s-adenosylmethionine has been researched along with folic acid in 247 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (16.60) | 18.7374 |
| 1990's | 32 (12.96) | 18.2507 |
| 2000's | 73 (29.55) | 29.6817 |
| 2010's | 80 (32.39) | 24.3611 |
| 2020's | 21 (8.50) | 2.80 |
| Authors | Studies |
|---|---|
| Benesh, FC; Carl, GF | 1 |
| Friedhoff, AJ; Rosengarten, H | 1 |
| Delk, AS; Rabinowitz, JC | 1 |
| Petri, WA; Poirier, LA | 1 |
| Blackwell, LA; Grover, TA; Middaugh, LD; Zemp, JW | 1 |
| Pearson, AG; Turner, AJ | 1 |
| Beuhring, KU; Shin, YS; Stokstad, EL | 1 |
| Poirier, LA; Wainfan, E | 1 |
| Bell, IR; Berkes, S; Morrow, FD; Perrone, G; Read, M | 1 |
| Balaghi, M; Wagner, C | 1 |
| Carl, GF; Eto, I; Furman, GM; Krumdieck, CL; Schatz, RA; Smith, ML | 1 |
| Reynolds, EH | 1 |
| Makar, AB; Osweiler, G; Sahin, G; Tephly, TR | 1 |
| Carl, GF | 2 |
| Carney, MW | 1 |
| Bottiglieri, T; Carney, MW; Edeh, J; Reynolds, EM; Toone, BK | 1 |
| Horne, DW | 1 |
| Fell, D; Steele, RD | 2 |
| Alarcon, RD; Kemp, B; Monti, JA; Morere, DA; Smythies, JR; Tolbert, LC; Walter-Ryan, WG | 1 |
| Bottiglieri, T; Clayton, PT; Hyland, K; Leonard, JV; Perry, J; Smith, I; Wendel, U | 1 |
| Abou-Saleh, MT; Coppen, A | 1 |
| Carl, GF; Gill, MW; Schatz, RA | 1 |
| Gawthorne, JM; Smith, RM | 1 |
| Cossins, EA; Lor, KL | 1 |
| Kutzbach, C; Stokstad, EL | 1 |
| Stokstad, EL; Vidal, AJ | 1 |
| Laduron, P | 1 |
| Decter, JB; Mansouri, A; Silber, R | 1 |
| Greene, RC; Kung, HF; Spears, C; Weissbach, H; Williams, RD | 1 |
| Banerjee, SP; Snyder, SH | 1 |
| Ordonez, LA; Wurtman, RJ | 1 |
| Taylor, RT; Weissbach, H | 1 |
| Mangum, JH; North, JA; Steuart, BW | 1 |
| Draper, MW; Mangum, JH; North, JA | 1 |
| Mangum, JH; North, JA | 1 |
| Brodie, JD; Burke, GT; Mangum, JH | 1 |
| Abels, J; Kroes, AC; Lindemans, J | 1 |
| Metz, J; van der Westhuyzen, J | 1 |
| Smythies, JR | 1 |
| Chanarin, I; Deacon, R; Lumb, M; Perry, J | 2 |
| Daubner, SC; Matthews, RG | 1 |
| Alonso-Aperte, E; Alvarez, L; Caballería, J; Deulofeu, R; Gassó, M; Mato, JM; Rodés, J; Rubio, M; Varela-Moreiras, G | 1 |
| Christman, JK; Cravo, ML; Fleet, JC; Kim, YI; Mason, JB; Ordovas, J; Salomon, RN; Selhub, J; Smith, D | 1 |
| García-Cuevas, M; Pérez-Olleros, L; Ruiz-Roso, B; Varela-Moreiras, G | 1 |
| Wood, RC | 1 |
| Ragel, C; Ruiz-Roso, B; Varela-Moreiras, G | 1 |
| Christensen, B; Ueland, PM | 1 |
| Balaghi, M; Horne, DW; Wagner, C; Woodward, SC | 1 |
| Metz, J | 1 |
| Balaghi, M; Horne, DW; Wagner, C | 1 |
| Schalinske, KL; Steele, RD | 1 |
| Allen, RH; Chandler, CJ; Halsted, CH; James, SJ; Muskhelishvili, L; Poirier, L; Stabler, SP; Villanueva, J | 1 |
| Basnakian, AG; James, SJ; Kim, YI; Mason, JB; Miller, JW; Pogribny, IP; Selhub, J | 1 |
| Choi, SW; Dallal, GE; Graeme-Cook, F; Kim, YI; Mason, JB; Salomon, RN; Smith, DE | 1 |
| Gottfries, CG; Regland, B; Smythies, JR | 1 |
| Assaraf, YG; Bunni, M; Drori, S; Jansen, G; Kathmann, I; Mauritz, RM; Peters, GJ; Pinedo, HM; Priest, DG; Schornagel, JH; Sprecher, H; Westerhof, GR | 1 |
| Guiloff, RJ; Tan, SV | 1 |
| Cooney, CA; Kodell, RL; Moore, SR; Wolff, GL | 1 |
| Allman-Farinelli, MA; Jacob, RA; Jenden, DJ; Swendseid, ME | 1 |
| Achón, M; Alonso-Aperte, E; Reyes, L; Ubeda, N; Varela-Moreiras, G | 1 |
| Scott, JM; Weir, DG | 1 |
| Bottiglieri, T; Carney, MW; Crellin, R; Laundy, M; Reynolds, EH; Toone, BK | 1 |
| Brand, GM; Duthie, SJ; Grant, G; Narayanan, S | 1 |
| Bailey, LB; Cerda, JJ; Hutson, AD; Kauwell, GP; Rampersaud, GC | 1 |
| Blache, D; Durand, P; Loreau, N; Lussier-Cacan, S; Prost, M | 1 |
| Arning, E; Bottiglieri, T; Dayal, S; Faraci, FM; Heistad, DD; Lentz, SR; Maeda, N; Malinow, MR; Sigmund, CD | 1 |
| Delongchamp, RR; Poirier, LA; Sinha, R; Wise, CK | 1 |
| Goodman, JE; Helzlsouer, KJ; Lavigne, JA; Selhub, J; Strickland, PT; Wu, K; Yager, JD | 1 |
| Varela-Moreiras, G | 1 |
| Capdevila, A; Kerins, DM; Koury, MJ; Rana, S; Wagner, C | 1 |
| Jhaveri, MS; Trepel, JB; Wagner, C | 1 |
| Appling, DR; Chan, SY; Hanson, AD; Horne, DW; Kaplan, F; Raymond, RK; Roje, S | 1 |
| Draudin-Krylenko, VA; Levchuk, AA; Mazurov, ST; Poddubniy, BK | 1 |
| Young, SN | 1 |
| Choi, SW; Ghandour, H; Lin, BF; Mason, JB; Selhub, J | 1 |
| Chiang, EP; Herbig, K; Hills, J; Lee, LR; Shane, B; Stover, PJ | 1 |
| Stephen, AM; Sun, D; Wollin, A | 1 |
| Alonso-Aperte, E; Ubeda, N; Varela-Moreiras, G | 1 |
| Becker, A; Bouter, LM; de Meer, K; Dekker, JM; Heine, RJ; Jakobs, C; Kostense, PJ; Nijpels, G; Smulders, YM; Stehouwer, CD; Struys, EA; Teerlink, T | 1 |
| Carmel, R; James, SJ; Melnyk, S | 1 |
| Deng, L; Hiou-Tim, F; James, SJ; Li, E; Melnyk, S; Oakes, C; Pogribny, I; Rozen, R; Sibani, S; Trasler, J | 1 |
| Kim, YI; Mason, JB; Reid, S; Shirwadkar, S; Sohn, KJ; Stempak, JM | 1 |
| Mason, JB | 1 |
| Anguera, MC; Ghandour, H; Nasrallah, IM; Selhub, J; Stover, PJ; Suh, JR | 1 |
| BUCHANAN, JM; ROSENTHAL, S; SMITH, LC | 1 |
| Finnell, RH; James, SJ; Le, XC; Lu, X; Melnyk, S; Selhub, J; Spiegelstein, O; Troen, A | 1 |
| Freeman, MP; Helgason, C; Hill, RA | 1 |
| Becker, A; Bouter, LM; Dekker, JM; Heine, RJ; Henry, RM; Jakobs, C; Kostense, PJ; Nijpels, G; Smulders, YM; Spijkerman, AM; Stehouwer, CD; Teerlink, T | 1 |
| Farmand, S; Fliessbach, K; Kleczar, N; Klockgether, T; Linnebank, M; Orlopp, K; Pels, H; Schlegel, U; Schmidt-Wolf, IG; Urbach, H | 1 |
| Fowler, B; Herrmann, W; Kuhlmann, MK; Makowski, J; Obeid, R; Schorr, H | 1 |
| Andrews, LG; Liu, L; Tollefsbol, TO; Ulrey, CL | 1 |
| Allegrucci, C; Denning, C; Lucas, E; Priddle, H; Sinclair, K; Singh, R; Steele, W; Young, L | 1 |
| Bamba, T; Fukusaki, E; Harada, K; Kim, JK; Kobayashi, A | 1 |
| Antelava, NA; Gogolauri, MI | 1 |
| Clarke, S; Farrar, CE | 1 |
| Priebe, S; Turner, T; Werneke, U | 1 |
| Bermejo, E; Castro, M; Desviat, LR; Leal, F; Mansilla, E; Martínez-Fernández, ML; Martínez-Frías, ML; Pérez, B; Prieto, D; Rodríguez, L; Rodríguez-Pinilla, E; Ugarte, M | 1 |
| García-Cánovas, F; Navarro-Martínez, MD; Rodríguez-López, JN | 1 |
| Toohey, JI | 1 |
| Davis, CD; Ross, SA; Uthus, EO | 1 |
| Maloney, CA; Rees, WD; Wilson, FA | 1 |
| Batra, V; Mishra, KP | 1 |
| Boynton, A; Gregory, JF; James, SJ; Neuhouser, ML; Nijhout, HF; Reed, MC; Shane, B; Ulrich, CM | 1 |
| Schalinske, KL; Williams, KT | 1 |
| Chiang, EP; Tang, FY; Wang, YC | 1 |
| Fischer, K; Weber, AP | 1 |
| Bottiglieri, T; Cross, JC; Elmore, CL; Gravel, RA; Krupenko, NI; Krupenko, SA; Leclerc, D; Matthews, RG; Rozen, R; Watson, ED; Wu, X | 1 |
| Alonso-Aperte, E; González, MP; Póo-Prieto, R; Varela-Moreiras, G | 1 |
| Benevenga, NJ | 1 |
| Achón, M; Alonso-Aperte, E; Ubeda, N; Varela-Moreiras, G | 1 |
| Burren, KA; Chitty, LS; Copp, AJ; Doudney, K; Dunlevy, LP; Greene, ND; Scott, R; Stanier, P; Stojilkovic-Mikic, T | 1 |
| Di Rocco, A; Werner, P | 1 |
| Chen, J; Matharu, KS; Perry, C; Stover, PJ; Yu, S | 1 |
| Allen, RH; Barbosa, PR; Braga, RC; Guerra-Shinohara, EM; Hirata, MH; Hirata, RD; Machado, AL; Sampaio-Neto, LF; Stabler, SP | 1 |
| Herrmann, W; Obeid, R | 1 |
| Abdelmalek, MF; Barve, S; Benevenga, NJ; Halsted, CH; Kaplowitz, N; Kharbanda, KK; Liu, QY; Lu, SC; McClain, CJ; Purohit, V; Swanson, C; Zakhari, S | 1 |
| Alberto, JM; Audonnet-Blaise, S; Blaise, SA; Daval, JL; Guéant, JL | 1 |
| Devaraj, S; Esfandiari, F; French, SW; Halsted, CH; Villanueva, JA; White, ME | 1 |
| Cavallaro, RA; Confaloni, A; D'Anselmi, F; Fuso, A; Piscopo, P; Scarpa, S; Zampelli, A | 1 |
| Bouter, LM; Dekker, JM; Heine, RJ; Jakobs, C; Nijpels, G; Polak, BC; Stehouwer, CD; Stolk, RP; Teerlink, T; Van Hecke, MV | 1 |
| Antelava, NA; Gogoluari, LI; Gogoluari, MI; Okudzhava, MV; Pirtskhalaĭshvili, NN | 1 |
| Chan, A; Graves, V; Rozen, R; Shea, TB; Tchantchou, F | 1 |
| Adams, ZF; Cole, NW; Miller, RR; Walcher, BN; Weaver, KR | 1 |
| Allen, RH; Carvalho, FR; Guerra-Shinohara, EM; Hirata, MH; Hirata, RD; Lopreato, FR; Robi, DL; Sampaio-Neto, LF; Stabler, SP | 1 |
| Chen, WW; Chiang, EP; Tang, FY; Wang, YC | 1 |
| Chan, A; Dubey, M; Gilman, V; Serra, M; Shea, TB | 1 |
| Fava, M; Mischoulon, D | 1 |
| Kavanagh, DJ; Sarris, J; Schoendorfer, N | 1 |
| Bistulfi, G; Diegelman, P; Foster, BA; Kramer, DL; Porter, CW; Smiraglia, DJ | 1 |
| Dillmann, U; Fassbender, K; Herrmann, W; Kostopoulos, P; Obeid, R; Schadt, A | 1 |
| de Jonge, R; de Vries, JH; Eijkemans, MJ; Steegers, EA; Steegers-Theunissen, RP; van Driel, LM; van Meurs, JB | 1 |
| Heijmans, BT; Kremer, D; Lindemans, J; Obermann-Borst, SA; Siebel, C; Slagboom, PE; Steegers, EA; Steegers-Theunissen, RP | 1 |
| Batra, V; Devasagayam, TP; Sridhar, S | 1 |
| Devlin, AM; Green, TJ; Innis, SM; McMahon, JA; Skeaff, CM; Venn, BJ; Williams, SM | 1 |
| Basten, GP; de Roos, B; Duncan, G; Duthie, SJ; Horgan, G; Pirie, L; Powers, HJ; Reid, M; Rucklidge, G | 1 |
| Chan, A; Kotyla, E; Lepore, A; Remington, R; Shea, TB; Zemianek, J | 1 |
| Fenech, M | 1 |
| Ahmed Ouameur, A; Dridi, L; Ouellette, M | 1 |
| Blom, H; Cvetanovska, G; Farkas, M; Jessen, F; Kölsch, H; Kulic, L; Linnebank, M; Popp, J; Semmler, A; Smith, D; Smulders, Y; Stoffel-Wagner, B; Weller, M | 1 |
| Cavallaro, RA; Fuso, A; Nicolia, V; Scarpa, S | 1 |
| Burren, K; Copp, AJ; De Castro, SC; Greene, ND; Leung, KY; Rozen, R; Savery, D | 1 |
| Eckert, R; Herrmann, W; Kasoha, M; Kirsch, SH; Obeid, R | 1 |
| Fava, M | 1 |
| Ho, V; King, WD; Massey, TE | 1 |
| Bassoli, BK; Chagas, CE; Dagli, ML; de Souza, CA; Deminice, R; Jordão Júnior, AA; Moreno, FS; Ong, TP; Paiva, SA | 1 |
| Nahas, R; Sheikh, O | 1 |
| Blom, HJ; Choi, SW; Corrocher, R; Friso, S; Girelli, D; Guarini, P; Martinelli, N; Olivieri, O; Pizzolo, F; Stanzial, AM | 1 |
| Batey, RT; Ceres, P; Reyes, FE; Trausch, JJ | 1 |
| Chiang, EP; Wang, YC | 1 |
| Kuzelicki, NK; Metspalu, A; Milek, M; Mlinaric-Rascan, I; Smid, A; Tamm, R | 1 |
| Cutler, S; Deng, X; Hou, YJ; La, H; Miki, D; Oh, J; Zhang, H; Zhu, JK | 1 |
| Casson, RI; Dodds, L; Ho, V; King, WD; Massey, TE; Perkins, SL | 1 |
| Belshaw, NJ; Charles, MA; Johnson, IT | 1 |
| Abo, RP; Chai, X; Chai, Y; Eckloff, BW; Fridley, BL; Hebbring, SJ; Jenkins, GD; Ji, Y; Moon, I; Nordgren, KK; Pelleymounter, LL; Peng, Y; Weinshilboum, RM; Wieben, ED; Yee, VC; Zhang, J | 1 |
| Alonso-Aperte, E; Partearroyo, T; Pérez-Miguelsanz, J; Úbeda, N; Valencia-Benítez, M; Varela-Moreiras, G | 1 |
| Drobná, Z; Fry, RC; Niculescu, MD; Paul, DS; Rager, JE; Saunders, J; Stýblo, M; Tsang, V; Waalkes, MP; Zeisel, SH | 1 |
| Blom, HJ; Farkas, M; Jessen, F; Linnebank, M; Popp, J; Semmler, A; Smith, DE; Smulders, YM | 1 |
| Barto, R; Blom, HJ; Imbard, A; Jakobs, C; Kok, RM; Smith, DE; Smulders, YM | 1 |
| Halsted, CH | 1 |
| Caudill, M; Jiang, X; Mikael, LG; Pancer, J; Rozen, R; Wu, Q | 1 |
| Cacciapuoti, F | 1 |
| Duncan, TM; Nijhout, HF; Reed, MC | 1 |
| Awaji, H; Horie, K; Kim, M; Nakata, R; Sugiyama, A | 1 |
| Huang, G; Liu, H; Luo, S; Wilson, JX; Yan, H; Yu, M; Zhang, X | 1 |
| Abeling, NG; Duran, M; Hagebeuk, EE; Poll-The, BT; Vyth, A | 1 |
| Baurley, J; Crott, JW; Figueiredo, JC; Haile, RW; Levine, AJ | 1 |
| Grashin, RA; Poliakova, AV; Telichko, IN | 1 |
| Mehedint, MG; Zeisel, SH | 1 |
| Bottiglieri, T | 1 |
| Cole, D; Cox, SE; da Costa, KA; Dominguez-Salas, P; Dyer, RA; Fulford, AJ; Hennig, BJ; Innis, SM; Moore, SE; Prentice, AM; Waterland, RA; Zeisel, SH | 1 |
| Devlin, AM; Glier, MB; Green, TJ | 1 |
| Chen, YM; Chiang, EP; Lin, WL; Lin, YJ; Tang, FY; Wang, YC | 1 |
| Cande, WZ; Guan, Q; Hammond, MC; Iavarone, AT; Li, F; Rine, J; Sadhu, MJ; Sales-Lee, J | 1 |
| Obeid, R | 1 |
| Deligiannidis, KM; Freeman, MP | 1 |
| Brenneman, D; Butcher, NJ; Grant, DM; Minchin, RF; Sugamori, KS; Witham, KL | 1 |
| da Cunha, SF; de Freitas, EC; Deminice, R; Franco, GS; Jordao, AA; Rosa, FT | 1 |
| Rogers, E; Shea, TB | 1 |
| Guan, T; Guan, Z; Guo, J; Li, G; Niu, B; Wang, F; Wang, G; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhang, Z; Zhu, Z | 1 |
| Alam, S; Gamble, MV; Graziano, JH; Hall, MN; Howe, CG; Ilievski, V; Liu, X; Niedzwiecki, MM; Siddique, AB; Slavkovich, V | 1 |
| Agamme, AL; D'Almeida, V; da Silva, VC; Fernandes, L; Guerra Shinohara, EM; Haseyama, EJ; Muniz, MT | 1 |
| Alam, S; Gamble, MV; Graziano, JH; Hall, MN; Ilievski, V; Levy, D; Liu, X; Niedzwiecki, MM; Parvez, F; Siddique, AB; Slavkovich, V | 1 |
| Doperé, I; Godderis, L; Huybrechts, I; Koppen, G; Pauwels, S; Vansant, G | 1 |
| Cao, CJ; Han, XB; Jiang, YD; Tian, J; Wang, J; Wang, YH; Xu, H; Yang, AN; Yang, XL; Zhang, HP | 1 |
| Guan, Z; Niu, B; Wang, J; Wang, X; Wang, Z; Xie, Q; Zhang, T; Zhao, X; Zhu, Z | 1 |
| Freundlich, JS; Jung, H; Koo, MS; Kumar, A; Liao, R; Nandakumar, M; Nixon, MR; Rhee, KY; Roberts, JP; Rustad, T; Sacchettini, JC; Saionz, KW; Sherman, DR; Szymonifka, MJ | 1 |
| de la Garza, AL; Haslberger, AG; Lovrecic, L; Martinez, AJ; Migliore, L; Milagro, FI; Peterlin, B; Remely, M | 1 |
| Cui, W; Liu, J; Sun, X; Xie, X; Zhang, D; Zhu, Y | 1 |
| Baltz, JM; Denomme, MM; Greene, ND; Lee, MB; Leung, KY; Mann, MR; Trasler, JM; White, CR; Zhang, B | 1 |
| Huang, G; Li, W; Liu, H; Wilson, JX; Yu, M; Zhang, M; Zhang, X | 1 |
| Bodis, M; Geisel, J; Herrmann, M; Herrmann, W; Hübner, U; Kirsch, SH; Laufs, U; Pusceddu, I; Wagenpfeil, S; Werner, C | 1 |
| Gamble, MV; Graziano, JH; Hall, MN; Ilievski, V; Islam, T; Liu, X; Parvez, F; Peters, BA; Shahriar, H; Siddique, AB; Uddin, MN | 1 |
| Brosnan, JT; Brosnan, ME; MacMillan, L; Stevens, JR | 1 |
| Chiang, EP; Ko, HA; Lin, YJ; Tang, FY; Wang, YC; Wu, MT | 1 |
| Locasale, JW; Mentch, SJ | 1 |
| Allaïli, N; Aouizerate, B; Bation, R; Bellivier, F; Bennabi, D; Bougerol, T; Bubrovszky, M; Camus, V; Charpeaud, T; Courtet, P; Courvoisier, P; d'Amato, T; Doumy, O; El-Hage, W; Garnier, M; Haesebaert, F; Haffen, E; Holtzmann, J; Lançon, C; Leboyer, M; Llorca, PM; Moliere, F; Nieto, I; Richieri, R; Saba, G; Vaiva, G | 1 |
| Koehler, P; Kopp, M; Morisset, R; Rychlik, M | 1 |
| Bischof, S; Cokus, SJ; Díaz de la Garza, RI; Feng, S; Garcia-Salinas, C; Groth, M; Hale, CJ; Hell, R; Jacobsen, SE; John, A; Long, JA; Moissiard, G; Ramos-Parra, PA; Smith, DC; Wang, H; Wirtz, M; Zhai, J | 1 |
| Kornhuber, J; Lewczuk, P; Linnebank, M; Oikonomidi, A; Popp, J; Semmler, A; Smulders, Y | 1 |
| Assaraf, YG; Raz, S; Stark, M | 1 |
| Arning, E; Bahous, RH; Bottiglieri, T; Caudill, MA; Christensen, KE; Deng, L; Hou, W; Jerome-Majewska, LA; Malysheva, OV; Rozen, R | 2 |
| Cui, S; Gao, Y; Huang, G; Li, W; Lv, X; Wang, P | 1 |
| Bhattacharjee, P; Giri, AK; Paul, S | 1 |
| Bhat, JA; Dar, NJ; Gupta, AP; Hamid, A; Kaur, J; Najar, RA; Rahat, B; Wani, NA | 1 |
| Brosnan, JT; Brosnan, ME; Clow, KA; MacMillan, L; Randell, EW; Tingley, G; Young, SK | 1 |
| Bahous, RH; Bedell, BJ; Caudill, MA; Cosín-Tomás, M; Deng, L; Ho, MK; Kaliman, P; Leclerc, D; Malysheva, O; Pallàs, M; Rozen, R | 1 |
| Ali, MA; Bakir, MB; Kamel, MA; Khalifa, EA; Refaat, R; Salama, MA | 1 |
| Chang, S; Li, B; Li, R; Liang, L; Liu, C; Niu, B; Qin, C; Wang, L; Wang, X; Zhang, L; Zhang, M; Zhang, T | 1 |
| Deng, J; Dong, H; Shen, Y; Xie, Z; Xiong, L; Zhang, P; Zhao, G | 1 |
| Du, J; O'Connor, TR; Riggs, AD; Singhal, J; Srivastava, A; Srivastava, AC; Stellern, J; Thompson, YG | 1 |
| Elango, R | 1 |
| Bottiglieri, T; Caudill, MA; Cosín-Tomás, M; Leclerc, D; Luan, Y; Malysheva, OV; Rozen, R; Wasek, B | 1 |
| Kim, R; Nijhout, HF; Reed, MC | 1 |
| Fustin, JM | 1 |
| Baltz, JM; McClatchie, T; Meredith, M; Trasler, JM; Tscherner, AK; Young, K; Zhang, B | 1 |
| Barták, BK; Felletár, I; Galamb, O; Igaz, P; Kalmár, A; Márkus, E; Micsik, T; Molnár, B; Nagy, ZB; Papp, M; Szigeti, KA; Takács, I; Tulassay, Z; V Patai, Á; Valcz, G; Zsigrai, S | 1 |
| Chen, F; Guo, L; Li, H; Li, W; Liu, Q; Wei, Y; Wu, L; Xia, H; Xu, Y; Ye, F; Zhang, G; Zhang, J | 1 |
| Beltrán, LJ; Bulleid, NJ; Johnstone, IL; Page, AP; Tjahjono, E; Winter, AD | 1 |
| Fogle, HM; Krupenko, NI; Krupenko, SA; McCormac, JP; Molina, S; Rushing, BR; Sharma, J; Sumner, S; You, M | 1 |
| Boerries, M; Klett, H; Michels, KB; van Otterdijk, SD | 1 |
| Caton, JS; Crouse, MS; Cushman, RA; Dahlen, CR; Freetly, HC; King, LE; Lee, RT; Lindholm-Perry, AK; Neville, BW; Oliver, WT; Reynolds, LP; Syring, JG; Ward, AK | 1 |
| Fan, Q; Feng, W; Guo, Z; Hao, L; Ju, M; Sun, X; Wang, L; Xiao, R; Yu, H; Zhou, C | 1 |
| Fujii, T; Iefuji, H; Kanai, M; Mizunuma, M | 1 |
| Bekdash, RA | 1 |
| Chen, H; Ishii, Y; Koga, T; Li, RS; Matsuo, Y; Nishida, K; Nishino, T; Sano, H; Takeda, T; Tanaka, Y; Yuan, M | 1 |
| Chen, YA; Chiang, CW; Kuo, KL; Lee, TS; Yu, CC | 1 |
| Fukuoka, H; Horiguchi, S; Kagawa, Y; Kawabata, T; Kubo, Y; Nishikawa, M; Shoji, K; Tajima, A | 1 |
| Chen, K; Gong, J; Liu, F; Peng, Y; Qiao, Y; Si, C; Song, F; Wang, P; Wang, X; Zhou, H | 1 |
| Clément, A; Clément, P; Menezo, YJR; Viot, G | 1 |
| Koutmos, M; Mendoza, J; Purchal, M; Yamada, K | 1 |
| Huang, G; Huang, L; Li, W; Li, Z; Ren, Q; Yan, J; Yan, R; Zhang, G; Zhang, Q; Zhou, D | 1 |
| BRESSLER, R; FRIEDBERG, SJ | 1 |
| Forsch, RA; Freisheim, JH; Moran, RG; Reich, VE; Rosowsky, A | 1 |
| Morrison, JF; Williams, EA | 1 |
| Ashford, VA; Davies, JF; Delcamp, TJ; Freisheim, JH; Kraut, J; Prendergast, NJ | 1 |
| Montgomery, JA; Morrison, JF; Stone, SR | 1 |
| Brown, KA; Kraut, J; Reyes, VM; Sawaya, MR | 1 |
| Forsch, RA; Moran, RG; Null, A; Rosowsky, A | 1 |
41 review(s) available for s-adenosylmethionine and folic acid
| Article | Year |
|---|---|
Methyl biogenesis.
Topics: Folic Acid; Homocysteine; Humans; Leucovorin; Mental Disorders; Methionine; Methionine Adenosyltransferase; Methylation; S-Adenosylmethionine; Tetrahydrofolates | 1978 |
A review of recent studies of the biosynthesis and excretion of hallucinogens formed by methylation of neurotransmitters or related substances.
Topics: Alcohol Oxidoreductases; Bufotenin; Carbolines; Dimethoxyphenylethylamine; Dopamine; Ethylamines; Folic Acid; Hallucinogens; Humans; Methylation; Methyltransferases; N,N-Dimethyltryptamine; Norepinephrine; S-Adenosylmethionine; Schizophrenia; Serotonin; Tryptamines | 1976 |
Interictal psychiatric disorders. Neurochemical aspects.
Topics: Anticonvulsants; Biogenic Amines; Depression; Epilepsy; Folic Acid; gamma-Aminobutyric Acid; Humans; Mental Disorders; S-Adenosylmethionine | 1991 |
Neuropharmacology of S-adenosyl methionine.
Topics: Animals; Antidepressive Agents; Biogenic Amines; Brain; Dementia; Depressive Disorder; Epilepsy; Folic Acid; Humans; Hydroxyindoleacetic Acid; Mental Disorders; Methionine Adenosyltransferase; Methylation; Nervous System Diseases; Phospholipids; Proteins; Rats; S-Adenosylmethionine; Schizophrenia; Synapses; Synaptic Transmission | 1986 |
The biology of folate in depression: implications for nutritional hypotheses of the psychoses.
Topics: Anorexia Nervosa; Biogenic Amines; Brain; Depressive Disorder; Diet; Folic Acid; Folic Acid Deficiency; Homocystinuria; Humans; Models, Theoretical; Pellagra; Pterins; S-Adenosylmethionine; Schizophrenia; Tryptophan; Vitamin B 12 Deficiency | 1986 |
Roles of vitamin B 12 and folic acid in methionine synthesis.
Topics: Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Escherichia coli; Folic Acid; Homocysteine; Methionine; Methylation; Methyltransferases; S-Adenosylmethionine; Transferases; Vitamin B 12 | 1970 |
Folate, alcohol, methionine, and colon cancer risk: is there a unifying theme?
Topics: Alcohol Drinking; Animals; Colonic Neoplasms; DNA; Ethanol; Folic Acid; Folic Acid Deficiency; Humans; Methylation; Risk Factors; S-Adenosylmethionine | 1994 |
Disturbances of one-carbon metabolism in neuropsychiatric disorders: a review.
Topics: Carbon; Folic Acid; Glycine Hydroxymethyltransferase; Humans; Methionine; Methionine Adenosyltransferase; Methylation; Neurocognitive Disorders; S-Adenosylmethionine; Schizophrenia | 1997 |
Hypothesis on the pathogenesis of vacuolar myelopathy, dementia, and peripheral neuropathy in AIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Cytokines; Demyelinating Diseases; Folic Acid; Glutathione; Humans; Macrophage Activation; Oligodendroglia; Peripheral Nervous System Diseases; S-Adenosylmethionine; Spinal Cord Diseases; Vacuoles; Vitamin B 12 | 1998 |
Brain function in the elderly: role of vitamin B12 and folate.
Topics: Aged; DNA; Folic Acid; Folic Acid Deficiency; Humans; Methylation; Nervous System Diseases; S-Adenosylmethionine; Vitamin B 12; Vitamin B 12 Deficiency | 1999 |
Impaired homocysteine metabolism and atherothrombotic disease.
Topics: Age Factors; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Models, Chemical; Risk Factors; S-Adenosylmethionine; Sex Factors | 2001 |
Nutritional regulation of homocysteine: effects of drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2001 |
Clinical nutrition: 3. The fuzzy boundary between nutrition and psychopharmacology.
Topics: Acetylcholine; Affect; Aggression; Behavior; Child, Preschool; Diet; Dietary Carbohydrates; Folic Acid; Humans; Male; Memory; S-Adenosylmethionine; Serotonin; Tryptophan | 2002 |
Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism.
Topics: Biomarkers; Carbon; Diet; DNA Methylation; Folic Acid; Homocysteine; Humans; Methylation; Nutritional Status; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B Complex | 2003 |
Selected integrative medicine treatments for depression: considerations for women.
Topics: 5-Hydroxytryptophan; Acupuncture Therapy; Complementary Therapies; Depressive Disorder; Exercise Therapy; Fatty Acids, Omega-3; Female; Folic Acid; Humans; Hypericum; Life Style; Phototherapy; Phytotherapy; Pregnancy; Randomized Controlled Trials as Topic; Research Design; S-Adenosylmethionine; Stress, Psychological; United States; Women's Health | 2004 |
The impact of metabolism on DNA methylation.
Topics: Alzheimer Disease; Animals; Arteriosclerosis; DNA Methylation; Folic Acid; Gene Expression Regulation; Glycine N-Methyltransferase; Homocysteine; Humans; Methionine; Methyltransferases; Models, Biological; S-Adenosylmethionine | 2005 |
Complementary medicines in psychiatry: review of effectiveness and safety.
Topics: Antidepressive Agents; Antipsychotic Agents; Cognition Disorders; Complementary Therapies; Dementia; Dyskinesias; Ergoloid Mesylates; Folic Acid; Humans; Hypnotics and Sedatives; Mental Disorders; Nootropic Agents; Phytotherapy; Plant Preparations; S-Adenosylmethionine; Selenium; Substance-Related Disorders | 2006 |
Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood?
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Biological Transport; Bone Marrow; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Methylation; Myelin Sheath; Nerve Tissue; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet.
Topics: Amino Acids, Sulfur; Animals; Choline; Diet; DNA Methylation; Drug Interactions; Endocrine System; Female; Fetal Development; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Methionine; Methylation; Nutritional Requirements; Pregnancy; Proteins; S-Adenosylmethionine | 2006 |
Making the connections--the crucial role of metabolite transporters at the interface between chloroplast and cytosol.
Topics: Adenine Nucleotide Translocator 1; Anion Transport Proteins; Arabidopsis Proteins; Biological Transport, Active; Chloroplasts; Cytosol; Endoplasmic Reticulum; Folic Acid; Genomics; Lipid Metabolism; Models, Biological; Phylogeny; Plants; Plastids; S-Adenosylmethionine; Systems Biology | 2007 |
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.
Topics: Animals; Betaine; Disease Models, Animal; Folic Acid; Humans; Liver Diseases, Alcoholic; Methionine; S-Adenosylmethionine | 2007 |
Major depressive disorder and nutritional medicine: a review of monotherapies and adjuvant treatments.
Topics: Amino Acids; Antidepressive Agents; Chemotherapy, Adjuvant; Depression; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Folic Acid; Humans; Nutritional Physiological Phenomena; Nutritional Status; S-Adenosylmethionine; Tryptophan | 2009 |
Folate, DNA damage and the aging brain.
Topics: Aging; Animals; Brain; Cell Nucleus; Cytosine; DNA; DNA Damage; Folic Acid; Folic Acid Deficiency; Methylation; Neurodegenerative Diseases; Rats; Reactive Oxygen Species; Risk Factors; S-Adenosylmethionine; Uracil | 2010 |
Complementary and alternative medicine for the treatment of major depressive disorder.
Topics: Acupuncture Therapy; Complementary Therapies; Depressive Disorder, Major; Dietary Supplements; Exercise Therapy; Fatty Acids, Omega-3; Folic Acid; Humans; Hypericum; Phytotherapy; S-Adenosylmethionine | 2011 |
B-Vitamin dependent methionine metabolism and alcoholic liver disease.
Topics: Epigenesis, Genetic; Ethanol; Folic Acid; Gene Expression Regulation; Humans; Kidney; Liver; Liver Diseases, Alcoholic; Methionine; S-Adenosylmethionine; Vitamin B Complex; Vitamin B Deficiency | 2013 |
Folate-genetics and colorectal neoplasia: what we know and need to know next.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Colorectal Neoplasms; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Risk Factors; S-Adenosylmethionine; Thymidylate Synthase | 2013 |
Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.
Topics: Animals; Choline; Diet; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Folic Acid; Gene Expression; Histones; Humans; Liver; Liver Cirrhosis; Models, Animal; Polymorphism, Genetic; S-Adenosylmethionine | 2013 |
Folate, vitamin B₁₂, and S-adenosylmethionine.
Topics: Clinical Trials as Topic; Dementia; Depression; Folic Acid; Humans; S-Adenosylmethionine; Vitamin B 12 | 2013 |
Methyl nutrients, DNA methylation, and cardiovascular disease.
Topics: Amino Acids; Atherosclerosis; Cardiovascular Diseases; Cysteine; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Humans; Hyperhomocysteinemia; Lipid Metabolism; Methionine; Nutritional Status; Risk Factors; S-Adenosylmethionine; Vitamin B Complex | 2014 |
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Models, Animal; DNA Methylation; Fasting; Fatty Liver; Folic Acid; Homocysteine; Humans; Liver; Metabolic Networks and Pathways; Methionine; Muscular Diseases; S-Adenosylmethionine | 2013 |
Complementary and alternative medicine therapies for perinatal depression.
Topics: Acupuncture Therapy; Complementary Therapies; Depression; Depression, Postpartum; Dietary Supplements; Exercise; Fatty Acids, Omega-3; Female; Folic Acid; Humans; Hypericum; Massage; Mothers; Peripartum Period; Phototherapy; Pregnancy; S-Adenosylmethionine | 2014 |
Lifetime requirement of the methionine cycle for neuronal development and maintenance.
Topics: Developmental Disabilities; Female; Folic Acid; Homocysteine; Humans; Methionine; Pregnancy; Prenatal Care; S-Adenosylmethionine; Vitamin B 12; Vitamin B Complex | 2014 |
Therapeutic perspectives of epigenetically active nutrients.
Topics: Antineoplastic Agents; Coffee; Curcumin; Diet; Epigenesis, Genetic; Folic Acid; Food; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Metabolic Syndrome; Neoplasms; Neurodegenerative Diseases; Phytoestrogens; Polyphenols; S-Adenosylmethionine; Selenium; Trace Elements; Vitamin B 12; Vitamin B Complex; Vitamins | 2015 |
Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?
Topics: Aldehyde Dehydrogenase; Amino Acids; Animals; Cytosol; Energy Metabolism; Folic Acid; Humans; Isoenzymes; Mitochondria; Models, Biological; Nutritional Requirements; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Serine | 2015 |
One-carbon metabolism and epigenetics: understanding the specificity.
Topics: Animals; Chromatin; Epigenesis, Genetic; Epigenomics; Folic Acid; Gene Expression Regulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Metabolic Networks and Pathways; Methionine; Methylation; S-Adenosylmethionine; Substrate Specificity | 2016 |
[Other therapeutic strategies].
Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Central Nervous System Stimulants; Depressive Disorder; Dietary Supplements; Dopamine Agonists; Double-Blind Method; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Fatty Acids, Omega-3; Folic Acid; Food-Drug Interactions; Humans; Ketamine; Monoamine Oxidase Inhibitors; Randomized Controlled Trials as Topic; S-Adenosylmethionine | 2016 |
Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Homeostasis; Humans; Methylation; Mice; Neoplasms; Peptide Synthases; Polyglutamic Acid; S-Adenosylmethionine; Signal Transduction | 2016 |
Arsenic toxicity and epimutagenecity: the new LINEage.
Topics: Arsenic; Arsenic Poisoning; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Environmental Exposure; Epigenesis, Genetic; Folic Acid; Genome, Human; Humans; Long Interspersed Nucleotide Elements; Neoplasms; Promoter Regions, Genetic; S-Adenosylmethionine | 2017 |
Methionine Nutrition and Metabolism: Insights from Animal Studies to Inform Human Nutrition.
Topics: Animals; Betaine; Choline; Creatine; Cysteine; Diet; Folic Acid; Glutathione; Homocysteine; Humans; Methionine; Methylation; Models, Animal; Nutritional Requirements; Nutritional Status; Phosphatidylcholines; S-Adenosylmethionine; Sulfur | 2020 |
Importance and mechanisms of S-adenosylmethionine and folate accumulation in sake yeast.
Topics: Alcoholic Beverages; Fermentation; Folic Acid; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2023 |
Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection.
Topics: Animals; Brain; Carbon; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Humans; Methionine; Micronutrients; S-Adenosylmethionine | 2023 |
14 trial(s) available for s-adenosylmethionine and folic acid
| Article | Year |
|---|---|
Affective illness and S-adenosyl methionine: a preliminary report.
Topics: Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Folic Acid; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Neurotic Disorders; S-Adenosylmethionine | 1986 |
Folate nutriture alters choline status of women and men fed low choline diets.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Choline; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lipids; Male; Methionine; Methylation; Middle Aged; Nutritional Physiological Phenomena; Nutritional Status; Phosphatidylcholines; Reference Values; S-Adenosylmethionine | 1999 |
Homocysteine, folate, methylation, and monoamine metabolism in depression.
Topics: Adult; Biogenic Monoamines; Blood Cell Count; Body Weight; Depression; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Methylation; Middle Aged; S-Adenosylmethionine; Vitamin B 12 | 2000 |
Genomic DNA methylation decreases in response to moderate folate depletion in elderly women.
Topics: Aged; Aged, 80 and over; Dietary Supplements; DNA; DNA Methylation; DNA-Cytosine Methylases; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Least-Squares Analysis; Leukocytes; Middle Aged; Nutrition Policy; S-Adenosylmethionine; Scintillation Counting; Statistics, Nonparametric | 2000 |
The effect of high doses of folic acid on the overexpression of ornithine decarboxylase and S-adenosylmethionine content in human colon adenomatous polyps.
Topics: Adenomatous Polyps; Colonic Polyps; Disease Progression; Double-Blind Method; Enzyme Induction; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Proteins; Ornithine Decarboxylase; S-Adenosylmethionine | 2001 |
S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study.
Topics: Aged; Brachial Artery; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nitroglycerin; Regional Blood Flow; Risk Factors; S-Adenosylmethionine; Tetrahydrofolates; Ultrasonography; Vasodilation; Vasodilator Agents; Vitamin B 12; Vitamin B 6 | 2005 |
Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Placebos; S-Adenosylhomocysteine; S-Adenosylmethionine; Vascular Diseases; Vitamin B 12; Vitamin B 6; Vitamins | 2010 |
Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation.
Topics: Adult; Blood Coagulation; Blood Proteins; Dietary Supplements; Drug Administration Schedule; Female; Folic Acid; Homocysteine; Humans; Immunity; Inflammation; Male; Proteome; Proteomics; S-Adenosylmethionine; Tetrahydrofolates | 2010 |
A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia.
Topics: Acetylcarnitine; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Dementia; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Humans; Institutionalization; Learning; Male; Memory; Middle Aged; Reference Values; S-Adenosylmethionine; Vitamin B 12; Vitamin E; Vitamins; Young Adult | 2010 |
Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults.
Topics: Aged; Aged, 80 and over; Aging; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B Complex | 2011 |
Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia.
Topics: Adult; Aged; Dietary Supplements; DNA Methylation; Folic Acid; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B Complex | 2011 |
S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid in Rett syndrome and the effect of folinic acid supplementation.
Topics: Adolescent; Adult; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Humans; Infant; Rett Syndrome; S-Adenosylhomocysteine; S-Adenosylmethionine; Young Adult | 2013 |
Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans.
Topics: Adolescent; Creatine; Cysteine; Dietary Supplements; Double-Blind Method; Energy Intake; Exercise; Feeding Behavior; Folic Acid; Glycine; Healthy Volunteers; Homocysteine; Humans; Male; Methionine; S-Adenosylmethionine; Soccer; Vitamin B 12 | 2014 |
Low-Dose Creatine Supplementation Lowers Plasma Guanidinoacetate, but Not Plasma Homocysteine, in a Double-Blind, Randomized, Placebo-Controlled Trial.
Topics: Adult; Bangladesh; Biomarkers; Cohort Studies; Creatine; Dietary Supplements; Double-Blind Method; Down-Regulation; Female; Folic Acid; Glycine; Homocysteine; Humans; Hyperhomocysteinemia; Intention to Treat Analysis; Male; Middle Aged; Patient Dropouts; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
192 other study(ies) available for s-adenosylmethionine and folic acid
| Article | Year |
|---|---|
Biosynthesis of ribosylthymine in the transfer RNA of Streptococcus faecalis: a folate-dependent methylation not involving S-adenosylmethionine.
Topics: Enterococcus faecalis; Folic Acid; Formates; Methionine; Methylation; RNA, Bacterial; RNA, Transfer; S-Adenosylmethionine; Thymine | 1975 |
A methionine-reversible folate deficiency in rats following the acute administration of diethylnitrosamine and alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Animals; Choline; Diet; Diethylnitrosamine; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Liver; Male; Methionine; Nitrosamines; Rats; S-Adenosylmethionine; Thiocyanates; Time Factors | 1977 |
Neurochemical and behavioral effects of diet related perinatal folic acid restriction.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Brain; Diet; Escape Reaction; Female; Folic Acid; Folic Acid Deficiency; Liver; Mice; Organ Size; Pregnancy; S-Adenosylmethionine; Stress, Physiological | 1976 |
Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Dopamine; Enzyme Activation; Flavin-Adenine Dinucleotide; Folic Acid; Liver; Methylenetetrahydrofolate Dehydrogenase (NADP); Methyltransferases; Oxidoreductases; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine | 1975 |
The relationships between vitamin B12 and folic acid and the effect of methionine on folate metabolism.
Topics: Animals; Biological Transport; Diet; Folic Acid; Formiminoglutamic Acid; Histidine; Liver; Male; Methionine; Perfusion; Rats; S-Adenosylmethionine; Vitamin B 12; Vitamin B 12 Deficiency | 1975 |
Methyl groups in carcinogenesis: effects on DNA methylation and gene expression.
Topics: Animals; Choline; DNA; Folic Acid; Food, Formulated; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, myc; Genes, ras; Liver; Male; Methionine; Methylation; Rats; Rats, Inbred F344; RNA, Messenger; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 1992 |
Low thyroxine levels in female psychiatric inpatients with riboflavin deficiency: implications for folate-dependent methylation.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Hospitalization; Humans; Male; Mental Disorders; Middle Aged; Pyridoxine; Riboflavin; Riboflavin Deficiency; S-Adenosylmethionine; Thiamine; Thyroid Function Tests; Thyroxine; Vitamin B 12 | 1992 |
Methyl group metabolism in the pancreas of folate-deficient rats.
Topics: Animals; Body Weight; Diet; Folic Acid; Folic Acid Deficiency; Male; Organ Size; Pancreas; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1992 |
Phenytoin treatment and folate supplementation affect folate concentrations and methylation capacity in rats.
Topics: Animals; Brain; Drug Interactions; Folic Acid; Liver; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Phenytoin; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Weight Gain | 1991 |
Formate metabolism in young swine.
Topics: Animals; Folic Acid; Formates; Humans; Kinetics; Liver; S-Adenosylmethionine; Species Specificity; Swine | 1990 |
Chronic carbamazepine treatment and folate-dependent one-carbon metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Brain; Carbamazepine; Carbon; Folic Acid; Glycine Hydroxymethyltransferase; Liver; Male; Methionine Adenosyltransferase; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 1990 |
Effects of nitrous oxide inactivation of vitamin B12 and of methionine on folate coenzyme metabolism in rat liver, kidney, brain, small intestine and bone marrow.
Topics: Animals; Bone Marrow; Brain; Folic Acid; Intestine, Small; Kidney; Liver; Male; Methionine; Nitrous Oxide; Organ Specificity; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 1989 |
The effects of vitamin A deficiency on hepatic folate metabolism in rats.
Topics: Animals; Diterpenes; Folic Acid; Formiminoglutamic Acid; Histidine; Histidine Ammonia-Lyase; Liver; Male; Rats; Rats, Inbred Strains; Retinyl Esters; S-Adenosylhomocysteine; S-Adenosylmethionine; Urocanate Hydratase; Vitamin A; Vitamin A Deficiency | 1985 |
One-carbon metabolism disturbances in affective disorders. A preliminary report.
Topics: Bipolar Disorder; Depressive Disorder; Erythrocytes; Folic Acid; Humans; Kinetics; Methionine Adenosyltransferase; Phosphatidylcholines; S-Adenosylmethionine; Schizophrenia; Transferases | 1985 |
Modification of hepatic folate metabolism in rats fed excess retinol.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Dioxide; Folic Acid; Formates; Histidine; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Vitamin A | 1986 |
Effect of chronic valproate treatment on folate-dependent methyl biosynthesis in the rat.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Brain; Carbon; Folic Acid; Glycine Hydroxymethyltransferase; Liver; Male; Methionine Adenosyltransferase; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Valproic Acid | 1986 |
Demyelination and decreased S-adenosylmethionine in 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Biogenic Amines; Biopterins; Child, Preschool; Female; Folic Acid; Humans; Infant; Infant, Newborn; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Myelin Sheath; Oxidoreductases; S-Adenosylmethionine | 1988 |
Effect of chronic primidone treatment on folate-dependent one-carbon metabolism in the rat.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Animals; Brain; Folic Acid; Glycine Hydroxymethyltransferase; Liver; Male; Methionine Adenosyltransferase; Oxidoreductases; Primidone; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1987 |
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Regulation of C metabolism by L-methionine in Saccharomyces cerevisiae.
Topics: Alcohol Oxidoreductases; Biological Assay; Carbon Isotopes; Cells, Cultured; Chromatography, DEAE-Cellulose; Culture Media; Folic Acid; Formates; Lacticaseibacillus casei; Ligases; Methionine; Methylation; Pediococcus; S-Adenosylmethionine; Saccharomyces cerevisiae; Serine; Tetrahydrofolates; Transferases | 1972 |
Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.
Topics: Adenosine; Alcohol Oxidoreductases; Ammonium Sulfate; Animals; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Drug Stability; Flavin-Adenine Dinucleotide; Folic Acid; Formaldehyde; Homocysteine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Liver; NAD; NADP; Rats; S-Adenosylmethionine; Spectrophotometry; Swine; Vitamin K | 1971 |
Urinary excretion of 5-methyltetrahydrofolate and liver S-adenosylmethionine levels of rats fed a vitamin B 12-deficient diet.
Topics: Animals; Bacteria; Biological Assay; Biological Transport; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Chromatography, Thin Layer; Drug Stability; Ethionine; Folic Acid; Liver; Male; Methionine; Rats; S-Adenosylmethionine; Tetrahydrofolates; Time Factors; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
N-methylation of dopamine to epinine in brain tissue using N-methyltetrahydrofolic acid as the methyl donor.
Topics: Animals; Brain; Carbon Isotopes; Coenzymes; Dopamine; Folic Acid; In Vitro Techniques; Methylation; Methyltransferases; Rats; S-Adenosylmethionine; Tetrahydrofolates | 1972 |
Studies on the regulation of one-carbon metabolism. II. Repression-derepression of serine hydroxymethyltransferase by methionine in Escherichia coli 113-3.
Topics: Ammonium Sulfate; Chemical Precipitation; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Enzyme Repression; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Hydroxyapatites; Kinetics; Methionine; Methyltransferases; Molecular Weight; Oxidoreductases; S-Adenosylmethionine; Serine; Tetrahydrofolate Dehydrogenase; Thymine Nucleotides; Transferases; Uracil Nucleotides; Vitamin B 12 | 1972 |
Effect of methionine and vitamin B-12 on the activities of methionine biosynthetic enzymes in metJ mutants of Escherichia coli K12.
Topics: Adenosine Triphosphate; Culture Media; Cystathionine; Enzyme Repression; Escherichia coli; Folic Acid; Homocysteine; Hydro-Lyases; L-Serine Dehydratase; Methionine; Methyltransferases; Mutation; Oxidoreductases; S-Adenosylmethionine; Time Factors; Transferases; Vitamin B 12 | 1973 |
Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines.
Topics: Animals; Biogenic Amines; Brain; Carbon Isotopes; Chickens; Coenzymes; Female; Folic Acid; Hallucinogens; Liver; Lung; Male; Methylamines; Methylation; Methyltransferases; Myocardium; Octopamine; Phenylethanolamine N-Methyltransferase; S-Adenosylmethionine; Serotonin; Tetrahydrofolates; Tryptamines; Tyramine | 1973 |
Folic acid deficiency and methyl group metabolism in rat brain: effects of L-dopa.
Topics: Animals; Body Weight; Brain; Dihydroxyphenylalanine; Folic Acid; Folic Acid Deficiency; Kidney; Liver; Male; Methionine; Organ Size; Organ Specificity; Rats; S-Adenosylmethionine; Time Factors; Vitamin B 12 | 1974 |
The isolation of N 5 -methyltetrahydrofolate-homocysteine transmethylase from bovine brain.
Topics: Ammonium Sulfate; Animals; Brain; Carbon Isotopes; Cattle; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Disc; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; Kidney; Liver; Methyltransferases; Organ Specificity; Protamines; S-Adenosylmethionine; Spectrophotometry | 1972 |
An assay for N 5 -methyltetrahydrofolate-homocysteine transmethylase activity using instant thin-layer chromatography.
Topics: Animals; Carbon Isotopes; Chromatography, Thin Layer; Folic Acid; Formaldehyde; Homocysteine; Kidney; Methionine; Methylation; Methyltransferases; S-Adenosylmethionine | 1972 |
Isolation of a cobalamin containing 5-methyltetrahydrofolate-homocysteine transmethylase from mammalian kidney.
Topics: Ammonium Sulfate; Animals; Calcium Phosphates; Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Drug Stability; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; Kidney; Methods; Methyltransferases; Protamines; S-Adenosylmethionine; Spectrophotometry; Sulfuric Acids; Swine; Ultraviolet Rays; Vitamin B 12 | 1971 |
Mechanism of mammalian cobalamin-dependent methionine biosynthesis.
Topics: Alkylation; Animals; Carbon Isotopes; Darkness; Dithiothreitol; Electrophoresis, Disc; Enzyme Activation; Flavin Mononucleotide; Folic Acid; Homocysteine; Hydroxocobalamin; Iodides; Kidney; Kinetics; Light; Mathematics; Mercaptoethanol; Methionine; Methylation; Methyltransferases; Models, Biological; Models, Chemical; Oxidation-Reduction; Radiation Effects; S-Adenosylmethionine; Swine; Tritium | 1971 |
The methyl-folate trap and the supply of S-adenosylomethionine.
Topics: Brain; Brain Diseases; Folic Acid; Methionine; Methylation; S-Adenosylmethionine; Vitamin B 12 Deficiency | 1981 |
Synergistic growth inhibiting effect of nitrous oxide and cycloleucine in experimental rat leukaemia.
Topics: Amino Acids; Animals; Cycloleucine; Deoxyuridine; Drug Synergism; Folic Acid; Leukemia, Experimental; Leukocyte Count; Liver; Male; Nitrous Oxide; Organ Size; Rats; Rats, Inbred BN; S-Adenosylmethionine; Spleen; Vitamin B 12 | 1984 |
Tissue S-adenosylmethionine levels in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced neuropathy.
Topics: Animals; Brain; Cerebellar Ataxia; Chiroptera; Diet; Folic Acid; Liver; Methionine; Nitrous Oxide; Paralysis; S-Adenosylmethionine; Vitamin B 12 | 1983 |
The transmethylation and one-carbon cycle hypotheses of schizophrenia.
Topics: Brain; Catecholamines; Folic Acid; Humans; Kinetics; Methionine; Methylation; S-Adenosylmethionine; Schizophrenia | 1983 |
Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.
Topics: Adenosine; Animals; Deoxyadenosines; Folic Acid; Formyltetrahydrofolates; Liver; Male; Methionine; Nitrous Oxide; Pteroylpolyglutamic Acids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Vitamin B 12; Vitamin B 12 Deficiency | 1983 |
Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alcohol Oxidoreductases; Animals; Folic Acid; In Vitro Techniques; Kinetics; Liver; Pteroylpolyglutamic Acids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Swine | 1982 |
How vitamin B12 acts.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Animals; Folic Acid; Humans; Methionine; Pteroylpolyglutamic Acids; S-Adenosylmethionine; Thymidine; Vitamin B 12 Deficiency | 1981 |
Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment.
Topics: Animals; Carbon Tetrachloride; Cystathionine; DNA; Folic Acid; Homocysteine; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1995 |
Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats.
Topics: Animals; Body Weight; Colon; Colorectal Neoplasms; DNA; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation, Neoplastic; Genes, myc; Liver; Male; Methionine; Methylation; Proto-Oncogene Proteins c-myc; Random Allocation; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine | 1995 |
Effects of ageing on folate metabolism in rats fed a long-term folate deficient diet.
Topics: Aging; Animals; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1994 |
Involvement of folic acid and methionine in the synthesis of certain membrane-associated nucleotide sugars by Enterococcus hirae.
Topics: Cell Fractionation; Cell Membrane; Cell-Free System; Enterococcus; Folic Acid; Methionine; Monosaccharides; S-Adenosylmethionine; Serine; Uridine Diphosphate Glucose; Uridine Diphosphate Sugars | 1994 |
Effects of prolonged aspirin or acetaminophen administration to rats on liver folate content and distribution. Relation to DNA methylation and S-adenosylmethionine.
Topics: Acetaminophen; Animals; Aspirin; DNA; Drug Administration Schedule; Folic Acid; Liver; Male; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1994 |
Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts. Homocysteine remethylation as determinant of enzyme inactivation and homocysteine export.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Cell Line; Enzyme Activation; Extracellular Space; Fetus; Fibroblasts; Folic Acid; Homocysteine; Humans; Infant; Lung; Male; Methionine; Methylation; Nitrous Oxide; S-Adenosylmethionine | 1993 |
Pancreatic one-carbon metabolism in early folate deficiency in rats.
Topics: Analysis of Variance; Animals; Cytoplasmic Granules; Folic Acid; Folic Acid Deficiency; Glycine N-Methyltransferase; Jejunum; Male; Methyltransferases; Pancreas; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1993 |
Pathogenesis of cobalamin neuropathy: deficiency of nervous system S-adenosylmethionine?
Topics: Child, Preschool; Folic Acid; Folic Acid Deficiency; Humans; Infant; Infant, Newborn; Metabolism, Inborn Errors; Nervous System Diseases; S-Adenosylmethionine; Vitamin B 12; Vitamin B 12 Deficiency | 1993 |
Hepatic one-carbon metabolism in early folate deficiency in rats.
Topics: Animals; Cytosol; Folic Acid; Folic Acid Deficiency; Glycine N-Methyltransferase; Liver; Male; Methyltransferases; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Weaning | 1993 |
Carbon flow through the hepatic folate-dependent one-carbon pool is not altered in vitamin A-deficient rats.
Topics: Animals; Carbon; Carbon Radioisotopes; Diterpenes; Folic Acid; Liver; Male; Methionine; Random Allocation; Rats; Rats, Sprague-Dawley; Retinyl Esters; S-Adenosylhomocysteine; S-Adenosylmethionine; Serine; Tritium; Vitamin A; Vitamin A Deficiency | 1996 |
Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Administration, Oral; Analysis of Variance; Animal Feed; Animals; Apoptosis; Cell Division; Deoxyuracil Nucleotides; Ethanol; Folic Acid; Homocysteine; Liver; Male; Methionine; Proliferating Cell Nuclear Antigen; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine; Swine, Miniature; Thymine Nucleotides | 1996 |
Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene.
Topics: Animals; Base Sequence; DNA; DNA Damage; DNA Methylation; Exons; Folic Acid; Folic Acid Deficiency; Genes, Suppressor; Male; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Suppressor Protein p53 | 1997 |
Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats.
Topics: Analysis of Variance; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Drug Administration Schedule; Folic Acid; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
Topics: Adenosine; Biological Transport; Carrier Proteins; Cell Division; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Reduced Folate Carrier Protein; S-Adenosylmethionine; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
Topics: 5-Methylcytosine; Agouti Signaling Protein; Animals; Betaine; Choline; Cytosine; Dietary Supplements; Female; Folic Acid; Gene Expression Regulation; Genomic Imprinting; Hair Color; Intercellular Signaling Peptides and Proteins; Male; Methionine; Mice; Mice, Inbred Strains; Pregnancy; Proteins; S-Adenosylmethionine; Vitamin B 12; Zinc | 1998 |
High-dose folic acid supplementation in rats: effects on gestation and the methionine cycle.
Topics: Animals; Dietary Supplements; Female; Fetal Weight; Folic Acid; Methionine; Methylation; Nutritional Status; Pregnancy; Pregnancy Outcome; Rats; Rats, Wistar; S-Adenosylmethionine | 2000 |
DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats.
Topics: Animals; Choline Deficiency; Colon; Colonic Neoplasms; Comet Assay; DNA; DNA Damage; DNA Methylation; Folic Acid; Folic Acid Deficiency; Liver; Male; Methionine; Rats; S-Adenosylmethionine; Vitamin B 12 | 2000 |
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Brain; Chronic Disease; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Folic Acid; Food, Fortified; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Thrombomodulin; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 2001 |
Blood determinations of S-adenosylmethionine, S-adenosylhomocysteine, and homocysteine: correlations with diet.
Topics: Body Mass Index; Diet; Dietary Fats; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Neoplasms; Pyridoxine; Reference Values; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine | 2001 |
COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk.
Topics: Breast Neoplasms; Case-Control Studies; Catechol O-Methyltransferase; Cysteine; Estrogens, Catechol; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylation; Micronutrients; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Pyridoxal Phosphate; Risk Factors; S-Adenosylmethionine; Vitamin B 12 | 2001 |
Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine.
Topics: Adult; Aged; Cardiovascular Diseases; Case-Control Studies; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Vitamin B 12 | 2001 |
Impact of extracellular folate levels on global gene expression.
Topics: Cadherins; Carrier Proteins; CpG Islands; DNA Methylation; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation; Humans; KB Cells; Promoter Regions, Genetic; Receptors, Cell Surface; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2001 |
Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo.
Topics: Amino Acid Sequence; Arabidopsis; Base Sequence; DNA Primers; Folic Acid; Genetic Complementation Test; Kinetics; Methylenetetrahydrofolate Reductase (NADPH2); Molecular Sequence Data; Mutation; NADP; Nuclear Magnetic Resonance, Biomolecular; Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Saccharomyces cerevisiae | 2002 |
Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins.
Topics: Age Factors; Aging; Animals; Aspartic Acid; Folic Acid; Folic Acid Deficiency; Isoaspartic Acid; Liver; Male; Methylation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine | 2002 |
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses.
Topics: Animals; Cell Line; Cytoplasm; Deoxyribonucleotides; DNA; Folic Acid; Glycine; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Methylation; S-Adenosylmethionine; Tetrahydrofolates; Thymidine Monophosphate | 2002 |
Moderate folate deficiency influences polyamine synthesis in rats.
Topics: Animals; Biogenic Polyamines; Brain; Folic Acid; Folic Acid Deficiency; Intestinal Mucosa; Liver; Male; Putrescine; Random Allocation; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Spermidine; Spermine | 2002 |
Acute valproate administration impairs methionine metabolism in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Anticonvulsants; Betaine-Homocysteine S-Methyltransferase; Female; Folic Acid; Glutathione; Glutathione Disulfide; Homocysteine; Liver; Methionine; Methionine Adenosyltransferase; Methyltransferases; Models, Animal; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Teratogens; Valproic Acid; Vitamin B 6 | 2002 |
S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations.
Topics: Aged; Aged, 80 and over; Body Constitution; Cardiovascular Diseases; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Humans; Male; Middle Aged; Regression Analysis; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2003 |
Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
Topics: Anemia; Anemia, Pernicious; Cysteine; Dipeptides; Folic Acid; Glutathione; Homocysteine; Humans; Memory Disorders; Methionine; Movement Disorders; Nervous System Diseases; Retrospective Studies; S-Adenosylmethionine; Sensation Disorders; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Topics: Animals; Cadherins; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Exons; Folic Acid; Folic Acid Deficiency; Mice; Mice, Inbred C57BL; Mutation; Neoplasms; Promoter Regions, Genetic; S-Adenosylmethionine; Tumor Suppressor Protein p53 | 2003 |
The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon.
Topics: Animals; Body Weight; Colon; Dietary Supplements; DNA Methylation; Folic Acid; Genome; Hemoglobins; Homocysteine; Rats; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tumor Suppressor Protein p53 | 2003 |
Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation.
Topics: Biological Transport; Blotting, Northern; Blotting, Western; Carbon-Nitrogen Ligases; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Cytoplasm; DNA Methylation; DNA, Complementary; Folic Acid; Humans; Leucovorin; Models, Biological; Oxygen; Polyglutamic Acid; RNA, Messenger; S-Adenosylmethionine; Time Factors; Tissue Distribution; Tumor Cells, Cultured | 2003 |
ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. IX. TRANSMETHYLATION FROM S-ADENOSYLMETHIONINE AND 5-METHYLTETRAHYDROFOLATE TO 2-MERCAPTOETHANOL AND HOMOCYSTEINE.
Topics: Alkylation; Biological Assay; Carbon Isotopes; Folic Acid; Homocysteine; Kinetics; Lactobacillus; Mercaptoethanol; Methionine; Nucleosides; Research; S-Adenosylmethionine; Spectrophotometry; Sulfhydryl Compounds; Tetrahydrofolates; Transferases | 1965 |
Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice.
Topics: Animals; Arsenates; Arsenic; Arsenic Poisoning; Arsenicals; Arsenites; Cacodylic Acid; Carrier Proteins; Cross-Over Studies; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Deficiency; Male; Mice; Mice, Knockout; Receptors, Cell Surface; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
Update on dietary supplements for depression.
Topics: Depression; Dietary Supplements; Fatty Acids, Omega-3; Folic Acid; Humans; Hypericum; Phytotherapy; S-Adenosylmethionine | 2004 |
MTX-induced white matter changes are associated with polymorphisms of methionine metabolism.
Topics: Aged; Brain; Central Nervous System Neoplasms; Demyelinating Diseases; DNA Mutational Analysis; Drug Resistance; Female; Folic Acid; Folic Acid Antagonists; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Haplotypes; Humans; Lymphoma; Male; Methionine; Methotrexate; Middle Aged; Myelin Sheath; Nerve Fibers, Myelinated; Neurotoxins; Polymorphism, Genetic; Risk Factors; S-Adenosylmethionine | 2005 |
Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes.
Topics: Aged; Cystathionine; Cysteine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Folic Acid; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Male; Methionine; Methylmalonic Acid; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcobalamins; Vitamin B 12; Vitamin B 6 | 2005 |
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
Topics: Cell Proliferation; Cells, Cultured; DNA Modification Methylases; Embryo, Mammalian; Enzymes; Epigenesis, Genetic; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Homocysteine; Humans; Methotrexate; Reproductive Techniques, Assisted; S-Adenosylmethionine; Stem Cells | 2005 |
Stable isotope dilution-based accurate comparative quantification of nitrogen-containing metabolites in Arabidopsis thaliana T87 cells using in vivo (15)N-isotope enrichment.
Topics: Arabidopsis; Chromatography, Liquid; Folic Acid; Indicator Dilution Techniques; Mass Spectrometry; Nitrogen; Nitrogen Isotopes; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
[Effect of heptral and folic acid on the hepatic functions during toxic hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Folic Acid; Male; Rats; S-Adenosylmethionine; Vasodilator Agents | 2005 |
Diet-dependent survival of protein repair-deficient mice.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Brain; Eating; Folic Acid; Methionine; Mice; Mice, Mutant Strains; Protein D-Aspartate-L-Isoaspartate Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Seizures; Survival Rate | 2005 |
Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome?
Topics: Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Mutation; Polymorphism, Single Nucleotide; Regression Analysis; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans.
Topics: Antifungal Agents; Azoles; Candida albicans; Candidiasis; Catechin; Drug Synergism; Enzyme Inhibitors; Ergosterol; Folic Acid; Folic Acid Antagonists; Fungal Proteins; Leucovorin; Microbial Sensitivity Tests; Models, Biological; Naphthalenes; S-Adenosylmethionine; Spectrum Analysis; Terbinafine; Tetrahydrofolate Dehydrogenase; Vitamin B Complex | 2006 |
Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats.
Topics: Animals; Colon; Deficiency Diseases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Folic Acid; Glutathione; Glutathione Peroxidase; Glycine N-Methyltransferase; Homocysteine; Liver; Male; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenium | 2006 |
[The impact of heptral, vitamin B6 and folic acid on the indices of hepatic biotransformation in toxic hepatitis].
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Folic Acid; Rats; S-Adenosylmethionine; Treatment Outcome; Vitamin B 6 | 2006 |
Modulation of DNA methyltransferase profile by methyl donor starvation followed by gamma irradiation.
Topics: Animals; Cell Nucleus; Choline; Comet Assay; Cytoplasm; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Methylation; DNA Repair; Dose-Response Relationship, Radiation; Folic Acid; Gamma Rays; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; S-Adenosylmethionine | 2007 |
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.
Topics: Betaine; Carbon; DNA Methylation; Folic Acid; Formate-Tetrahydrofolate Ligase; Homocysteine; Humans; Kinetics; Mathematics; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Molecular Biology; Nutritional Physiological Phenomena; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Polymorphism, Genetic; S-Adenosylmethionine; Vitamin B 12 Deficiency | 2006 |
New insights into the regulation of methyl group and homocysteine metabolism.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Folic Acid; Glycine N-Methyltransferase; Homocysteine; Humans; Mice; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylmethionine | 2007 |
Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate-dependent remethylation in human-transformed lymphoblasts.
Topics: Cell Division; Cell Line, Transformed; Cells, Cultured; DNA Methylation; Folic Acid; Humans; Lymphocyte Activation; Lymphocytes; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; S-Adenosylmethionine | 2007 |
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Topics: Animals; Brain; Disease Models, Animal; Embryo, Mammalian; Female; Ferredoxin-NADP Reductase; Folic Acid; Heart; Homocysteine; Hyperhomocysteinemia; Kidney; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Folate status and S-adenosylmethionine/S-adenosylhomocysteine ratio in colorectal adenocarcinoma in humans.
Topics: Adenocarcinoma; Aged; Colon; Colorectal Neoplasms; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Intestinal Mucosa; Male; Nutritional Status; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Consideration of betaine and one-carbon sources of N5-methyltetrahydrofolate for use in homocystinuria and neural tube defects.
Topics: Betaine; Dietary Supplements; Folic Acid; Homocysteine; Homocystinuria; Humans; Methionine; Methylation; Neural Tube Defects; Nutritional Physiological Phenomena; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B Complex | 2007 |
Supranormal dietary folic acid supplementation: effects on methionine metabolism in weanling rats.
Topics: Animals; Biomarkers; Dietary Supplements; DNA Methylation; Folic Acid; Homocysteine; Liver; Male; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamins; Weaning | 2007 |
Abnormal folate metabolism in foetuses affected by neural tube defects.
Topics: Anencephaly; Animals; Antimetabolites; Deoxyuridine; Female; Ferredoxin-NADP Reductase; Fetal Diseases; Fetus; Fibroblasts; Folic Acid; Genotype; Humans; Methylation; Mice; Neural Tube Defects; NIH 3T3 Cells; Polymorphism, Genetic; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Spinal Dysraphism | 2007 |
Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.
Topics: Antiparkinson Agents; Carbon; Catechol O-Methyltransferase Inhibitors; Catechols; Folic Acid; Humans; Hyperhomocysteinemia; Levodopa; Nitriles; Parkinson Disease; Randomized Controlled Trials as Topic; S-Adenosylmethionine; Time Factors; Vitamin B 12; Vitamin B 6 | 2007 |
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells.
Topics: Cell Line, Tumor; Cytoplasm; Dose-Response Relationship, Drug; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Kinetics; Mitochondria; Protein Isoforms; Pyridoxine; S-Adenosylmethionine; Vitamin B 6 | 2007 |
Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alleles; Analysis of Variance; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Young Adult | 2008 |
Priorities in the discovery of the implications of water channels in epilepsy and Duchenne muscular dystrophy.
Topics: Aquaporins; Brain; Epilepsy; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Muscular Dystrophy, Duchenne; S-Adenosylmethionine; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Influence of preconditioning-like hypoxia on the liver of developing methyl-deficient rats.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Proliferation; Choline Deficiency; Cystathionine beta-Synthase; Female; Folic Acid; Folic Acid Deficiency; Food, Formulated; Glutathione; Homocysteine; Hypoxia; Liver; Nitric Oxide Synthase Type II; Pregnancy; Rats; Rats, Wistar; Riboflavin; Riboflavin Deficiency; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Deficiency | 2007 |
S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet.
Topics: Animals; Body Weight; Disease Models, Animal; Ethanol; Fatty Liver; Female; Folic Acid; Folic Acid Deficiency; Linear Models; Liver; Liver Diseases, Alcoholic; Male; Methionine; Necrosis; Oxidative Stress; S-Adenosylmethionine; Swine; Swine, Miniature | 2007 |
gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Antioxidants; Aspartic Acid Endopeptidases; Blotting, Western; Cell Line, Tumor; DNA Methylation; DNA Primers; Folic Acid; Glioblastoma; Homocysteine; Humans; Neuroblastoma; Oxidative Stress; Polymerase Chain Reaction; Presenilin-1; S-Adenosylmethionine; Up-Regulation; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2007 |
Homocysteine, S-adenosylmethionine and S-adenosylhomocysteine are associated with retinal microvascular abnormalities: the Hoorn Study.
Topics: Aged; Aged, 80 and over; Arterioles; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Folic Acid; Follow-Up Studies; Glucose Tolerance Test; Homocysteine; Humans; Male; Middle Aged; Retinal Diseases; Retinal Vessels; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Cytochromes b5; Disease Models, Animal; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Hepatocytes; Homocysteine; Male; Rats; S-Adenosylmethionine; Treatment Outcome; Vitamin B 6; Vitamin B Complex | 2007 |
Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: critical role of S-adenosyl methionine.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Acetylcholine; Aggression; Aging; Animals; Apolipoproteins E; Cognition; Folic Acid; Folic Acid Deficiency; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Random Allocation; S-Adenosylmethionine | 2008 |
Hyperglycemia-induced membrane lipid peroxidation and elevated homocysteine levels are poorly attenuated by exogenous folate in embryonic chick brains.
Topics: Animals; Blood Glucose; Brain; Chick Embryo; Fatty Acids; Folic Acid; Glucose; Homocysteine; Lipid Peroxidation; Lipid Peroxides; Membrane Lipids; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Relationships between gene polymorphisms of folate-related proteins and vitamins and metabolites in pregnant women and neonates.
Topics: Adult; Brazil; DNA; Embryonic Development; Ethnicity; Female; Folic Acid; Glutamate Carboxypeptidase II; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pregnancy; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylhomocysteine; S-Adenosylmethionine; Socioeconomic Factors; Vitamin B 12; Vitamin B Complex; Young Adult | 2008 |
Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation.
Topics: Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Folic Acid; Glucose; Homocysteine; Humans; Insulin; Methionine; Methylation; S-Adenosylmethionine; Sulfur | 2009 |
Folate and S-adenosylmethionine modulate synaptic activity in cultured cortical neurons: acute differential impact on normal and apolipoprotein-deficient mice.
Topics: Acetylcholine; Animals; Apolipoproteins E; Cells, Cultured; Cerebral Cortex; Folic Acid; Mice; Mice, Inbred C57BL; Neurons; Reference Values; S-Adenosylmethionine; Synapses; Time Factors | 2008 |
Are nutritional supplements ready for prime time?
Topics: Antidepressive Agents; Depressive Disorder; Dietary Supplements; Dose-Response Relationship, Drug; Fatty Acids, Omega-3; Folic Acid; Humans; Hypericum; Randomized Controlled Trials as Topic; S-Adenosylmethionine; Treatment Outcome | 2008 |
Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools.
Topics: Biogenic Polyamines; Cell Line, Tumor; Cell Proliferation; Colon; Folic Acid; Humans; Male; Nucleotides; Prostate; S-Adenosylmethionine | 2009 |
Methylation status and neurodegenerative markers in Parkinson disease.
Topics: Aged; alpha-Synuclein; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Biomarkers; Blood Platelets; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Nerve Degeneration; Parkinson Disease; Peptide Fragments; S-Adenosylhomocysteine; S-Adenosylmethionine; Substantia Nigra; Ultrasonography; Vitamin B 6 | 2009 |
Body mass index is an important determinant of methylation biomarkers in women of reproductive ages.
Topics: Adult; Biomarkers; Body Mass Index; Female; Fertility; Folic Acid; Homocysteine; Humans; Life Style; Methylation; Middle Aged; Multivariate Analysis; Netherlands; S-Adenosylhomocysteine; S-Adenosylmethionine; Surveys and Questionnaires; Vitamin B 12; Young Adult | 2009 |
Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child.
Topics: Adult; Birth Weight; CpG Islands; Cross-Sectional Studies; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Gene Expression Regulation; Humans; Infant; Insulin-Like Growth Factor II; Male; Preconception Care; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine | 2009 |
Enhanced one-carbon flux towards DNA methylation: Effect of dietary methyl supplements against gamma-radiation-induced epigenetic modifications.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon; Choline; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Folic Acid; Gamma Rays; Homocysteine; Male; Mice; S-Adenosylmethionine; Time Factors | 2010 |
High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family.
Topics: Adenosine; Antiprotozoal Agents; Biological Transport; Biopterins; Blotting, Western; Cell Membrane; Drug Resistance, Bacterial; Folic Acid; Folic Acid Antagonists; Green Fluorescent Proteins; Leishmania; Membrane Transport Proteins; Methotrexate; Microscopy, Fluorescence; Mutation; Protozoan Proteins; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylmethionine | 2010 |
S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Apolipoprotein E4; Chi-Square Distribution; Cross-Sectional Studies; Fasting; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Mental Status Schedule; Middle Aged; S-Adenosylmethionine; White People | 2010 |
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Carbon; Cell Line; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Epigenomics; Female; Folic Acid; Humans; Male; Methylation; Mice; Mice, 129 Strain; Mice, Transgenic; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency | 2011 |
Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation.
Topics: Animals; Carbon; DNA-Binding Proteins; Female; Fibroblasts; Folic Acid; Folic Acid Deficiency; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Mutant Strains; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Thymidine Monophosphate; Transcription Factors | 2010 |
Using complementary and alternative medicines for depression.
Topics: Antidepressive Agents; Complementary Therapies; Depressive Disorder; Fatty Acids, Omega-3; Folic Acid; Humans; Hypericum; Phytotherapy; S-Adenosylmethionine | 2010 |
Thymidylate synthase gene polymorphisms and markers of DNA methylation capacity.
Topics: Adult; Case-Control Studies; Cholesterol; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Genetic Association Studies; Genetic Markers; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; S-Adenosylhomocysteine; S-Adenosylmethionine; Serum Albumin; Thymidylate Synthase; Vitamin B 12 | 2011 |
Folic acid supplementation during early hepatocarcinogenesis: cellular and molecular effects.
Topics: Animals; Apoptosis; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Dietary Supplements; DNA Damage; DNA Methylation; Folic Acid; Gene Expression; Genes, myc; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Precancerous Conditions; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
The structure of a tetrahydrofolate-sensing riboswitch reveals two ligand binding sites in a single aptamer.
Topics: Aptamers, Nucleotide; Bacillus subtilis; Bacterial Proteins; Base Sequence; Binding Sites; Calorimetry; Folic Acid; Gene Expression Regulation, Bacterial; Guanine; Leucovorin; Ligands; Magnesium; Molecular Sequence Data; Nucleic Acid Conformation; Point Mutation; Protein Binding; Protein Structure, Secondary; Riboswitch; RNA; S-Adenosylmethionine; Streptococcus mutans; Terminator Regions, Genetic; Tetrahydrofolates; Thermodynamics; Transcription, Genetic | 2011 |
Natural supplements for mental health. Some complementary and alternative therapies may be worth trying.
Topics: Complementary Therapies; Dietary Supplements; Fatty Acids, Omega-3; Folic Acid; Ginkgo biloba; Humans; Hypericum; Melatonin; Mental Disorders; Mental Health; S-Adenosylmethionine; Valerian | 2011 |
Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo.
Topics: Animals; Antirheumatic Agents; Dactinomycin; Dexamethasone; Enzyme Inhibitors; Folic Acid; Gene Expression Regulation; Hep G2 Cells; Humans; Male; Methionine; Methionine Adenosyltransferase; Methotrexate; Mice; Mice, Inbred C57BL; RNA, Messenger; S-Adenosylmethionine | 2012 |
Post-translational stabilization of thiopurine S-methyltransferase by S-adenosyl-L-methionine reveals regulation of TPMT*1 and *3C allozymes.
Topics: Cell Culture Techniques; Culture Media; Enzyme Inhibitors; Erythrocytes; Folic Acid; Genotype; HEK293 Cells; Hep G2 Cells; Humans; Isoenzymes; Methionine; Methionine Adenosyltransferase; Methyltransferases; Protein Processing, Post-Translational; Protein Stability; S-Adenosylmethionine | 2012 |
Sulfamethazine suppresses epigenetic silencing in Arabidopsis by impairing folate synthesis.
Topics: 4-Aminobenzoic Acid; Arabidopsis; DNA Methylation; DNA Transposable Elements; DNA, Plant; Epigenesis, Genetic; Folic Acid; Gene Expression Regulation, Plant; Gene Silencing; Histones; Molecular Sequence Data; Plants, Genetically Modified; RNA, Plant; RNA, Small Interfering; S-Adenosylmethionine; Sulfamethazine; Transgenes | 2012 |
Relationships among biomarkers of one-carbon metabolism.
Topics: Adult; Aging; Biomarkers; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; One-Carbon Group Transferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Characteristics; Vitamin B 12; Young Adult | 2012 |
Supra-physiological folic acid concentrations induce aberrant DNA methylation in normal human cells in vitro.
Topics: Cell Line; CpG Islands; DNA Methylation; Enterocytes; Fibroblasts; Folic Acid; Humans; Long Interspersed Nucleotide Elements; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenium | 2012 |
Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation.
Topics: Asian People; Biopsy; Black or African American; Blotting, Western; Folic Acid; Gene Expression Regulation, Enzymologic; Genes, Reporter; Genetic Association Studies; Genomics; Genotype; Glycine N-Methyltransferase; HEK293 Cells; Hep G2 Cells; Humans; Liver; Methionine; Methionine Adenosyltransferase; Phenotype; Polymorphism, Single Nucleotide; S-Adenosylmethionine; Sequence Analysis, DNA; Transfection; White People | 2012 |
Dietary folic acid intake differentially affects methionine metabolism markers and hippocampus morphology in aged rats.
Topics: Aging; Animals; Astrocytes; Biomarkers; Cognitive Dysfunction; Diet; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Hippocampus; Hyperhomocysteinemia; Male; Methionine; Methylation; Neurons; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic.
Topics: Animals; Arsenites; Epigenomics; Female; Fetal Weight; Fetus; Folic Acid; Gene Expression Regulation, Developmental; Liver; Male; Mice; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Sodium Compounds | 2012 |
Determinants of the essential one-carbon metabolism metabolites, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine and folate, in cerebrospinal fluid.
Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Immunoassay; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Vitamin B 12 | 2012 |
Plasma choline and betaine correlate with serum folate, plasma S-adenosyl-methionine and S-adenosyl-homocysteine in healthy volunteers.
Topics: Adolescent; Adult; Betaine; Choline; Chromatography, High Pressure Liquid; DNA Methylation; Female; Folic Acid; Gonadal Steroid Hormones; Humans; Linear Models; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Sex Factors; Tandem Mass Spectrometry; Young Adult | 2013 |
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Homocystinuria; Interferon-gamma; Liver; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Mice, Transgenic; Muscle Spasticity; Placenta; Pregnancy; Pregnancy Complications; Psychotic Disorders; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 2013 |
Lowering homocysteine levels may prevent cardiovascular impairments? Possible therapeutic behaviors.
Topics: Acetylcysteine; Aspirin; Blood Vessels; Cardiovascular Diseases; Clopidogrel; Diuretics; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Platelet Aggregation Inhibitors; S-Adenosylmethionine; Ticlopidine; Vitamin B 12; Vitamin B 6 | 2012 |
The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model.
Topics: Cystathionine beta-Synthase; Down Syndrome; Folic Acid; Folic Acid Deficiency; Half-Life; Homocysteine; Humans; Methionine; Methylation; Models, Theoretical; Nutrition Surveys; Nutritional Status; Oxidative Stress; S-Adenosylmethionine; Vitamin B 12 Deficiency; Vitamin B Complex; Vitamins | 2013 |
The beneficial effect of folate-enriched egg on the folate and homocysteine levels in rats fed a folate- and choline-deficient diet.
Topics: Animal Feed; Animals; Choline; Diet; Egg Yolk; Folic Acid; Food, Fortified; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 2012 |
Folic acid acts through DNA methyltransferases to induce the differentiation of neural stem cells into neurons.
Topics: Animals; Cell Differentiation; Cytidine; DNA (Cytosine-5-)-Methyltransferases; Folic Acid; Intracellular Space; Neural Stem Cells; Neurons; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
[State of thiol exchange in patients with psoriasis and its possible correction].
Topics: Ascorbic Acid; Calcium Gluconate; Erythrocytes; Female; Folic Acid; Glutathione; Glutathione Peroxidase; Humans; Infusions, Intravenous; Male; Psoriasis; S-Adenosylmethionine; Severity of Illness Index; Succinates; Sulfhydryl Compounds; Vitamin B 12 | 2013 |
DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.
Topics: Adolescent; Adult; Betaine; Biomarkers; Choline; Cysteine; Diet; Diet Records; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; DNA Methylation; Feeding Behavior; Female; Folic Acid; Gambia; Homocysteine; Humans; Linear Models; Methionine; Middle Aged; Nutrition Assessment; Prospective Studies; Riboflavin; Rural Population; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Vitamin B 12; Vitamin B 6; Young Adult | 2013 |
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Topics: Adenosine; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; DNA Methylation; Female; Fluorescent Antibody Technique, Indirect; Folic Acid; Glycine N-Methyltransferase; Hepatocytes; Homocysteine; Humans; Liver; Liver Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Knockout; Minor Histocompatibility Antigens; Protein Transport; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uracil | 2014 |
Nutritional control of epigenetic processes in yeast and human cells.
Topics: Epigenesis, Genetic; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Histones; Humans; Infant, Newborn; K562 Cells; Methionine; Methylation; Neural Tube Defects; Pregnancy; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Species Specificity | 2013 |
5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion.
Topics: Acetylation; Animals; Arylamine N-Acetyltransferase; Female; Folic Acid; Glutamates; Humans; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; S-Adenosylmethionine; Sequence Deletion; Sex Factors; Tetrahydrofolates | 2013 |
Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects.
Topics: Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Disease Models, Animal; DNA Copy Number Variations; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Leucovorin; Methotrexate; Mice, Inbred C57BL; MicroRNAs; Neural Tube Defects; Real-Time Polymerase Chain Reaction; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2014 |
Folate and cobalamin modify associations between S-adenosylmethionine and methylated arsenic metabolites in arsenic-exposed Bangladeshi adults.
Topics: Adult; Aged; Arsenic; Arsenic Poisoning; Arsenicals; Bangladesh; Cross-Sectional Studies; Drinking Water; Environmental Exposure; Female; Folic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 2014 |
Effect of vitamin B deprivation during pregnancy and lactation on homocysteine metabolism and related metabolites in brain and plasma of mice offspring.
Topics: Animals; Brain; Female; Folic Acid; Homocysteine; Lactation; Male; Mice; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Vitamin B Deficiency | 2014 |
Interaction of plasma glutathione redox and folate deficiency on arsenic methylation capacity in Bangladeshi adults.
Topics: Adult; Aged; Arsenic; Arsenicals; Bangladesh; Cacodylic Acid; Cross-Sectional Studies; Drinking Water; Environmental Exposure; Female; Folic Acid; Folic Acid Deficiency; Glutathione; Glutathione Disulfide; Humans; Male; Methylation; Methyltransferases; Middle Aged; Oxidation-Reduction; S-Adenosylmethionine | 2014 |
Validation of a food-frequency questionnaire assessment of methyl-group donors using estimated diet records and plasma biomarkers: the method of triads.
Topics: Adolescent; Adult; Belgium; Betaine; Biomarkers; Choline; Diet; Diet Records; Energy Intake; Feeding Behavior; Female; Folic Acid; Humans; Methionine; Methylation; Middle Aged; Nutrition Assessment; Nutritional Status; Reproducibility of Results; S-Adenosylhomocysteine; S-Adenosylmethionine; Surveys and Questionnaires; Young Adult | 2014 |
Aberrant DNA methylation of the PDGF gene in homocysteine‑mediated VSMC proliferation and its underlying mechanism.
Topics: Cell Proliferation; Cells, Cultured; DNA Methylation; Folic Acid; G1 Phase Cell Cycle Checkpoints; Homocysteine; Humans; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Promoter Regions, Genetic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Umbilical Cord | 2014 |
Quantification of folate metabolites in serum using ultraperformance liquid chromatography tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Limit of Detection; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolates | 2014 |
Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Dihydropteroate Synthase; Drug Evaluation, Preclinical; Drug Synergism; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Bacterial; Humans; Methionine; Mycobacterium tuberculosis; S-Adenosylmethionine; Species Specificity; Tetrahydrofolate Dehydrogenase; Triazines | 2014 |
Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.
Topics: Angiotensin II; Animals; Binding Sites; CCCTC-Binding Factor; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; DNA Methylation; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Male; Mice, Inbred C57BL; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; S-Adenosylmethionine; Sp1 Transcription Factor; Telomerase; Telomere; Telomere Shortening; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2015 |
Both the folate cycle and betaine-homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts.
Topics: 5-Methylcytosine; Animals; Antimetabolites, Antineoplastic; Betaine-Homocysteine S-Methyltransferase; Blastocyst; Cell Lineage; Cells, Cultured; DNA Methylation; Embryo, Mammalian; Female; Fluorescent Antibody Technique; Folic Acid; Gene Expression Regulation, Enzymologic; Liver; Methotrexate; Mice; S-Adenosylmethionine; snRNP Core Proteins | 2015 |
Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Folic Acid; Folic Acid Deficiency; Gene Silencing; Hippocampus; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Presenilin-1; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, DNA | 2015 |
Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation.
Topics: Aged; Blood Cells; Calcium; Cross-Sectional Studies; Dietary Supplements; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine; Telomere; Tetrahydrofolates; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin D | 2016 |
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Topics: Animals; Carbon; DNA Damage; DNA Methylation; Folic Acid; Genotype; Glycine N-Methyltransferase; Hep G2 Cells; Homocysteine; Humans; Liver; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Neoplasms; Nucleotides; Nutritional Status; Purines; S-Adenosylmethionine; Uracil | 2015 |
Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies.
Topics: Animals; Chickens; Deuterium; Folic Acid; Folic Acid Deficiency; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
MTHFD1 controls DNA methylation in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cytoplasm; DNA Demethylation; DNA Methylation; Epigenesis, Genetic; Folic Acid; Gene Expression Regulation, Plant; Gene Silencing; Green Fluorescent Proteins; Histones; Homeostasis; Lysine; Methenyltetrahydrofolate Cyclohydrolase; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Models, Biological; Mutation; Protein Transport; S-Adenosylmethionine; Tetrahydrofolates | 2016 |
Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta.
Topics: Adult; Albumins; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Apolipoprotein E4; Female; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Reference Values; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 | 2016 |
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.
Topics: Aminohydrolases; Animals; Choline; Dietary Supplements; Embryo, Mammalian; Embryonic Development; Female; Folic Acid; Formate-Tetrahydrofolate Ligase; Logistic Models; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Transgenic; Multienzyme Complexes; Placenta; Polymorphism, Single Nucleotide; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro.
Topics: Animals; Apolipoproteins E; Chemokine CCL2; Dietary Supplements; DNA Methylation; Folic Acid; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Plaque, Atherosclerotic; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Vascular Endothelial Growth Factor A; Vitamin B Complex | 2017 |
Modulation of dietary folate with age confers selective hepatocellular epigenetic imprints through DNA methylation.
Topics: Aging; Animals; Cyclins; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Epigenesis, Genetic; Folic Acid; Gene Expression Regulation; Genes, myc; Genes, Tumor Suppressor; JNK Mitogen-Activated Protein Kinases; Liver; Male; Rats, Wistar; S-Adenosylmethionine; Tetrahydrofolates | 2018 |
Cobalamin Deficiency Results in Increased Production of Formate Secondary to Decreased Mitochondrial Oxidation of One-Carbon Units in Rats.
Topics: Animals; Carbon; Carbon Dioxide; Cytosol; Folic Acid; Formates; Glycine; Liver; Male; Mitochondria, Liver; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Random Allocation; Rats, Sprague-Dawley; S-Adenosylmethionine; Sarcosine; Serine; Vitamin B 12; Vitamin B 12 Deficiency | 2018 |
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.
Topics: Animals; Congenital Abnormalities; Diet; Disease Models, Animal; DNA Methylation; Female; Fetal Development; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Formate-Tetrahydrofolate Ligase; Genotype; Ligases; Liver; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Mice; Multifunctional Enzymes; Placenta; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Pregnancy, Animal; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 2018 |
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
Topics: Aging; Amyloid beta-Peptides; Animals; Anxiety; Brain; Cell Survival; Cerebral Cortex; Choline; CpG Islands; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Glutamic Acid; Homocystinuria; Liver; Male; Memory Disorders; Memory, Short-Term; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice, Inbred BALB C; Muscle Spasticity; Nerve Growth Factors; Neurons; Phospholipids; Psychotic Disorders; RNA, Messenger; S-Adenosylmethionine; Synaptic Transmission | 2019 |
Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease.
Topics: Animals; Betaine; Carbon; Choline; Diet, High-Fat; Dietary Supplements; DNA Methylation; Folic Acid; Glutathione; Homocysteine; Liver; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; S-Adenosylmethionine | 2019 |
Low Maternal Dietary Folate Alters Retrotranspose by Methylation Regulation in Intrauterine Growth Retardation (IUGR) Fetuses in a Mouse Model.
Topics: Animals; Disease Models, Animal; DNA Methylation; Female; Fetal Growth Retardation; Fetus; Folic Acid; Folic Acid Deficiency; Long Interspersed Nucleotide Elements; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 2019 |
Hyperhomocysteinemia is key for increased susceptibility to PND in aged mice.
Topics: Animals; Cognition; Dietary Supplements; Folic Acid; Homocysteine; Hyperhomocysteinemia; Mice; Postoperative Cognitive Complications; Postoperative Period; Preoperative Period; Risk Factors; S-Adenosylmethionine; Vitamin B 12 | 2019 |
Elimination of human folypolyglutamate synthetase alters programming and plasticity of somatic cells.
Topics: Cell Differentiation; Cell Division; Cell Line; Cell Plasticity; Cell Proliferation; DNA Methylation; Folic Acid; gamma-Aminobutyric Acid; Gene Expression; Genes, Homeobox; Glutamic Acid; HEK293 Cells; Humans; Metabolic Networks and Pathways; Myocytes, Cardiac; Nanog Homeobox Protein; Neural Stem Cells; Octamer Transcription Factor-3; Peptide Synthases; S-Adenosylmethionine; Sex-Determining Region Y Protein | 2019 |
Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-Specific Placental Transcription Changes.
Topics: Animals; Dietary Supplements; DNA Methylation; Female; Folic Acid; Gene Expression; Homocystinuria; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Muscle Spasticity; Phthalic Acids; Placenta; Pregnancy; Psychotic Disorders; S-Adenosylmethionine; Sex Factors; Transcriptome | 2021 |
One-carbon metabolism during the menstrual cycle and pregnancy.
Topics: Carbon; Estradiol; Female; Folic Acid; Homocysteine; Humans; Menstrual Cycle; Pregnancy; S-Adenosylmethionine; Vitamin B 12 | 2021 |
Methyl Metabolism and the Clock: An Ancient Story With New Perspectives.
Topics: Animals; Circadian Rhythm; Folic Acid; Humans; Mammals; Methionine; Methylation; S-Adenosylmethionine | 2022 |
5,10-Methylenetetrahydrofolate reductase becomes phosphorylated during meiotic maturation in mouse oocytes.
Topics: Animals; Carbon; Folic Acid; Meiosis; Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Mice; Oocytes; S-Adenosylmethionine | 2022 |
Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content.
Topics: Adenoma; Colorectal Neoplasms; DNA; DNA Methylation; Folate Receptor 2; Folic Acid; Humans; Inflammatory Bowel Diseases; Liquid Biopsy; RNA, Messenger; S-Adenosylmethionine | 2022 |
As3MT-mediated SAM consumption, which inhibits the methylation of histones and LINE1, is involved in arsenic-induced male reproductive damage.
Topics: 5-Methylcytosine; Animals; Arsenic; Arsenic Poisoning; DNA; DNA Methylation; Folic Acid; Histones; Male; Methyltransferases; Mice; S-Adenosylmethionine; Semen; Vitamin B 12 | 2022 |
Dietary-derived vitamin B12 protects Caenorhabditis elegans from thiol-reducing agents.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Caenorhabditis elegans; Carbon; Dithiothreitol; Folic Acid; Homocysteine; Hydrogen Sulfide; Ligases; Lipids; Mercaptoethanol; Methionine; Methyltransferases; Nucleic Acids; Oxygen; Reducing Agents; S-Adenosylmethionine; Sulfhydryl Compounds; Vitamin B 12; Vitamins | 2022 |
Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions.
Topics: Aldehyde Dehydrogenase 1 Family; Folic Acid; Glycine; Humans; Metabolomics; Methylation; Neoplasms; Retinal Dehydrogenase; S-Adenosylmethionine | 2022 |
The impact of pre-pregnancy folic acid intake on placental DNA methylation in a fortified cohort.
Topics: Carbon; DNA Methylation; Female; Folic Acid; Genotype; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Placenta; Pregnancy; S-Adenosylmethionine; Vitamin B 12 | 2023 |
One-carbon metabolite supplementation to heifers for the first 14 d of the estrous cycle alters the plasma and hepatic one-carbon metabolite pool and methionine-folate cycle enzyme transcript abundance in a dose-dependent manner.
Topics: Animals; Carbon; Cattle; Choline; Dietary Supplements; Estrous Cycle; Female; Folic Acid; Liver; Methionine; Racemethionine; Rumen; S-Adenosylmethionine | 2023 |
Vitamin D, Folic Acid and Vitamin B
Topics: Animals; Folic Acid; Memory Disorders; Mice; Mice, Inbred C57BL; S-Adenosylmethionine; Vitamin B 12; Vitamin B Complex; Vitamin D; Vitamin D Deficiency | 2022 |
α-Lipoic acid eliminates dioxin-induced offspring sexual immaturity by improving abnormalities in folic acid metabolism.
Topics: Animals; Female; Fetus; Folic Acid; Hypothalamus; Male; Maternal Exposure; Polychlorinated Dibenzodioxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Reproduction; S-Adenosylmethionine; Sex Characteristics; Sexual Development; Thioctic Acid | 2023 |
Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase.
Topics: Animals; Fibrosis; Folic Acid; Glycine N-Methyltransferase; Humans; Kidney; Kidney Diseases; Liver; Mice; S-Adenosylmethionine; Ureteral Obstruction | 2023 |
Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women.
Topics: Adolescent; Adult; Betaine; Carbon; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Pregnancy; S-Adenosylmethionine; Young Adult | 2023 |
Plasma One-Carbon Metabolism-Related Micronutrients and the Risk of Breast Cancer: Involvement of DNA Methylation.
Topics: Breast Neoplasms; Carbon; Case-Control Studies; Choline; Cysteine; DNA Methylation; Female; Folic Acid; Humans; Methionine; Micronutrients; Racemethionine; S-Adenosylmethionine; Trace Elements | 2023 |
The importance of preconception Hcy testing: identification of a folate trap syndrome in a woman attending an assisted reproduction program.
Topics: Female; Folic Acid; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy; Reproduction; S-Adenosylmethionine | 2023 |
Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Folic Acid; Methionine; S-Adenosylmethionine; Vitamin B 12 | 2023 |
SAM/SAH Mediates Parental Folate Deficiency-Induced Neural Cell Apoptosis in Neonatal Rat Offspring: The Expression of Bcl-2, Bax, and Caspase-3.
Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Female; Folic Acid; Folic Acid Deficiency; Male; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine | 2023 |
THE FORMATION AND ISOLATION OF LONG-CHAIN ACYL CARNITINES IN MITOCHONDRIA.
Topics: Animals; Carbon Isotopes; Carnitine; Cattle; Chromatography; Folic Acid; Metabolism; Mitochondria; Myocardium; Palmitic Acid; Phospholipids; Research; Vitamin B Complex | 1965 |
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.
Topics: Acyltransferases; Animals; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Leukemia, Lymphoid; Liver; Mice; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Tetrahydrofolates; Tumor Cells, Cultured | 1992 |
Human dihydrofolate reductase: reduction of alternative substrates, pH effects, and inhibition by deazafolates.
Topics: Folic Acid; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kinetics; Mathematics; Models, Theoretical; Oxidation-Reduction; Recombinant Proteins; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1992 |
Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate.
Topics: Binding Sites; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Molecular; Molecular Structure; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase; X-Ray Diffraction | 1990 |
Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues.
Topics: Aminopterin; Animals; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Liver; Methotrexate; Protein Binding; Structure-Activity Relationship | 1984 |
Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Topics: Binding Sites; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Escherichia coli; Folic Acid; Ligands; Models, Molecular; Molecular Structure; Protein Conformation; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 1995 |
5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: synthesis and binding interaction with folylpolyglutamate synthetase.
Topics: Cell Division; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamic Acid; Humans; Ornithine; Peptide Synthases; Recombinant Proteins | 1999 |