocardium; Organometallic Compounds; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon.
Topics: Animals; Body Weight; Colon; Dietary Supplements; DNA Methylation; Folic Acid; Genome; Hemoglobins; Homocysteine; Rats; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tumor Suppressor Protein p53 | 2003 |
Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis.
Topics: Acetylcysteine; Adenosine; Animals; Apoptosis; Cattle; Cells, Cultured; Cysteine; Diterpenes; Endothelium, Vascular; Enzyme Inhibitors; Mitogen-Activated Protein Kinases; Protein Methyltransferases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; ras Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; Ultraviolet Rays | 2003 |
The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine.
Topics: Cells, Cultured; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Green Fluorescent Proteins; Humans; Hydroxamic Acids; In Vitro Techniques; Indicators and Reagents; Kidney; Luminescent Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Transfection | 2003 |
Insertional inactivation of the methionine s-methyltransferase gene eliminates the s-methylmethionine cycle and increases the methylation ratio.
Topics: Amino Acids; Arabidopsis; Methylation; Methyltransferases; Mutagenesis, Insertional; S-Adenosylhomocysteine; S-Adenosylmethionine; Seeds; Sulfhydryl Compounds; Sulfur; Vitamin U; Zea mays | 2003 |
Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.
Topics: Aminoimidazole Carboxamide; Animals; Bucladesine; Cell-Free System; Enzyme Inhibitors; Flavanones; Flavonoids; Glycine; Glycine N-Methyltransferase; Hepatocytes; Methyltransferases; Okadaic Acid; Peptide Fragments; Phosphorylation; Rats; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
Simultaneous detection of S-adenosylmethionine and S-adenosylhomocysteine in mouse and rat tissues by capillary electrophoresis.
Topics: Animals; Electrophoresis, Capillary; Kidney; Liver; Mice; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
Efficiency of lignin biosynthesis: a quantitative analysis.
Topics: Biological Transport; Carbohydrate Metabolism; Cell Respiration; Cyclohexanecarboxylic Acids; Cyclohexenes; Glycosylation; Lignin; Plants; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
S-adenosylmethionine transport in Rickettsia prowazekii.
Topics: Adenosine; Anion Transport Proteins; Bacterial Proteins; Biological Transport; Carrier Proteins; Cloning, Molecular; Escherichia coli; Ethionine; Ethylmaleimide; Methionine; Rickettsia prowazekii; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
Kinetic mechanism of the tRNA-modifying enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA).
Topics: Adenosine; Binding, Competitive; Catalysis; Escherichia coli; Isomerases; Kinetics; Magnetic Resonance Spectroscopy; Nucleoside Q; Pentosyltransferases; Ribose; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
Effect of acute betaine administration on hepatic metabolism of S-amino acids in rats and mice.
Topics: Alkynes; Amino Acids; Animals; Betaine; Biological Transport; Cystathionine; Cystathionine gamma-Lyase; Cysteine Dioxygenase; Dioxygenases; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Glycine; Liver; Methionine; Mice; Mice, Inbred ICR; Oxygenases; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Taurine | 2003 |
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Binding Sites; Crystallization; Crystallography, X-Ray; Drug Resistance, Bacterial; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligosaccharides; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Homology, Amino Acid; Streptomyces | 2003 |
Altered methionine metabolism in long living Ames dwarf mice.
Topics: Aging; Animals; Brain; Cystathionine beta-Synthase; DNA Methylation; Glycine N-Methyltransferase; Liver; Male; Methionine; Methionine Adenosyltransferase; Methyltransferases; Mice; Mice, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
Anthocyanin administration elevates plasma homocysteine in rats.
Topics: Animals; Anthocyanins; Female; Homocysteine; Kidney; Liver; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain.
Topics: Amino Acid Sequence; Binding Sites; Cloning, Molecular; Conserved Sequence; Crystallography, X-Ray; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Structure, Tertiary; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Substrate Specificity; Thermotoga maritima | 2003 |
Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii.
Topics: Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins; Crystallography, X-Ray; Methanococcus; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Open Reading Frames; Protein Binding; Protein Conformation; Recombinant Fusion Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Sequence Homology, Amino Acid; Site-Specific DNA-Methyltransferase (Adenine-Specific); Structure-Activity Relationship | 2002 |
Betaine lowers elevated s-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats.
Topics: Administration, Oral; Animals; Betaine; Ethanol; Hepatocytes; Male; Methionine; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
Utilization of S-adenosylmethionine by micro-organisms.
Topics: Adenine; Bacteria; Methionine; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur | 1962 |
Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice.
Topics: Animals; Arsenates; Arsenic; Arsenic Poisoning; Arsenicals; Arsenites; Cacodylic Acid; Carrier Proteins; Cross-Over Studies; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Deficiency; Male; Mice; Mice, Knockout; Receptors, Cell Surface; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
A mathematical model of the methionine cycle.
Topics: Animals; Computational Biology; Cystathionine; Homocysteine; Methionine; Models, Biological; S-Adenosylhomocysteine; S-Adenosylmethionine | 2004 |
Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry.
Topics: Adult; Animals; Chromatography, Liquid; Erythrocytes; Female; Humans; Indicator Dilution Techniques; Liver; Lung; Male; Mass Spectrometry; Middle Aged; Rats; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine | 2004 |
Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Animals; Biological Transport; Brain Chemistry; Bromcresol Purple; Calcium-Binding Proteins; CHO Cells; Cloning, Molecular; Cricetinae; Cytosol; DNA, Complementary; Escherichia coli; Expressed Sequence Tags; Genes; Humans; Hydrolyzable Tannins; Membrane Transport Modulators; Membrane Transport Proteins; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Organ Specificity; Phylogeny; Recombinant Fusion Proteins; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Sequence Homology, Amino Acid | 2004 |
Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells.
Topics: Amino Acids, Sulfur; Carcinoma; Cell Line, Tumor; Cell Survival; Cystathionine; Cysteine; DNA; Glutathione; Humans; Lung Neoplasms; Methionine; Nicotiana; S-Adenosylhomocysteine; S-Adenosylmethionine; Smoke; Time Factors | 2004 |
Structure and mechanism of mRNA cap (guanine-N7) methyltransferase.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Catalysis; Crystallography, X-Ray; Encephalitozoon cuniculi; Ligands; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Point Mutation; Protein Structure, Secondary; Protozoan Proteins; RNA Cap Analogs; RNA Caps; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Homology, Amino Acid; Static Electricity; Structure-Activity Relationship; Substrate Specificity | 2004 |
Homocystinuria due to cystathionine beta-synthase deficiency: novel biochemical findings and treatment efficacy.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Homocystinuria; Humans; Male; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
Influence of an altered methylation potential on mRNA methylation and gene expression in HepG2 cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Line, Tumor; Cyclophilins; DNA Methylation; Down-Regulation; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcription Factors; Up-Regulation; Vascular Endothelial Growth Factor A | 2004 |
S-Adenosyl methionine/S-adenosyl-L-homocysteine ratio determination by capillary electrophoresis employed as a monitoring tool for the antiviral effectiveness of adenosine analogs.
Topics: Acetaldehyde; Antiviral Agents; Electrophoresis, Capillary; Humans; S-Adenosylhomocysteine; S-Adenosylmethionine | 2004 |
Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase.
Topics: Age Factors; Aging; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Diet, Reducing; Exploratory Behavior; Genotype; Homocysteine; Hyperkinesis; Mice; Mice, Knockout; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Rotarod Performance Test; S-Adenosylhomocysteine; S-Adenosylmethionine; Stereotyped Behavior; Survival Rate; Time Factors | 2004 |
Homocysteine clearance and methylation flux rates in health and end-stage renal disease: association with S-adenosylhomocysteine.
Topics: Adult; Aged; Case-Control Studies; Female; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methylation; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur | 2004 |
Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid.
Topics: Animals; Cystathionine beta-Synthase; Diabetes Mellitus, Experimental; Glycine N-Methyltransferase; Homocysteine; Male; Methyltransferases; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Streptozocin; Tretinoin | 2004 |
S-adenosylhomocysteine hydrolase, S-adenosylmethionine, S-adenosylhomocysteine: correlations with ribavirin induced anemia.
Topics: Adenosylhomocysteinase; Anemia; Animals; Antiviral Agents; Erythrocytes; Hepatitis C, Chronic; Humans; Models, Biological; Ribavirin; S-Adenosylhomocysteine; S-Adenosylmethionine; Statistics as Topic | 2004 |
Low ratio of S-adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns.
Topics: Adult; Birth Weight; Brazil; Female; Fetal Blood; Gestational Age; Homocysteine; Humans; Infant, Newborn; Pregnancy; ROC Curve; S-Adenosylhomocysteine; S-Adenosylmethionine; Social Class; Vitamin B 12 Deficiency | 2004 |
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
Topics: Adenosine; Autistic Disorder; Betaine; Biomarkers; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cysteine; Female; Glutathione; Homocysteine; Humans; Leucovorin; Male; Methionine; Methylation; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 2004 |
Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Carrier Proteins; Cell Cycle; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Folate Receptors, GPI-Anchored; Gene Expression Profiling; Gene Silencing; Genetic Predisposition to Disease; Kidney; Male; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Receptors, Cell Surface; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
Phosphatidylcholine and lysophosphatidylcholine excretion is increased in children with cystic fibrosis and is associated with plasma homocysteine, S-adenosylhomocysteine, and S-adenosylmethionine.
Topics: Case-Control Studies; Child; Choline Deficiency; Cross-Sectional Studies; Cystic Fibrosis; Diet Records; Dietary Fats; Feces; Female; Homocysteine; Humans; Intestinal Absorption; Lysophosphatidylcholines; Male; Phosphatidylcholines; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis.
Topics: Adenosine; Animals; Binding Sites; Crystallization; Encephalitozoon cuniculi; Enzyme Inhibitors; Guanosine Triphosphate; Hydrogen-Ion Concentration; Methylation; Methyltransferases; Models, Molecular; Molecular Structure; Mutagenesis; Mutation, Missense; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Substrate Specificity | 2005 |
Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis.
Topics: Analysis of Variance; Animals; Bile Ducts; Cholestasis; Cysteine; Glutathione; Homocysteine; Ligation; Liver; Liver Cirrhosis, Biliary; Male; Methionine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 2005 |
Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes.
Topics: Aged; Cystathionine; Cysteine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Folic Acid; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Male; Methionine; Methylmalonic Acid; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcobalamins; Vitamin B 12; Vitamin B 6 | 2005 |
Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Amino Acids, Sulfur; Analysis of Variance; Animals; Aspartate Aminotransferases; Betaine; Bilirubin; Cholestasis; Cysteine; Dietary Supplements; Glutathione; Kinetics; Liver; Male; Mice; Mice, Inbred ICR; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma.
Topics: Chromatography, Liquid; Deuterium; Humans; Radioisotope Dilution Technique; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
The role of phospholipid methylation in 1-methyl-4-phenyl-pyridinium ion (MPP+)-induced neurotoxicity in PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Lysophosphatidylcholines; Methylation; MPTP Poisoning; PC12 Cells; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Phospholipids; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
S-adenosylhomocysteine metabolism in different cell lines: effect of hypoxia and cell density.
Topics: Adenosylhomocysteinase; Anaerobiosis; Cell Count; Cell Hypoxia; Cell Line; Cell Survival; Energy Metabolism; Humans; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
The transmethylation cycle in the brain of Alzheimer patients.
Topics: Aged; Alzheimer Disease; Brain; Chromatography, High Pressure Liquid; Female; Humans; Male; Mass Spectrometry; Membrane Proteins; Methylation; Middle Aged; Presenilin-1; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 2005 |
Stable isotope dilution-based accurate comparative quantification of nitrogen-containing metabolites in Arabidopsis thaliana T87 cells using in vivo (15)N-isotope enrichment.
Topics: Arabidopsis; Chromatography, Liquid; Folic Acid; Indicator Dilution Techniques; Mass Spectrometry; Nitrogen; Nitrogen Isotopes; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
Diet-dependent survival of protein repair-deficient mice.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Brain; Eating; Folic Acid; Methionine; Mice; Mice, Mutant Strains; Protein D-Aspartate-L-Isoaspartate Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Seizures; Survival Rate | 2005 |
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.
Topics: 2-Hydroxyphenethylamine; Binding Sites; Catalysis; Crystallography, X-Ray; Humans; Kinetics; Models, Molecular; Mutation; Phenylethanolamine N-Methyltransferase; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydroisoquinolines | 2005 |
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cell Line, Tumor; Choline Dehydrogenase; Diabetes Mellitus, Experimental; Gene Expression; Glucocorticoids; Insulin; Liver; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcription, Genetic; Triamcinolone | 2006 |
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biomarkers; Choline; Chromatography, High Pressure Liquid; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Heterozygote; Methionine; Mice; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Severity of Illness Index; Up-Regulation | 2006 |
An enzyme-coupled continuous spectrophotometric assay for S-adenosylmethionine-dependent methyltransferases.
Topics: Aminohydrolases; Animals; Chromatography, High Pressure Liquid; Hypoxanthine; Kinetics; Methyltransferases; N-Glycosyl Hydrolases; Protein-Arginine N-Methyltransferases; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry | 2006 |
Mild folate deficiency induces a proatherosclerotic phenotype in endothelial cells.
Topics: Atherosclerosis; Cell Division; Cell Line; Chemokine CCL2; DNA Methylation; Endothelium, Vascular; Folic Acid Deficiency; Gene Expression; Humans; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Cofactor dependence of reduction potentials for [4Fe-4S]2+/1+ in lysine 2,3-aminomutase.
Topics: Clostridium; Coenzymes; Electron Spin Resonance Spectroscopy; Escherichia coli; Intramolecular Transferases; Iron; Oxidation-Reduction; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur | 2006 |
Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Catalytic Domain; Cell Line; Chromatin; Coenzymes; Dose-Response Relationship, Drug; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Methyltransferases; Models, Biological; Molecular Sequence Data; Peptides; Protein Methyltransferases; Recombinant Proteins; Repressor Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Spodoptera; Substrate Specificity; Time Factors | 2006 |
Insights into cephamycin biosynthesis: the crystal structure of CmcI from Streptomyces clavuligerus.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Catalysis; Cephalosporins; Cephamycins; Crystallization; Crystallography, X-Ray; Magnesium; Methyltransferases; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Polyethylene Glycols; Protein Binding; Protein Structure, Tertiary; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Homology, Amino Acid; Streptomyces | 2006 |
Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome?
Topics: Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Mutation; Polymorphism, Single Nucleotide; Regression Analysis; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats.
Topics: Animals; Colon; Deficiency Diseases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Folic Acid; Glutathione; Glutathione Peroxidase; Glycine N-Methyltransferase; Homocysteine; Liver; Male; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenium | 2006 |
The 5th workshop on the assessment of adequate intake of dietary amino acids: general discussion 1.
Topics: Amino Acids; Animals; Creatine; Cysteine; Diet; Glutathione; Homocysteine; Humans; Methionine; Nutritional Requirements; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man.
Topics: Adenosylhomocysteinase; Adult; Choline; DNA Methylation; Erythrocytes; Family Health; Humans; Magnetic Resonance Imaging; Male; Metabolism, Inborn Errors; Muscular Diseases; Mutation, Missense; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Crystal structures of BchU, a methyltransferase involved in bacteriochlorophyll c biosynthesis, and its complex with S-adenosylhomocysteine: implications for reaction mechanism.
Topics: Amino Acid Sequence; Bacterial Proteins; Bacteriochlorophylls; Binding Sites; Chlorobium; Crystallography, X-Ray; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Structure, Quaternary; Protein Structure, Tertiary; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Substrate Specificity; Tetrapyrroles; Zinc | 2006 |
Exogenous glycine partially attenuates homocysteine-induced apoptosis and membrane peroxidation in chick embryos.
Topics: Animals; Apoptosis; Brain; Brain Chemistry; Caspase 3; Caspases; Chick Embryo; Fatty Acids; Glycine; Homocysteine; Lipid Peroxides; Liver; Membranes; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Suppression of methionine-induced hyperhomocysteinemia by dietary eritadenine in rats.
Topics: Adenine; Animals; Cystathionine beta-Synthase; Diet; Dose-Response Relationship, Drug; Enzyme Activation; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 2006 |
Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Embryo, Mammalian; Female; Male; Mice; Pregnancy; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Tandem Mass Spectrometry | 2006 |
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism.
Topics: Adolescent; Autistic Disorder; Catechol O-Methyltransferase; Child; Child, Preschool; DNA Primers; Female; Gene Frequency; Glutathione Transferase; Humans; Male; Membrane Transport Proteins; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidative Stress; Reduced Folate Carrier Protein; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcobalamins | 2006 |
L-NAME has opposite effects on the productions of S-adenosylhomocysteine and S-adenosylmethionine in V12-H-Ras and M-CR3B-Ras pheochromocytoma cells.
Topics: Animals; NG-Nitroarginine Methyl Ester; PC12 Cells; Pheochromocytoma; Proto-Oncogene Proteins p21(ras); Rats; Reactive Oxygen Species; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Dietary eritadenine suppresses guanidinoacetic Acid-induced hyperhomocysteinemia in rats.
Topics: Adenine; Animals; Diet; Glycine; Hyperhomocysteinemia; Male; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in HepG2 cells.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosylhomocysteinase; Apoptosis; Caspase Inhibitors; Caspases; Dipyridamole; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Homocysteine; Humans; Methylation; Nucleoside Transport Proteins; Oligonucleotide Array Sequence Analysis; Pentostatin; Proto-Oncogene Proteins c-mdm2; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Arabidopsis SAMT1 defines a plastid transporter regulating plastid biogenesis and plant development.
Topics: Anion Transport Proteins; Arabidopsis; Arabidopsis Proteins; DNA, Bacterial; Gene Expression Profiling; Gene Silencing; Lipids; Membrane Transport Proteins; Molecular Sequence Data; Mutation; Nicotiana; Phenotype; Pigments, Biological; Plant Viruses; Plants, Genetically Modified; Plastids; Protein Transport; Protoplasts; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 2006 |
Structural change of tRNA (Gm18) methyltransferase by binding of methyl donor analogues.
Topics: Catalysis; Chromatography, Gel; Dimerization; Protein Subunits; S-Adenosylhomocysteine; S-Adenosylmethionine; Thermus thermophilus; tRNA Methyltransferases | 2005 |
Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway.
Topics: Animals; Betaine; Diet; Ethanol; Fatty Liver, Alcoholic; Lipotropic Agents; Liver; Male; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides | 2007 |
Nitric oxide modulates glutathione synthesis during endotoxemia.
Topics: Animals; Body Weight; Catalase; Cysteine; Disease Models, Animal; Eating; Endotoxemia; Glutamate-Cysteine Ligase; Glutathione; Injections; Lipopolysaccharides; Liver; Male; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase | 2006 |
Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses.
Topics: Amino Acid Sequence; Binding Sites; Biological Evolution; Biotransformation; Crystallography, X-Ray; Immunity, Innate; Medicago truncatula; Methylation; Methyltransferases; Molecular Sequence Data; Phenols; Plant Diseases; Plant Proteins; Protein Structure, Secondary; Pterocarpans; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2006 |
Methyl balance and transmethylation fluxes in humans.
Topics: Animals; Betaine; Creatine; Diet; Guanidinoacetate N-Methyltransferase; Humans; Kinetics; Liver; Methylation; Mice; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine | 2007 |
Crystal structures of CbiL, a methyltransferase involved in anaerobic vitamin B biosynthesis, and CbiL in complex with S-adenosylhomocysteine--implications for the reaction mechanism.
Topics: Amino Acid Sequence; Bacterial Proteins; Chlorobium; Cobalt; Crystallography, X-Ray; Methylation; Methyltransferases; Molecular Sequence Data; Protein Structure, Quaternary; Protein Structure, Tertiary; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Homology, Amino Acid; Substrate Specificity; Vitamin B Complex | 2007 |
Increase in S-adenosylhomocysteine content and its effect on the S-adenosylhomocysteine hydrolase activity under transient high plasma homocysteine levels in rats.
Topics: Adenosylhomocysteinase; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Homocysteine; Infusions, Intravenous; Liver; Male; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Sodium Chloride | 2006 |
Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-L-isoaspartyl methyltransferase activity.
Topics: Alcohols; Animals; Betaine; Catalysis; Diet; Ethanol; Liver; Male; Microsomes; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Subcellular Fractions | 2007 |
DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients.
Topics: Chromatography, Liquid; Cystathionine beta-Synthase; DNA; DNA Methylation; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, DNA; Spectrometry, Mass, Electrospray Ionization | 2007 |
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Topics: Animals; Brain; Disease Models, Animal; Embryo, Mammalian; Female; Ferredoxin-NADP Reductase; Folic Acid; Heart; Homocysteine; Hyperhomocysteinemia; Kidney; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Folate status and S-adenosylmethionine/S-adenosylhomocysteine ratio in colorectal adenocarcinoma in humans.
Topics: Adenocarcinoma; Aged; Colon; Colorectal Neoplasms; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Intestinal Mucosa; Male; Nutritional Status; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Supranormal dietary folic acid supplementation: effects on methionine metabolism in weanling rats.
Topics: Animals; Biomarkers; Dietary Supplements; DNA Methylation; Folic Acid; Homocysteine; Liver; Male; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamins; Weaning | 2007 |
Abnormal folate metabolism in foetuses affected by neural tube defects.
Topics: Anencephaly; Animals; Antimetabolites; Deoxyuridine; Female; Ferredoxin-NADP Reductase; Fetal Diseases; Fetus; Fibroblasts; Folic Acid; Genotype; Humans; Methylation; Mice; Neural Tube Defects; NIH 3T3 Cells; Polymorphism, Genetic; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Spinal Dysraphism | 2007 |
Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Cell Membrane; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression Regulation; Homocysteine; Membrane Fluidity; Membrane Glycoproteins; Membrane Potential, Mitochondrial; Mitochondria, Heart; Models, Biological; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Necrosis; Phospholipids; Protein Processing, Post-Translational; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alleles; Analysis of Variance; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Young Adult | 2008 |
Study of bacteriophage T4-encoded Dam DNA (adenine-N6)-methyltransferase binding with substrates by rapid laser UV cross-linking.
Topics: DNA; DNA Methylation; Lasers; Models, Molecular; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity; Ultraviolet Rays; Viral Proteins | 2007 |
Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs.
Topics: Adenosylhomocysteinase; Atherosclerosis; Base Sequence; Blotting, Western; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Enzyme Induction; Homocysteine; Humans; Molecular Sequence Data; Muscle, Smooth, Vascular; Polymerase Chain Reaction; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes.
Topics: Animals; Apolipoproteins B; Betaine; Betaine-Homocysteine S-Methyltransferase; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Fatty Liver; Gene Transfer Techniques; Hepatocytes; Homocysteine; Humans; Lipid Metabolism; Liver Neoplasms; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Sterol Regulatory Element Binding Protein 1 | 2007 |
Influence of preconditioning-like hypoxia on the liver of developing methyl-deficient rats.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Proliferation; Choline Deficiency; Cystathionine beta-Synthase; Female; Folic Acid; Folic Acid Deficiency; Food, Formulated; Glutathione; Homocysteine; Hypoxia; Liver; Nitric Oxide Synthase Type II; Pregnancy; Rats; Rats, Wistar; Riboflavin; Riboflavin Deficiency; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Deficiency | 2007 |
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
Topics: Alanine Transaminase; Animals; ATPases Associated with Diverse Cellular Activities; Chromosome Mapping; Disease Models, Animal; Down-Regulation; Embryo, Mammalian; Female; Gene Expression; Gene Expression Profiling; Glycine N-Methyltransferase; Glycogen; Glycogen Storage Disease; Hepatitis, Chronic; Homocysteine; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Homocysteine, S-adenosylmethionine and S-adenosylhomocysteine are associated with retinal microvascular abnormalities: the Hoorn Study.
Topics: Aged; Aged, 80 and over; Arterioles; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Folic Acid; Follow-Up Studies; Glucose Tolerance Test; Homocysteine; Humans; Male; Middle Aged; Retinal Diseases; Retinal Vessels; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Ethanol-induced increased endogenous homocysteine levels and decreased ratios of SAM/SAH are only partially attenuated by exogenous glycine in developing chick brains.
Topics: Animals; Apoptosis; Brain; Caspase 3; Central Nervous System Depressants; Chick Embryo; Chickens; Down-Regulation; Embryonic Development; Enzyme Activation; Ethanol; Glycine; Homocysteine; S-Adenosylhomocysteine; S-Adenosylmethionine; Up-Regulation | 2008 |
Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.
Topics: Animals; Cystathionine beta-Synthase; DNA Methylation; Fatty Acids; Gene Silencing; Heterozygote; Hyperhomocysteinemia; Linoleoyl-CoA Desaturase; Lipid Metabolism; Liver; Mice; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Homocysteine-mediated PPARalpha,gamma DNA methylation and its potential pathogenic mechanism in monocytes.
Topics: Base Sequence; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Activation; Foam Cells; Homocysteine; Humans; Lipoproteins, LDL; Macrophage Activation; Molecular Sequence Data; Monocytes; PPAR alpha; PPAR gamma; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetradecanoylphorbol Acetate | 2008 |
Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women.
Topics: Adult; Aging; Alleles; Anemia, Iron-Deficiency; Avitaminosis; Brazil; Female; Genotype; Homocysteine; Humans; Methylmalonic Acid; Nutritional Physiological Phenomena; Polymorphism, Genetic; Reproduction; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Vitamins | 2008 |
A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases.
Topics: Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Fluorescence Polarization Immunoassay; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA; DNA Methylation; Dose-Response Relationship, Drug; Down-Regulation; HL-60 Cells; Humans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Stereoisomerism; Telomerase | 2008 |
B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Gene Expression Regulation; Hyperhomocysteinemia; Male; Mice; Mice, Transgenic; Presenilin-1; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B Deficiency | 2008 |
A kinetic study of human protein arginine N-methyltransferase 6 reveals a distributive mechanism.
Topics: Arginine; Humans; Kinetics; Methylation; Nuclear Proteins; Peptides; Protein Binding; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 2008 |
Stability of plasma homocysteine, S-adenosylmethionine, and S-adenosylhomocysteine in EDTA, acidic citrate, and Primavette collection tubes.
Topics: Adult; Aged; Aged, 80 and over; Blood Specimen Collection; Citrates; Edetic Acid; Homocysteine; Humans; Hydrogen-Ion Concentration; Middle Aged; Plasma; S-Adenosylhomocysteine; S-Adenosylmethionine; Temperature | 2007 |
Riboswitches that sense S-adenosylhomocysteine and activate genes involved in coenzyme recycling.
Topics: 5' Untranslated Regions; Base Sequence; Binding Sites; Coenzymes; Conserved Sequence; Gene Expression Regulation; Homocysteine; Kinetics; Methionine; Nucleic Acid Conformation; RNA; RNA, Bacterial; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases.
Topics: Chromatin; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Models, Molecular; Quantum Theory; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Hyperglycemia-induced membrane lipid peroxidation and elevated homocysteine levels are poorly attenuated by exogenous folate in embryonic chick brains.
Topics: Animals; Blood Glucose; Brain; Chick Embryo; Fatty Acids; Folic Acid; Glucose; Homocysteine; Lipid Peroxidation; Lipid Peroxides; Membrane Lipids; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8.
Topics: Catalysis; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Quantum Theory; S-Adenosylhomocysteine; S-Adenosylmethionine; Static Electricity; Substrate Specificity | 2008 |
Taurine supplementation improves the utilization of sulfur-containing amino acids in rats continually administrated alcohol.
Topics: Alcohol Drinking; Animals; Cysteine; Ethanol; Methionine; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Taurine | 2009 |
Elevated serum levels of S-adenosylhomocysteine, but not homocysteine, are associated with cardiovascular disease in stage 5 chronic kidney disease patients.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Chronic Disease; Female; Homocysteine; Humans; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Predictive Value of Tests; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Severity of Illness Index | 2008 |
Maternal global methylation status and risk of congenital heart diseases.
Topics: Adult; Biomarkers; Case-Control Studies; Child; Down Syndrome; Female; Heart; Heart Defects, Congenital; Humans; Hyperhomocysteinemia; Infant; Linear Models; Methylation; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prenatal Exposure Delayed Effects; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura.
Topics: Adolescent; Adult; Aged; Chromatography, High Pressure Liquid; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Female; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Purpura, Thrombocytopenic, Idiopathic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet.
Topics: Animals; Brain; Diet, Reducing; DNA Modification Methylases; DNA-Binding Proteins; Epigenesis, Genetic; Folic Acid Deficiency; Homocysteine; Male; Methionine; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Regulatory Factor X Transcription Factors; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Transcription Factors | 2008 |
S-Adenosylhomocysteine hydrolase overexpression in HEK-293 cells: effect on intracellular adenosine levels, cell viability, and DNA methylation.
Topics: Adenosine; Adenosine Deaminase; Adenosylhomocysteinase; Caspases; Cell Death; Cell Line; Cell Shape; Cell Survival; Clone Cells; DNA; DNA Fragmentation; DNA Methylation; Electrophoresis, Agar Gel; Energy Metabolism; Gene Expression Regulation, Enzymologic; Humans; Intracellular Space; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Subcellular Fractions; Transfection | 2008 |
Crystal structure of tRNA N2,N2-guanosine dimethyltransferase Trm1 from Pyrococcus horikoshii.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Protein Structure, Tertiary; Pyrococcus horikoshii; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; tRNA Methyltransferases | 2008 |
Relationships between gene polymorphisms of folate-related proteins and vitamins and metabolites in pregnant women and neonates.
Topics: Adult; Brazil; DNA; Embryonic Development; Ethnicity; Female; Folic Acid; Glutamate Carboxypeptidase II; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pregnancy; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylhomocysteine; S-Adenosylmethionine; Socioeconomic Factors; Vitamin B 12; Vitamin B Complex; Young Adult | 2008 |
Methionine metabolism in an animal model of sepsis.
Topics: Animals; Cysteine; Disease Models, Animal; Glutathione; Homocysteine; Lipopolysaccharides; Male; Methionine; Oxidation-Reduction; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sepsis | 2008 |
Wheat coleoptile endonuclease Wen2 is dependent on S-adenosyl-L-methionine and sensitive to DNA methylation status.
Topics: Apoptosis; Cotyledon; DNA; DNA Methylation; Endonucleases; Plant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Seedlings; Substrate Specificity; Triticum | 2008 |
Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells.
Topics: Cell Line; Cells, Cultured; Disulfides; Epithelial Cells; Humans; Lung; Metabolic Networks and Pathways; Methionine; Methylation; Methyltransferases; Models, Biological; Oxidation-Reduction; Oxidative Stress; Peroxides; Respiratory Mucosa; S-Adenosylhomocysteine; S-Adenosylmethionine | 2009 |
Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine.
Topics: Animals; Brain; Cognition Disorders; Dietary Supplements; Folic Acid Deficiency; Homocystine; Lecithins; Male; Maze Learning; Methionine; Psychomotor Performance; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Resveratrol supplementation worsen the dysregulation of genes involved in hepatic lipid homeostasis observed in hyperhomocysteinemic mice.
Topics: Animals; Apolipoprotein A-I; Cystathionine beta-Synthase; Dietary Supplements; Gene Expression Regulation; Genotype; Hyperhomocysteinemia; Lipid Metabolism; Liver; Mice; Phosphatidylcholine-Sterol O-Acyltransferase; Resveratrol; S-Adenosylhomocysteine; S-Adenosylmethionine; Scavenger Receptors, Class B; Stilbenes | 2009 |
Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.
Topics: Amino Acids; Animals; Apoptosis Inducing Factor; Caloric Restriction; Diet; Dietary Proteins; Fatty Acids; Liver; Male; Mitochondria, Liver; Oxidative Stress; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Sirtuin 1; Sirtuins | 2009 |
Experimental folate and vitamin B12 deficiency does not alter bone quality in rats.
Topics: Animals; Biomarkers; Biomechanical Phenomena; Body Weight; Bone and Bones; Bone Remodeling; Disease Models, Animal; Female; Folic Acid Deficiency; Homocysteine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 Deficiency | 2009 |
Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone.
Topics: Aged; Animals; Bone and Bones; Collagen; Female; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Male; Methionine; Myocardium; Osteoporosis; Porosity; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Stress, Mechanical | 2009 |
Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism.
Topics: Autistic Disorder; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dietary Supplements; Female; Glutathione; Humans; Leucovorin; Male; Methylation; Nutritional Status; Oxidation-Reduction; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Treatment Outcome; Vitamin B 12; Vitamin B Complex | 2009 |
Dietary selenium (Se) and copper (Cu) interact to affect homocysteine metabolism in rats.
Topics: Animal Feed; Animals; Copper; Drug Interactions; Glutathione; Liver; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenium | 2009 |
A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding.
Topics: Binding, Competitive; Cell Line; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Green Fluorescent Proteins; Humans; Immunoprecipitation; Recombinant Fusion Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrometry, Fluorescence; Substrate Specificity | 2009 |
Possible role of S-adenosylmethionine, S-adenosylhomocysteine, and polyunsaturated fatty acids in predementia syndromes and Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Dementia; Fatty Acids, Unsaturated; Humans; S-Adenosylhomocysteine; S-Adenosylmethionine | 2009 |
Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.
Topics: Carbon Dioxide; Catalytic Domain; Mass Spectrometry; Methylation; Models, Molecular; Nucleosides; Phosphoprotein Phosphatases; Protein Phosphatase 2C; Protein Structure, Tertiary; RNA, Transfer, Phe; S-Adenosylhomocysteine; S-Adenosylmethionine; Saccharomyces cerevisiae Proteins; tRNA Methyltransferases | 2009 |
Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics.
Topics: Actinomycetales; Adenosine; Anti-Bacterial Agents; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Methyltransferases; Models, Molecular; Point Mutation; Protein Binding; Protein Multimerization; S-Adenosylhomocysteine; S-Adenosylmethionine; Teicoplanin | 2009 |
Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice.
Topics: Acatalasia; Amino Acids, Sulfur; Animals; Catalase; Cytochrome P-450 CYP2E1; Ethanol; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Liver; Male; Metabolomics; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Reactive Oxygen Species; S-Adenosylhomocysteine; S-Adenosylmethionine | 2009 |
Hepatic cystathionine beta-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: association with plasma homocysteine concentrations.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Caseins; Cystathionine beta-Synthase; Cysteine; Dietary Proteins; Dietary Supplements; Dose-Response Relationship, Drug; Energy Intake; Glycine; Homocysteine; Liver; Male; Methionine; Organ Size; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Serine; Weight Gain | 2009 |
S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases.
Topics: Adenosine; Catalytic Domain; Cell Division; Crystallography, X-Ray; Enzyme Inhibitors; Methyltransferases; Models, Molecular; Molecular Structure; Mycobacterium; Mycobacterium tuberculosis; Mycolic Acids; Protein Binding; Protein Structure, Tertiary; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity | 2009 |
Determination of S-Adenosylmethionine and S-Adenosylhomocysteine by LC-MS/MS and evaluation of their stability in mice tissues.
Topics: Animals; Chromatography, Liquid; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry | 2009 |
S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice.
Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Presenilin-1; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry | 2009 |
Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine.
Topics: Animals; Antioxidants; Cysteine; Gas Chromatography-Mass Spectrometry; Liver; Male; Methylation; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Thioctic Acid | 2009 |
Simultaneous analysis of catechol-O-methyl transferase activity, S-adenosylhomocysteine and adenosine.
Topics: Adenosine; Animals; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Vanillic Acid | 2010 |
An enzyme-coupled continuous spectrophotometric assay for magnesium protoporphyrin IX methyltransferases.
Topics: Adenine; Aminohydrolases; Biological Assay; Cyanobacteria; Escherichia coli; Hypoxanthine; Kinetics; Methyltransferases; Molecular Structure; Protoporphyrins; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry; Substrate Specificity; Synechocystis; Transformation, Bacterial | 2009 |
Methylation status and neurodegenerative markers in Parkinson disease.
Topics: Aged; alpha-Synuclein; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Biomarkers; Blood Platelets; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Nerve Degeneration; Parkinson Disease; Peptide Fragments; S-Adenosylhomocysteine; S-Adenosylmethionine; Substantia Nigra; Ultrasonography; Vitamin B 6 | 2009 |
Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.
Topics: Antibiotics, Antineoplastic; Catalytic Domain; Crystallography, X-Ray; Enediynes; Naphthols; Protein Binding; Protein O-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Zinostatin | 2009 |
Sources of S-adenosyl-L-homocysteine background in measuring protein arginine N-methyltransferase activity using tandem mass spectrometry.
Topics: Artifacts; Chromatography, Liquid; Enzyme Assays; Humans; Mass Spectrometry; Methylation; Protein-Arginine N-Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry | 2010 |
DNA hypomethylation induced by tributyltin, triphenyltin, and a mixture of these in Sebastiscus marmoratus liver.
Topics: 5-Methylcytosine; Animals; DNA Methylation; Fishes; Genome; Liver; Organotin Compounds; S-Adenosylhomocysteine; S-Adenosylmethionine; Trialkyltin Compounds; Water Pollutants, Chemical | 2009 |
Body mass index is an important determinant of methylation biomarkers in women of reproductive ages.
Topics: Adult; Biomarkers; Body Mass Index; Female; Fertility; Folic Acid; Homocysteine; Humans; Life Style; Methylation; Middle Aged; Multivariate Analysis; Netherlands; S-Adenosylhomocysteine; S-Adenosylmethionine; Surveys and Questionnaires; Vitamin B 12; Young Adult | 2009 |
Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry.
Topics: Adult; Chromatography, Liquid; Humans; Isotope Labeling; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Young Adult | 2009 |
Impaired transmethylation potential in Parkinson's disease patients treated with L-Dopa.
Topics: Aged; Antiparkinson Agents; Cross-Sectional Studies; Erythrocytes; Female; Genotype; Homocysteine; Humans; Levodopa; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Parkinson Disease; Polymorphism, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child.
Topics: Adult; Birth Weight; CpG Islands; Cross-Sectional Studies; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Gene Expression Regulation; Humans; Infant; Insulin-Like Growth Factor II; Male; Preconception Care; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine | 2009 |
Discrimination between closely related cellular metabolites by the SAM-I riboswitch.
Topics: Adenosine; Base Pairing; Conserved Sequence; Crystallography, X-Ray; Kinetics; Models, Molecular; Mutation; Nucleic Acid Conformation; RNA, Bacterial; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Impaired methylation as a novel mechanism for proteasome suppression in liver cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chymotrypsin; Ethanol; Humans; Liver; Methylation; Mice; Mice, Inbred C57BL; Proteasome Endopeptidase Complex; Rabbits; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 2010 |
Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection.
Topics: Animals; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Ethanol; Liver Diseases, Alcoholic; Male; Mitochondria, Liver; Mitochondrial Proteins; Oxygen Consumption; Proteome; Proteomics; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcription, Genetic | 2010 |
Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases.
Topics: Amino Acid Sequence; Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Calorimetry; Catalytic Domain; Conserved Sequence; Drug Resistance, Bacterial; Methylation; Methyltransferases; Micromonospora; Models, Molecular; Molecular Sequence Data; Ribosome Subunits, Small, Bacterial; RNA, Ribosomal, 16S; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Homology, Amino Acid | 2010 |
An enzyme-coupled ultrasensitive luminescence assay for protein methyltransferases.
Topics: Enzyme Assays; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Luminescent Measurements; Protein Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity | 2010 |
Regulation of homocysteine metabolism and methylation in human and mouse tissues.
Topics: Animals; Computational Biology; Enzymes; Gene Expression Profiling; Gene Expression Regulation; Homocysteine; Humans; Infant, Newborn; Metabolic Networks and Pathways; Methylation; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
[The role of DNA methylation in the pathogenesis of adult idiopathic thrombocytopenic purpura].
Topics: Adolescent; Adult; Aged; Case-Control Studies; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Humans; Male; Middle Aged; Purpura, Thrombocytopenic, Idiopathic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; T-Lymphocytes; Young Adult | 2010 |
Molecular architecture of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose.
Topics: Aminoglycosides; Binding Sites; Catalysis; Glucose; Macromolecular Substances; Methyltransferases; Protein Binding; Protein Structure, Secondary; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation.
Topics: Animals; Carbon; DNA-Binding Proteins; Female; Fibroblasts; Folic Acid; Folic Acid Deficiency; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Mutant Strains; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Thymidine Monophosphate; Transcription Factors | 2010 |
Atomistic details of the ligand discrimination mechanism of S(MK)/SAM-III riboswitch.
Topics: Hydrogen Bonding; Ligands; Molecular Dynamics Simulation; Protein Structure, Tertiary; Riboswitch; RNA, Bacterial; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria.
Topics: Actinomycetales; Bacterial Proteins; Crystallography, X-Ray; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Methyltransferases; Models, Molecular; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, Protein; Substrate Specificity; tRNA Methyltransferases | 2010 |
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.
Topics: Amino Acids; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cystathionine beta-Synthase; Diet; Enzyme Inhibitors; Glycine N-Methyltransferase; Homocysteine; Hyperhomocysteinemia; Liver; Male; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Förster resonance energy transfer measurements of cofactor-dependent effects on protein arginine N-methyltransferase homodimerization.
Topics: Dimerization; Fluorescence Resonance Energy Transfer; Kinetics; Luminescent Proteins; Models, Molecular; Nuclear Proteins; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Repressor Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules.
Topics: Binding Sites; Catalysis; Catalytic Domain; Deoxyadenosines; Kinetics; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Sulfurtransferases; Thionucleosides | 2010 |
Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner.
Topics: Animals; Arsenites; Carcinogens; Choline Deficiency; Deoxycytidine; Diet; DNA; DNA Methylation; DNA Modification Methylases; Female; Folic Acid Deficiency; Gene Expression Regulation, Enzymologic; Isoenzymes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Characteristics; Sodium Compounds | 2011 |
Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit.
Topics: Adenine; Base Sequence; Escherichia coli; Escherichia coli Proteins; Humans; Kanamycin Resistance; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Footprinting; Ribosome Subunits, Small, Bacterial; RNA, Ribosomal, 16S; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
Some more comments on 'folate deficiency in chronic pancreatitis'.
Topics: Folic Acid Deficiency; Glycine N-Methyltransferase; Homocysteine; Humans; Metabolic Networks and Pathways; Methionine; Pancreatitis, Chronic; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.
Topics: Aminohydrolases; Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; DNA, Neoplasm; Female; Formate-Tetrahydrofolate Ligase; Gene Expression Profiling; Immunoenzyme Techniques; Male; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Inbred C57BL; Mice, Knockout; Multienzyme Complexes; Multifunctional Enzymes; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Uracil | 2011 |
Thymidylate synthase gene polymorphisms and markers of DNA methylation capacity.
Topics: Adult; Case-Control Studies; Cholesterol; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Genetic Association Studies; Genetic Markers; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; S-Adenosylhomocysteine; S-Adenosylmethionine; Serum Albumin; Thymidylate Synthase; Vitamin B 12 | 2011 |
Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system.
Topics: 1-Propanol; Animals; Anti-Infective Agents, Local; Ethanol; Liver; Male; NAD; Oxidation-Reduction; Perfusion; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver.
Topics: Animals; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; Chromatography, High Pressure Liquid; Colipases; DNA Methylation; Enzyme Precursors; Esters; Female; Immunohistochemistry; Lipase; Liver; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Rats; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylhomocysteine; S-Adenosylmethionine; Tretinoin | 2011 |
Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation.
Topics: Carcinoma, Hepatocellular; Cysteine; Cytidine; DNA Methylation; DNA Modification Methylases; Gene Expression; Glycine N-Methyltransferase; Hep G2 Cells; Hepatocytes; Homeostasis; Homocysteine; Humans; Kinetics; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; Methylation; Osmolar Concentration; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats.
Topics: Animals; Dietary Supplements; DNA Methylation; Doxorubicin; Genes, p53; Genomic Instability; Glutathione; Kidney; Male; Methionine; Promoter Regions, Genetic; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells.
Topics: Binding Sites; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Transformed; Chromatin Immunoprecipitation; CpG Islands; DNA; DNA Methylation; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Histone Deacetylase 1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Methionine Adenosyltransferase; Mutagenesis, Site-Directed; p300-CBP Transcription Factors; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Microenvironment; Up-Regulation | 2011 |
Folic acid supplementation during early hepatocarcinogenesis: cellular and molecular effects.
Topics: Animals; Apoptosis; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Dietary Supplements; DNA Damage; DNA Methylation; Folic Acid; Gene Expression; Genes, myc; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Precancerous Conditions; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue.
Topics: Amino Acid Substitution; Animals; Base Sequence; Catalytic Domain; Cysteine; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Humans; In Vitro Techniques; Kinetics; Methylation; Mice; Models, Molecular; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 2011 |
High bone concentrations of homocysteine are associated with altered bone morphology in humans.
Topics: Adult; Aged; Aged, 80 and over; Bone and Bones; Collagen; Extracellular Matrix; Female; Femur; Hip; Homocysteine; Humans; Male; Methylation; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay.
Topics: Azacitidine; Bacteria; Cytosine; Deoxyadenosines; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Assays; Humans; Kinetics; Light; Luciferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 2011 |
Identification and characterization of the Chlamydia trachomatis L2 S-adenosylmethionine transporter.
Topics: Amino Acid Sequence; Anion Transport Proteins; Chlamydia trachomatis; Escherichia coli; Gene Deletion; Genetic Complementation Test; Kinetics; Molecular Sequence Data; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Homology | 2011 |
A maternal dietary pattern characterised by fish and seafood in association with the risk of congenital heart defects in the offspring.
Topics: Adult; Biomarkers; Case-Control Studies; Feeding Behavior; Female; Fish Products; Heart Defects, Congenital; Homocysteine; Humans; Methylation; Netherlands; Odds Ratio; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Seafood; Surveys and Questionnaires; Vitamin B Complex | 2011 |
[Function of luxS gene in sulfurmetabolism of Streptococcus mutans].
Topics: Bacterial Proteins; Biofilms; Carbon-Sulfur Lyases; Culture Media; Culture Techniques; Cysteine; Gene Expression Regulation, Bacterial; Methionine; Microscopy, Confocal; Quorum Sensing; S-Adenosylhomocysteine; S-Adenosylmethionine; Streptococcus mutans; Sulfur | 2011 |
Modeling a new water channel that allows SET9 to dimethylate p53.
Topics: Catalysis; Crystallography, X-Ray; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Tumor Suppressor Protein p53; Water | 2011 |
Oxidative stress is implicated in arsenic-induced neural tube defects in chick embryos.
Topics: Acetylcysteine; Animals; Arsenic; Chick Embryo; Epigenesis, Genetic; Female; Glutathione Peroxidase; Malondialdehyde; Neural Tube Defects; Oxidative Stress; Reactive Oxygen Species; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase | 2011 |
Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox).
Topics: Adenosine; Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Cell Membrane; Cell Nucleus; Cell Survival; Extracellular Space; Homocysteine; Intracellular Space; Membrane Glycoproteins; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Phospholipid Transfer Proteins; Rats; Reactive Oxygen Species; S-Adenosylhomocysteine; S-Adenosylmethionine; Tyrosine | 2011 |
Structural characterization of BVU_3255, a methyltransferase from human intestine antibiotic resistant pathogen Bacteroides vulgatus.
Topics: Bacterial Proteins; Bacteroides; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Drug Resistance, Bacterial; Humans; Intestines; Methylation; Methyltransferases; Protein Folding; Protein Structure, Secondary; S-Adenosylhomocysteine; S-Adenosylmethionine; Ubiquinone | 2011 |
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function.
Topics: Adenosine Kinase; Adult; Amino Acid Metabolism, Inborn Errors; Brain Diseases; Child; Developmental Disabilities; Family Health; Female; Fibroblasts; Homocysteine; Humans; Liver Diseases; Male; Methionine; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
A conformational switch in the active site of BT_2972, a methyltransferase from an antibiotic resistant pathogen B. thetaiotaomicron.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacteroides; Calorimetry; Catalytic Domain; Crystallography, X-Ray; Drug Resistance, Bacterial; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, Protein; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity; Thermodynamics | 2011 |
Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Colonic Neoplasms; Dextran Sulfate; Inflammation; Interleukin-10; Interleukin-6; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; STAT3 Transcription Factor; Transcriptional Activation; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2012 |
Atomic-level insights into metabolite recognition and specificity of the SAM-II riboswitch.
Topics: Ligands; Molecular Dynamics Simulation; Nucleic Acid Conformation; Peptide Chain Initiation, Translational; Principal Component Analysis; Protein Binding; Ribosomes; Riboswitch; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Static Electricity | 2012 |
Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosylhomocysteinase; Amino Acids, Sulfur; Animals; Cardiovascular Diseases; Cystathionine beta-Synthase; Cysteine Dioxygenase; Diet, High-Fat; Dipeptides; Down-Regulation; Homocysteine; Lipid Peroxidation; Liver; Male; Methionine Adenosyltransferase; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides; Up-Regulation | 2013 |
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetylation; Animals; Carcinogens; Cell Line; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Liver; Liver Neoplasms, Experimental; Male; Methionine Adenosyltransferase; Methylenetetrahydrofolate Reductase (NADPH2); MicroRNAs; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Crystallography, X-Ray; Deoxyadenosines; Hydrolases; Lupinus; Methylation; Models, Molecular; Molecular Conformation; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine | 2012 |
Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus.
Topics: Antiviral Agents; Binding Sites; Dengue; Dengue Virus; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Ligands; Methyltransferases; Models, Molecular; RNA Caps; S-Adenosylhomocysteine; S-Adenosylmethionine; Viral Nonstructural Proteins | 2011 |
The association between plasma homocysteine levels, methylation capacity and incident osteoporotic fractures.
Topics: Aged; Bone Density; Female; Homocysteine; Humans; Incidence; Linear Models; Methylation; Middle Aged; Netherlands; Osteoporotic Fractures; Proportional Hazards Models; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine | 2012 |
Methionine sulfoxide reductase contributes to meeting dietary methionine requirements.
Topics: Animals; Base Sequence; Diet; DNA Primers; Glycine N-Methyltransferase; Methionine; Methionine Sulfoxide Reductases; Mice; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine | 2012 |
Relationships among biomarkers of one-carbon metabolism.
Topics: Adult; Aging; Biomarkers; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; One-Carbon Group Transferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Characteristics; Vitamin B 12; Young Adult | 2012 |
Nutritional B vitamin deficiency disrupts lipid metabolism causing accumulation of proatherogenic lipoproteins in the aorta adventitia of ApoE null mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholesterol; Connective Tissue; Diet, Atherogenic; Disease Models, Animal; Fatty Acids; Hyperhomocysteinemia; Lipid Metabolism; Lipoproteins; Liver; Male; Mice; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Severity of Illness Index; Vitamin B Deficiency | 2012 |
Supra-physiological folic acid concentrations induce aberrant DNA methylation in normal human cells in vitro.
Topics: Cell Line; CpG Islands; DNA Methylation; Enterocytes; Fibroblasts; Folic Acid; Humans; Long Interspersed Nucleotide Elements; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenium | 2012 |
Biomarkers of the one-carbon pathway in association with congenital diaphragmatic hernia.
Topics: Adult; Biomarkers; Birth Weight; Female; Fetal Blood; Gestational Age; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Homocysteine; Humans; Infant, Newborn; Male; Regression Analysis; S-Adenosylhomocysteine; S-Adenosylmethionine | 2012 |
Dietary folic acid intake differentially affects methionine metabolism markers and hippocampus morphology in aged rats.
Topics: Aging; Animals; Astrocytes; Biomarkers; Cognitive Dysfunction; Diet; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Hippocampus; Hyperhomocysteinemia; Male; Methionine; Methylation; Neurons; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.
Topics: Adolescent; Adult; Betaine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Choline; Cystathionine; Cysteine; Down Syndrome; Female; Glutathione; Humans; Infant; Male; Methionine; Methylation; Models, Theoretical; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Young Adult | 2012 |
The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic.
Topics: Animals; Arsenites; Epigenomics; Female; Fetal Weight; Fetus; Folic Acid; Gene Expression Regulation, Developmental; Liver; Male; Mice; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Sodium Compounds | 2012 |
Determinants of the essential one-carbon metabolism metabolites, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine and folate, in cerebrospinal fluid.
Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Immunoassay; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Vitamin B 12 | 2012 |
The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis.
Topics: Adenosine; Adenosine Triphosphate; Amino Acid Sequence; Bacillus cereus; Bacterial Proteins; Biotin; Carrier Proteins; Chromatography, Gel; Conserved Sequence; Escherichia coli; Fatty Acids; Genetic Complementation Test; Hydrogen-Ion Concentration; Methionine; Molecular Sequence Data; Protein O-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity | 2012 |
The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholesterol; Cholesterol, Dietary; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Gene Expression; Homocysteine; Hyperhomocysteinemia; Hyperlipidemias; Lipids; Male; Methionine; Mice; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides | 2012 |
S-adenosyl-L-methionine usage during climacteric ripening of tomato in relation to ethylene and polyamine biosynthesis and transmethylation capacity.
Topics: Adenosine Kinase; Adenosylmethionine Decarboxylase; Cyclopropanes; Ethylenes; Fruit; Gene Expression Regulation, Plant; Metabolic Networks and Pathways; Methylation; Plant Growth Regulators; Plant Proteins; Polyamines; S-Adenosylhomocysteine; S-Adenosylmethionine; Solanum lycopersicum; Up-Regulation | 2013 |
Genes encoding Cher-TPR fusion proteins are predominantly found in gene clusters encoding chemosensory pathways with alternative cellular functions.
Topics: Amino Acid Sequence; Bacterial Proteins; Conserved Sequence; Genes, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Membrane Proteins; Methyl-Accepting Chemotaxis Proteins; Methyltransferases; Molecular Sequence Data; Multigene Family; Phylogeny; Protein Binding; Protein Structure, Quaternary; Protein Structure, Tertiary; Pseudomonas putida; Recombinant Fusion Proteins; Repetitive Sequences, Amino Acid; S-Adenosylhomocysteine; S-Adenosylmethionine; Thermodynamics | 2012 |
SuperTAG methylation-specific digital karyotyping reveals uremia-induced epigenetic dysregulation of atherosclerosis-related genes.
Topics: Atherosclerosis; Case-Control Studies; Databases, Genetic; DNA Methylation; Epigenesis, Genetic; Humans; Karyotyping; Male; Middle Aged; Renal Dialysis; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Uremia | 2012 |
Plasma choline and betaine correlate with serum folate, plasma S-adenosyl-methionine and S-adenosyl-homocysteine in healthy volunteers.
Topics: Adolescent; Adult; Betaine; Choline; Chromatography, High Pressure Liquid; DNA Methylation; Female; Folic Acid; Gonadal Steroid Hormones; Humans; Linear Models; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Sex Factors; Tandem Mass Spectrometry; Young Adult | 2013 |
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Homocystinuria; Interferon-gamma; Liver; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Mice, Transgenic; Muscle Spasticity; Placenta; Pregnancy; Pregnancy Complications; Psychotic Disorders; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 2013 |
Elevation of cysteine consumption in tamoxifen-resistant MCF-7 cells.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cystathionine gamma-Lyase; Cysteine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Glutamate-Cysteine Ligase; Glutathione; Humans; Membrane Transport Modulators; Methionine; Methylation; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Tamoxifen; Taurine; Up-Regulation | 2013 |
Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia.
Topics: Alleles; Animals; Base Sequence; Body Weight; Brain; Crosses, Genetic; Diet; DNA Methylation; Female; Genetic Loci; Genomic Imprinting; Homocysteine; Hyperhomocysteinemia; Insulin-Like Growth Factor II; Liver; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Organ Specificity; RNA, Long Noncoding; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity | 2013 |
The beneficial effect of folate-enriched egg on the folate and homocysteine levels in rats fed a folate- and choline-deficient diet.
Topics: Animal Feed; Animals; Choline; Diet; Egg Yolk; Folic Acid; Food, Fortified; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 2012 |
Folic acid acts through DNA methyltransferases to induce the differentiation of neural stem cells into neurons.
Topics: Animals; Cell Differentiation; Cytidine; DNA (Cytosine-5-)-Methyltransferases; Folic Acid; Intracellular Space; Neural Stem Cells; Neurons; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
Validated HPLC-Fl method for the analysis of S-adenosylmethionine and S-adenosylhomocysteine biomarkers in human blood.
Topics: Biomarkers; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Humans; Linear Models; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrometry, Fluorescence | 2013 |
LC-MS/MS identification of the one-carbon cycle metabolites in human plasma.
Topics: Adult; Chromatography, Liquid; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Multiple Sclerosis; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry | 2013 |
Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma.
Topics: Adult; Female; Graft Rejection; Humans; Kidney Transplantation; Longitudinal Studies; Male; Middle Aged; Pilot Projects; Predictive Value of Tests; Prognosis; Reference Values; Reproducibility of Results; Retrospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
Methylation metabolism in sepsis and systemic inflammatory response syndrome.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; DNA Methylation; Female; Homocysteine; Humans; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Sepsis; Systemic Inflammatory Response Syndrome; Young Adult | 2013 |
DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.
Topics: Adolescent; Adult; Betaine; Biomarkers; Choline; Cysteine; Diet; Diet Records; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; DNA Methylation; Feeding Behavior; Female; Folic Acid; Gambia; Homocysteine; Humans; Linear Models; Methionine; Middle Aged; Nutrition Assessment; Prospective Studies; Riboflavin; Rural Population; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Vitamin B 12; Vitamin B 6; Young Adult | 2013 |
[Measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma with high performance liquid chromatography].
Topics: Chromatography, High Pressure Liquid; Humans; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity | 2013 |
Methylation metabolites in amniotic fluid depend on gestational age.
Topics: Adult; Amniotic Fluid; Betaine; Choline; Female; Gestational Age; Humans; Methionine; Methylation; Methyltransferases; Pregnancy; Retrospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine | 2013 |
The endosymbiont Amoebophilus asiaticus encodes an S-adenosylmethionine carrier that compensates for its missing methylation cycle.
Topics: Antiporters; Bacteroidetes; Cloning, Molecular; Computational Biology; Escherichia coli; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 2013 |
The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL.
Topics: Amino Acid Sequence; Amino Acids, Basic; Catalytic Domain; Coenzymes; Escherichia coli Proteins; Methyltransferases; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Multimerization; RNA, Transfer, Leu; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment | 2013 |
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Topics: Adenosine; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; DNA Methylation; Female; Fluorescent Antibody Technique, Indirect; Folic Acid; Glycine N-Methyltransferase; Hepatocytes; Homocysteine; Humans; Liver; Liver Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Knockout; Minor Histocompatibility Antigens; Protein Transport; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uracil | 2014 |
Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ.
Topics: Adenine; Adenosine Monophosphate; Amino Acid Sequence; Binding Sites; Catalytic Domain; Coenzymes; Escherichia coli; Escherichia coli Proteins; Methyltransferases; Models, Molecular; Molecular Sequence Data; RNA, Ribosomal, 23S; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment | 2013 |
Levels of key enzymes of methionine-homocysteine metabolism in preeclampsia.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Female; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Topics: Amino Acid Sequence; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Guanine; Methyltransferases; Models, Molecular; Molecular Sequence Data; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; Saccharomyces cerevisiae Proteins; Schizosaccharomyces pombe Proteins; tRNA Methyltransferases | 2014 |
Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas.
Topics: Amidinotransferases; Amino Acids; Animals; Creatine; Creatinine; Diet; Dietary Supplements; Glycine; Guanidinoacetate N-Methyltransferase; Kidney; Liver; Male; Pancreas; Phosphocreatine; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2014 |
Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two Caucasian populations.
Topics: Adipose Tissue; Aged; Aged, 80 and over; Amino Acids, Sulfur; Cohort Studies; Cross-Sectional Studies; Cystathionine; Cysteine; Diet; Dipeptides; Exercise; Fatty Acids; Female; Glutathione; Homocysteine; Humans; Male; Methionine; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Stearoyl-CoA Desaturase; Surveys and Questionnaires; White People | 2013 |
Metabolism of selenite to selenosugar and trimethylselenonium in vivo: tissue dependency and requirement for S-adenosylmethionine-dependent methylation.
Topics: Adenosine; Animals; Dietary Supplements; Erythrocytes; Kidney; Liver; Male; Methylation; Molecular Weight; Organoselenium Compounds; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenious Acid; Selenium; Selenium Compounds; Selenoproteins | 2013 |
S-adenosylhomocysteine is associated with subclinical atherosclerosis and renal function in a cardiovascular low-risk population.
Topics: Asymptomatic Diseases; Atherosclerosis; Cardiovascular Diseases; Female; Glomerular Filtration Rate; Homocysteine; Humans; Male; Middle Aged; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine | 2014 |
Folate and cobalamin modify associations between S-adenosylmethionine and methylated arsenic metabolites in arsenic-exposed Bangladeshi adults.
Topics: Adult; Aged; Arsenic; Arsenic Poisoning; Arsenicals; Bangladesh; Cross-Sectional Studies; Drinking Water; Environmental Exposure; Female; Folic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 2014 |
Effect of vitamin B deprivation during pregnancy and lactation on homocysteine metabolism and related metabolites in brain and plasma of mice offspring.
Topics: Animals; Brain; Female; Folic Acid; Homocysteine; Lactation; Male; Mice; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Vitamin B Deficiency | 2014 |
Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression.
Topics: Cell Adhesion; Endothelial Cells; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Leukocytes; Methylation; Methyltransferases; Oxidative Stress; RNA, Transfer, Amino Acyl; RNA, Transfer, Ser; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenium; Selenoproteins | 2014 |
Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7.
Topics: Amino Acid Sequence; Arginine; Catalytic Domain; Crystallography, X-Ray; Guanidine; Histones; Methylation; Models, Molecular; Molecular Sequence Data; Protein Multimerization; Protein-Arginine N-Methyltransferases; Protozoan Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Trypanosoma brucei brucei | 2014 |
Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse.
Topics: Animals; Betaine; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Ethanol; Fatty Liver, Alcoholic; Gene Expression Regulation; Homocystinuria; Liver; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; PPAR alpha; S-Adenosylhomocysteine; S-Adenosylmethionine | 2014 |
Metabolism of arsenic trioxide in acute promyelocytic leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cacodylic Acid; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Glutathione; Humans; Leukemia, Promyelocytic, Acute; Methyltransferases; Oxides; S-Adenosylhomocysteine; S-Adenosylmethionine | 2014 |
Validation of a food-frequency questionnaire assessment of methyl-group donors using estimated diet records and plasma biomarkers: the method of triads.
Topics: Adolescent; Adult; Belgium; Betaine; Biomarkers; Choline; Diet; Diet Records; Energy Intake; Feeding Behavior; Female; Folic Acid; Humans; Methionine; Methylation; Middle Aged; Nutrition Assessment; Nutritional Status; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Surveys and Questionnaires; Young Adult | 2014 |
Aberrant DNA methylation of the PDGF gene in homocysteine‑mediated VSMC proliferation and its underlying mechanism.
Topics: Cell Proliferation; Cells, Cultured; DNA Methylation; Folic Acid; G1 Phase Cell Cycle Checkpoints; Homocysteine; Humans; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Promoter Regions, Genetic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Umbilical Cord | 2014 |
Increased methylation demand exacerbates ethanol-induced liver injury.
Topics: Alcohol Drinking; Amidinotransferases; Animals; Chemical and Drug Induced Liver Injury; Diet; Ethanol; Fatty Liver, Alcoholic; Glycine; Guanidinoacetate N-Methyltransferase; Homocysteine; Liver; Male; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides | 2014 |
Quantification of folate metabolites in serum using ultraperformance liquid chromatography tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Limit of Detection; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolates | 2014 |
Using S-adenosyl-L-homocysteine capture compounds to characterize S-adenosyl-L-methionine and S-adenosyl-L-homocysteine binding proteins.
Topics: Catechol O-Methyltransferase; DNA-Binding Proteins; Fluorescence Polarization; Histone-Lysine N-Methyltransferase; Humans; Hydrolases; Nuclear Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcription Factors | 2014 |
S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages.
Topics: Cardiovascular Diseases; Cell Line; DNA Methylation; Gene Expression Regulation; Gene Regulatory Networks; Humans; Inflammation; Interleukin-10; Macrophages; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Necrosis Factor-alpha | 2014 |
Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase.
Topics: Crystallography, X-Ray; Dengue; Dengue Virus; Humans; Methyltransferases; Models, Molecular; Protein Refolding; S-Adenosylhomocysteine; S-Adenosylmethionine; West Nile Fever; West Nile virus | 2015 |
Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis.
Topics: Amino Acid Sequence; Ascomycota; Basidiomycota; Betaine; Catalytic Domain; Crystallography, X-Ray; Ergothioneine; Escherichia coli; Fungal Proteins; Gene Expression; Histidine; Methyltransferases; Models, Molecular; Molecular Sequence Data; Mutation; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan | 2015 |
Whey protein supplementation increases methionine intake but not homocysteine plasma concentration in rats.
Topics: Advanced Oxidation Protein Products; Animals; Biomarkers; Caseins; Dietary Supplements; Glutathione; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Methionine; Muscle, Skeletal; Oxidation-Reduction; Oxidative Stress; Random Allocation; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Whey Proteins | 2015 |
Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism.
Topics: Acyltransferases; Animals; Betaine; Carbon; Diet, High-Fat; Dietary Supplements; Fatty Liver; Glycine N-Methyltransferase; Humans; Liver; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides | 2015 |
Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats.
Topics: Animals; Glutathione Peroxidase; Glutathione Transferase; Homocysteine; Liver; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 6 Deficiency | 2015 |
Daily variation in global and local DNA methylation in mouse livers.
Topics: Animals; Circadian Rhythm; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Knockout Techniques; Liver; Male; Mice; Period Circadian Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways.
Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Cytosine; Deoxyguanosine; DNA Methylation; Fatty Liver; Gene Expression Regulation, Enzymologic; Liver; Male; Methionine; Mice, Inbred C57BL; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
Reversed phase and cation exchange liquid chromatography with spectrophotometric and elemental/molecular mass spectrometric detection for S-adenosyl methionine/S-adenosyl homocysteine ratios as methylation index in cell cultures of ovarian cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chromatography, Reverse-Phase; Cisplatin; DNA Methylation; Drug Resistance, Neoplasm; Female; Homocysteine; Humans; Methylation; Molecular Weight; Ovarian Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Folic Acid; Folic Acid Deficiency; Gene Silencing; Hippocampus; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Presenilin-1; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, DNA | 2015 |
Sulfur amino acid metabolism in Zucker diabetic fatty rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosylhomocysteinase; Animals; Area Under Curve; Betaine; Betaine-Homocysteine S-Methyltransferase; Cysteine; Dipeptides; Gene Expression Regulation; Glutamate-Cysteine Ligase; Glutathione; Homocysteine; Liver; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Rats; Rats, Zucker; S-Adenosylhomocysteine; S-Adenosylmethionine; Spermidine; Spermine; Taurine | 2015 |
Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.
Topics: Aminoglycosides; Bacterial Proteins; Crystallography, X-Ray; Micromonospora; Models, Molecular; Protein Folding; Protein O-Methyltransferase; Protein Structure, Secondary; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation.
Topics: Aged; Blood Cells; Calcium; Cross-Sectional Studies; Dietary Supplements; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine; Telomere; Tetrahydrofolates; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin D | 2016 |
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism.
Topics: Animals; Carbon; Chromatin; Epigenesis, Genetic; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Liver; Methionine; Methylation; Mice; One-Carbon Group Transferases; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
[Measurement of S-adenosylmethionine and S-adenosylhomocysteine in mice liver with high performance liquid chromatography].
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Filtration; Indicators and Reagents; Liver; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Ultrasonics | 2015 |
S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation.
Topics: Cell Line; Endothelial Cells; Enhancer of Zeste Homolog 2 Protein; Humans; Inflammation; Methylation; Methyltransferases; NF-kappa B; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
Biochemical Studies of Mycobacterial Fatty Acid Methyltransferase: A Catalyst for the Enzymatic Production of Biodiesel.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Biocatalysis; Biofuels; Catalytic Domain; Crystallography, X-Ray; Fatty Acids; Kinetics; Methyltransferases; Molecular Dynamics Simulation; Molecular Sequence Data; Mutagenesis, Site-Directed; Mycobacterium marinum; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Substrate Specificity | 2015 |
Heterologous Expression and Functional Characterization of the Exogenously Acquired Aminoglycoside Resistance Methyltransferases RmtD, RmtD2, and RmtG.
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Cloning, Molecular; Drug Resistance, Bacterial; Escherichia coli; Gene Expression; Isoenzymes; Kinetics; Klebsiella pneumoniae; Methyltransferases; Pseudomonas aeruginosa; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Transgenes | 2016 |
Quantitation of S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma Using Liquid Chromatography-Electrospray Tandem Mass Spectrometry.
Topics: Analytic Sample Preparation Methods; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Humans; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrometry, Mass, Electrospray Ionization; Statistics as Topic; Tandem Mass Spectrometry | 2016 |
An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii.
Topics: Adenosine; Adenosylhomocysteinase; Bacterial Proteins; Binding Sites; Biocatalysis; Bradyrhizobium; Crystallography, X-Ray; Escherichia coli; Gene Expression; Homocysteine; Models, Molecular; NAD; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options.
Topics: Adenosine; Adenosine Kinase; Adolescent; Adult; Biomarkers; Child; Child, Preschool; Diet; Female; Humans; Hypoglycemia; Infant; Liver; Liver Diseases; Male; Metabolic Diseases; Methionine; Retrospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine; Young Adult | 2016 |
Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism.
Topics: Aged; Bacteria; Betaine; Cardiovascular Diseases; Choline; Creatinine; Diabetes Mellitus; Female; Gastrointestinal Microbiome; Humans; Lipoproteins, HDL; Male; Methylamines; Methylation; Middle Aged; Phosphatidylcholines; Phospholipids; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Factors | 2016 |
Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice.
Topics: Animals; Choline; Diet; Dietary Fats; Dietary Sucrose; Dietary Supplements; Fatty Liver; Feeding Behavior; Female; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C3H; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.
Topics: Anti-Bacterial Agents; Binding Sites; Catalysis; Crystallography, X-Ray; Kinetics; Methylation; Methyltransferases; Models, Molecular; Protein Conformation; Riboflavin; S-Adenosylhomocysteine; S-Adenosylmethionine; Streptomyces | 2016 |
Cloning, expression and characterization of histidine-tagged biotin synthase of Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Biotin; Cloning, Molecular; Cysteine; Deoxyadenosines; Enzyme Inhibitors; Enzyme Stability; Histidine; Hydrogen-Ion Concentration; Kinetics; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Protein Engineering; Protein Multimerization; Recombinant Fusion Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Sulfurtransferases; Temperature | 2016 |
Ratio of S-adenosylmethionine to S-adenosylhomocysteine as a sensitive indicator of atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Biomarkers; Chemokine CCL2; Disease Models, Animal; DNA Methylation; Fatty Acid-Binding Proteins; Homocysteine; Interspersed Repetitive Sequences; Male; Mice; Mice, Knockout; Plaque, Atherosclerotic; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase | 2016 |
Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies.
Topics: Animals; Chickens; Deuterium; Folic Acid; Folic Acid Deficiency; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism.
Topics: Archaeal Proteins; Crystallography, X-Ray; Gene Deletion; Gene Expression Regulation, Archaeal; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Protein Methyltransferases; Protein Structure, Secondary; Proteomics; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfolobus | 2016 |
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Topics: Adenosine; Allosteric Regulation; Binding Sites; Catalytic Domain; HEK293 Cells; Humans; Methylation; Methyltransferases; Models, Molecular; Mutation; Protein Binding; Protein Conformation; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 2016 |
Lack of global epigenetic methylation defects in CBS deficient mice.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Homocysteine; Homocystinuria; Kidney; Liver; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
Capillary electrophoresis and phenylboronic acid solid phase extraction for the determination of S-adenosylmethionine/S-adenosylhomocysteine ratio in human urine.
Topics: Adult; Aged; Boronic Acids; Electrophoresis, Capillary; Female; Humans; Linear Models; Male; Middle Aged; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Solid Phase Extraction; Young Adult | 2016 |
Restriction of dietary methyl donors limits methionine availability and affects the partitioning of dietary methionine for creatine and phosphatidylcholine synthesis in the neonatal piglet.
Topics: Animals; Animals, Newborn; Betaine; Choline Deficiency; Creatine; Diet; Female; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Phosphatidylcholines; Protein Biosynthesis; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine; Swine, Miniature; Tritium | 2016 |
Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis.
Topics: Amidinotransferases; Animals; Creatine; Dietary Supplements; Fatty Liver, Alcoholic; Guanidinoacetate N-Methyltransferase; Kidney; Liver; Male; Myocardium; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
Methionine Metabolites in Patients With Sepsis.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Catheter-Related Infections; Cohort Studies; Female; Homocysteine; Hospital Mortality; Humans; Intraabdominal Infections; Logistic Models; Male; Methionine; Middle Aged; Prognosis; Prospective Studies; Respiratory Tract Infections; S-Adenosylhomocysteine; S-Adenosylmethionine; Sepsis; Skin Diseases, Infectious; Urinary Tract Infections | 2018 |
Intracerebral Administration of S-Adenosylhomocysteine or S-Adenosylmethionine Attenuates the Increases in the Cortical Extracellular Levels of Dimethylarginines Without Affecting cGMP Level in Rats with Acute Liver Failure.
Topics: Animals; Arginine; Cyclic GMP; Disease Models, Animal; Extracellular Space; Hepatic Encephalopathy; Liver Failure, Acute; Male; Prefrontal Cortex; Protein-Arginine N-Methyltransferases; Rats, Sprague-Dawley; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction | 2017 |
Differential neurogenic effects of casein-derived opioid peptides on neuronal stem cells: implications for redox-based epigenetic changes.
Topics: Analgesics, Opioid; Animals; Apoptosis; Astrocytes; Caseins; Cattle; Cell Proliferation; Cells, Cultured; DNA Methylation; Endorphins; Epigenesis, Genetic; Glutathione; Humans; Methylation; Morphine; Neural Stem Cells; Neurogenesis; Opioid Peptides; Oxidation-Reduction; Peptide Fragments; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.
Topics: Aminohydrolases; Animals; Choline; Dietary Supplements; Embryo, Mammalian; Embryonic Development; Female; Folic Acid; Formate-Tetrahydrofolate Ligase; Logistic Models; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Transgenic; Multienzyme Complexes; Placenta; Polymorphism, Single Nucleotide; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury.
Topics: Alanine Transaminase; Amidinotransferases; Animals; Aspartate Aminotransferases; Body Weight; Calcium-Binding Proteins; Cholesterol; Dietary Supplements; DNA-Binding Proteins; Ethanol; Fatty Acids; Fatty Liver; Glycine; Guanidinoacetate N-Methyltransferase; Homocysteine; Inflammation; Insulin; Liver; Liver Diseases; Male; Nerve Tissue Proteins; Nucleobindins; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides | 2016 |
Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions.
Topics: Binding Sites; Deuterium Exchange Measurement; Escherichia coli; Escherichia coli Proteins; Ligands; Mass Spectrometry; Methyltransferases; Ribosome Subunits, Small, Bacterial; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
The conformational changes of Zika virus methyltransferase upon converting SAM to SAH.
Topics: Catalytic Domain; Crystallography, X-Ray; Humans; Methyltransferases; Models, Molecular; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Viral Nonstructural Proteins; Zika Virus | 2017 |
Identifying Unknown Enzyme-Substrate Pairs from the Cellular Milieu with Native Mass Spectrometry.
Topics: Carbon Radioisotopes; Escherichia coli; Isotope Labeling; Mass Spectrometry; Methyltransferases; Molecular Probes; Nitrogen Radioisotopes; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 2017 |
Structural, mechanistic and functional insight into gliotoxin
Topics: Aspergillus fumigatus; Crystallography, X-Ray; Fungal Proteins; Gliotoxin; Metabolomics; Methyltransferases; Models, Molecular; Mutation; Oxidoreductases; Protein Binding; Protein Conformation; Proteomics; S-Adenosylhomocysteine; S-Adenosylmethionine; Toluene | 2017 |
Novel immunoassays to detect methionine adenosyltransferase activity and quantify S-adenosylmethionine.
Topics: Active Transport, Cell Nucleus; Animals; Antibody Specificity; Cell Line; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cytoplasm; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hep G2 Cells; Hepatocytes; Humans; Methionine Adenosyltransferase; Methylation; Mice; Microscopy, Fluorescence; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
A Metabolic Function for Phospholipid and Histone Methylation.
Topics: Cysteine; Energy Metabolism; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Mutation; Oxidative Stress; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Protein Phosphatase 2; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Transcription, Genetic | 2017 |
Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain.
Topics: Alcohol Drinking; Animals; Brain; Carbon; DNA Methylation; Ethanol; Liver; Male; One-Carbon Group Transferases; Random Allocation; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS-2B Cells.
Topics: Cell Line; Histones; Humans; Intercellular Signaling Peptides and Proteins; MAP Kinase Kinase 3; Methylation; Nickel; Nicotinamide N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells.
Topics: Adenosine; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Cell Proliferation; Cellular Senescence; Chromatin; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Epigenomics; Hep G2 Cells; Histones; Humans; Liver Neoplasms; Metabolic Networks and Pathways; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Suppressor Protein p53 | 2017 |
Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro.
Topics: Animals; Apolipoproteins E; Chemokine CCL2; Dietary Supplements; DNA Methylation; Folic Acid; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Plaque, Atherosclerotic; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Vascular Endothelial Growth Factor A; Vitamin B Complex | 2017 |
Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Topics: Bacterial Proteins; Binding Sites; Burkholderia; Catalytic Domain; Crystallography, X-Ray; Histidine; Hydrogen Bonding; Methylation; Methyltransferases; Models, Molecular; Multigene Family; Oxidation-Reduction; Phylogeny; Protein Conformation; Pyrimidinones; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity; Stereoisomerism; Triazines | 2017 |
The relationship between S-adenosylhomocysteine and coronary artery lesions: A case control study.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Chromatography, High Pressure Liquid; Coronary Artery Disease; Female; Humans; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice.
Topics: Animals; Carbon; DNA Methylation; Glycine Hydroxymethyltransferase; Glycolysis; Lipid Metabolism; Liver; Mice, Inbred C57BL; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenium; Sterol Regulatory Element Binding Protein 1; Triglycerides; Up-Regulation | 2017 |
Mechanistic features of the atypical tRNA m1G9 SPOUT methyltransferase, Trm10.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Biocatalysis; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Methylation; Models, Molecular; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Recombinant Proteins; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; tRNA Methyltransferases | 2017 |
Aberrant promoter methylation of multiple genes in VSMC proliferation induced by Hcy.
Topics: Alu Elements; Atherosclerosis; Cell Proliferation; CpG Islands; DNA Methylation; Epigenesis, Genetic; Female; GTP Phosphohydrolases; Homocysteine; Humans; Long Interspersed Nucleotide Elements; Mitochondrial Proteins; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Primary Cell Culture; Promoter Regions, Genetic; PTEN Phosphohydrolase; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Suppressor Protein p53; Umbilical Veins | 2017 |
Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on δ-Containing GABAA Receptor Expression in the Cerebellum of Subjects with Alcohol Use Disorders (AUD).
Topics: Adenosine; Alcoholism; Carbon; Cerebellum; Chromatography, High Pressure Liquid; Cohort Studies; DNA Methylation; Female; Gene Expression; Humans; Immunoprecipitation; Male; Middle Aged; Mixed Function Oxygenases; Postmortem Changes; Promoter Regions, Genetic; Proto-Oncogene Proteins; Receptors, GABA-A; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction | 2017 |
NosN, a Radical S-Adenosylmethionine Methylase, Catalyzes Both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide.
Topics: Methylation; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Thiazoles | 2017 |
Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon; Colonic Neoplasms; DNA Methylation; Electron Transport Complex I; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Hypoglycemic Agents; Metformin; Mice; Mitochondria; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 2018 |
Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase.
Topics: Anti-Bacterial Agents; Deoxyadenosines; Hydrogen; Methylation; Methyltransferases; Peptides, Cyclic; Protons; S-Adenosylhomocysteine; S-Adenosylmethionine; Solvents; Thiazoles | 2017 |
Acute exercise alters homocysteine plasma concentration in an intensity-dependent manner due increased methyl flux in liver of rats.
Topics: Animals; Body Weight; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine Adenosyltransferase; Methylation; Physical Conditioning, Animal; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Swimming | 2018 |
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.
Topics: Animals; Congenital Abnormalities; Diet; Disease Models, Animal; DNA Methylation; Female; Fetal Development; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Formate-Tetrahydrofolate Ligase; Genotype; Ligases; Liver; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Mice; Multifunctional Enzymes; Placenta; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Pregnancy, Animal; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 2018 |
Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Binding Sites; Carbon; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Hydrogen Bonding; Oxygen; Protein Binding; Protein Conformation; Protein Domains; S-Adenosylhomocysteine; S-Adenosylmethionine; Water | 2018 |
Structural and biochemical analysis of the dual-specificity Trm10 enzyme from
Topics: Adenosine; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Guanosine; Models, Molecular; Molecular Docking Simulation; RNA Processing, Post-Transcriptional; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Thermococcus; tRNA Methyltransferases | 2018 |
A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis.
Topics: Antibiotics, Antineoplastic; Bacterial Proteins; Biocatalysis; Cloning, Molecular; Cyclopropanes; Duocarmycins; Escherichia coli; Gene Expression; Genetic Vectors; Indoles; Iron; Iron-Sulfur Proteins; Methyltransferases; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Streptomyces; Sulfur | 2018 |
NMR resonance assignments for the SAM/SAH-binding riboswitch RNA bound to S-adenosylhomocysteine.
Topics: Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Riboswitch; S-Adenosylhomocysteine; S-Adenosylmethionine | 2018 |
The high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) may explain naked mole-rat's distinct methionine metabolite profile compared to mouse.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Enzyme Activation; Homocysteine; Homocystinuria; Methionine; Mice; Mole Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2018 |
A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds.
Topics: Amides; Catalysis; Crystallography, X-Ray; Electrons; Methylation; Methyltransferases; Nitrogen; Peptide Fragments; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine | 2018 |
Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis.
Topics: Agaricales; Amino Acid Sequence; Catalytic Domain; Fungal Proteins; Methylation; Methyltransferases; Models, Chemical; Mutation; Peptides; Protein Binding; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 2018 |
Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism.
Topics: Animals; Gene Knockdown Techniques; Glycine N-Methyltransferase; Hepatocytes; Liver; Mice; Nicotinamide N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine | 2018 |
The structure of the SAM/SAH-binding riboswitch.
Topics: Evolution, Molecular; Genomics; Ligands; Protein Biosynthesis; Riboswitch; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 2019 |
Altered Methionine Metabolism in Cancer Cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Homocysteine; Humans; Methionine; Methylation; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine | 2019 |
Metabolic footprint and intestinal microbial changes in response to dietary proteins in a pig model.
Topics: Acetylation; Amino Acids; Animals; Blood Glucose; Body Weight; Caseins; Dietary Proteins; Feces; Female; Gastrointestinal Microbiome; Histones; Lipids; Liver; Methylation; Red Meat; S-Adenosylhomocysteine; S-Adenosylmethionine; Seed Storage Proteins; Swine | 2019 |
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
Topics: Cancer-Associated Fibroblasts; Cell Line, Tumor; Cells, Cultured; Disease Progression; DNA Methylation; Female; Histones; Humans; Neoplasm Metastasis; Niacinamide; Nicotinamide N-Methyltransferase; Ovarian Neoplasms; Phenotype; Prognosis; Proteomics; S-Adenosylhomocysteine; S-Adenosylmethionine | 2019 |
Low Maternal Dietary Folate Alters Retrotranspose by Methylation Regulation in Intrauterine Growth Retardation (IUGR) Fetuses in a Mouse Model.
Topics: Animals; Disease Models, Animal; DNA Methylation; Female; Fetal Growth Retardation; Fetus; Folic Acid; Folic Acid Deficiency; Long Interspersed Nucleotide Elements; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 2019 |
Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Female; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; S-Adenosylhomocysteine; S-Adenosylmethionine | 2020 |
DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism.
Topics: Black or African American; Chromatography, Liquid; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glucuronic Acid; Humans; Inactivation, Metabolic; Metabolomics; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Urinary Bladder Neoplasms; White People | 2019 |
Determination of S-adenosylmethionine and S-adenosylhomocysteine in blood plasma by UPLC with fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Fluorescence; Humans; Plasma; S-Adenosylhomocysteine; S-Adenosylmethionine; Solid Phase Extraction | 2019 |
Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations.
Topics: Allosteric Regulation; Amino Acid Sequence; Binding Sites; Cloning, Molecular; Escherichia coli; Gene Expression; Genetic Vectors; Humans; Kinetics; Methyltransferases; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins; RNA Caps; RNA Polymerase II; RNA-Binding Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Thermodynamics; Transcription, Genetic | 2019 |
Unraveling the role of quorum sensing-dependent metabolic homeostasis of the activated methyl cycle in a cooperative population of Burkholderia glumae.
Topics: Adenosylhomocysteinase; Bacterial Proteins; Burkholderia; Homeostasis; Ligases; Methylation; Methyltransferases; Mutation; Quorum Sensing; S-Adenosylhomocysteine; S-Adenosylmethionine | 2019 |
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation.
Topics: A549 Cells; Animals; Cell Proliferation; Cysteine; Extracellular Space; Female; Gene Knockout Techniques; Hep G2 Cells; Heterografts; Humans; Male; MCF-7 Cells; Methionine; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasms; Protamines; S-Adenosylhomocysteine; S-Adenosylmethionine; Serine; Tumor Burden | 2019 |
Determination of S-adenosylmethionine, S-adenosylhomocysteine, and methylthioadenosine in urine using solvent-modified micellar electrokinetic chromatography.
Topics: Adenosine; Adolescent; Adult; Child; Child, Preschool; Chromatography, Micellar Electrokinetic Capillary; Female; Humans; Limit of Detection; Linear Models; Male; Middle Aged; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Young Adult | 2020 |
Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies.
Topics: Adult; Case-Control Studies; DNA Methylation; Female; Humans; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine | 2019 |
LINC00662 promotes hepatocellular carcinoma progression via altering genomic methylation profiles.
Topics: 3' Untranslated Regions; 5-Methylcytosine; Adenosylhomocysteinase; Adult; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Progression; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Liver Neoplasms; Methionine Adenosyltransferase; Proteolysis; RNA, Long Noncoding; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Survival Analysis; Ubiquitin; Up-Regulation | 2020 |
Williams-Beuren syndrome-related methyltransferase WBSCR27: cofactor binding and cleavage.
Topics: Animals; Apoenzymes; Deoxyadenosines; Methyltransferases; Mice; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 2020 |
Crystal structure and ligand-induced folding of the SAM/SAH riboswitch.
Topics: Base Pairing; Fluorescence Resonance Energy Transfer; Riboswitch; RNA Folding; S-Adenosylhomocysteine; S-Adenosylmethionine | 2020 |
Urine S-Adenosylmethionine are Related to Degree of Renal Insufficiency in Patients with Chronic Kidney Disease.
Topics: Adult; Aged; Aged, 80 and over; Female; Glomerular Filtration Rate; Homocysteine; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; S-Adenosylhomocysteine; S-Adenosylmethionine | 2021 |
S-Adenosylmethionine Deficiency and Brain Accumulation of S-Adenosylhomocysteine in Thioacetamide-Induced Acute Liver Failure.
Topics: Animals; Brain; Cystathionine beta-Synthase; Glutathione; Hepatic Encephalopathy; Liver; Liver Failure, Acute; Male; Methionine Adenosyltransferase; Oxidative Stress; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Thioacetamide | 2020 |
Crystal structure of a S-adenosyl-L-methionine-dependent O-methyltransferase-like enzyme from Aspergillus flavus.
Topics: Amino Acid Sequence; Aspergillus flavus; Catalytic Domain; Crystallography, X-Ray; Evolution, Molecular; Fungal Proteins; Gene Expression; Hydrogen Bonding; Methyltransferases; Models, Molecular; Phylogeny; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity | 2021 |
High-resolution structures of the SARS-CoV-2 2'-
Topics: Adenosine; Betacoronavirus; Binding Sites; Catalytic Domain; Coronavirus Infections; COVID-19; Crystallography, X-Ray; Dimerization; Genes, Viral; Humans; Methylation; Methyltransferases; Models, Molecular; Open Reading Frames; Pandemics; Pneumonia, Viral; Protein Binding; Protein Conformation; RNA Cap Analogs; RNA Processing, Post-Transcriptional; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; SARS-CoV-2; Structure-Activity Relationship; Viral Nonstructural Proteins | 2020 |
Intracellular homocysteine metabolites in SLE: plasma S-adenosylhomocysteine correlates with coronary plaque burden.
Topics: Adult; Aged; Female; Homocysteine; Humans; Leukocytes, Mononuclear; Lupus Erythematosus, Systemic; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine | 2021 |
2'-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography.
Topics: Crystallography; Methylation; Methyltransferases; Multiprotein Complexes; RNA Cap Analogs; RNA Caps; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; SARS-CoV-2; Synchrotrons; Viral Nonstructural Proteins; Viral Regulatory and Accessory Proteins | 2021 |
Association between plasma S-adenosylmethionine and risk of mortality in patients with coronary artery disease: A cohort study.
Topics: Aged; Cohort Studies; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Prospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine | 2021 |
Rapid analysis of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) isotopologues in stable isotope-resolved metabolomics (SIRM) using direct infusion nanoelectrospray ultra-high-resolution Fourier transform mass spectrometry (DI-nESI-UHR-FTMS).
Topics: Adaptor Proteins, Signal Transducing; Animals; Epigenesis, Genetic; Fourier Analysis; Isotopes; Mass Spectrometry; Metabolomics; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 2021 |
Maternal and neonatal one-carbon metabolites and the epigenome-wide infant response.
Topics: Adult; Betaine; Carbon; Choline; Cohort Studies; DNA Methylation; Epigenome; Female; Fetal Blood; Histone Code; Humans; Infant, Newborn; Male; Maternal Nutritional Physiological Phenomena; Metabolomics; Methionine; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine | 2022 |
Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease.
Topics: Animals; Methylation; Mice; Mitochondria; Mitochondrial Diseases; S-Adenosylhomocysteine; S-Adenosylmethionine | 2022 |
Comparative Analysis of Sulfonium-π, Ammonium-π, and Sulfur-π Interactions and Relevance to SAM-Dependent Methyltransferases.
Topics: Ammonium Compounds; Bacterial Proteins; Methylamines; Methyltransferases; Molecular Structure; Peptides; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Static Electricity; Sulfonium Compounds; Thermodynamics; Thermus thermophilus | 2022 |
A High-Throughput Continuous Spectroscopic Assay to Measure the Activity of Natural Product Methyltransferases.
Topics: Biological Products; High-Throughput Screening Assays; Methylation; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine | 2022 |
Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment.
Topics: Archaeal Proteins; Caco-2 Cells; DNA; Humans; Methyltransferases; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine | 2022 |
Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community.
Topics: Dementia; Humans; Methionine; Proportional Hazards Models; S-Adenosylhomocysteine; S-Adenosylmethionine | 2022 |
Synthetic Reagents for Enzyme-Catalyzed Methylation.
Topics: Biocatalysis; Indicators and Reagents; Methylation; Methyltransferases; Pharmaceutical Preparations; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfates; Toluene | 2022 |
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Humans; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; SARS-CoV-2; Viral Nonstructural Proteins | 2022 |
Structures and mechanisms of tRNA methylation by METTL1-WDR4.
Topics: Biocatalysis; Catalytic Domain; Cryoelectron Microscopy; Crystallography, X-Ray; GTP-Binding Proteins; Humans; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 2023 |
Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine.
Topics: Adult; Carbon; Child; Chromatography, Liquid; Female; Homocysteine; Humans; Infant; Methionine; Milk, Human; Racemethionine; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry | 2023 |
NAD+ enhances the activity and thermostability of S-adenosyl-L-homocysteine hydrolase from Pyrococcus horikoshii OT3.
Topics: Homocysteine; Hydrolases; NAD; Pyrococcus horikoshii; S-Adenosylhomocysteine; S-Adenosylmethionine | 2023 |
S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study.
Topics: Critical Illness; Disease Progression; Humans; Hypoxia; Lactic Acid; Multiple Organ Failure; Oxygen; Prospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine | 2023 |
Synthesis and biological activity of sinefungin analogues.
Topics: Adenosine; Animals; Antiprotozoal Agents; Kinetics; Leishmania donovani; Magnetic Resonance Spectroscopy; Thymidine | 1991 |
Structure-based activity prediction for an enzyme of unknown function.
Topics: Adenine; Catalysis; Crystallography, X-Ray; Deamination; Deoxyadenosines; Enzymes; Homocysteine; Inosine; Models, Molecular; Nucleoside Deaminases; Protein Conformation; S-Adenosylhomocysteine; Structure-Activity Relationship; Substrate Specificity; Thermotoga maritima; Thionucleosides | 2007 |
Rational design of SAM analogues targeting SAM-II riboswitch aptamer.
Topics: Crystallography, X-Ray; Drug Design; Molecular Structure; S-Adenosylmethionine | 2011 |