Compounds > s-adenosyl-3-thio-1,8-diaminooctane
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s-adenosyl-3-thio-1,8-diaminooctane and adenosine

s-adenosyl-3-thio-1,8-diaminooctane has been researched along with adenosine in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19908 (66.67)18.7374
1990's1 (8.33)18.2507
2000's3 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Coward, JK; Liu, C1
Coward, JK; Kufe, DW; Shafman, TD; Sherman, ML1
Berchtold, CM; Casero, RA; Celano, P; Giardiello, FM1
Heby, O; Holm, I; Pegg, AE; Persson, L1
Coward, JK; Pegg, AE1
Coward, JK; Pegg, AE; Tang, KC2
Bitonti, AJ; Coward, JK; McCann, PP; Pegg, AE1
Pegg, AE1
Ain, KB; Butterfield, DA; Varadarajan, S; Yatin, M; Yatin, SM1
Arrowsmith, C; Beasley, S; Edwards, A; Ikeguchi, Y; Joachimiak, A; Korolev, S; Pegg, AE; Savchenko, A; Skarina, T1
Heby, O; Persson, L; Rentala, M1

Reviews

1 review(s) available for s-adenosyl-3-thio-1,8-diaminooctane and adenosine

ArticleYear
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
    Amino acids, 2007, Volume: 33, Issue:2

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornithine; Enzyme Inhibitors; Glutathione; Humans; Leishmania; Leishmaniasis; Ornithine Decarboxylase Inhibitors; Robenidine; Spermidine; Spermidine Synthase; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African

2007

Other Studies

11 other study(ies) available for s-adenosyl-3-thio-1,8-diaminooctane and adenosine

ArticleYear
Stereospecific synthesis of (R)- and (S)-S-adenosyl-1,8-diamino-3-thiooctane, a potent inhibitor of polyamine biosynthesis. Comparison of asymmetric induction vs enantiomeric synthesis.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:7

    Topics: Adenosine; Chemical Phenomena; Chemistry; Escherichia coli; Spermidine Synthase; Stereoisomerism

1991
Selective inhibition of spermidine biosynthesis and differentiation by S-adenosyl-1,8-diamino-3-thiooctane in murine erythroleukemia cells.
    Biochemical pharmacology, 1986, Aug-01, Volume: 35, Issue:15

    Topics: Adenosine; Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Globins; Leukemia, Erythroblastic, Acute; Mice; RNA; Spermidine

1986
Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells.
    Biochemical and biophysical research communications, 1989, Nov-30, Volume: 165, Issue:1

    Topics: Adenosine; Blotting, Northern; Cell Division; Cell Line; Colonic Neoplasms; Eflornithine; Gene Expression Regulation, Neoplastic; Humans; Polyamines; Proto-Oncogenes; Putrescine; RNA, Messenger; Spermidine; Spermine; Transcription, Genetic; Tumor Cells, Cultured

1989
Effects of S-adenosyl-1,8-diamino-3-thio-octane and S-methyl-5'-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells.
    The Biochemical journal, 1989, Jul-01, Volume: 261, Issue:1

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carcinoma, Ehrlich Tumor; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermidine Synthase; Spermine; Spermine Synthase; Thionucleosides; Tumor Cells, Cultured

1989
Specific multisubstrate adduct inhibitors of aminopropyltransferases and their effect on polyamine biosynthesis in cultured cells.
    Advances in enzyme regulation, 1987, Volume: 26

    Topics: Adenosine; Animals; Cells, Cultured; Ornithine Decarboxylase Inhibitors; Polyamines; Spermidine Synthase; Spermine Synthase; Transferases

1987
Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism.
    Biochemistry, 1982, Sep-28, Volume: 21, Issue:20

    Topics: Adenosine; Animals; Cell Transformation, Viral; Cells, Cultured; Fibroblasts; Liver Neoplasms, Experimental; Mice; Putrescine; Rats; Simian virus 40; Spermidine; Spermidine Synthase; Spermine

1982
Inhibition of bacterial aminopropyltransferases by S-adenosyl-1,8-diamino-3-thiooctane and by dicyclohexylamine.
    FEBS letters, 1983, May-08, Volume: 155, Issue:2

    Topics: Adenosine; Bacteria; Cyclohexylamines; Escherichia coli; Polyamines; Pseudomonas aeruginosa; Serratia marcescens; Spermidine Synthase; Transferases

1983
Inhibition of aminopropyltransferases.
    Methods in enzymology, 1983, Volume: 94

    Topics: Adenosine; Animals; Cattle; Deoxyadenosines; In Vitro Techniques; Male; Polyamines; Rats; S-Adenosylmethionine; Spermidine Synthase; Thionucleosides; Transferases

1983
Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane.
    Biochemical and biophysical research communications, 1980, Oct-16, Volume: 96, Issue:3

    Topics: Adenosine; Alkylation; Animals; Male; Prostate; Rats; Spermidine Synthase; Structure-Activity Relationship; Transferases

1980
Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity.
    Journal of neuroscience research, 2001, Mar-01, Volume: 63, Issue:5

    Topics: Adenosine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cells, Cultured; Eflornithine; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Neurons; Oxidative Stress; Peptide Fragments; Polyamines; Rats; Rats, Sprague-Dawley; Spermidine Synthase; Spermine

2001
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor.
    Nature structural biology, 2002, Volume: 9, Issue:1

    Topics: Adenosine; Amino Acid Sequence; Apoenzymes; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Enzyme Inhibitors; Models, Molecular; Molecular Sequence Data; Molecular Weight; Polyamines; Protein Conformation; Sequence Alignment; Spermidine Synthase; Structure-Activity Relationship; Substrate Specificity; Thermotoga maritima

2002