Page last updated: 2024-09-04

s 8921 and taurocholic acid

s 8921 has been researched along with taurocholic acid in 2 studies

*Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic. [MeSH]

*Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic. [MeSH]

Compound Research Comparison

Studies
(s 8921)
Trials
(s 8921)
Recent Studies (post-2010)
(s 8921)
Studies
(taurocholic acid)
Trials
(taurocholic acid)
Recent Studies (post-2010) (taurocholic acid)
11003,78926654

Protein Interaction Comparison

ProteinTaxonomys 8921 (IC50)taurocholic acid (IC50)
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)6
Sodium/bile acid cotransporterRattus norvegicus (Norway rat)6
Sodium/bile acid cotransporterHomo sapiens (human)5.3

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goh, Y; Hara, S; Higaki, J; Higashino, K; Iwai, M; Miyata, K; Mizui, T; Nagata, K; Takasu, N; Tonda, K1
Baba, T; Hara, S; Horie, K; Kanazu, T; Kusuhara, H; Matsuo, Y; Miyata, K; Nomura, K; Okamura, N; Sakamoto, S; Shimaoka, H; Sugiyama, Y1

Other Studies

2 other study(ies) available for s 8921 and taurocholic acid

ArticleYear
S-8921, an ileal Na+/bile acid cotransporter inhibitor decreases serum cholesterol in hamsters.
    Life sciences, 1997, Volume: 60, Issue:24

    Topics: Absorption; Animals; Anticholesteremic Agents; Body Weight; Carrier Proteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; COS Cells; Cricetinae; Dose-Response Relationship, Drug; Naphthols; Organic Anion Transporters, Sodium-Dependent; Symporters; Taurocholic Acid

1997
Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2

    Topics: Animals; Anticholesteremic Agents; Cell Line; Cells, Cultured; Cholesterol; Cholesterol, HDL; Glucuronosyltransferase; Hepatocytes; Humans; Hypercholesterolemia; Intestinal Absorption; Kinetics; Male; Molecular Structure; Naphthols; Organic Anion Transporters, Sodium-Dependent; Portal Vein; Rats; Rats, Gunn; Rats, Wistar; Symporters; Taurocholic Acid; Transfection; Uridine Diphosphate Glucuronic Acid

2007