s-1360 and chicoric-acid

s-1360 has been researched along with chicoric-acid* in 1 studies

Reviews

1 review(s) available for s-1360 and chicoric-acid

ArticleYear
HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial.
    Current topics in medicinal chemistry, 2004, Volume: 4, Issue:10

    AIDS is currently treated with a combination therapy of reverse transcriptase and protease inhibitors. Recently, the FDA approved a drug targeting HIV-1 entry into cells. There are currently no FDA approved drugs targeting HIV-1 integrase, though many scientists and drug companies are actively in pursuit of clinically useful integrase inhibitors. The objective of this review is to provide an update on integrase inhibitors reported in the last two years, including two novel inhibitors in early clinical trials, recently developed hydroxylated aromatics, natural products, peptide, antibody and oligonucleotide inhibitors. Additionally, the proposed mechanism of diketo acid inhibition is reviewed.

    Topics: Acetoacetates; Anti-HIV Agents; Biological Factors; Caffeic Acids; Clinical Trials as Topic; Furans; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Indoles; Models, Molecular; Molecular Structure; Oligonucleotides; Pyrroles; Reverse Transcriptase Inhibitors; Succinates; Tetrazoles; Triazoles

2004