s-(1,2-dichlorovinyl)cysteine has been researched along with cysteine in 143 studies
| Studies (s-(1,2-dichlorovinyl)cysteine) | Trials (s-(1,2-dichlorovinyl)cysteine) | Recent Studies (post-2010) (s-(1,2-dichlorovinyl)cysteine) | Studies (cysteine) | Trials (cysteine) | Recent Studies (post-2010) (cysteine) |
|---|---|---|---|---|---|
| 154 | 1 | 15 | 40,132 | 418 | 11,457 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (18.88) | 18.7374 |
| 1990's | 63 (44.06) | 18.2507 |
| 2000's | 38 (26.57) | 29.6817 |
| 2010's | 13 (9.09) | 24.3611 |
| 2020's | 2 (1.40) | 2.80 |
| Authors | Studies |
|---|---|
| Jaken, S; Jones, TW; Stevens, JL; Wallin, A; Zhang, G | 1 |
| Anders, MW; Bittner, D; Dekant, W; Vamvakas, S | 1 |
| Stijntjes, GJ; te Koppele, JM; Vermeulen, NP | 1 |
| Chen, Q; Stevens, JL; Yu, K | 1 |
| Anders, MW; Ballatori, N; Simmons, TW | 1 |
| Chen, Q; Holbrook, NJ; Stevens, JL; Yu, K | 1 |
| Blagbrough, IS; Buckberry, LD; Bycroft, BW; Shaw, PN | 1 |
| Abraham, DG; Cooper, AJ | 1 |
| Cooley, AJ; Elfarra, AA; Sausen, PJ | 1 |
| Darnerud, PO; Feil, VJ; Gustafson, AL; Törnwall, U | 1 |
| Koechel, DA; Krejci, ME; Ridgewell, RE | 2 |
| Boogaard, PJ; Commandeur, JN; Mulder, GJ; Vermeulen, NP | 1 |
| Chakrabarti, S; Côté, MG; Vu, DD | 1 |
| Darnerud, PO; Hagberg, GB; Nordlander, U | 1 |
| Anders, MW; Vamvakas, S | 1 |
| Bakke, JE; Davison, KL | 1 |
| Cojocel, C; Mayer, D; Müller, W | 1 |
| Anders, MW; Sharma, VK; Sheu, SS; Vamvakas, S | 1 |
| Brown, PC; Chen, Q; Jones, TW; Stevens, JL | 1 |
| Chen, JC; Jones, TW; Stevens, JL; Trifillis, AL | 1 |
| Darnerud, PO; Olsson, L | 1 |
| Brendel, K; Gandolfi, AJ; Nagle, RB; Stevens, JL; Wolfgang, GH | 1 |
| Beuter, W; Cojocel, C; Donaubauer, HH; Mayer, D; Müller, W | 1 |
| Stevens, JL; Zhang, GH | 1 |
| Cojocel, C; Mayer, D | 1 |
| Brendel, K; Gandolfi, AJ; Stevens, JL; Wolfgang, GH | 2 |
| Bakke, JE; Brandt, I; Darnerud, PO; Feil, VJ | 2 |
| Anders, MW; Elfarra, AA; Jakobson, I | 1 |
| Anders, MW; Lash, LH | 3 |
| Schaeffer, VH; Stevens, JL | 2 |
| Anders, MW; Dekant, W; Elfarra, AA; Henschler, D; Vamvakas, S | 1 |
| Gandolfi, AJ; Meadows, SD; Nagle, RB; Shively, JW | 1 |
| Dekant, W; Henschler, D; Schiffmann, D; Vamvakas, S | 1 |
| Ayoubi, N; Robbins, JD; Stevens, JL | 1 |
| Hayden, P; Stevens, J; Taylor, G | 1 |
| Byrd, RA; Robbins, JD; Stevens, JL | 1 |
| Anders, MW; Elfarra, AA; Lash, LH | 1 |
| Brendel, K; Gandolfi, AJ; Silber, PM | 1 |
| Brendel, K; Gandolfi, AJ; Hassall, CD; Jaffe, DR | 1 |
| Beuter, W; Mayring, L; Schmid, A | 1 |
| Gandolfi, AJ; Jaffe, DR; Nagle, RB | 1 |
| Brendel, K; Duhamel, RC; Gandolfi, AJ; Hassall, CD | 1 |
| Brendel, K; Gandolfi, AJ; Hassall, CD | 2 |
| de Bont, HJ; Nagelkerke, JF; van de Water, B; Zoeteweij, JP | 1 |
| Chen, Q; Jones, TW; Stevens, JL | 1 |
| Anders, MW; Finkelstein, MB; Patel, NJ | 1 |
| Kays, SE; Schnellmann, RG | 1 |
| Dantzler, WH; Evans, KK; Wright, SH | 1 |
| Chen, Q; Liu, H; Stevens, JL; Yu, K; Zhan, Y | 1 |
| Jaspers, JJ; Maasdam, DH; Mulder, GJ; Nagelkerke, JF; Van de Water, B | 1 |
| Davis, JW; Petry, TW | 1 |
| Cooley, AJ; Duescher, RJ; Elfarra, AA; Lash, LH; Sausen, PJ | 1 |
| Lock, EA; Miller, GW; Schnellmann, RG | 1 |
| de Bont, HJ; Mulder, GJ; Nagelkerke, JF; van de Water, B; Zoeteweij, JP | 1 |
| Anders, MW; Fullone, JS; Patel, NJ | 1 |
| Berdanier, CD; Kays, SE; Lock, EA; Schnellmann, RG; Swagler, AR | 1 |
| Dong, L; Fabbro, D; Jaken, S; Stevens, JL | 1 |
| Groves, CE; Hayden, PJ; Lock, EA; Schnellmann, RG | 1 |
| de Bont, HJ; Mulder, GJ; Nagelkerke, JF; van de Water, B; Zoetewey, JP | 1 |
| Bull, RJ; Eyre, RJ; Parker, JC; Stevens, DK | 2 |
| Bittner, D; Richter, H; Vamvakas, S | 2 |
| Nagelkerke, JF; van de Water, B; Zoeteweij, JP | 1 |
| Bouthillier, L; Brodeur, J; Charbonneau, M | 1 |
| Gibson, G; Goldfarb, P; Harries, H; King, L; Lock, T; Perry, S; Scholfield, C | 1 |
| Ilinskaja, O; Vamvakas, S | 1 |
| Anders, MW; Finkelstein, MB; Lock, EA; Moore, RB; Sani, Y; Seawright, AA | 1 |
| Adcock, HJ; Buckberry, LD; Gaskin, PJ; Shaw, PN; Teesdale-Spittle, PH | 1 |
| Asano, Y; Cooper, AJ; Kato, Y | 1 |
| Kruidering, M; Nagelkerke, JF; Van de Water, B | 1 |
| Bernauer, U; Birner, G; Dekant, W; Henschler, D | 1 |
| Anders, MW; Otieno, MA | 1 |
| Dow, J; Ellis, MK; Foster, JR; Green, T; Odum, J | 1 |
| Aleo, MD; Walsh Clang, CM | 1 |
| Cleveland, JL; Stevens, JL; Zhan, Y | 1 |
| Bernauer, U; Birner, G; Dekant, W; Werner, M | 1 |
| North, J; Stevens, JL; Wright, SH; Wunz, TM | 1 |
| Richter, H; Vamvakas, S | 1 |
| Dantzler, WH; Evans, KK; Groves, CE; North, J; Stevens, JL; Welborn, JR; Wright, SH | 1 |
| Dekant, W; Völkel, W | 1 |
| Keasler, KB; McKeller, DE; Nowak, G; Schnellmann, RG | 1 |
| Nagelkerke, JF; Stevens, JL; van de Water, B | 1 |
| Cummings, BS; Lash, LH | 1 |
| Carter, CA; Nowak, G; Schnellmann, RG | 1 |
| Cummings, BS; Lash, LH; Novak, RF; Zangar, RC | 1 |
| Anders, MW; Cai, J; Chen, Y; Jones, DP; Stevens, JL | 1 |
| Nony, PA; Nowak, G; Schnellmann, RG | 1 |
| Hueni, SE; Lash, LH; Putt, DA | 1 |
| Anders, MW; Bruschi, SA; Cooper, AJ | 1 |
| Lash, LH; Matherly, LH; Putt, DA | 1 |
| Elfarra, AA; Krause, RJ; Lash, LH | 1 |
| Elfarra, AA; Hueni, SE; Krause, RJ; Lash, LH; Putt, DA | 1 |
| Nowak, G | 1 |
| Bucci, TJ; Lock, EA; Mehendale, HM; Shankar, K; Vaidya, VS | 2 |
| Hawksworth, GM; Lock, EA; McGoldrick, TA; Rodilla, V | 1 |
| DeGroot, DE; DuTeaux, SB; Hengel, MJ; Jelks, KA; Miller, MG | 1 |
| Godwin, ML; Liu, X; Nowak, G | 1 |
| Korrapati, MC; Lock, EA; Mehendale, HM | 1 |
| Corless, S; Cramer, R; de Graauw, M; Tijdens, I; Timms, JF; van de Water, B | 1 |
| Horwitz, BP; Hueni, SE; Lash, LH; Putt, DA | 1 |
| Liang, YL; Su, JM; Wang, LY; Zha, XL | 1 |
| Dnyanmote, AV; Latendresse, JR; Lock, EA; Mehendale, HM; Sawant, SP; Warbritton, AA | 1 |
| Latendresse, JR; Mehendale, HM; Reddy, RN | 1 |
| Dekant, W; Everitt, JI; Mally, A; Vamvakas, S; Walker, CL | 1 |
| Argraves, SW; Barth, JL; Lock, EA; Schnellmann, RG | 1 |
| Fifer, EK; Nowak, G; Shaik, ZP | 2 |
| Caldwell, JC; Keshava, N | 1 |
| de Graauw, M; Deelder, AM; Le Dévédec, S; Smeets, MB; Tijdens, I; van de Water, B | 1 |
| Hueni, SE; Lash, LH; Payton, SG; Putt, DA; Zwickl, J | 1 |
| Chilakapati, J; Korrapati, MC; Lock, EA; Mehendale, HM; Rao, C; Witzmann, FA | 1 |
| Barshteyn, N; Elfarra, AA | 3 |
| Clay, P | 1 |
| Lash, LH; Papanayotou, I; Putt, DA; Wang, J; Xu, F | 1 |
| Berger, T; Wu, KL | 1 |
| Collins, LB; Kim, D; Kim, S; Pollack, GM; Rusyn, I | 1 |
| Ball, LM; Boysen, G; Bradford, BU; Collins, LB; Gold, A; Kim, S; Rusyn, I; Swenberg, JA | 1 |
| Breuning, MH; de Heer, E; Happé, H; Kunnen, SJ; Leonhard, WN; Peters, DJ; van der Wal, AM | 1 |
| Brownfield, MS; Elfarra, AA; Irving, RM | 1 |
| Elfarra, AA; Irving, RM | 1 |
| Hagiwara, H; Hagiwara, K; Hirose, S; Ohtsuji, M; Ohtsuji, N; Shirai, N; Tomisawa, H | 1 |
| Ball, LM; Bodnar, WM; Bradford, BU; Collins, LB; Gold, A; Kosyk, O; Rusyn, I; Shymonyak, S; Uehara, T; Yoo, HS | 2 |
| Boldenow, E; Chames, MC; Hassan, I; Loch-Caruso, R; Xi, C | 1 |
| Hassan, I; Kumar, AM; Lash, LH; Loch-Caruso, R; Park, HR | 1 |
| Elkin, ER; Harris, SM; Loch-Caruso, R | 1 |
| Chiu, W; Furuya, S; Luo, YS; Rusyn, I | 1 |
| Formica, C; Happé, H; McNeill, H; Peters, DJ; Scharpfenecker, M; Veraar, KA; Vortkamp, A | 1 |
| Bridges, D; Elkin, ER; Loch-Caruso, R | 1 |
| 't Hoen, PAC; Balog, J; Formica, C; Malas, T; Peters, DJM; Verburg, L | 1 |
| Bridges, D; Elkin, ER; Harris, SM; Loch-Caruso, RK | 1 |
| Baldovini, J; Capinha, L; Carta, G; Commandeur, JNM; Dinnyes, A; Grillari, J; Holzer, AK; Jennings, P; Leist, M; Mazidi, Z; Murphy, C; Ückert, AK; van de Water, B; Zana, M; Zhang, Y | 1 |
5 review(s) available for s-(1,2-dichlorovinyl)cysteine and cysteine
| Article | Year |
|---|---|
Perturbation of calcium homeostasis as a link between acute cell injury and carcinogenesis in the kidney.
Topics: Animals; Calcium; Cysteine; Homeostasis; Humans; Kidney; Kidney Neoplasms; Mercuric Chloride; Trichloroethylene | 1990 |
Poly(ADP-ribosyl)ation and nuclear matrix/intermediate filament proteins in renal carcinogenesis.
Topics: Animals; Carcinogens; Cell Line; Cysteine; DNA Damage; Humans; Intermediate Filament Proteins; Kidney; Kidney Neoplasms; Nuclear Matrix; Nuclear Proteins; Poly Adenosine Diphosphate Ribose | 1997 |
Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism.
Topics: Animals; Carbon-Sulfur Lyases; Cysteine; Energy Metabolism; Humans; Hydrocarbons, Fluorinated; Lyases; Mitochondria; Pyridoxal Phosphate | 2002 |
Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
Topics: Animals; Carcinogenicity Tests; Chloral Hydrate; Cysteine; Dichloroacetic Acid; Environmental Pollutants; History, 21st Century; Humans; Kidney Neoplasms; Liver Neoplasms; Risk Assessment; Risk Factors; Signal Transduction; Trichloroacetic Acid; Trichloroethylene; United States | 2006 |
Role of reactive metabolites in the circulation in extrahepatic toxicity.
Topics: Acetylcysteine; Cysteine; Humans; Kidney; Liver; Trichloroethylene | 2012 |
1 trial(s) available for s-(1,2-dichlorovinyl)cysteine and cysteine
| Article | Year |
|---|---|
The transport of S-cysteine conjugates in LLC-PK1 cells and its role in toxicity.
Topics: Animals; Binding, Competitive; Biological Transport; Cell Line; Cysteine; Kidney; Kinetics; Sodium; Structure-Activity Relationship | 1987 |
137 other study(ies) available for s-(1,2-dichlorovinyl)cysteine and cysteine
| Article | Year |
|---|---|
Mechanism of the nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1,2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells.
Topics: Alkaline Phosphatase; Animals; Cell Division; Cells, Cultured; Cysteine; gamma-Glutamyltransferase; Keratins; Kidney; Kidney Tubules, Proximal; Male; Microvilli; Models, Biological; Necrosis; Rats; Rats, Inbred Strains; Urea; Vimentin | 1992 |
Events that precede and that follow S-(1,2-dichlorovinyl)-L-cysteine-induced release of mitochondrial Ca2+ and their association with cytotoxicity to renal cells.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Benzamides; Biotransformation; Calcium; Cell Division; Cell Line; Cysteine; DNA Damage; Down-Regulation; Kidney Cortex; Methylnitronitrosoguanidine; Mitochondria; Nuclear Proteins; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Swine | 1992 |
High-performance liquid chromatography-fluorescence assay of pyruvic acid to determine cysteine conjugate beta-lyase activity: application to S-1,2-dichlorovinyl-L-cysteine and S-2-benzothiazolyl-L-cysteine.
Topics: Animals; Benzothiazoles; Carbon-Sulfur Lyases; Cell Fractionation; Chromatography, High Pressure Liquid; Cysteine; Cytosol; Kidney; Kinetics; Lyases; Male; Mitochondria; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar; Spectrometry, Fluorescence | 1992 |
Regulation of the cellular stress response by reactive electrophiles. The role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock protein gene by nephrotoxic cysteine conjugates.
Topics: Aminooxyacetic Acid; Animals; Calcium; Cell Line; Cycloheximide; Cysteine; Dactinomycin; Dithiothreitol; Gene Expression Regulation; Heat-Shock Proteins; Hydrocarbons, Fluorinated; Kidney; Kinetics; Lipid Peroxidation; Molecular Weight; Protein Conformation; RNA, Messenger; Signal Transduction; Transcription, Genetic | 1992 |
L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine transport in rat liver canalicular membrane vesicles: potential reabsorption mechanisms for biliary metabolites of glutathione and its S-conjugates.
Topics: Absorption; Amino Acids; Animals; Bile; Biological Transport; Cell Membrane; Cysteine; Glutathione; Liver; Male; Rats; Rats, Inbred Strains | 1992 |
Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol.
Topics: Aminooxyacetic Acid; Calcium; Cations, Divalent; Cell Line; Cycloheximide; Cysteine; Dactinomycin; Dithiothreitol; DNA Damage; Drug Interactions; Kidney; Protein Biosynthesis; RNA, Messenger; Transcription, Genetic | 1992 |
Kynurenine aminotransferase activity in human liver: identity with human hepatic C-S lyase activity and a physiological role for this enzyme.
Topics: Adult; Carbon-Sulfur Lyases; Cysteine; Electrophoresis, Polyacrylamide Gel; Female; Humans; Isoelectric Point; Liver; Lyases; Male; Microsomes, Liver; Mitochondria, Liver; Molecular Weight; Pregnancy; Sodium Dodecyl Sulfate; Transaminases | 1992 |
Glutamine transaminase K and cysteine S-conjugate beta-lyase activity stains.
Topics: Animals; Cysteine; Electrophoresis, Polyacrylamide Gel; Kidney; Lyases; Methionine; Molecular Weight; Nitroblue Tetrazolium; Phenylalanine; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Staining and Labeling; Transaminases | 1991 |
Methimazole protection of rats against chemically induced kidney damage in vivo.
Topics: Animals; Blood Urea Nitrogen; Cephaloridine; Cisplatin; Cysteine; Hydroquinones; Kidney; Kidney Diseases; Male; Methimazole; Oxidation-Reduction; Oxygen; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1992 |
Age- and sex-dependent dichlorovinyl cysteine (DCVC) accumulation and toxicity in the mouse kidney: relation to development of organic anion transport and beta-lyase activity.
Topics: Aging; Animals; Animals, Newborn; Blood Urea Nitrogen; Cysteine; Kidney; Kidney Diseases; Liver; Mice; Mice, Inbred C57BL; Sex Factors | 1991 |
The acute effects of S-(1,2-dichlorovinyl)-L-cysteine and related chemicals on renal function and ultrastructure in the pentobarbital-anesthetized dog: structure-activity relationships, biotransformation, and unique site-specific nephrotoxicity.
Topics: Anesthesia; Animals; Biotransformation; Carbon-Sulfur Lyases; Chromatography, High Pressure Liquid; Cysteine; Dogs; Female; Kidney; Kidney Diseases; Lyases; Male; Pentobarbital; Respiration, Artificial; Structure-Activity Relationship; Urodynamics | 1991 |
Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.
Topics: Acetylcysteine; Animals; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Male; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium; Stereoisomerism; Trichloroethylene | 1991 |
Acute effects of the D-isomer of S-(1,2-dichlorovinyl)cysteine on renal function and ultrastructure in the pentobarbital-anesthetized dog: site-specific toxicity involving the S1 and S2 cells of the proximal tubule.
Topics: Animals; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cysteine; Dogs; Female; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Oxidoreductases; Pentobarbital; Stereoisomerism; Urine | 1991 |
Effects of S-(1,2-dichlorovinyl)-L-cysteine on the transport of para-aminohippurate ion in renal plasma membrane vesicles.
Topics: Animals; Biological Transport; Cell Membrane; Cysteine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Kidney; Kidney Tubules; Male; Microvilli; p-Aminohippuric Acid; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase | 1990 |
Dichlorovinyl cysteine (DCVC)-induced enzymuria in mice: potential application in occupational toxicology?
Topics: Alkaline Phosphatase; Animals; Blood Urea Nitrogen; Cysteine; Female; gamma-Glutamyltransferase; Kidney; L-Lactate Dehydrogenase; Mice; Toxicology | 1990 |
Elimination of 14C by calves, pigs and rats renally perfused with radiolabelled dichlorovinyl or acetamide substrates.
Topics: Acetanilides; Acetylation; Acetylcysteine; Animals; Carbon Radioisotopes; Cattle; Cysteine; Herbicides; Iodoacetamide; Kidney; Perfusion; Rats; Rats, Inbred Strains; Swine; Trichloroethylene | 1990 |
Effects of antioxidants and of different metabolic activation systems on dichlorovinylcysteine-induced genotoxicity.
Topics: Animals; Antioxidants; Cysteine; DNA Damage; Escherichia coli; Glutathione; Humans; Kidney Cortex; Liver; Mice; Mutagenesis; Rats; Salmonella typhimurium | 1990 |
Perturbations of intracellular calcium distribution in kidney cells by nephrotoxic haloalkenyl cysteine S-conjugates.
Topics: Animals; Calcium; Cell Line; Cysteine; Homeostasis; Homocysteine; Kidney; Mitochondria; Probenecid; Swine | 1990 |
The mechanism of cysteine conjugate cytotoxicity in renal epithelial cells. Covalent binding leads to thiol depletion and lipid peroxidation.
Topics: Animals; Antioxidants; Carbon-Sulfur Lyases; Cell Line; Cell Survival; Cysteine; Deferoxamine; Dithiothreitol; Epithelium; In Vitro Techniques; Kidney; Lipid Peroxides; Lyases; Phenylenediamines; Rats; Sulfhydryl Compounds | 1990 |
Renal cysteine conjugate beta-lyase-mediated toxicity studied with primary cultures of human proximal tubular cells.
Topics: Adolescent; Adult; Aminooxyacetic Acid; Butadienes; Carbon-Sulfur Lyases; Cells, Cultured; Child; Cysteine; Dose-Response Relationship, Drug; Epithelial Cells; Female; Glutathione; Humans; Hydrocarbons, Fluorinated; Kidney Tubules, Proximal; Lyases; Male; Middle Aged; Structure-Activity Relationship | 1990 |
Transplacental passage and fetal kidney binding of 14C-dichlorovinyl cysteine (DCVC) in mice.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Cysteine; Female; Fetus; Kidney; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; Scintillation Counting | 1990 |
Assessment of S-(1,2-dichlorovinyl)-L-cysteine induced toxic events in rabbit renal cortical slices. Biochemical and histological evaluation of uptake, covalent binding, and toxicity.
Topics: Animals; Cell Membrane; Cysteine; In Vitro Techniques; Kidney Cortex; Lyases; Mitochondria; Rabbits | 1990 |
Peroxidative damage and nephrotoxicity of dichlorovinylcysteine in mice.
Topics: Animals; Blood Urea Nitrogen; Chromatography, High Pressure Liquid; Cysteine; Ethane; Gluconeogenesis; Glutathione; In Vitro Techniques; Kidney Cortex; Kidney Diseases; Lipid Peroxidation; Liver; Male; Malondialdehyde; Mice; p-Aminohippuric Acid; Tetraethylammonium Compounds | 1989 |
Transport and activation of S-(1,2-dichlorovinyl)-L-cysteine and N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine in rat kidney proximal tubules.
Topics: Acetylcysteine; Animals; Biological Transport; Biotransformation; Cysteine; Drug Interactions; In Vitro Techniques; Kidney Tubules, Proximal; Male; Probenecid; Rats; Rats, Inbred Strains; Sulfur Radioisotopes | 1989 |
Depletion of cytochrome P-450 and alterations in activities of drug metabolizing enzymes by S-(1,2-dichlorovinyl)-L-cysteine in mouse kidney cortex.
Topics: Animals; Cysteine; Cytochrome b Group; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Kidney Cortex; Liver; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases | 1989 |
N-acetyl S-(1,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-L-cysteine in rabbit renal slices: differential transport and metabolism.
Topics: Acetylation; Aminooxyacetic Acid; Animals; Biological Transport; Cysteine; Dose-Response Relationship, Drug; Hydrocarbons, Halogenated; Kidney Cortex; Kidney Tubules, Proximal; p-Aminohippuric Acid; Potassium; Probenecid; Rabbits | 1989 |
In vitro and in vivo nephrotoxicity of the L and D isomers of S-(1,2-dichlorovinyl)-cysteine.
Topics: Animals; Blood Urea Nitrogen; Culture Techniques; Cysteine; Isomerism; Kidney Cortex; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Male; Potassium; Rabbits; Time Factors | 1989 |
Dichlorovinyl cysteine (DCVC) in the mouse kidney: tissue-binding and toxicity after glutathione depletion and probenecid treatment.
Topics: Animals; Autoradiography; Cysteine; Female; Glutathione; Kidney; Kidney Diseases; Kidney Tubules; Mice; Mice, Inbred C57BL; Probenecid; Sulfhydryl Compounds | 1989 |
Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.
Topics: Aminooxyacetic Acid; Animals; Blood Urea Nitrogen; Carbon-Sulfur Lyases; Cysteine; gamma-Glutamyltransferase; Glutathione; Glycosuria; Isoxazoles; Kidney; Liver; Lyases; Male; Mitochondria; Probenecid; Rats; Rats, Inbred F344; Subcellular Fractions | 1986 |
Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells.
Topics: Adenine Nucleotides; Aminooxyacetic Acid; Aminopeptidases; Animals; CD13 Antigens; Cell Survival; Cysteine; Dipeptides; Dose-Response Relationship, Drug; Glutathione; Glycylglycine; Isoxazoles; Kidney Tubules, Proximal; Male; Oxygen Consumption; Phenanthrolines; Rats; Rats, Inbred F344; Time Factors | 1986 |
Mutagenicity of amino acid and glutathione S-conjugates in the Ames test.
Topics: Acetylcysteine; Animals; Carbon-Sulfur Lyases; Cysteine; gamma-Glutamyltransferase; Glutathione; Homocysteine; Kidney; Liver; Lyases; Rats; Salmonella typhimurium; Structure-Activity Relationship | 1988 |
S-(1,2-dichloro-[14C]vinyl)-L-cysteine (DCVC) in the mouse kidney: correlation between tissue-binding and toxicity.
Topics: Animals; Autoradiography; Cysteine; Female; gamma-Glutamyltransferase; Intestinal Mucosa; Kidney; Liver; Mice; Mice, Inbred C57BL; Sulfhydryl Compounds; Tissue Distribution | 1988 |
Uptake of nephrotoxic S-conjugates by isolated rat renal proximal tubular cells.
Topics: Aminooxyacetic Acid; Animals; Biological Transport; Cysteine; Homocysteine; In Vitro Techniques; Kidney Tubules, Proximal; Male; Probenecid; Rats; Rats, Inbred F344; Sodium | 1989 |
Enhancement of DMN-induced kidney tumors by 1,2-dichlorovinylcysteine in Swiss-Webster mice.
Topics: Animals; beta-Cyclodextrins; Cocarcinogenesis; Cyclodextrins; Cysteine; Dimethylnitrosamine; Drug Synergism; Kidney; Kidney Neoplasms; Mice | 1988 |
Induction of unscheduled DNA synthesis and micronucleus formation in Syrian hamster embryo fibroblasts treated with cysteine S-conjugates of chlorinated hydrocarbons.
Topics: Animals; Cell Survival; Cricetinae; Cysteine; DNA Repair; Fibroblasts; Hydrocarbons, Chlorinated; Mesocricetus; Micronucleus Tests | 1988 |
The role of mitochondrial matrix enzymes in the metabolism and toxicity of cysteine conjugates.
Topics: Aminooxyacetic Acid; Animals; Benzothiazoles; Cysteine; Cytosol; Keto Acids; Kidney; Lyases; Male; Methionine; Mitochondria; Rats; Rats, Inbred Strains; Transaminases | 1988 |
Mechanism of transport for toxic cysteine conjugates in rat kidney cortex membrane vesicles.
Topics: Animals; Biological Transport; Cell Membrane; Cell-Free System; Cysteine; In Vitro Techniques; Kidney Cortex; Kinetics; Microvilli; Osmolar Concentration; Rats; Sodium; Structure-Activity Relationship | 1987 |
Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity.
Topics: Adenosine Triphosphate; Cysteine; Glutathione; Homocysteine; Kidney; Lipid Peroxides; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption | 1987 |
The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells.
Topics: Acetylcysteine; Aminooxyacetic Acid; Animals; Carbon-Sulfur Lyases; Cell Line; Cell Survival; Cysteine; Glutathione; Isoxazoles; Kidney Tubules, Proximal; Lyases; Microscopy, Electron; Pyruvates; Pyruvic Acid; Structure-Activity Relationship; Swine | 1986 |
A purified cysteine conjugate beta-lyase from rat kidney cytosol. Requirement for an alpha-keto acid or an amino acid oxidase for activity and identity with soluble glutamine transaminase K.
Topics: Amino Acid Oxidoreductases; Animals; Chromatography, High Pressure Liquid; Cysteine; Cytosol; Kidney Cortex; Kinetics; L-Amino Acid Oxidase; Lyases; Male; Methionine; Rats; Rats, Inbred Strains; Spectrophotometry; Transaminases | 1986 |
Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Animals; Benzothiazoles; Cysteine; Drug Synergism; Keto Acids; Kidney; Lyases; Male; Mitochondria; Oxygen Consumption; Rats; Thiazoles; Transaminases | 1987 |
Early biological indicators of S-(1,2-dichlorovinyl)-L-cysteine nephrotoxicity in the rabbit.
Topics: Animals; Blood Urea Nitrogen; Cysteine; Glomerular Filtration Rate; Glycosuria; Kidney; Kidney Diseases; Male; Proteinuria; Rabbits | 1986 |
Production of DNA single strand breaks in rabbit renal tissue after exposure to 1,2-dichlorovinylcysteine.
Topics: Animals; Cysteine; DNA; Dose-Response Relationship, Drug; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Male; Perfusion; Rabbits | 1985 |
[Mechanism of action of S-(dichlorovinyl)-L-cysteine].
Topics: Animals; Biotransformation; Carbon Dioxide; Cysteine; Drug Antagonism; Ethane; Kidney; Male; Malondialdehyde; Metyrapone; Mice; Pulmonary Gas Exchange | 1983 |
Chronic toxicity of S-(trans-1,2-dichlorovinyl)-L-cysteine in mice.
Topics: Animals; Cataract; Cysteine; Glutathione; Kidney; Kidney Tubules; Male; Mice | 1984 |
The formation and biotransformation of cysteine conjugates of halogenated ethylenes by rabbit renal tubules.
Topics: Animals; Biotransformation; Chlorofluorocarbons; Cysteine; Glutathione; Hydrocarbons, Halogenated; Kidney Tubules; Rabbits | 1984 |
Correlation of the in vivo and in vitro renal toxicity of S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Animals; Biological Transport, Active; Cysteine; In Vitro Techniques; Kidney; Kidney Tubules; Rabbits; Time Factors | 1983 |
Regulation of a S(trans-1,2-dichlorovinyl)-L-cysteine-induced renal tubular toxicity by glutathione.
Topics: Animals; Biological Transport, Active; Cysteine; Glutathione; Kidney Tubules; Rabbits | 1983 |
Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury.
Topics: Animals; Cell Death; Cysteine; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex IV; Hydrogen Peroxide; Kidney; Male; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Oxidative Stress; Oxidoreductases; Potassium Cyanide; Rats; Rats, Wistar; Succinate Dehydrogenase; Ubiquinone | 1995 |
Early cellular events couple covalent binding of reactive metabolites to cell killing by nephrotoxic cysteine conjugates.
Topics: Aminooxyacetic Acid; Animals; Antioxidants; Calcium; Cell Death; Chelating Agents; Cysteine; Extracellular Space; Intracellular Membranes; Ionomycin; Kidney; Lipid Peroxides; LLC-PK1 Cells; Ruthenium Red; Swine | 1994 |
Metabolism of [14C]- and [35S]S-(1,2-dichlorovinyl)-L-cysteine in the male Fischer 344 rat.
Topics: Aminooxyacetic Acid; Animals; Biotransformation; Chromatography, High Pressure Liquid; Cysteine; Half-Life; Injections, Intraperitoneal; Injections, Intravenous; Male; Rats; Rats, Inbred F344; Sulfates; Tissue Distribution | 1995 |
Regeneration of renal proximal tubule cells in primary culture following toxicant injury: response to growth factors.
Topics: Animals; Cells, Cultured; Cysteine; Epidermal Growth Factor; Female; Growth Substances; Insulin; Insulin-Like Growth Factor I; Kidney Tubules, Proximal; Oligopeptides; Peroxides; Rabbits; Reactive Oxygen Species; Regeneration; tert-Butylhydroperoxide | 1995 |
Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules.
Topics: Acetylcysteine; Animals; Anion Transport Proteins; Carrier Proteins; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Mercuric Chloride; p-Aminohippuric Acid; Probenecid; Rabbits | 1995 |
Signalling the molecular stress response to nephrotoxic and mutagenic cysteine conjugates: differential roles for protein synthesis and calcium in the induction of c-fos and c-myc mRNA in LLC-PK1 cells.
Topics: Animals; Calcium; Cell Death; Cysteine; Kidney; LLC-PK1 Cells; Mutagens; Protein Biosynthesis; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; RNA, Messenger; Signal Transduction; Swine; Transcription, Genetic | 1994 |
In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function.
Topics: Actins; Aminooxyacetic Acid; Animals; Cell Death; Cell Membrane; Cells, Cultured; Cysteine; Cytoskeleton; Egtazic Acid; Kidney Medulla; Kidney Tubules, Proximal; Kinetics; Lipid Peroxidation; Male; Rats; Rats, Wistar; Time Factors | 1994 |
Inhibition of S-(1,2-dichlorovinyl)-L-cysteine-induced lipid peroxidation by antioxidants in rabbit renal cortical slices: dissociation of lipid peroxidation and toxicity.
Topics: Aminooxyacetic Acid; Animals; Antioxidants; Chromans; Cysteine; Deferoxamine; DNA; In Vitro Techniques; Kidney Cortex; Lipid Peroxidation; Male; Piperazines; Potassium; Pregnatrienes; Rabbits; Thiobarbituric Acid Reactive Substances | 1994 |
Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide.
Topics: Animals; Biotransformation; Carbon-Sulfur Lyases; Cells, Cultured; Cysteine; Cysteine Dioxygenase; Dioxygenases; Enzyme Activation; Kidney Diseases; Kidney Tubular Necrosis, Acute; Kidney Tubules, Distal; Kidney Tubules, Proximal; Lyases; Male; Oxidation-Reduction; Oxygenases; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sulfoxides | 1994 |
Strychnine and glycine protect renal proximal tubules from various nephrotoxicants and act in the late phase of necrotic cell injury.
Topics: Animals; Antimycin A; Cell Death; Cysteine; Glycine; Hydrocarbons, Fluorinated; Hydroquinones; In Vitro Techniques; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Necrosis; Peroxides; Rabbits; Sodium Cyanide; Strychnine; tert-Butylhydroperoxide | 1994 |
Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine.
Topics: Animals; Antioxidants; Benzene Derivatives; Calcium; Cysteine; Deferoxamine; Egtazic Acid; Flow Cytometry; In Vitro Techniques; Intracellular Membranes; Kidney Tubules, Proximal; Kinetics; Male; Membrane Potentials; Mitochondria; Oxygen; Phenylenediamines; Rats; Rats, Wistar | 1994 |
Brain uptake of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of the neurotoxin dichloroacetylene.
Topics: Acetylene; Animals; Biological Transport; Biotransformation; Blood-Brain Barrier; Brain; Cysteine; Glutathione; Neurotoxins; Rats | 1993 |
An in vitro model of renal proximal tubule cell regeneration.
Topics: Animals; Cell Survival; Cells, Cultured; Cysteine; Female; In Vitro Techniques; Kidney Diseases; Kidney Tubules, Proximal; Kinetics; Models, Biological; Rabbits; Regeneration | 1993 |
Regulation of protein kinase C isozymes in kidney regeneration.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cysteine; Folic Acid; Hypertrophy; Immunoblotting; Isoenzymes; Kidney; Male; Necrosis; Nephrectomy; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reference Values; Regeneration; Subcellular Fractions | 1993 |
Differential cellular effects in the toxicity of haloalkene and haloalkane cysteine conjugates to rabbit renal proximal tubules.
Topics: Aminooxyacetic Acid; Animals; Biotransformation; Cell Death; Cysteine; Female; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; In Vitro Techniques; Kidney Tubules, Proximal; Lipid Peroxidation; Mitochondria; Oxygen Consumption; Rabbits; Sulfur Radioisotopes | 1993 |
The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine.
Topics: Aminoquinolines; Animals; Calcium; Cysteine; Edetic Acid; Egtazic Acid; Flow Cytometry; Kidney Tubules, Proximal; Male; Membrane Potentials; Mitochondria; Rats; Rats, Wistar; Time Factors | 1993 |
Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethene metabolism.
Topics: Amino Acids; Animals; Biomarkers; Carbon Radioisotopes; Cysteine; Dichloroacetic Acid; Hydrolysis; Kidney; Liver; Male; Mice; Rats; Rats, Inbred F344; Species Specificity; Time Factors; Trichloroethylene | 1995 |
Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice.
Topics: Animals; Carrier Proteins; Cell Division; Cysteine; Dose-Response Relationship, Drug; Kidney; Kidney Diseases; Male; Mice; Rats; Rats, Inbred F344; Species Specificity; Trichloroethylene | 1995 |
Induction of dedifferentiated clones of LLC-PK1 cells upon long-term exposure to dichlorovinylcysteine.
Topics: Ammonia; Animals; Antigens, Nuclear; Cell Differentiation; Clone Cells; Cysteine; Gene Expression; Genes, fos; Glucose; Immunoblotting; Intermediate Filament Proteins; Kidney Tubules, Proximal; LLC-PK1 Cells; Nuclear Proteins; Poly(ADP-ribose) Polymerases; Subcellular Fractions; Swine; Time Factors | 1996 |
Alkylation-induced oxidative cell injury of renal proximal tubular cells: involvement of glutathione redox-cycle inhibition.
Topics: Alkylation; Animals; Carmustine; Cell Death; Cysteine; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Hydrogen Peroxide; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; Male; Oxidation-Reduction; Pentanoic Acids; Rats; Rats, Wistar; Sulfur Radioisotopes | 1996 |
Assessment of the role of glutathione conjugation in the protection afforded by anethol dithiolthione against hexachloro-1,3-butadiene-induced nephrotoxicity.
Topics: Anethole Trithione; Animals; Bile; Binding Sites; Butadienes; Cholagogues and Choleretics; Cysteine; Cytosol; Female; Fungicides, Industrial; gamma-Glutamyltransferase; Glutathione; Glycosuria; Kidney Cortex; Liver; Lyases; p-Aminohippuric Acid; Proteinuria; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds | 1996 |
Molecular cloning and expression of cDNAs for rat and human kidney cysteine conjugate beta-lyase.
Topics: Animals; Carbon-Sulfur Lyases; Cell Line; Cell Survival; Cloning, Molecular; Cysteine; Gene Expression; Gene Library; Humans; Kidney; Kinetics; Lyases; Rats; Recombinant Proteins; Transaminases; Transfection | 1996 |
Alterations of the renal function in the isolated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine.
Topics: Animals; Cysteine; In Vitro Techniques; Injections, Intraperitoneal; Kidney; Kidney Function Tests; Male; Perfusion; Rats; Rats, Wistar | 1996 |
Bone marrow and renal injury associated with haloalkene cysteine conjugates in calves.
Topics: Animals; Bone Marrow; Butadienes; Cattle; Cysteine; Female; Fungicides, Industrial; Hydrocarbons, Halogenated; Kidney; Male | 1996 |
Novel sources of mammalian C-S lyase activity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biotransformation; Cysteine; Cysteine Synthase; Models, Molecular; Myocardium; Substrate Specificity; Swine | 1996 |
Inactivation of brain and kidney aspartate aminotransferases by S-(1,2,-dichlorovinyl)-L-cysteine and by S-(1,1,2,2,-tetrafluoroethyl)-L-cysteine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Brain; Cysteine; Cytosol; Enzyme Activation; Hydrocarbons, Fluorinated; Kidney; Male; Mitochondria; Myocardium; Rats; Rats, Wistar; Swine | 1996 |
F-actin disorganization in apoptotic cell death of cultured rat renal proximal tubular cells.
Topics: Actins; Animals; Antioxidants; Apoptosis; Calcium; Cells, Cultured; Cycloheximide; Cysteine; Dactinomycin; Dithiothreitol; Kidney Tubules, Proximal; Lyases; Male; Phenylenediamines; Rats; Rats, Wistar | 1996 |
Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.
Topics: Acetylcysteine; Administration, Inhalation; Adult; Aged; Animals; Biotransformation; Cysteine; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Male; Middle Aged; Rats; Trichloroethylene | 1996 |
Cysteine S-conjugates activate transcription factor NF-kappa B in cultured renal epithelial cells.
Topics: Acetylcysteine; Aminooxyacetic Acid; Animals; Antioxidants; Base Sequence; Cell Line; Cell Nucleus; Consensus Sequence; Cysteine; Cytosol; Epithelium; Genes, Reporter; Kidney; Luciferases; Macromolecular Substances; NF-kappa B; Oligodeoxyribonucleotides; Recombinant Fusion Proteins; Swine; Transcriptional Activation; Transfection; Tumor Necrosis Factor-alpha | 1997 |
The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene.
Topics: Animals; Arylamine N-Acetyltransferase; Carbon-Sulfur Lyases; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Humans; In Vitro Techniques; Isomerism; Kidney; Kidney Neoplasms; Kinetics; Lyases; Male; Mice; Rats; Rats, Inbred F344; Trichloroethylene | 1997 |
Mechanistic analysis of S-(1,2-dichlorovinyl)-L-cysteine-induced cataractogenesis in vitro.
Topics: Adenosine Triphosphate; Animals; Cataract; Cysteine; Glutathione; Male; Methimazole; Rats; Rats, Sprague-Dawley | 1997 |
A role for c-myc in chemically induced renal-cell death.
Topics: Apoptosis; Cell Death; Cells, Cultured; Cysteine; Epithelial Cells; Gene Expression Regulation; Kidney Tubules; Kinetics; Necrosis; Ornithine Decarboxylase; Proto-Oncogene Proteins c-myc; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transcriptional Activation | 1997 |
Biotransformation, excretion and nephrotoxicity of haloalkene-derived cysteine S-conjugates.
Topics: Acetylation; Acetylcysteine; Animals; Biotransformation; Butadienes; Cysteine; Female; gamma-Glutamyltransferase; Kidney; Liver; Male; Necrosis; Rats; Rats, Wistar; Sex Factors | 1997 |
Na-dependent transport of S-(1,2-dichlorovinyl)-L-cysteine by renal brush-border membrane vesicles.
Topics: Animals; Antiporters; Biological Transport; Cysteine; Kidney; Membrane Potentials; Microvilli; Phenylalanine; Rabbits; Sodium | 1998 |
S-(1,2-dichlorovinyl)-L-cysteine-induced dedifferentiation and p53 gene mutations in LLC-PK1 cells: a comparative investigation with S-(2-chloroethyl)cysteine, potassium bromate, cis-platinum and styrene oxide.
Topics: Ammonia; Animals; Bromates; Carcinogens; Cells, Cultured; Cisplatin; Cysteine; Epoxy Compounds; Genes, p53; Hydrogen-Ion Concentration; LLC-PK1 Cells; Methylglucosides; Point Mutation; Poly Adenosine Diphosphate Ribose; Polymorphism, Single-Stranded Conformational; Protein Biosynthesis; Proteins; Swine; Tumor Suppressor Protein p53 | 1998 |
Relation of cysteine conjugate nephrotoxicity to transport by the basolateral organic anion transport system in isolated S2 segments of rabbit proximal renal tubules.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Probenecid; Rabbits; Rubidium Radioisotopes | 1998 |
Chlorothioketene, the ultimate reactive intermediate formed by cysteine conjugate beta-lyase-mediated cleavage of the trichloroethene metabolite S-(1,2-Dichlorovinyl)-L-cysteine, forms cytosine adducts in organic solvents, but not in aqueous solution.
Topics: Acetates; Animals; Carbon-Sulfur Lyases; Cattle; Cysteine; Cytosine; DNA; DNA Adducts; Gas Chromatography-Mass Spectrometry; Ketones; Sensitivity and Specificity; Solutions; Solvents; Water | 1998 |
Differential effects of EGF on repair of cellular functions after dichlorovinyl-L-cysteine-induced injury.
Topics: Animals; Cell Division; Cysteine; Epidermal Growth Factor; Female; Intracellular Membranes; Kidney Diseases; Kidney Tubules, Proximal; Microvilli; Mitochondria; Oxygen Consumption; Rabbits; Regeneration; Wound Healing | 1999 |
Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Adhesion Molecules; Cells, Cultured; Cysteine; Cytoskeletal Proteins; Enzyme Activation; Epithelial Cells; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hydrolysis; Kidney Tubules, Proximal; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats | 1999 |
Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells.
Topics: Adult; Aged; Aminooxyacetic Acid; Chloral Hydrate; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Glutathione; Humans; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Male; Metyrapone; Microsomes; Middle Aged; Trichloroethylene | 2000 |
Ascorbic acid promotes recovery of cellular functions following toxicant-induced injury.
Topics: Animals; Antioxidants; Ascorbic Acid; Cell Division; Cell Membrane; Collagen; Cysteine; DNA; Female; Kidney Tubules, Proximal; Mitochondria; Rabbits; Sodium-Potassium-Exchanging ATPase | 2000 |
Cytotoxicity of trichloroethylene and S-(1, 2-dichlorovinyl)-L-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells.
Topics: Animals; Cells, Cultured; Cysteine; Cytochrome P-450 Enzyme System; DNA; Isoenzymes; Keratins; Kidney Tubules, Distal; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Male; Rats; Rats, Inbred F344; RNA, Messenger; Trichloroethylene; Vimentin | 2000 |
Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l-cysteine-induced apoptosis.
Topics: Aminooxyacetic Acid; Animals; Apoptosis; Caspases; Cells, Cultured; Cysteine; Cytochrome c Group; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Intracellular Membranes; Kidney Tubules, Proximal; Membrane Potentials; Mitochondria; Models, Animal; Swine | 2001 |
Collagen IV promotes repair of renal cell physiological functions after toxicant injury.
Topics: Animals; Ascorbic Acid; Basement Membrane; Cell Division; Cells, Cultured; Collagen; Cysteine; Female; Hydroxyproline; Kidney Tubules, Proximal; Kinetics; Oxygen Consumption; Procollagen-Proline Dioxygenase; Rabbits; Sodium-Potassium-Exchanging ATPase | 2001 |
Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
Topics: Adult; Aged; Annexin A5; Apoptosis; Caspases; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Cysteine; DNA; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Male; Methimazole; Microscopy, Confocal; Middle Aged; Necrosis; Tacrolimus; Time Factors | 2001 |
Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Cysteine; Dicarboxylic Acid Transporters; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Glutathione; Kidney Tubules, Proximal; Kinetics; Liposomes; Male; Malonates; Mitochondria; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; tert-Butylhydroperoxide; Transfection | 2002 |
Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity.
Topics: Adolescent; Adult; Aged; Blotting, Western; Chromatography, High Pressure Liquid; Cysteine; DNA, Complementary; Female; Humans; In Vitro Techniques; Isoenzymes; Kidney; Kidney Diseases; Male; Microsomes; Microsomes, Liver; Middle Aged; Monoamine Oxidase; Racial Groups; Sex Characteristics; Spectrophotometry, Ultraviolet | 2003 |
Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells.
Topics: Apoptosis; Cell Size; Cell Survival; Cysteine; Dose-Response Relationship, Drug; Glutathione; Humans; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Mitochondria; Necrosis; Sulfoxides | 2003 |
Protein kinase C mediates repair of mitochondrial and transport functions after toxicant-induced injury in renal cells.
Topics: Animals; Biological Transport; Cysteine; Cytosol; Female; Glucose; Kidney Tubules, Proximal; Mitochondria; Protein Kinase C; Rabbits; Regeneration; Sodium; Subcellular Fractions; tert-Butylhydroperoxide; Wound Healing | 2003 |
Renal injury and repair following S-1, 2 dichlorovinyl-L-cysteine administration to mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cysteine; Dose-Response Relationship, Drug; Enzymes; Glucose; Kidney; Kidney Diseases; Kinetics; Liver; Male; Mice; Proliferating Cell Nuclear Antigen; Regeneration | 2003 |
Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells.
Topics: Animals; Cells, Cultured; Cysteine; Glutathione; Humans; Hydrocarbons, Fluorinated; Kidney Tubules, Proximal; Lyases; Rats; Species Specificity; Time Factors; Urothelium | 2003 |
Evidence for trichloroethylene bioactivation and adduct formation in the rat epididymis and efferent ducts.
Topics: Animals; Biotransformation; Cysteine; Cytochrome P-450 CYP2E1; DNA Adducts; Dose-Response Relationship, Drug; Environmental Pollutants; Epididymis; Immunohistochemistry; Lyases; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Solvents; Transaminases; Trichloroethylene; Vas Deferens | 2003 |
Role of tissue repair in survival from s-(1,2-dichlorovinyl)-L-cysteine-induced acute renal tubular necrosis in the mouse.
Topics: Animals; Blood Urea Nitrogen; Cysteine; Cytosol; DNA; Enzymes; Glutathione; Kidney; Kidney Tubular Necrosis, Acute; Male; Mercuric Chloride; Mice; Oxidation-Reduction; Proliferating Cell Nuclear Antigen; S Phase; Survival; Thymidine; Urodynamics | 2003 |
Protein kinase C-alpha inhibits the repair of oxidative phosphorylation after S-(1,2-dichlorovinyl)-L-cysteine injury in renal cells.
Topics: Animals; Cysteine; Female; Isoenzymes; Kidney Tubules, Proximal; Membrane Potentials; Mitochondria; Oxidation-Reduction; Oxygen Consumption; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Proton-Translocating ATPases; Rabbits | 2004 |
Molecular mechanisms of enhanced renal cell division in protection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death.
Topics: Acute Kidney Injury; Animals; Cysteine; DNA Replication; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; G1 Phase; Kidney; Male; Mice; S Phase | 2005 |
Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis.
Topics: Animals; Apoptosis; Cell Adhesion; Cysteine; Electrophoretic Mobility Shift Assay; Epithelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Heat-Shock Proteins; JNK Mitogen-Activated Protein Kinases; Kidney; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proteomics; Swine | 2005 |
Molecular markers of trichloroethylene-induced toxicity in human kidney cells.
Topics: Apoptosis; Biomarkers; Cell Proliferation; Cells, Cultured; Cysteine; Humans; Kidney Tubules, Proximal; Necrosis; Signal Transduction; Trichloroethylene | 2005 |
Role of cell adhesion signal molecules in hepatocellular carcinoma cell apoptosis.
Topics: Apoptosis; beta Catenin; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Line, Tumor; Cysteine; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Liver Neoplasms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Trans-Activators | 2005 |
Diabetic mice are protected from normally lethal nephrotoxicity of S-1,2-dichlorovinyl-L-cysteine (DCVC): role of nephrogenic tissue repair.
Topics: Animals; Area Under Curve; Blood Urea Nitrogen; Bromodeoxyuridine; Cell Nucleus; Colchicine; Creatinine; Cysteine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Drug; Half-Life; Immunohistochemistry; Injections, Intraperitoneal; Kidney Tubules, Proximal; Lyases; Male; Mice; Proliferating Cell Nuclear Antigen; Regeneration; S Phase; Streptozocin; Thymidine; Tritium | 2006 |
Colchicine antimitosis causes progression of S-(1,2-dichlorovinyl)-L-cysteine-induced injury leading to acute renal failure and death in mice.
Topics: Acute Kidney Injury; Animals; Antimitotic Agents; Calpain; Colchicine; Cysteine; Kidney; Male; Mice; Urinalysis | 2006 |
Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Renal Cell; Cell Proliferation; Cell Transformation, Neoplastic; Cysteine; DNA; DNA Mutational Analysis; Gene Expression Regulation, Neoplastic; Kidney; Kidney Cortex; Kidney Diseases; Kidney Neoplasms; Loss of Heterozygosity; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction; Solvents; Trichloroethylene | 2006 |
Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene.
Topics: Adenosine Kinase; Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Cell Survival; Complement Factor H; Cysteine; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Gene Expression; Gene Expression Profiling; Glucose; Glutathione; Humans; In Vitro Techniques; Isoenzymes; Kidney Tubules, Proximal; Kruppel-Like Transcription Factors; Lyases; Male; Middle Aged; RNA, Messenger; Transcription Factors; Trichloroethylene | 2006 |
Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells.
Topics: Adenosine Triphosphate; Adenoviridae; Animals; Cell Death; Cells, Cultured; Cysteine; DNA, Complementary; Female; Fluorescent Dyes; Immunoblotting; Immunohistochemistry; Indoles; Kidney Diseases; Kidney Tubules; L-Lactate Dehydrogenase; Mitochondria; Necrosis; Oncogene Protein v-akt; Oxygen Consumption; Proto-Oncogene Proteins c-akt; Rabbits; Transfection | 2007 |
Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells.
Topics: Actin-Related Protein 2; Animals; Apoptosis; Cell Communication; Cells, Cultured; Cysteine; Kidney Tubules, Proximal; Male; Phosphorylation; Protein-Tyrosine Kinases; Proteomics; Rats; Rats, Wistar; Tyrosine | 2007 |
Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: effects on apoptosis, necrosis, and glutathione status.
Topics: Adaptation, Physiological; Animals; Apoptosis; Cells, Cultured; Cysteine; Drug Administration Schedule; Drug Interactions; Environmental Pollutants; Glutathione; Glutathione Transferase; Humans; Kidney Tubules, Proximal; Male; Mercury; Necrosis; Rats; Rats, Inbred F344; Time Factors; Trichloroethylene | 2007 |
Proteomics of S-(1, 2-dichlorovinyl)-L-cysteine-induced acute renal failure and autoprotection in mice.
Topics: Acute Kidney Injury; Animals; Apoptosis Regulatory Proteins; Carrier Proteins; Coenzyme A Ligases; Creatinine; Cysteine; Dose-Response Relationship, Drug; Down-Regulation; Fatty Acid Transport Proteins; Free Radical Scavengers; Heat-Shock Proteins; Hemopexin; HSP70 Heat-Shock Proteins; Kidney; Male; Membrane Proteins; Mice; Proteomics | 2007 |
Formation of three N-acetyl-L-cysteine monoadducts and one diadduct by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with N-acetyl-L-cysteine at physiological conditions: chemical mechanisms and toxicological implications.
Topics: Acetylcysteine; Cross-Linking Reagents; Cysteine; Free Radical Scavengers; Kidney; Kidney Diseases; Sulfoxides | 2007 |
Assessment of the genotoxicity of trichloroethylene and its metabolite, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), in the comet assay in rat kidney.
Topics: Animals; Cells, Cultured; Comet Assay; Cysteine; DNA; DNA Damage; Dose-Response Relationship, Drug; Kidney Tubules, Proximal; Male; Mutagens; Rats; Rats, Sprague-Dawley; Solvents; Trichloroethylene | 2008 |
Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Chromones; Cysteine; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex III; Electron Transport Complex IV; Environmental Pollutants; Enzyme Inhibitors; Kidney Diseases; Kidney Tubules, Proximal; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Morpholines; Oligomycins; Oxidative Phosphorylation; Oxygen Consumption; Phosphorylation; Proto-Oncogene Proteins c-akt; Proton-Translocating ATPases; Rabbits; Transfection | 2008 |
Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
Topics: Apoptosis; Caspases; Cell Death; Cell Proliferation; Cell Respiration; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Hazardous Substances; Humans; Kidney Tubules, Proximal; Mitochondria; Time Factors | 2008 |
Reduction in rat oocyte fertilizability mediated by S-(1, 2-dichlorovinyl)-L-cysteine: a trichloroethylene metabolite produced by the glutathione conjugation pathway.
Topics: Animals; Biotransformation; Body Weight; Cysteine; Female; Fertilization in Vitro; Glutathione; Immunohistochemistry; In Vitro Techniques; Male; Oocytes; Rats; Rats, Sprague-Dawley; Reproduction; Solvents; Trichloroethylene | 2008 |
Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Administration, Oral; Animals; Biological Availability; Carcinogens; Cysteine; Dichloroacetic Acid; Glutathione; Half-Life; Male; Mice; Models, Biological; Oxidation-Reduction; Risk Assessment; Time Factors; Trichloroacetic Acid; Trichloroethylene | 2009 |
Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Animals; Chromatography, High Pressure Liquid; Cysteine; Dichloroacetic Acid; Glutathione; Male; Mice; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichloroacetic Acid; Trichloroethylene | 2009 |
Cysteine conjugate beta-lyase activity of rat erythrocytes and formation of beta-lyase-derived globin monoadducts and cross-links after in vitro exposure of erythrocytes to S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Amino Acid Sequence; Animals; Benzothiazoles; Carbon-Sulfur Lyases; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Cysteine; Erythrocytes; Hemoglobins; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Trypsin | 2009 |
Globin monoadducts and cross-links provide evidence for the presence of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, chlorothioketene, and 2-chlorothionoacetyl chloride in the circulation in rats administered S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Cysteine; Erythrocytes; Globins; Male; Molecular Sequence Data; Peptides; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Thiones; Trichloroethylene; Trypsin | 2009 |
Altered Hippo signalling in polycystic kidney disease.
Topics: Animals; Cell Nucleus; Cysteine; Disease Models, Animal; Disease Progression; Epithelial Cells; Humans; Kidney; Kidney Tubules; Mice; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Polycystic Kidney, Autosomal Recessive; Proto-Oncogene Proteins c-yes; Regeneration; Signal Transduction; Transcriptional Activation; TRPP Cation Channels; Up-Regulation | 2011 |
N-biotinyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide as a potential model for S-(1,2-dichlorovinyl)-L-cysteine sulfoxide: characterization of stability and reactivity with glutathione and kidney proteins in vitro.
Topics: Animals; Binding Sites; Binding, Competitive; Biotin; Biotinylation; Blotting, Western; Cysteine; Dose-Response Relationship, Drug; Drug Stability; Electrophoresis, Polyacrylamide Gel; Glutathione Reductase; Half-Life; Humans; Indicators and Reagents; Kidney; Kidney Neoplasms; Malate Dehydrogenase; Protein Binding; Rats, Sprague-Dawley | 2011 |
Nephrotoxic effect of subchronic exposure to S-(1,2-dichlorovinyl)-L-cysteine in mice.
Topics: Animals; Blood Urea Nitrogen; Cyclooxygenase 2; Cysteine; Fibrosis; Interleukin-6; Kidney; Male; Mice; Mice, Inbred BALB C; Necrosis; Organ Size; RNA, Messenger; Tumor Necrosis Factor-alpha | 2012 |
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.
Topics: Administration, Oral; Animals; Carcinogens; Cell Proliferation; Cysteine; Cytochrome P-450 Enzyme System; Dichloroacetic Acid; Dose-Response Relationship, Drug; Ethylene Chlorohydrin; Gene Expression; Glutathione; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Oxidation-Reduction; Oxidative Stress; Real-Time Polymerase Chain Reaction; Solvents; Trichloroacetic Acid; Trichloroethylene | 2015 |
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.
Topics: Animals; Carcinogens; Cell Proliferation; Cysteine; Cytochrome P-450 Enzyme System; Dichloroacetic Acid; Ethylene Chlorohydrin; Glutathione; Hepatitis A Virus Cellular Receptor 1; Kidney; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Oxidation-Reduction; PPAR alpha; Trichloroacetic Acid; Trichloroethylene | 2015 |
The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro.
Topics: Chorion; Cysteine; Decidua; Disease Resistance; Extraembryonic Membranes; Female; Humans; Immunity; Lipopolysaccharides; Pregnancy; Streptococcal Infections; Streptococcus agalactiae; Teichoic Acids; Tissue Culture Techniques; Trichloroacetic Acid; Trichloroethylene; Tumor Necrosis Factor-alpha | 2015 |
Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine.
Topics: Cell Line, Transformed; Cysteine; Female; Humans; Interleukin-6; Membrane Potential, Mitochondrial; Oxidative Stress; Placenta; Pregnancy; Reactive Oxygen Species; Trichloroethylene; Trophoblasts | 2016 |
Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line.
Topics: Apoptosis; Caspase 3; Caspase 7; Cell Cycle Proteins; Cells, Cultured; Cysteine; Female; Humans; Lipid Peroxidation; NF-kappa B p50 Subunit; Nuclear Proteins; Placenta; Pregnancy; Pregnancy Trimester, First; Reactive Oxygen Species | 2018 |
Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.
Topics: Acetylcysteine; Animals; Cysteine; Glutathione; Liver; Male; Mice; Mice, Inbred Strains; Signal-To-Noise Ratio; Tissue Distribution; Trichloroethylene | 2018 |
Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury.
Topics: Acute Kidney Injury; Animals; Cysteine; Disease Models, Animal; Disease Progression; Fibrosis; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Failure, Chronic; Male; Mice, Knockout; Mutation; Polycystic Kidney, Autosomal Dominant; Time Factors; TRPP Cation Channels; Wnt Signaling Pathway | 2019 |
The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces progressive mitochondrial dysfunction in HTR-8/SVneo trophoblasts.
Topics: Cell Line; Cysteine; DNA, Mitochondrial; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxygen Consumption; Trichloroethylene; Trophoblasts | 2019 |
Characterisation of transcription factor profiles in polycystic kidney disease (PKD): identification and validation of STAT3 and RUNX1 in the injury/repair response and PKD progression.
Topics: Animals; Chromatin Immunoprecipitation; Core Binding Factor Alpha 2 Subunit; Cysteine; Disease Models, Animal; Disease Progression; Epithelial Cells; Gene Expression Regulation; Humans; Kidney; Male; Mice; Mice, Transgenic; Polycystic Kidney, Autosomal Dominant; Promoter Regions, Genetic; Protein Binding; STAT3 Transcription Factor; Transcription Factors; TRPP Cation Channels | 2019 |
Exposure to Trichloroethylene Metabolite
Topics: Amino Acids; AMP-Activated Protein Kinases; Cell Line; Cell Survival; Cysteine; Energy Metabolism; Glucose; Glycerol; Humans; Lipid Metabolism; Nutrients; Phosphofructokinase-1; Solvents; Trichloroethylene | 2020 |
Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models.
Topics: Cysteine; Glutathione; Humans; Induced Pluripotent Stem Cells; NF-E2-Related Factor 2; Phenotype; Transcriptome; Trichloroethylene | 2023 |