Compounds > s 8921
Page last updated: 2024-09-04

s 8921 and 2-naphthol

s 8921 has been researched along with 2-naphthol in 9 studies

Compound Research Comparison

Studies
(s 8921)		Trials
(s 8921)		Recent Studies (post-2010)
(s 8921)		Studies
(2-naphthol)		Trials
(2-naphthol)		Recent Studies (post-2010) (2-naphthol)
11004,120161,458

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (55.56)18.2507
2000's4 (44.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goh, Y; Hara, S; Higaki, J; Higashino, K; Iwai, M; Miyata, K; Mizui, T; Nagata, K; Takasu, N; Tonda, K1
Hirano, K; Ichihashi, T; Izawa, M; Miyata, K; Mizui, T; Takagishi, Y1
Kominami, G; Misaki, A; Sakai, K; Ueda, A1
Hara, S; Higaki, J; Miyata, K; Mizui, T; Nagata, K; Shike, T; Takasu, N; Tonda, K1
Inazawa, K; Iwatani, K; Kadono, K; Kanazu, T; Mizobuchi, M; Nakajima, Y; Ohkawa, T; Yamaguchi, T1
Booker, ML1
Ichihashi, T1
Baba, T; Hara, S; Horie, K; Kanazu, T; Kusuhara, H; Matsuo, Y; Miyata, K; Nomura, K; Okamura, N; Sakamoto, S; Shimaoka, H; Sugiyama, Y1
Baba, T; Horie, K; Ishizaki, J; Kusuhara, H; Sakamoto, S; Sugiyama, Y; Takahashi, K1

Reviews

1 review(s) available for s 8921 and 2-naphthol

ArticleYear
[Hypolipidemic drugs--ileal Na+/bile acid cotransporter inhibitors (S-8921 etc)].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:1

    Topics: Animals; Bile Acids and Salts; Carrier Proteins; Cholesterol; Drug Design; Enterohepatic Circulation; Humans; Hypercholesterolemia; Hypolipidemic Agents; Ileum; Naphthols; Organic Anion Transporters, Sodium-Dependent; Symporters; Thiazepines

2002

Other Studies

8 other study(ies) available for s 8921 and 2-naphthol

ArticleYear
S-8921, an ileal Na+/bile acid cotransporter inhibitor decreases serum cholesterol in hamsters.
    Life sciences, 1997, Volume: 60, Issue:24

    Topics: Absorption; Animals; Anticholesteremic Agents; Body Weight; Carrier Proteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; COS Cells; Cricetinae; Dose-Response Relationship, Drug; Naphthols; Organic Anion Transporters, Sodium-Dependent; Symporters; Taurocholic Acid

1997
Mechanism of hypocholesterolemic action of S-8921 in rats: S-8921 inhibits ileal bile acid absorption.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:1

    Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Biological Transport; Ileum; Intestinal Absorption; Male; Naphthols; Rats; Rats, Sprague-Dawley

1998
Radioimmunoassay for a novel lignan-related hypocholesterolemic agent, S-8921, in human plasma after high-performance liquid chromatography purification and in human urine after immunoaffinity extraction.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Dec-19, Volume: 704, Issue:1-2

    Topics: Anticholesteremic Agents; Centrifugation; Chromatography, High Pressure Liquid; Humans; Immunologic Techniques; Kinetics; Naphthols; Radioimmunoassay

1997
Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits.
    Arteriosclerosis, thrombosis, and vascular biology, 1998, Volume: 18, Issue:8

    Topics: Animals; Anticholesteremic Agents; Aorta; Arteriosclerosis; Bile Acids and Salts; Cholesterol; Cholesterol, Dietary; Depression, Chemical; Feces; Heterozygote; Ileum; Ion Transport; Lipids; Liver; Male; Naphthols; Rabbits; Sodium

1998
Disposition and metabolism of the new hypocholesterolemic compound S-8921 in rats and dogs.
    Arzneimittel-Forschung, 1998, Volume: 48, Issue:10

    Topics: Administration, Oral; Animals; Anticholesteremic Agents; Autoradiography; Bile; Biotransformation; Carbon Radioisotopes; Dogs; Half-Life; Intestinal Absorption; Male; Metabolic Clearance Rate; Naphthols; Rats; Rats, Sprague-Dawley; Tissue Distribution

1998
S-8921 (Shionogi).
    Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:3

    Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Biological Transport; Carrier Proteins; Clinical Trials, Phase I as Topic; Drug Evaluation, Preclinical; Drugs, Investigational; Forecasting; Glucuronides; Humans; Hydroxysteroid Dehydrogenases; Hyperlipidemias; Intestinal Mucosa; Membrane Glycoproteins; Molecular Structure; Naphthols

2001
Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2

    Topics: Animals; Anticholesteremic Agents; Cell Line; Cells, Cultured; Cholesterol; Cholesterol, HDL; Glucuronosyltransferase; Hepatocytes; Humans; Hypercholesterolemia; Intestinal Absorption; Kinetics; Male; Molecular Structure; Naphthols; Organic Anion Transporters, Sodium-Dependent; Portal Vein; Rats; Rats, Gunn; Rats, Wistar; Symporters; Taurocholic Acid; Transfection; Uridine Diphosphate Glucuronic Acid

2007
Identification of the transporters involved in the hepatobiliary transport and intestinal efflux of methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) glucuronide, a pharmacologically active metabolite of S-
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:8

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biliary Tract; Blotting, Western; Carbon Radioisotopes; Cells, Cultured; Dogs; Glucuronides; Hepatocytes; Humans; Intestinal Mucosa; Liver; Male; Multidrug Resistance-Associated Protein 2; Naphthols; Organic Anion Transporters; Rats; Rats, Sprague-Dawley

2008