s 8921 has been researched along with taurocholic acid in 2 studies
*Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic. [MeSH]
*Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic. [MeSH]
| Studies (s 8921) | Trials (s 8921) | Recent Studies (post-2010) (s 8921) | Studies (taurocholic acid) | Trials (taurocholic acid) | Recent Studies (post-2010) (taurocholic acid) |
|---|---|---|---|---|---|
| 11 | 0 | 0 | 3,789 | 26 | 654 |
| Protein | Taxonomy | s 8921 (IC50) | taurocholic acid (IC50) |
|---|---|---|---|
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 6 | |
| Sodium/bile acid cotransporter | Rattus norvegicus (Norway rat) | 6 | |
| Sodium/bile acid cotransporter | Homo sapiens (human) | 5.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goh, Y; Hara, S; Higaki, J; Higashino, K; Iwai, M; Miyata, K; Mizui, T; Nagata, K; Takasu, N; Tonda, K | 1 |
| Baba, T; Hara, S; Horie, K; Kanazu, T; Kusuhara, H; Matsuo, Y; Miyata, K; Nomura, K; Okamura, N; Sakamoto, S; Shimaoka, H; Sugiyama, Y | 1 |
2 other study(ies) available for s 8921 and taurocholic acid
| Article | Year |
|---|---|
S-8921, an ileal Na+/bile acid cotransporter inhibitor decreases serum cholesterol in hamsters.
Topics: Absorption; Animals; Anticholesteremic Agents; Body Weight; Carrier Proteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; COS Cells; Cricetinae; Dose-Response Relationship, Drug; Naphthols; Organic Anion Transporters, Sodium-Dependent; Symporters; Taurocholic Acid | 1997 |
Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action.
Topics: Animals; Anticholesteremic Agents; Cell Line; Cells, Cultured; Cholesterol; Cholesterol, HDL; Glucuronosyltransferase; Hepatocytes; Humans; Hypercholesterolemia; Intestinal Absorption; Kinetics; Male; Molecular Structure; Naphthols; Organic Anion Transporters, Sodium-Dependent; Portal Vein; Rats; Rats, Gunn; Rats, Wistar; Symporters; Taurocholic Acid; Transfection; Uridine Diphosphate Glucuronic Acid | 2007 |