Page last updated: 2024-09-03

s(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid and l 663536

s(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid has been researched along with l 663536 in 4 studies

Compound Research Comparison

Studies
(s(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid)
Trials
(s(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid)
Recent Studies (post-2010)
(s(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid)
Studies
(l 663536)
Trials
(l 663536)
Recent Studies (post-2010) (l 663536)
14004854138

Protein Interaction Comparison

ProteinTaxonomys(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid (IC50)l 663536 (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.023
Prostaglandin E synthaseHomo sapiens (human)2.2274
Prostaglandin G/H synthase 1Ovis aries (sheep)8
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)0.57
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.023
Arachidonate 5-lipoxygenase-activating proteinHomo sapiens (human)0.025
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.023
Prostaglandin G/H synthase 2Homo sapiens (human)2.4
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.023
Leukotriene C4 synthaseHomo sapiens (human)3
Macrophage-expressed gene 1 proteinHomo sapiens (human)2.2
GABA theta subunitRattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.023
Prostaglandin E synthase 2Homo sapiens (human)1.6

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Howell, RE; Jenkins, LP; Rubin, EB; Sickels, BD; Weichman, BM; Woeppel, SL1
Berkenkopf, JW; Carlson, RP; Grimes, D; Kreft, AF; Marinari, LR; Musser, JH; Sturm, RJ; Weichman, BM1
Berkenkopf, JW; Grimes, D; Heaslip, RJ; Ilsemann, BA; Sickels, BD; Weichman, BM1
Carlson, R; Glaser, K; Hartman, D; Kreft, A; Lock, Y; Tomchek, L; Weichman, B1

Other Studies

4 other study(ies) available for s(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid and l 663536

ArticleYear
Leukotrienes mediate antigen-induced airway hyper-reactivity in guinea pigs.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:1

    Topics: Acetophenones; Animals; Antigens; Bronchoconstriction; Eosinophilia; Guinea Pigs; Hydroxyurea; Indoles; Leukotriene D4; Leukotrienes; Lipoxygenase Inhibitors; Male; Naphthaleneacetic Acids; Quinolines; Tetrazoles

1994
WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity.
    European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2

    Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asthma; Female; Guinea Pigs; Humans; Hydroxyurea; Indoles; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Naphthaleneacetic Acids; Prostaglandin-Endoperoxide Synthases; Quinolines; Rabbits; Rats; Rats, Wistar

1993
Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues.
    European journal of pharmacology, 1993, Apr-06, Volume: 234, Issue:2-3

    Topics: Acetophenones; Animals; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung; Male; Muscle Contraction; Muscle, Smooth; Naphthaleneacetic Acids; Quinolines; SRS-A; Tetrazoles; Trachea

1993
WY-50295 tromethamine: a 5-lipoxygenase inhibitor without activity in human whole blood.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 60, Issue:1

    Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Eicosanoids; Guinea Pigs; Humans; Hydroxyurea; Indoles; Leukocytes; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Naphthaleneacetic Acids; Neutrophils; Quinolines; Rats; Serum Albumin

1999