s-adenosylmethionine has been researched along with methotrexate in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (19.23) | 18.7374 |
| 1990's | 8 (30.77) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 6 (23.08) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Dorner, RW; Moore, TL; Nesher, G | 1 |
| Moore, TL; Nesher, G | 1 |
| Aarsaether, N; Aarsland, A; Berge, RK; Lønning, PE; Refsum, H; Svardal, AM; Ueland, PM | 1 |
| Lillehaug, JR; Male, R; Refsum, H; Ueland, PM | 1 |
| Gawthorne, JM; Smith, RM | 1 |
| Hilton, MA; Hoffman, JL; Sparks, MK | 1 |
| Bottiglieri, T; Hyland, K; Reynolds, EH | 1 |
| Chmurzyńska, W; Grzelakowska-Sztabert, B; Manteuffel-Cymborowska, M; Szlazak, M | 1 |
| Blom, HJ; Bökkerink, JP; De Abreu, RA; Keuzenkamp-Jansen, CW; Trijbels, JM | 1 |
| Assaraf, YG; Bunni, M; Drori, S; Jansen, G; Kathmann, I; Mauritz, RM; Peters, GJ; Pinedo, HM; Priest, DG; Schornagel, JH; Sprecher, H; Westerhof, GR | 1 |
| Clelland, J; Hann, I; Surtees, R | 1 |
| Varela-Moreiras, G | 1 |
| Igarashi, K; Kashiwagi, K; Kimura, E; Nishimura, K; Oga, S; Sakata, K | 1 |
| Drummelsmith, J; Girard, I; Ouellette, M; Trudel, N | 1 |
| Farmand, S; Fliessbach, K; Kleczar, N; Klockgether, T; Linnebank, M; Orlopp, K; Pels, H; Schlegel, U; Schmidt-Wolf, IG; Urbach, H | 1 |
| Allegrucci, C; Denning, C; Lucas, E; Priddle, H; Sinclair, K; Singh, R; Steele, W; Young, L | 1 |
| Becker, A; Bode, U; Jaehde, U; Linnebank, M; Pels, H; Schlegel, U; Vezmar, S | 1 |
| Ahmed Ouameur, A; Dridi, L; Ouellette, M | 1 |
| Chiang, EP; Wang, YC | 1 |
| Guan, T; Guan, Z; Guo, J; Li, G; Niu, B; Wang, F; Wang, G; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhang, Z; Zhu, Z | 1 |
| Baltz, JM; Denomme, MM; Greene, ND; Lee, MB; Leung, KY; Mann, MR; Trasler, JM; White, CR; Zhang, B | 1 |
| de Jonge, R; den Hoed, MAH; Griffioen, PH; Heil, SG; Oosterom, N; Pieters, R; Tissing, WJE; van den Heuvel-Eibrink, MM | 1 |
| Albrecht, LV; Bui, MH; De Robertis, EM | 1 |
| Eich, ML; Robinson, AD; Varambally, S | 1 |
| Ashford, VA; Davies, JF; Delcamp, TJ; Freisheim, JH; Kraut, J; Prendergast, NJ | 1 |
| Montgomery, JA; Morrison, JF; Stone, SR | 1 |
3 review(s) available for s-adenosylmethionine and methotrexate
| Article | Year |
|---|---|
The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders.
Topics: AIDS Dementia Complex; Animals; Brain Diseases; Dementia; Disease Models, Animal; Epilepsy; Humans; Metabolism, Inborn Errors; Methotrexate; Methylation; Multiple Sclerosis; Neurotransmitter Agents; Parkinson Disease; Receptors, Neurotransmitter; S-Adenosylmethionine; Spinal Cord Diseases | 1994 |
Nutritional regulation of homocysteine: effects of drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2001 |
Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities.
Topics: Antimetabolites, Antineoplastic; Biosynthetic Pathways; Cell Proliferation; Energy Metabolism; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Protein Processing, Post-Translational; Purine Nucleotides; Pyrimidine Nucleotides; S-Adenosylmethionine; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2020 |
2 trial(s) available for s-adenosylmethionine and methotrexate
| Article | Year |
|---|---|
Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies.
Topics: Antidotes; Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Demyelinating Diseases; Drug Interactions; Humans; Infant; Leucovorin; Methionine; Methotrexate; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Tetrahydrofolates | 1998 |
Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.
Topics: Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Brain Chemistry; Central Nervous System Neoplasms; Cytarabine; Excitatory Amino Acids; Female; Homocysteine; Humans; Injections, Intravenous; Injections, Intraventricular; Lymphoma; Male; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Pilot Projects; S-Adenosylmethionine; Statistics, Nonparametric; Time Factors | 2007 |
21 other study(ies) available for s-adenosylmethionine and methotrexate
| Article | Year |
|---|---|
In vitro effects of methotrexate on peripheral blood monocytes: modulation by folinic acid and S-adenosylmethionine.
Topics: Cell Movement; Cells, Cultured; Chemotaxis; Culture Media; Humans; Leucovorin; Methotrexate; Monocytes; S-Adenosylmethionine; Spermidine; Superoxides | 1991 |
The in vitro effects of methotrexate on peripheral blood mononuclear cells. Modulation by methyl donors and spermidine.
Topics: Antibody-Producing Cells; Antigens, Differentiation, T-Lymphocyte; B-Lymphocytes; CD4-Positive T-Lymphocytes; Humans; Immunoglobulins; Leucovorin; Methotrexate; Monocytes; S-Adenosylmethionine; Spermidine; T-Lymphocytes | 1990 |
Effect of methotrexate on homocysteine and other sulfur compounds in tissues of rats fed a normal or a defined, choline-deficient diet.
Topics: Analysis of Variance; Animals; Choline Deficiency; Diet; Glutathione; Homocysteine; Kidney; Liver; Male; Methotrexate; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 1988 |
Disposition of endogenous homocysteine by mouse fibroblast C3H/10T1/2 Cl 8 and the chemically transformed C3H/10T1/2 MCA Cl 16 cells following methotrexate exposure.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromatography, Ion Exchange; Culture Media; Fibroblasts; Homocysteine; Methotrexate; Methylcholanthrene; Mice; Mice, Inbred C3H; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids.
Topics: Animals; Diet; Homocysteine; Homocystine; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Liver; Male; Methotrexate; Mice; Mice, Inbred DBA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1983 |
MTX does not affect enhanced biosynthesis and metabolism of S-adenosylmethionine in testosterone-induced hypertrophic mouse kidney.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosylmethionine Decarboxylase; Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Female; Hypertrophy; Kidney; Liver; Methionine Adenosyltransferase; Methotrexate; Methyltransferases; Mice; Organ Size; Ornithine Decarboxylase; S-Adenosylmethionine; Testosterone; Tetrahydrofolate Dehydrogenase | 1993 |
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Homocysteine; Humans; Mercaptopurine; Methionine; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
Topics: Adenosine; Biological Transport; Carrier Proteins; Cell Division; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Reduced Folate Carrier Protein; S-Adenosylmethionine; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Methotrexate differentially affects growth of suspension and adherent cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Adhesion; Cell Division; Cell Line, Tumor; DNA; Growth Inhibitors; Humans; Methotrexate; Mice; Nucleic Acids; Ornithine Decarboxylase; Polyamines; Proteins; RNA; S-Adenosylmethionine; Tetrahydrofolates; Thymidine Monophosphate | 2004 |
Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance.
Topics: Animals; Blotting, Northern; Blotting, Southern; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Gene Expression; Hydrogen-Ion Concentration; Hydroxyprostaglandin Dehydrogenases; Leishmania major; Methionine Adenosyltransferase; Methotrexate; Mutation; Phosphopyruvate Hydratase; Polymerase Chain Reaction; Protozoan Proteins; S-Adenosylmethionine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
MTX-induced white matter changes are associated with polymorphisms of methionine metabolism.
Topics: Aged; Brain; Central Nervous System Neoplasms; Demyelinating Diseases; DNA Mutational Analysis; Drug Resistance; Female; Folic Acid; Folic Acid Antagonists; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Haplotypes; Humans; Lymphoma; Male; Methionine; Methotrexate; Middle Aged; Myelin Sheath; Nerve Fibers, Myelinated; Neurotoxins; Polymorphism, Genetic; Risk Factors; S-Adenosylmethionine | 2005 |
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
Topics: Cell Proliferation; Cells, Cultured; DNA Modification Methylases; Embryo, Mammalian; Enzymes; Epigenesis, Genetic; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Homocysteine; Humans; Methotrexate; Reproductive Techniques, Assisted; S-Adenosylmethionine; Stem Cells | 2005 |
High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family.
Topics: Adenosine; Antiprotozoal Agents; Biological Transport; Biopterins; Blotting, Western; Cell Membrane; Drug Resistance, Bacterial; Folic Acid; Folic Acid Antagonists; Green Fluorescent Proteins; Leishmania; Membrane Transport Proteins; Methotrexate; Microscopy, Fluorescence; Mutation; Protozoan Proteins; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylmethionine | 2010 |
Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo.
Topics: Animals; Antirheumatic Agents; Dactinomycin; Dexamethasone; Enzyme Inhibitors; Folic Acid; Gene Expression Regulation; Hep G2 Cells; Humans; Male; Methionine; Methionine Adenosyltransferase; Methotrexate; Mice; Mice, Inbred C57BL; RNA, Messenger; S-Adenosylmethionine | 2012 |
Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects.
Topics: Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Disease Models, Animal; DNA Copy Number Variations; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Leucovorin; Methotrexate; Mice, Inbred C57BL; MicroRNAs; Neural Tube Defects; Real-Time Polymerase Chain Reaction; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2014 |
Both the folate cycle and betaine-homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts.
Topics: 5-Methylcytosine; Animals; Antimetabolites, Antineoplastic; Betaine-Homocysteine S-Methyltransferase; Blastocyst; Cell Lineage; Cells, Cultured; DNA Methylation; Embryo, Mammalian; Female; Fluorescent Antibody Technique; Folic Acid; Gene Expression Regulation, Enzymologic; Liver; Methotrexate; Mice; S-Adenosylmethionine; snRNP Core Proteins | 2015 |
Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; DNA Methylation; Female; Humans; Immunophenotyping; Infant; Long Interspersed Nucleotide Elements; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Stomatitis | 2018 |
Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation.
Topics: Carbon; Endosomes; Glycogen Synthase Kinase 3 beta; HEK293 Cells; HeLa Cells; Humans; Lysosomes; Methionine; Methotrexate; Methylation; Niacinamide; Protein-Arginine N-Methyltransferases; Repressor Proteins; S-Adenosylmethionine; Wnt Signaling Pathway | 2019 |
Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate.
Topics: Binding Sites; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Molecular; Molecular Structure; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase; X-Ray Diffraction | 1990 |
Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues.
Topics: Aminopterin; Animals; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Liver; Methotrexate; Protein Binding; Structure-Activity Relationship | 1984 |