Page last updated: 2024-09-05

s-(1,2-dichlorovinyl)cysteine and trichloroethylene

s-(1,2-dichlorovinyl)cysteine has been researched along with trichloroethylene in 29 studies

Compound Research Comparison

Studies
(s-(1,2-dichlorovinyl)cysteine)
Trials
(s-(1,2-dichlorovinyl)cysteine)
Recent Studies (post-2010)
(s-(1,2-dichlorovinyl)cysteine)
Studies
(trichloroethylene)
Trials
(trichloroethylene)
Recent Studies (post-2010) (trichloroethylene)
1541154,599441,003

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (24.14)18.2507
2000's13 (44.83)29.6817
2010's7 (24.14)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Boogaard, PJ; Commandeur, JN; Mulder, GJ; Vermeulen, NP1
Anders, MW; Vamvakas, S1
Bakke, JE; Davison, KL1
Bull, RJ; Eyre, RJ; Parker, JC; Stevens, DK2
Bernauer, U; Birner, G; Dekant, W; Henschler, D1
Dow, J; Ellis, MK; Foster, JR; Green, T; Odum, J1
Cummings, BS; Lash, LH1
Cummings, BS; Lash, LH; Novak, RF; Zangar, RC1
DeGroot, DE; DuTeaux, SB; Hengel, MJ; Jelks, KA; Miller, MG1
Horwitz, BP; Hueni, SE; Lash, LH; Putt, DA1
Dekant, W; Everitt, JI; Mally, A; Vamvakas, S; Walker, CL1
Argraves, SW; Barth, JL; Lock, EA; Schnellmann, RG1
Caldwell, JC; Keshava, N1
Hueni, SE; Lash, LH; Payton, SG; Putt, DA; Zwickl, J1
Clay, P1
Berger, T; Wu, KL1
Collins, LB; Kim, D; Kim, S; Pollack, GM; Rusyn, I1
Ball, LM; Boysen, G; Bradford, BU; Collins, LB; Gold, A; Kim, S; Rusyn, I; Swenberg, JA1
Barshteyn, N; Elfarra, AA1
Elfarra, AA; Irving, RM1
Ball, LM; Bodnar, WM; Bradford, BU; Collins, LB; Gold, A; Kosyk, O; Rusyn, I; Shymonyak, S; Uehara, T; Yoo, HS2
Boldenow, E; Chames, MC; Hassan, I; Loch-Caruso, R; Xi, C1
Hassan, I; Kumar, AM; Lash, LH; Loch-Caruso, R; Park, HR1
Chiu, W; Furuya, S; Luo, YS; Rusyn, I1
Bridges, D; Elkin, ER; Loch-Caruso, R1
Bridges, D; Elkin, ER; Harris, SM; Loch-Caruso, RK1
Baldovini, J; Capinha, L; Carta, G; Commandeur, JNM; Dinnyes, A; Grillari, J; Holzer, AK; Jennings, P; Leist, M; Mazidi, Z; Murphy, C; Ückert, AK; van de Water, B; Zana, M; Zhang, Y1

Reviews

3 review(s) available for s-(1,2-dichlorovinyl)cysteine and trichloroethylene

ArticleYear
Perturbation of calcium homeostasis as a link between acute cell injury and carcinogenesis in the kidney.
    Toxicology letters, 1990, Volume: 53, Issue:1-2

    Topics: Animals; Calcium; Cysteine; Homeostasis; Humans; Kidney; Kidney Neoplasms; Mercuric Chloride; Trichloroethylene

1990
Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
    Environmental health perspectives, 2006, Volume: 114, Issue:9

    Topics: Animals; Carcinogenicity Tests; Chloral Hydrate; Cysteine; Dichloroacetic Acid; Environmental Pollutants; History, 21st Century; Humans; Kidney Neoplasms; Liver Neoplasms; Risk Assessment; Risk Factors; Signal Transduction; Trichloroacetic Acid; Trichloroethylene; United States

2006
Role of reactive metabolites in the circulation in extrahepatic toxicity.
    Expert opinion on drug metabolism & toxicology, 2012, Volume: 8, Issue:9

    Topics: Acetylcysteine; Cysteine; Humans; Kidney; Liver; Trichloroethylene

2012

Other Studies

26 other study(ies) available for s-(1,2-dichlorovinyl)cysteine and trichloroethylene

ArticleYear
Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.
    Archives of toxicology, 1991, Volume: 65, Issue:5

    Topics: Acetylcysteine; Animals; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Male; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium; Stereoisomerism; Trichloroethylene

1991
Elimination of 14C by calves, pigs and rats renally perfused with radiolabelled dichlorovinyl or acetamide substrates.
    Toxicology letters, 1990, Volume: 53, Issue:1-2

    Topics: Acetanilides; Acetylation; Acetylcysteine; Animals; Carbon Radioisotopes; Cattle; Cysteine; Herbicides; Iodoacetamide; Kidney; Perfusion; Rats; Rats, Inbred Strains; Swine; Trichloroethylene

1990
Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethene metabolism.
    Journal of toxicology and environmental health, 1995, Volume: 46, Issue:4

    Topics: Amino Acids; Animals; Biomarkers; Carbon Radioisotopes; Cysteine; Dichloroacetic Acid; Hydrolysis; Kidney; Liver; Male; Mice; Rats; Rats, Inbred F344; Species Specificity; Time Factors; Trichloroethylene

1995
Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice.
    Journal of toxicology and environmental health, 1995, Volume: 46, Issue:4

    Topics: Animals; Carrier Proteins; Cell Division; Cysteine; Dose-Response Relationship, Drug; Kidney; Kidney Diseases; Male; Mice; Rats; Rats, Inbred F344; Species Specificity; Trichloroethylene

1995
Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.
    Archives of toxicology, 1996, Volume: 70, Issue:6

    Topics: Acetylcysteine; Administration, Inhalation; Adult; Aged; Animals; Biotransformation; Cysteine; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Male; Middle Aged; Rats; Trichloroethylene

1996
The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene.
    Chemico-biological interactions, 1997, Jul-11, Volume: 105, Issue:2

    Topics: Animals; Arylamine N-Acetyltransferase; Carbon-Sulfur Lyases; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Humans; In Vitro Techniques; Isomerism; Kidney; Kidney Neoplasms; Kinetics; Lyases; Male; Mice; Rats; Rats, Inbred F344; Trichloroethylene

1997
Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 53, Issue:2

    Topics: Adult; Aged; Aminooxyacetic Acid; Chloral Hydrate; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Glutathione; Humans; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Male; Metyrapone; Microsomes; Middle Aged; Trichloroethylene

2000
Cytotoxicity of trichloroethylene and S-(1, 2-dichlorovinyl)-L-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells.
    Toxicology, 2000, Sep-07, Volume: 150, Issue:1-3

    Topics: Animals; Cells, Cultured; Cysteine; Cytochrome P-450 Enzyme System; DNA; Isoenzymes; Keratins; Kidney Tubules, Distal; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Male; Rats; Rats, Inbred F344; RNA, Messenger; Trichloroethylene; Vimentin

2000
Evidence for trichloroethylene bioactivation and adduct formation in the rat epididymis and efferent ducts.
    Biology of reproduction, 2003, Volume: 69, Issue:3

    Topics: Animals; Biotransformation; Cysteine; Cytochrome P-450 CYP2E1; DNA Adducts; Dose-Response Relationship, Drug; Environmental Pollutants; Epididymis; Immunohistochemistry; Lyases; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Solvents; Transaminases; Trichloroethylene; Vas Deferens

2003
Molecular markers of trichloroethylene-induced toxicity in human kidney cells.
    Toxicology and applied pharmacology, 2005, Aug-07, Volume: 206, Issue:2

    Topics: Apoptosis; Biomarkers; Cell Proliferation; Cells, Cultured; Cysteine; Humans; Kidney Tubules, Proximal; Necrosis; Signal Transduction; Trichloroethylene

2005
Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro.
    Toxicology, 2006, Jul-05, Volume: 224, Issue:1-2

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Renal Cell; Cell Proliferation; Cell Transformation, Neoplastic; Cysteine; DNA; DNA Mutational Analysis; Gene Expression Regulation, Neoplastic; Kidney; Kidney Cortex; Kidney Diseases; Kidney Neoplasms; Loss of Heterozygosity; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction; Solvents; Trichloroethylene

2006
Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene.
    Toxicology and applied pharmacology, 2006, Oct-15, Volume: 216, Issue:2

    Topics: Adenosine Kinase; Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Cell Survival; Complement Factor H; Cysteine; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Gene Expression; Gene Expression Profiling; Glucose; Glutathione; Humans; In Vitro Techniques; Isoenzymes; Kidney Tubules, Proximal; Kruppel-Like Transcription Factors; Lyases; Male; Middle Aged; RNA, Messenger; Transcription Factors; Trichloroethylene

2006
Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: effects on apoptosis, necrosis, and glutathione status.
    Toxicology and applied pharmacology, 2007, Jun-15, Volume: 221, Issue:3

    Topics: Adaptation, Physiological; Animals; Apoptosis; Cells, Cultured; Cysteine; Drug Administration Schedule; Drug Interactions; Environmental Pollutants; Glutathione; Glutathione Transferase; Humans; Kidney Tubules, Proximal; Male; Mercury; Necrosis; Rats; Rats, Inbred F344; Time Factors; Trichloroethylene

2007
Assessment of the genotoxicity of trichloroethylene and its metabolite, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), in the comet assay in rat kidney.
    Mutagenesis, 2008, Volume: 23, Issue:1

    Topics: Animals; Cells, Cultured; Comet Assay; Cysteine; DNA; DNA Damage; Dose-Response Relationship, Drug; Kidney Tubules, Proximal; Male; Mutagens; Rats; Rats, Sprague-Dawley; Solvents; Trichloroethylene

2008
Reduction in rat oocyte fertilizability mediated by S-(1, 2-dichlorovinyl)-L-cysteine: a trichloroethylene metabolite produced by the glutathione conjugation pathway.
    Bulletin of environmental contamination and toxicology, 2008, Volume: 81, Issue:5

    Topics: Animals; Biotransformation; Body Weight; Cysteine; Female; Fertilization in Vitro; Glutathione; Immunohistochemistry; In Vitro Techniques; Male; Oocytes; Rats; Rats, Sprague-Dawley; Reproduction; Solvents; Trichloroethylene

2008
Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
    Toxicology and applied pharmacology, 2009, Jul-01, Volume: 238, Issue:1

    Topics: Administration, Oral; Animals; Biological Availability; Carcinogens; Cysteine; Dichloroacetic Acid; Glutathione; Half-Life; Male; Mice; Models, Biological; Oxidation-Reduction; Risk Assessment; Time Factors; Trichloroacetic Acid; Trichloroethylene

2009
Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
    Toxicology, 2009, Aug-21, Volume: 262, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Cysteine; Dichloroacetic Acid; Glutathione; Male; Mice; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichloroacetic Acid; Trichloroethylene

2009
Globin monoadducts and cross-links provide evidence for the presence of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, chlorothioketene, and 2-chlorothionoacetyl chloride in the circulation in rats administered S-(1,2-dichlorovinyl)-L-cysteine.
    Chemical research in toxicology, 2009, Volume: 22, Issue:9

    Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Cysteine; Erythrocytes; Globins; Male; Molecular Sequence Data; Peptides; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Thiones; Trichloroethylene; Trypsin

2009
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.
    Journal of toxicology and environmental health. Part A, 2015, Volume: 78, Issue:1

    Topics: Administration, Oral; Animals; Carcinogens; Cell Proliferation; Cysteine; Cytochrome P-450 Enzyme System; Dichloroacetic Acid; Dose-Response Relationship, Drug; Ethylene Chlorohydrin; Gene Expression; Glutathione; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Oxidation-Reduction; Oxidative Stress; Real-Time Polymerase Chain Reaction; Solvents; Trichloroacetic Acid; Trichloroethylene

2015
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.
    Journal of toxicology and environmental health. Part A, 2015, Volume: 78, Issue:1

    Topics: Animals; Carcinogens; Cell Proliferation; Cysteine; Cytochrome P-450 Enzyme System; Dichloroacetic Acid; Ethylene Chlorohydrin; Glutathione; Hepatitis A Virus Cellular Receptor 1; Kidney; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Oxidation-Reduction; PPAR alpha; Trichloroacetic Acid; Trichloroethylene

2015
The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro.
    Reproductive toxicology (Elmsford, N.Y.), 2015, Volume: 52

    Topics: Chorion; Cysteine; Decidua; Disease Resistance; Extraembryonic Membranes; Female; Humans; Immunity; Lipopolysaccharides; Pregnancy; Streptococcal Infections; Streptococcus agalactiae; Teichoic Acids; Tissue Culture Techniques; Trichloroacetic Acid; Trichloroethylene; Tumor Necrosis Factor-alpha

2015
Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine.
    Biology of reproduction, 2016, Volume: 95, Issue:3

    Topics: Cell Line, Transformed; Cysteine; Female; Humans; Interleukin-6; Membrane Potential, Mitochondrial; Oxidative Stress; Placenta; Pregnancy; Reactive Oxygen Species; Trichloroethylene; Trophoblasts

2016
Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.
    Journal of toxicology and environmental health. Part A, 2018, Volume: 81, Issue:1-3

    Topics: Acetylcysteine; Animals; Cysteine; Glutathione; Liver; Male; Mice; Mice, Inbred Strains; Signal-To-Noise Ratio; Tissue Distribution; Trichloroethylene

2018
The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces progressive mitochondrial dysfunction in HTR-8/SVneo trophoblasts.
    Toxicology, 2019, 11-01, Volume: 427

    Topics: Cell Line; Cysteine; DNA, Mitochondrial; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxygen Consumption; Trichloroethylene; Trophoblasts

2019
Exposure to Trichloroethylene Metabolite
    Chemical research in toxicology, 2020, 06-15, Volume: 33, Issue:6

    Topics: Amino Acids; AMP-Activated Protein Kinases; Cell Line; Cell Survival; Cysteine; Energy Metabolism; Glucose; Glycerol; Humans; Lipid Metabolism; Nutrients; Phosphofructokinase-1; Solvents; Trichloroethylene

2020
Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models.
    Archives of toxicology, 2023, Volume: 97, Issue:2

    Topics: Cysteine; Glutathione; Humans; Induced Pluripotent Stem Cells; NF-E2-Related Factor 2; Phenotype; Transcriptome; Trichloroethylene

2023