Page last updated: 2024-08-23

s-adenosylmethionine and 5-methyltetrahydrofolate

s-adenosylmethionine has been researched along with 5-methyltetrahydrofolate in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (16.98)	18.7374
1990's	18 (33.96)	18.2507
2000's	7 (13.21)	29.6817
2010's	15 (28.30)	24.3611
2020's	4 (7.55)	2.80

Authors

Authors	Studies
Hyland, K; Smith, I; Surtees, R	1
Hyland, K; Surtees, R	2
Liteplo, RG	1
Bottiglieri, T; Chanarin, I; Deacon, R; Lumb, M; Perry, J	1
Chanarin, I; Deacon, R; Lumb, M; Perry, J	2
Fell, D; Steele, RD	1
Hilton, MA; Hoffman, JL; Sparks, MK	1
Makar, AB; Tephly, TR	1
Bowron, A; Heales, S; Surtees, R	1
Stubbe, J	1
Drummond, JT; Matthews, RG	1
Blumenthal, RM; Drummond, JT; Huang, S; Matthews, RG	1
May, BA	1
Angst, CP; Fowler, B; Haefeli, WE; Jordan, PP; Loehrer, FM; Ritz, R	1
Angst, CP; Browne, G; Fowler, B; Frick, G; Haefeli, WE; Loehrer, FM	1
Goulding, CW; Matthews, RG; Postigo, D	1
Angst, CP; Fowler, B; Haefeli, WE; Loehrer, FM; Schwab, R	1
Assaraf, YG; Bunni, M; Drori, S; Jansen, G; Kathmann, I; Mauritz, RM; Peters, GJ; Pinedo, HM; Priest, DG; Schornagel, JH; Sprecher, H; Westerhof, GR	1
Brunone, M; De Santo, NG; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V	1
Huang, S; Jarrett, JT; Matthews, RG	1
Clelland, J; Hann, I; Surtees, R	1
Bottiglieri, T; Charles, HC; Gray, L; Hyland, K; Jaeken, J; Kahler, SG; Lazeyras, F; Van Hove, JL; Zeisel, SH	1
Finkelstein, JD	1
Quadros, EV; Rothenberg, SP; Sobti, P	1
Bandarian, V; Ludwig, ML; Matthews, RG	1
BUCHANAN, JM; ROSENTHAL, S; SMITH, LC	1
Becker, A; Bouter, LM; Dekker, JM; Heine, RJ; Henry, RM; Jakobs, C; Kostense, PJ; Nijpels, G; Smulders, YM; Spijkerman, AM; Stehouwer, CD; Teerlink, T	1
Jakobs, C; Jansen, EE; Mulder, C; Scheltens, P; Schoonenboom, NS; van Kamp, GJ; Verhoeven, NM	1
Miller, AL	1
Cvetanovska, G; Frommann, I; Jessen, F; Kölsch, H; Kornhuber, J; Lewczuk, P; Linnebank, M; Maier, W; Popp, J; Smulders, Y	1
Basten, GP; de Roos, B; Duncan, G; Duthie, SJ; Horgan, G; Pirie, L; Powers, HJ; Reid, M; Rucklidge, G	1
Eckert, R; Herrmann, W; Kasoha, M; Kirsch, SH; Obeid, R	1
Howland, RH	1
Alpert, JE; Arning, E; Bottiglieri, T; Fava, M; Mischoulon, D; Papakostas, GI	1
Cassiello, CF; Iovieno, N; Papakostas, GI	1
Chen, YM; Chiang, EP; Lin, WL; Lin, YJ; Tang, FY; Wang, YC	1
Brenneman, D; Butcher, NJ; Grant, DM; Minchin, RF; Sugamori, KS; Witham, KL	1
Guan, T; Guan, Z; Guo, J; Li, G; Niu, B; Wang, F; Wang, G; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhang, Z; Zhu, Z	1
Bottiglieri, T; Cassiello, C; Fava, M; Papakostas, GI; Roffman, J; Shelton, RC; Stahl, SM; Zajecka, JM	1
Guan, Z; Niu, B; Wang, J; Wang, X; Wang, Z; Xie, Q; Zhang, T; Zhao, X; Zhu, Z	1
Bodis, M; Geisel, J; Herrmann, M; Herrmann, W; Hübner, U; Kirsch, SH; Laufs, U; Pusceddu, I; Wagenpfeil, S; Werner, C	1
Kornhuber, J; Lewczuk, P; Linnebank, M; Oikonomidi, A; Popp, J; Semmler, A; Smulders, Y	1
Bhat, JA; Dar, NJ; Gupta, AP; Hamid, A; Kaur, J; Najar, RA; Rahat, B; Wani, NA	1
Cantley, LC; Johnson, JL; Li, Q; Ramsamooj, S; Sharra, K; Yaron, TM; Zheng, Y	1
Chang, S; Li, B; Li, R; Liang, L; Liu, C; Niu, B; Qin, C; Wang, L; Wang, X; Zhang, L; Zhang, M; Zhang, T	1
Lande, RG	1
Bharadwaj, B; Dhiman, P; Pillai, RR; Premkumar, N; Rajendiran, S; Ranjan, VP; Wilson, AB	1
Fukuoka, H; Horiguchi, S; Kagawa, Y; Kawabata, T; Kubo, Y; Nishikawa, M; Shoji, K; Tajima, A	1
Chedia, AM; Finegold, DN; McClain, LL; Pan, L; Peters, DG; Rengasamy, M; Sabol, R; Segretti, AM; Shaw, P	1

Reviews

6 review(s) available for s-adenosylmethionine and 5-methyltetrahydrofolate

Article	Year
Nitrous oxide, vitamin B12 deficiency and the methyl folate trap. Nutrition reviews, 1982, Volume: 40, Issue:5 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Humans; Liver; Macaca fascicularis; Methionine; Methylmalonyl-CoA Mutase; Nervous System Diseases; Nitrous Oxide; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 Deficiency	1982
Binding site revealed of nature's most beautiful cofactor. Science (New York, N.Y.), 1994, Dec-09, Volume: 266, Issue:5191 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Binding Sites; Escherichia coli; Methylation; Oxidation-Reduction; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12	1994
Pathways and regulation of homocysteine metabolism in mammals. Seminars in thrombosis and hemostasis, 2000, Volume: 26, Issue:3 Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Heme; Homocysteine; Isoenzymes; Kinetics; Mammals; Methionine; Methionine Adenosyltransferase; Organ Specificity; Oxidation-Reduction; Pyridoxal Phosphate; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Tetrahydrofolates	2000
The methylation, neurotransmitter, and antioxidant connections between folate and depression. Alternative medicine review : a journal of clinical therapeutic, 2008, Volume: 13, Issue:3 Topics: Antioxidants; Biopterins; Depression; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Methylation; Neurotransmitter Agents; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates	2008
Folates and S-adenosylmethionine for major depressive disorder. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2012, Volume: 57, Issue:7 Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Double-Blind Method; Drug Therapy, Combination; Evidence-Based Medicine; Humans; One-Carbon Group Transferases; Pteroylpolyglutamic Acids; Randomized Controlled Trials as Topic; S-Adenosylmethionine; Tetrahydrofolates	2012
Nutraceutical Augmentation Strategies for Depression: A Narrative Review. The Journal of the American Osteopathic Association, 2020, Feb-01, Volume: 120, Issue:2 Topics: Antidepressive Agents; Depressive Disorder; Dietary Supplements; Fatty Acids, Omega-3; Humans; Hydroxycholecalciferols; Meta-Analysis as Topic; S-Adenosylmethionine; Systematic Reviews as Topic; Tetrahydrofolates	2020

Trials

7 trial(s) available for s-adenosylmethionine and 5-methyltetrahydrofolate

Article	Year
Metabolic consequences of folate-induced reduction of hyperhomocysteinemia in uremia. Journal of the American Society of Nephrology : JASN, 1997, Volume: 8, Issue:12 Topics: Erythrocyte Membrane; Homocysteine; Humans; Membrane Proteins; Methionine; Methylation; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uremia	1997
Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:4 Topics: Antidotes; Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Demyelinating Diseases; Drug Interactions; Humans; Infant; Leucovorin; Methionine; Methotrexate; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Tetrahydrofolates	1998
S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study. Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:4 Topics: Aged; Brachial Artery; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nitroglycerin; Regional Blood Flow; Risk Factors; S-Adenosylmethionine; Tetrahydrofolates; Ultrasonography; Vasodilation; Vasodilator Agents; Vitamin B 12; Vitamin B 6	2005
Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation. Journal of proteome research, 2010, Apr-05, Volume: 9, Issue:4 Topics: Adult; Blood Coagulation; Blood Proteins; Dietary Supplements; Drug Administration Schedule; Female; Folic Acid; Homocysteine; Humans; Immunity; Inflammation; Male; Proteome; Proteomics; S-Adenosylmethionine; Tetrahydrofolates	2010
Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults. Metabolism: clinical and experimental, 2011, Volume: 60, Issue:5 Topics: Aged; Aged, 80 and over; Aging; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B Complex	2011
Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. The Journal of clinical psychiatry, 2012, Volume: 73, Issue:6 Topics: Biological Availability; Depressive Disorder, Major; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Psychiatric Status Rating Scales; S-Adenosylhomocysteine; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates	2012
Effect of adjunctive L-methylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results from a randomized clinical trial. The Journal of clinical psychiatry, 2014, Volume: 75, Issue:8 Topics: Adolescent; Adult; Aged; Aldehydes; Biomarkers; C-Reactive Protein; Depressive Disorder, Treatment-Resistant; Drug Therapy, Combination; Female; Genotype; Humans; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates; Young Adult	2014

Other Studies

40 other study(ies) available for s-adenosylmethionine and 5-methyltetrahydrofolate

Article	Year
Central-nervous-system methyl-group metabolism in children with neurological complications of HIV infection. Lancet (London, England), 1990, Mar-17, Volume: 335, Issue:8690 Topics: Biopterins; Child, Preschool; Encephalitis; HIV Seropositivity; Humans; Infant; Methionine; Methylation; Neopterin; S-Adenosylmethionine; Tetrahydrofolates	1990
Cerebrospinal fluid concentrations of S-adenosylmethionine, methionine, and 5-methyltetrahydrofolate in a reference population: cerebrospinal fluid S-adenosylmethionine declines with age in humans. Biochemical medicine and metabolic biology, 1990, Volume: 44, Issue:2 Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Methionine; S-Adenosylmethionine; Tetrahydrofolates	1990
Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis. Experimental cell research, 1990, Volume: 186, Issue:2 Topics: Adenosine; Cell Division; Culture Media; Deoxyadenosines; Homocysteine; Humans; Melanoma, Experimental; Methionine; Phenotype; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Tumor Cells, Cultured	1990
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans. Journal of neurology, neurosurgery, and psychiatry, 1990, Volume: 53, Issue:7 Topics: Adolescent; Akinetic Mutism; Biopterins; Child, Preschool; Humans; Infant; Levodopa; Methionine; NADH, NADPH Oxidoreductases; Phenylketonurias; Pyridoxine; S-Adenosylmethionine; Tetrahydrofolates; Tyrosine	1990
Regulation of 5-methyltetrahydrofolate synthesis. The Biochemical journal, 1989, Mar-01, Volume: 258, Issue:2 Topics: Animals; Liver; Methionine; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates	1989
Oxidation of 5-methyltetrahydrofolate in cobalamin-inactivated rats. The Biochemical journal, 1989, Mar-15, Volume: 258, Issue:3 Topics: Animals; Formyltetrahydrofolates; Methionine; Oxidation-Reduction; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12	1989
Modification of hepatic folate metabolism in rats fed excess retinol. Life sciences, 1986, May-26, Volume: 38, Issue:21 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Dioxide; Folic Acid; Formates; Histidine; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Vitamin A	1986
In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate. Journal of clinical pathology, 1988, Volume: 41, Issue:11 Topics: Adenosine; Animals; Betaine; Carbon Dioxide; Deoxyadenosines; Formyltetrahydrofolates; Glycine; Liver; Male; Methionine; Oxidation-Reduction; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Serine; Tetrahydrofolates; Thionucleosides; Time Factors	1988
Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids. Cancer research, 1983, Volume: 43, Issue:11 Topics: Animals; Diet; Homocysteine; Homocystine; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Liver; Male; Methotrexate; Mice; Mice, Inbred DBA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates	1983
Methionine can open the methyl folate trap. Nutrition reviews, 1983, Volume: 41, Issue:10 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Methionine; Nitrous Oxide; Rats; S-Adenosylmethionine; Tetrahydrofolates	1983
Effect of nitrous oxide and methionine treatments on hepatic S-adenosylmethionine and methylation reactions in the rat. Molecular pharmacology, 1983, Volume: 24, Issue:1 Topics: Animals; Formates; Liver; Male; Methionine; Methylation; Nitrous Oxide; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Tetrahydrofolates	1983
Association of cerebrospinal fluid deficiency of 5-methyltetrahydrofolate, but not S-adenosylmethionine, with reduced concentrations of the acid metabolites of 5-hydroxytryptamine and dopamine. Clinical science (London, England : 1979), 1994, Volume: 86, Issue:6 Topics: Adult; Child; Child, Preschool; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Metabolism, Inborn Errors; S-Adenosylmethionine; Serotonin; Tetrahydrofolates	1994
Nitrous oxide inactivation of cobalamin-dependent methionine synthase from Escherichia coli: characterization of the damage to the enzyme and prosthetic group. Biochemistry, 1994, Mar-29, Volume: 33, Issue:12 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Sequence; Binding Sites; Electrochemistry; Escherichia coli; Homocysteine; Methionine; Molecular Sequence Data; Nitrous Oxide; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; S-Adenosylmethionine; Tetrahydrofolates; Trypsin; Vitamin B 12	1994
Assignment of enzymatic function to specific protein regions of cobalamin-dependent methionine synthase from Escherichia coli. Biochemistry, 1993, Sep-14, Volume: 32, Issue:36 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Binding Sites; Catalysis; Escherichia coli; Homocysteine; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12	1993
A novel antiviral strategy for HIV infection. Medical hypotheses, 1993, Volume: 40, Issue:2 Topics: Acquired Immunodeficiency Syndrome; DNA, Viral; HIV; HIV Infections; HIV Seropositivity; Humans; Methylation; Proviruses; S-Adenosylmethionine; Tetrahydrofolates; Virus Replication; Vitamin B 12	1993
Low whole-blood S-adenosylmethionine and correlation between 5-methyltetrahydrofolate and homocysteine in coronary artery disease. Arteriosclerosis, thrombosis, and vascular biology, 1996, Volume: 16, Issue:6 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Case-Control Studies; Cohort Studies; Coronary Disease; Erythrocytes; Female; Follow-Up Studies; Homocysteine; Humans; Isoenzymes; Lymphocytes; Male; Methionine Adenosyltransferase; Methylation; Middle Aged; Risk Factors; S-Adenosylmethionine; Tetrahydrofolates	1996
Effect of methionine loading on 5-methyltetrahydrofolate, S-adenosylmethionine and S-adenosylhomocysteine in plasma of healthy humans. Clinical science (London, England : 1979), 1996, Volume: 91, Issue:1 Topics: Adult; Chromatography, High Pressure Liquid; Female; Homocysteine; Humans; Kinetics; Male; Methionine; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates	1996
Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine. Biochemistry, 1997, Jul-01, Volume: 36, Issue:26 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bacterial Proteins; Binding Sites; Escherichia coli; Homocysteine; Methylation; Protein Binding; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12	1997
Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2 Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Administration, Oral; Adult; Female; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates	1997
Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells. Advances in enzyme regulation, 1997, Volume: 37 Topics: Adenosine; Biological Transport; Carrier Proteins; Cell Division; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Reduced Folate Carrier Protein; S-Adenosylmethionine; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured	1997
Methionine synthase exists in two distinct conformations that differ in reactivity toward methyltetrahydrofolate, adenosylmethionine, and flavodoxin. Biochemistry, 1998, Apr-21, Volume: 37, Issue:16 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alkyl and Aryl Transferases; Binding, Competitive; Flavodoxin; Glycine; Histidine; Hydrolysis; Methylation; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Conformation; S-Adenosylmethionine; Tetrahydrofolates; Trypsin; Vitamin B 12	1998
One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. Journal of inherited metabolic disease, 1998, Volume: 21, Issue:8 Topics: Amino Acid Metabolism, Inborn Errors; Benzoic Acid; Brain Diseases; Choline; Coma; Female; Glycine; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methionine; Methylation; Phosphatidylcholines; S-Adenosylmethionine; Seizures; Serine; Tetrahydrofolates	1998
Radioenzymatic assay for reductive catalysis of N(5)N(10)-methylenetetrahydrofolate by methylenetetrahydrofolate reductase. Journal of biochemical and biophysical methods, 2000, Nov-20, Volume: 46, Issue:1-2 Topics: Animals; Carbon Radioisotopes; Catalysis; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Flavin-Adenine Dinucleotide; Humans; Kinetics; Liver; Methylenetetrahydrofolate Reductase (NADPH2); NADP; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Tetrahydrofolates; Tumor Cells, Cultured	2000
Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase. Proceedings of the National Academy of Sciences of the United States of America, 2003, Jul-08, Volume: 100, Issue:14 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Substitution; Catalysis; Escherichia coli; Escherichia coli Proteins; Homocysteine; Methionine; Methylation; Mutation, Missense; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Substrate Specificity; Temperature; Tetrahydrofolates; Vitamin B 12	2003
ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. IX. TRANSMETHYLATION FROM S-ADENOSYLMETHIONINE AND 5-METHYLTETRAHYDROFOLATE TO 2-MERCAPTOETHANOL AND HOMOCYSTEINE. The Journal of biological chemistry, 1965, Volume: 240 Topics: Alkylation; Biological Assay; Carbon Isotopes; Folic Acid; Homocysteine; Kinetics; Lactobacillus; Mercaptoethanol; Methionine; Nucleosides; Research; S-Adenosylmethionine; Spectrophotometry; Sulfhydryl Compounds; Tetrahydrofolates; Transferases	1965
The transmethylation cycle in the brain of Alzheimer patients. Neuroscience letters, 2005, Sep-30, Volume: 386, Issue:2 Topics: Aged; Alzheimer Disease; Brain; Chromatography, High Pressure Liquid; Female; Humans; Male; Mass Spectrometry; Membrane Proteins; Methylation; Middle Aged; Presenilin-1; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates	2005
Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2009, Volume: 18, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Biomarkers; Case-Control Studies; Female; Genotype; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Neuropsychological Tests; Peptide Fragments; S-Adenosylmethionine; tau Proteins; Tetrahydrofolates; Young Adult	2009
Dietary supplement drug therapies for depression. Journal of psychosocial nursing and mental health services, 2012, Volume: 50, Issue:6 Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Depressive Disorder; Dietary Supplements; Drug Approval; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Fatty Acids, Omega-3; Humans; Inositol; S-Adenosylmethionine; Self Medication; Tetrahydrofolates; Treatment Outcome; Tryptophan; United States; United States Food and Drug Administration	2012
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage. International journal of cancer, 2014, Feb-15, Volume: 134, Issue:4 Topics: Adenosine; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; DNA Methylation; Female; Fluorescent Antibody Technique, Indirect; Folic Acid; Glycine N-Methyltransferase; Hepatocytes; Homocysteine; Humans; Liver; Liver Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Knockout; Minor Histocompatibility Antigens; Protein Transport; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uracil	2014
5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. PloS one, 2013, Volume: 8, Issue:10 Topics: Acetylation; Animals; Arylamine N-Acetyltransferase; Female; Folic Acid; Glutamates; Humans; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; S-Adenosylmethionine; Sequence Deletion; Sex Factors; Tetrahydrofolates	2013
Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects. Developmental neurobiology, 2014, Volume: 74, Issue:9 Topics: Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Disease Models, Animal; DNA Copy Number Variations; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Leucovorin; Methotrexate; Mice, Inbred C57BL; MicroRNAs; Neural Tube Defects; Real-Time Polymerase Chain Reaction; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates	2014
Quantification of folate metabolites in serum using ultraperformance liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Jul-01, Volume: 962 Topics: Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Limit of Detection; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolates	2014
Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation. European journal of nutrition, 2016, Volume: 55, Issue:5 Topics: Aged; Blood Cells; Calcium; Cross-Sectional Studies; Dietary Supplements; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine; Telomere; Tetrahydrofolates; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin D	2016
Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta. Journal of neurochemistry, 2016, Volume: 139, Issue:2 Topics: Adult; Albumins; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Apolipoprotein E4; Female; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Reference Values; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12	2016
Modulation of dietary folate with age confers selective hepatocellular epigenetic imprints through DNA methylation. The Journal of nutritional biochemistry, 2018, Volume: 53 Topics: Aging; Animals; Cyclins; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Epigenesis, Genetic; Folic Acid; Gene Expression Regulation; Genes, myc; Genes, Tumor Suppressor; JNK Mitogen-Activated Protein Kinases; Liver; Male; Rats, Wistar; S-Adenosylmethionine; Tetrahydrofolates	2018
Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase. Scientific reports, 2019, 03-12, Volume: 9, Issue:1 Topics: Allosteric Regulation; HCT116 Cells; HeLa Cells; Humans; MCF-7 Cells; Methylenetetrahydrofolate Reductase (NADPH2); Phosphorylation; S-Adenosylmethionine; Tetrahydrofolates	2019
Low Maternal Dietary Folate Alters Retrotranspose by Methylation Regulation in Intrauterine Growth Retardation (IUGR) Fetuses in a Mouse Model. Medical science monitor : international medical journal of experimental and clinical research, 2019, May-07, Volume: 25 Topics: Animals; Disease Models, Animal; DNA Methylation; Female; Fetal Growth Retardation; Fetus; Folic Acid; Folic Acid Deficiency; Long Interspersed Nucleotide Elements; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates	2019
Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women. BMC pregnancy and childbirth, 2021, Feb-17, Volume: 21, Issue:1 Topics: Adolescent; Adult; Cesarean Section; Cross-Sectional Studies; Depression, Postpartum; Diet; Female; Homocysteine; Humans; India; Methylmalonic Acid; Pregnancy; Pregnancy, Unplanned; Risk Factors; S-Adenosylmethionine; Serotonin; Social Class; Tetrahydrofolates; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult	2021
Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women. International journal of molecular sciences, 2023, Jul-01, Volume: 24, Issue:13 Topics: Adolescent; Adult; Betaine; Carbon; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Pregnancy; S-Adenosylmethionine; Young Adult	2023
Rare variants and biological pathways identified in treatment-refractory depression. Journal of neuroscience research, 2020, Volume: 98, Issue:7 Topics: Adolescent; Adult; Alleles; Biopterins; Carnitine; Computer Simulation; Depressive Disorder, Treatment-Resistant; Exome Sequencing; Female; Genetic Predisposition to Disease; Humans; Male; Phenotype; Polymorphism, Single Nucleotide; Tetrahydrofolates; Young Adult	2020