Page last updated: 2024-09-03

s-(3-hydroxypropyl)cysteine n-acetate and acetylcysteine

s-(3-hydroxypropyl)cysteine n-acetate has been researched along with acetylcysteine in 36 studies

Compound Research Comparison

Studies
(s-(3-hydroxypropyl)cysteine n-acetate)
Trials
(s-(3-hydroxypropyl)cysteine n-acetate)
Recent Studies (post-2010)
(s-(3-hydroxypropyl)cysteine n-acetate)
Studies
(acetylcysteine)
Trials
(acetylcysteine)
Recent Studies (post-2010) (acetylcysteine)
3612614,5801,0465,960

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.56)18.7374
1990's3 (8.33)18.2507
2000's4 (11.11)29.6817
2010's24 (66.67)24.3611
2020's3 (8.33)2.80

Authors

AuthorsStudies
Ansari, GA; Boor, PJ; Sanduja, R1
Gibson, J; Jones, AR1
Krenmayr, P; Scherer, G; Schmid, ER; Stanek, W1
Frantík, E; Linhart, I; Mitera, J; Smejkal, J; Vodicková, L; Vosmanská, M1
Boogaard, PJ; Commandeur, JN; de Rooij, BM; van Sittert, NJ; Vermeulen, NP1
Mascher, DG; Mascher, HJ; Scherer, G; Schmid, ER1
Athersuch, TJ; Keun, H; Nicholson, JK; Tang, H1
Carmella, SG; Chen, M; Hatsukami, DK; Hecht, SS; Zhang, S; Zhang, Y1
Auerbach, SS; Irwin, RD; Mahler, J; Travlos, GS1
Borgerding, MF; Brown, BG; Byrd, GD; Yan, W1
Cheung, F; Errington, G; Minet, E; Scherer, G; Sterz, K1
Fukuda, K; Higashi, K; Igarashi, K; Ishii, I; Kashiwagi, K; Mikami, T; Mizoi, M; Nakamura, T; Nishimura, K; Saiki, R; Toida, T; Tomitori, H; Yoshida, M1
Carmella, SG; Chen, M; Hecht, SS; Zarth, A1
Benowitz, NL; Carmella, SG; Chatfield, DA; Chen, M; Daffa, RM; Hecht, SS; Hovell, MF; Jackson, SR; Jacob, P; Kassem, NO; Liles, S; Matt, GE; Mehta, S; Younis, MA1
Abplanalp, W; Becher, C; Bhatnagar, A; Chugh, A; Ciszewski, T; Conklin, DJ; DeFilippis, A; DeJarnett, N; Hamzeh, I; Higdon, D; McCracken, J; Myers, JA; O'Toole, TE; Prabhu, SD; Rai, SN; Ramos, KS; Riggs, DW; Srivastava, S; Tollerud, DJ; Wagner, S; Wyatt, B; Xie, Z; Yeager, R1
Carmella, SG; Chen, M; Hatsukami, DK; Hecht, SS; Kotandeniya, D; Murphy, SE; Pillsbury, ME; Ransom, BW; Thompson, E; Vogel, RI1
Acosta, G; Shi, R; Tian, R; Tully, M; Zheng, L1
Higashi, K; Igarashi, K; Kashiwagi, K; Kuni, K; Mizoi, M; Nakamura, M; Saiki, R; Toida, T; Uemura, K; Waragai, M; Yoshida, M1
Carmella, SG; Chen, M; Hecht, SS; Koh, WP; Murphy, SE; Wang, R; Yuan, JM1
Alwis, KU; Blount, BC; deCastro, BR; Morrow, JC1
Carmella, SG; Chen, M; Haiman, CA; Hecht, SS; Le Marchand, L; Park, SL; Patel, Y; Stram, DO1
Goniewicz, ML; Hajek, P; Knight-West, O; McRobbie, H; Phillips, A; Przulj, D; Smith, KM1
Acosta, G; Cao, P; Chen, Z; Muratori, B; Park, J; Shi, R; Vega-Alvarez, S; Zheng, L1
Attanasio, R; Feroe, AG; Scinicariello, F1
Higashi, K; Igarashi, K; Toida, T1
Bentley, RT; Packer, RA; Sangster, AM; Shi, R; Zheng, L1
Carmella, SG; Chatfield, DA; Daffa, RM; Hecht, SS; Hovell, MF; Jackson, SR; Kassem, NO; Kassem, NOF; Liles, S; Zarth, AT1
Higashi, K; Igarashi, K; Kuni, K; Shibasaki, M; Toida, T; Uemura, K; Uemura, T; Waragai, M1
Chen, SP; Fuh, JL; Hsu, WC; Liu, TY; Tsou, HH; Wang, HT1
Cox, S; Dawkins, L; Doig, M; Goniewicz, M; Kimber, C; Kośmider, L; McRobbie, H1
al'Absi, M; Allen, SS; Benowitz, NL; Carmella, SG; Chen, M; Cinciripini, PM; Denlinger-Apte, R; Donny, EC; Drobes, DJ; Hatsukami, DK; Hecht, SS; Jensen, JA; Koopmeiners, JS; Lane, T; Le, CT; Leischow, S; Luo, K; Luo, X; McClernon, FJ; Murphy, SE; Paiano, V; Robinson, JD; Severson, H; Sipe, C; Strasser, AA; Strayer, LG; Tang, MK; Vandrey, R1
al'Absi, M; Allen, SS; Benowitz, NL; Carmella, SG; Chen, M; Cinciripini, PM; Denlinger-Apte, R; Donny, EC; Hatsukami, D; Hecht, SS; Jensen, J; Le, CT; Luo, X; McClernon, FJ; Murphy, SE; Robinson, JD; Sipe, C; Strasser, AA; Vandrey, R1
Abraham, K; Bakuradze, T; Eisenbrand, G; Goerke, K; Lampen, A; Richling, E; Ruenz, M1
Harahap, Y; Melhan, M; Muhammad, C; Purwanto, DJ; Yanuar, A1
Acosta, G; Andrews, KD; Cao, J; Dietrich, AD; Liu, Z; Lu, KH; Lungwitz, EA; Majumdar, S; Race, NS; Shekhar, A; Shi, R; Truitt, WA; Vega Alvarez, SM; Warner, TR1
Bhatnagar, A; Conklin, DJ; Jin, L; Lorkiewicz, P; Srivastava, S; Xie, Z1

Reviews

1 review(s) available for s-(3-hydroxypropyl)cysteine n-acetate and acetylcysteine

ArticleYear
Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:6

    Topics: Acetylcysteine; Acrolein; Animals; Biomarkers; Humans; Severity of Illness Index; Stroke

2016

Trials

1 trial(s) available for s-(3-hydroxypropyl)cysteine n-acetate and acetylcysteine

ArticleYear
Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial.
    JAMA, 2018, 09-04, Volume: 320, Issue:9

    Topics: Acetylcysteine; Adult; Area Under Curve; Biomarkers; Breath Tests; Carbon Monoxide; Creatinine; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotiana; Nicotine; Phenanthrenes; Smoke; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Products; Tobacco Use Disorder

2018

Other Studies

34 other study(ies) available for s-(3-hydroxypropyl)cysteine n-acetate and acetylcysteine

ArticleYear
3-Hydroxypropylmercapturic acid: a biologic marker of exposure to allylic and related compounds.
    Journal of applied toxicology : JAT, 1989, Volume: 9, Issue:4

    Topics: Acetylcysteine; Allyl Compounds; Animals; Biomarkers; Buffers; Chromatography, High Pressure Liquid; Male; Rats; Rats, Inbred Strains; Reference Standards

1989
1,2-Dichloropropane: metabolism and fate in the rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1980, Volume: 10, Issue:11

    Topics: Acetylcysteine; Animals; Chlorohydrins; Hydrocarbons, Chlorinated; Inactivation, Metabolic; Liver; Male; Models, Chemical; Propane; Rats; Sulfhydryl Compounds

1980
Quantitative determination of N-acetyl(-L-)cysteine derivatives in human urine by tandem mass spectrometry.
    Biological mass spectrometry, 1993, Volume: 22, Issue:2

    Topics: Acetylcysteine; Electrochemistry; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Smoking

1993
Biotransformation of acrolein in rat: excretion of mercapturic acids after inhalation and intraperitoneal injection.
    Toxicology and applied pharmacology, 1996, Volume: 136, Issue:1

    Topics: Acetylcysteine; Acrolein; Administration, Inhalation; Animals; Biotransformation; Blood-Air Barrier; Dose-Response Relationship, Drug; Ethers; Injections, Intraperitoneal; Male; Mice; Rats; Rats, Wistar

1996
Allylmercapturic acid as urinary biomarker of human exposure to allyl chloride.
    Occupational and environmental medicine, 1997, Volume: 54, Issue:9

    Topics: Acetylcysteine; Adult; Air Pollutants, Occupational; Allyl Compounds; Biomarkers; Creatinine; Environmental Monitoring; Garlic; Humans; Male; Middle Aged; Plants, Medicinal; Regression Analysis; Smoking

1997
High-performance liquid chromatographic-tandem mass spectrometric determination of 3-hydroxypropylmercapturic acid in human urine.
    Journal of chromatography. B, Biomedical sciences and applications, 2001, Jan-05, Volume: 750, Issue:1

    Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Reference Standards; Reproducibility of Results; Sensitivity and Specificity

2001
Quantitative urinalysis of the mercapturic acid conjugates of allyl formate using high-resolution NMR spectroscopy.
    Journal of pharmaceutical and biomedical analysis, 2006, Feb-13, Volume: 40, Issue:2

    Topics: Acetylcysteine; Animals; Biomarkers; Dose-Response Relationship, Drug; Formic Acid Esters; Glutathione; Injections, Intraperitoneal; Liver; Magnetic Resonance Spectroscopy; Male; Necrosis; Rats; Rats, Sprague-Dawley; Time Factors

2006
Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking.
    Chemical research in toxicology, 2007, Volume: 20, Issue:7

    Topics: Acetylcysteine; Acrolein; Atmospheric Pressure; Biomarkers; Chromatography, Liquid; Humans; Molecular Structure; Smoking; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors

2007
A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein.
    Toxicology, 2008, Nov-20, Volume: 253, Issue:1-3

    Topics: Acetates; Acetylcysteine; Acrolein; Allyl Compounds; Animals; Blood Cell Count; Female; Gastric Mucosa; Hematopoietic System; Liver; Lymphoid Tissue; Male; Mice; Propanols; Rats; Rats, Inbred F344; Stomach; Survival Rate; Toxicity Tests

2008
Development and validation of a direct LC-MS-MS method to determine the acrolein metabolite 3-HPMA in urine.
    Journal of chromatographic science, 2010, Volume: 48, Issue:3

    Topics: Acetylcysteine; Acrolein; Chromatography, Liquid; Humans; Limit of Detection; Tandem Mass Spectrometry

2010
Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2011, Volume: 16, Issue:1

    Topics: Acetylcysteine; Acrylonitrile; Biomarkers; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; Molecular Structure; Nicotine; Nitrosamines; Pyridines; Smoking; Tandem Mass Spectrometry; Tars

2011
Inverse correlation between stroke and urinary 3-hydroxypropyl mercapturic acid, an acrolein-glutathione metabolite.
    Clinica chimica acta; international journal of clinical chemistry, 2012, Apr-11, Volume: 413, Issue:7-8

    Topics: Acetylcysteine; Acrolein; Adult; Aged; Case-Control Studies; Chromatography, Liquid; Female; Glutathione; Humans; Male; Middle Aged; Stroke; Tandem Mass Spectrometry

2012
High throughput liquid chromatography-tandem mass spectrometry assay for mercapturic acids of acrolein and crotonaldehyde in cigarette smokers' urine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Sep-15, Volume: 935

    Topics: Acetylcysteine; Acrolein; Aldehydes; Chromatography, Liquid; High-Throughput Screening Assays; Humans; Limit of Detection; Reproducibility of Results; Smoking; Solid Phase Extraction; Tandem Mass Spectrometry

2013
Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014, Volume: 16, Issue:7

    Topics: Acetylcysteine; Air; Biomarkers; Carcinogens; Child, Preschool; Cotinine; Cross-Sectional Studies; Environmental Exposure; Family Characteristics; Female; Housing; Humans; Male; Nicotine; Nitrosamines; Pyridines; Smoking; Tobacco Smoke Pollution

2014
Acrolein exposure is associated with increased cardiovascular disease risk.
    Journal of the American Heart Association, 2014, Aug-06, Volume: 3, Issue:4

    Topics: Acetylcysteine; Acrolein; Adult; Aged; Blood Platelets; C-Reactive Protein; Cardiovascular Diseases; Environmental Exposure; Female; Humans; Kentucky; Leukocytes; Linear Models; Male; Middle Aged; Platelet Activation; Smoking

2014
Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015, Volume: 17, Issue:6

    Topics: Acetylcysteine; Adult; Carcinogens; Cotinine; Electronic Nicotine Delivery Systems; Female; Hazardous Substances; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Pyrenes; Pyridines; Smoking; Tobacco Products; Young Adult

2015
Acute systemic accumulation of acrolein in mice by inhalation at a concentration similar to that in cigarette smoke.
    Neuroscience bulletin, 2014, Volume: 30, Issue:6

    Topics: Acetylcysteine; Acrolein; Administration, Inhalation; Animals; Creatinine; Mice; Spinal Cord

2014
Distinguishing mild cognitive impairment from Alzheimer's disease with acrolein metabolites and creatinine in urine.
    Clinica chimica acta; international journal of clinical chemistry, 2015, Feb-20, Volume: 441

    Topics: Acetylcysteine; Acrolein; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Creatinine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged

2015
Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Acetylcysteine; Acrolein; Aged; Aldehydes; Asian People; Benzene; Biomarkers; Carcinogens; Cooking; Female; Humans; Lung Neoplasms; Middle Aged; Singapore; Smoking

2015
Acrolein Exposure in U.S. Tobacco Smokers and Non-Tobacco Users: NHANES 2005-2006.
    Environmental health perspectives, 2015, Volume: 123, Issue:12

    Topics: Acetylcysteine; Acrolein; Adolescent; Adult; Biomarkers; Child; Cotinine; Environmental Pollutants; Female; Humans; Male; Middle Aged; Nutrition Surveys; Smoking; United States

2015
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Acetylcysteine; Acrolein; Aged; Aldehydes; Ethnicity; Female; Hawaii; Humans; Lung Neoplasms; Male; Middle Aged; Risk Factors; Smoking

2015
Effects of Switching to Electronic Cigarettes with and without Concurrent Smoking on Exposure to Nicotine, Carbon Monoxide, and Acrolein.
    Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:9

    Topics: Acetylcysteine; Acrolein; Adult; Aerosols; Biomarkers; Breath Tests; Carbon Monoxide; Cohort Studies; Cotinine; Electronic Nicotine Delivery Systems; Female; Humans; Male; Middle Aged; Nicotine; Smoke; Smoking; Smoking Cessation

2015
Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury.
    Journal of neurochemistry, 2015, Volume: 135, Issue:5

    Topics: Acetylcysteine; Acrolein; Animals; Disease Models, Animal; Ganglia, Spinal; Hydralazine; Hyperalgesia; Locomotion; Male; Neuralgia; Pain Threshold; Rats; Rats, Sprague-Dawley; Skin; Spinal Cord; Spinal Cord Injuries; TRPA1 Cation Channel; TRPC Cation Channels; Up-Regulation; Vasodilator Agents

2015
Acrolein metabolites, diabetes and insulin resistance.
    Environmental research, 2016, Volume: 148

    Topics: Acetylcysteine; Acrolein; Adult; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Insulin Resistance; Male; Nutrition Surveys

2016
Urinary 3-hydroxypropyl mercapturic acid (3-HPMA) concentrations in dogs with acute spinal cord injury due to intervertebral disc herniation.
    Veterinary journal (London, England : 1997), 2017, Volume: 219

    Topics: Acetylcysteine; Animals; Biomarkers; Dogs; Female; Intervertebral Disc Displacement; Male; Prospective Studies; Spinal Cord Injuries

2017
Acrolein Exposure in Hookah Smokers and Non-Smokers Exposed to Hookah Tobacco Secondhand Smoke: Implications for Regulating Hookah Tobacco Products.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2018, 03-06, Volume: 20, Issue:4

    Topics: Acetylcysteine; Acrolein; Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Non-Smokers; Smoking Water Pipes; Tobacco Products; Tobacco Smoke Pollution; Tobacco, Waterpipe; Water Pipe Smoking; Young Adult

2018
Determination of 3-hydroxypropylmercapturic acid in urine by three column-switching high-performance liquid chromatography with electrochemical detection using a diamond electrode.
    Journal of chromatography. A, 2017, Sep-29, Volume: 1517

    Topics: Acetylcysteine; Calibration; Chromatography, High Pressure Liquid; Chromatography, Liquid; Diamond; Electrochemistry; Electrodes; Humans; Limit of Detection; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Urinalysis

2017
Alterations in Acrolein Metabolism Contribute to Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 61, Issue:2

    Topics: Acetylcysteine; Acrolein; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Case-Control Studies; Creatinine; Disease Progression; Early Diagnosis; Female; Humans; Male; Middle Aged

2018
'Real-world' compensatory behaviour with low nicotine concentration e-liquid: subjective effects and nicotine, acrolein and formaldehyde exposure.
    Addiction (Abingdon, England), 2018, Volume: 113, Issue:10

    Topics: Acetylcysteine; Acrolein; Adult; Cotinine; Craving; England; Female; Formaldehyde; Formates; Humans; Inhalation Exposure; Male; Middle Aged; Nicotine; Nicotinic Agonists; Saliva; Substance Withdrawal Syndrome; Vaping; Young Adult

2018
Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Acetylcysteine; Acrolein; Acrylonitrile; Adult; Biomarkers; Cigarette Smoking; Female; Hazardous Substances; Humans; Longitudinal Studies; Male; Middle Aged; Randomized Controlled Trials as Topic; Smokers; Tobacco Products; Toxicology

2019
Sustained Human Background Exposure to Acrolein Evidenced by Monitoring Urinary Exposure Biomarkers.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:24

    Topics: Acetylcysteine; Acrolein; Biomarkers; Cigarette Smoking; Cooking; Diet; Environmental Exposure; Female; Hot Temperature; Humans; Male

2019
Quantification of 3-Hydroxypropyl Mercapturic Acid in the Urine of Patients with Breast Cancer to Monitor Cyclophosphamide Toxicity.
    Therapeutic drug monitoring, 2020, Volume: 42, Issue:4

    Topics: Acetylcysteine; Acrolein; Adult; Alkylating Agents; Biomarkers; Breast Neoplasms; Chromatography, Liquid; Cyclophosphamide; Female; Hematuria; Humans; Middle Aged; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2020
Psychosocial impairment following mild blast-induced traumatic brain injury in rats.
    Behavioural brain research, 2021, 08-27, Volume: 412

    Topics: Acetylcysteine; Acrolein; Animals; Blast Injuries; Brain; Brain Concussion; Brain Injuries; Disease Models, Animal; Magnetic Resonance Imaging; Male; Prefrontal Cortex; Psychosocial Functioning; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate

2021
Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications.
    Toxicology and applied pharmacology, 2021, 09-01, Volume: 426

    Topics: Acetylcysteine; Acrolein; Animals; Aorta, Thoracic; Female; Glutathione S-Transferase pi; GTPase-Activating Proteins; Male; Mesenteric Artery, Superior; Mice, Inbred C57BL; Mice, Knockout; TRPA1 Cation Channel

2021